Biomedicine & Pharmacotherapy

β-adrenergic activation may promote myosin light chain kinase degradation through calpain in pressure overload-induced cardiac hypertrophy: β-adrenergic activation results in MLCK degradation

Publication date: September 2020Source: Biomedicine & Pharmacotherapy, Volume 129Author(s): Shun Wang, Haixiong Wang, Xiaoling Su, Beilei Liu, Le Wang, Hui Yan, Shuai Mao, He Huang, Congxin Huang, Mian Cheng, Gang Wu

Biomedicine & Pharmacotherapy

Sun Jul 05, 2020 19:44

Huoxuezhitong capsule ameliorates MIA-induced osteoarthritis of rats through suppressing PI3K/ Akt/ NF-κB pathway

Publication date: September 2020Source: Biomedicine & Pharmacotherapy, Volume 129Author(s): Linjie Ju, Peipei Hu, Ping Chen, Xue Xue, Zhuoqun Li, Feiyan He, Zhixia Qiu, Jun Cheng, Fang Huang

Biomedicine & Pharmacotherapy

Sun Jul 05, 2020 19:44

Low dose HSP90 inhibition with AUY922 blunts rapid evolution of metastatic and drug resistant phenotypes induced by TGF-β and paclitaxel in A549 cells

Publication date: September 2020Source: Biomedicine & Pharmacotherapy, Volume 129Author(s): Nickolas A. Bacon, Isabel Larre, Abdalla A. Lawag, Carlen Merritt, Mackinzie Smith, Matthew Rosolen, Vincent E. Sollars

Biomedicine & Pharmacotherapy

Sun Jul 05, 2020 19:44

Curcumin may reverse 5-fluorouracil resistance on colonic cancer cells by regulating TET1-NKD-Wnt signal pathway to inhibit the EMT progress

Publication date: September 2020Source: Biomedicine & Pharmacotherapy, Volume 129Author(s): Yi Lu, Runzhe Zhang, Xinjie Zhang, Bo Zhang, Qinghua Yao

Biomedicine & Pharmacotherapy

Sun Jul 05, 2020 19:44

Qiangji Jianli Decoction promotes mitochondrial biogenesis in skeletal muscle of myasthenia gravis rats via AMPK/PGC-1α signaling pathway

Publication date: September 2020Source: Biomedicine & Pharmacotherapy, Volume 129Author(s): Wei Jiao, Fangyu Hu, Jinqiu Li, Jingwei Song, Jian Liang, Lanqi Li, Yafang Song, Zhiwei Chen, Qing Li, Lingling Ke

Biomedicine & Pharmacotherapy

Sun Jul 05, 2020 19:44

Antioxidant, anti-inflammatory and anti-apoptotic effects of hydro-ethanolic extract of <em>Cyperus esculentus</em> L. (tigernut) on lead acetate-induced testicular dysfunction in Wistar rats

Publication date: September 2020Source: Biomedicine & Pharmacotherapy, Volume 129Author(s): Augustine Lishilinimye Udefa, Ernest Atelhe Amama, Efiok Aniekan Archibong, Justina Nwandimma Nwangwa, Sebastian Adama, Vincent Ukam Inyang, Gladys Unye-uti Inyaka, Glory Jean Aju, Sunday Okpa, Inah Onete Inah

Biomedicine & Pharmacotherapy

Sat Jul 04, 2020 17:39

<em>Ziziphora clinopodioides</em> flavonoids based on network pharmacology attenuates atherosclerosis in rats induced by high-fat emulsion combined with vitamin D₃ by down-regulating VEGF/AKT/NF-κB signaling pathway

Publication date: September 2020Source: Biomedicine & Pharmacotherapy, Volume 129Author(s): Yuche Wu, Yanming Wang, Xiao Liu, Lin Jiang, Aman Guli, Jalehasibike Sailike, Xin Sun, Nigare Abuduwaili, Hapula Tuoliuhan, Kulxax Maney, Xinhua Nabi

Biomedicine & Pharmacotherapy

Sat Jul 04, 2020 17:39

Oligosaccharides composition of <em>Descurainiae sophia</em> exerts anti-heart failure by improving heart function and water-liquid metabolism in rats with heart failure

Publication date: September 2020Source: Biomedicine & Pharmacotherapy, Volume 129Author(s): Yingying Ke, Mengmeng Wang, Yage Li, Zengfu Shan, Wangyang Mi, Peipei Yuan, Weisheng Feng, Xiaoke Zheng

Biomedicine & Pharmacotherapy

Sat Jul 04, 2020 17:39

A review: Natural polysaccharides from medicinal plants and microorganisms and their anti-herpetic mechanism

Publication date: September 2020Source: Biomedicine & Pharmacotherapy, Volume 129Author(s): Zi-hao Liu, Feng-ju Niu, Ya-xin Xie, Shi-min Xie, Ying-nan Liu, Ying-ying Yang, Chang-zheng Zhou, Xin-huan Wan

Biomedicine & Pharmacotherapy

Sat Jul 04, 2020 17:39

The role of P2X4 receptors in chronic pain: A potential pharmacological target

Publication date: September 2020Source: Biomedicine & Pharmacotherapy, Volume 129Author(s): Wen-jun Zhang, Hong-liang Luo, Zheng-ming Zhu

Biomedicine & Pharmacotherapy

Sat Jul 04, 2020 17:39

Circular RNA YAP1 attenuates osteoporosis through up-regulation of YAP1 and activation of Wnt/β-catenin pathway

Publication date: September 2020Source: Biomedicine & Pharmacotherapy, Volume 129Author(s): Yongxiong Huang, Dan Xiao, Shuaihao Huang, Jianxiong Zhuang, Xiaoqing Zheng, Yunbing Chang, Dong Yin

Biomedicine & Pharmacotherapy

Fri Jul 03, 2020 16:00

Serum proteomics analysis of candidate predictive biomarker panel for the diagnosis of trastuzumab-based therapy resistant breast cancer

Publication date: September 2020Source: Biomedicine & Pharmacotherapy, Volume 129Author(s): Ting Yang, Ziyi Fu, Yin Zhang, Min Wang, Changfei Mao, Weihong Ge

Biomedicine & Pharmacotherapy

Fri Jul 03, 2020 16:00

FGF21 attenuates neurodegeneration through modulating neuroinflammation and oxidant-stress

Publication date: September 2020Source: Biomedicine & Pharmacotherapy, Volume 129Author(s): Kai Kang, Pengfei Xu, Mengxia Wang, Jian Chunyu, Xu Sun, Guiping Ren, Wei Xiao, Deshan Li

Biomedicine & Pharmacotherapy

Fri Jul 03, 2020 16:00

Umbelliferone (7-hydroxycoumarin): A non-toxic antidiarrheal and antiulcerogenic coumarin

Publication date: September 2020Source: Biomedicine & Pharmacotherapy, Volume 129Author(s): Luisa Ferreira Cruz, Geisa Fantini de Figueiredo, Lidiane Paula Pedro, Yuri Martins Amorin, Jessica Tauany Andrade, Tiago Faustino Passos, Felipe Fernandes Rodrigues, Israel Lucas Antunes Souza, Thaís Paula Rodrigues Gonçalves, Luciana Alves Rodrigues dos Santos Lima, Jaqueline Maria Siqueira Ferreira, Marcelo Gonzaga de Freitas Araújo

Biomedicine & Pharmacotherapy

Fri Jul 03, 2020 16:00

Oxidative stress and inflammation in osteoarthritis pathogenesis: Role of polyphenols

Publication date: September 2020Source: Biomedicine & Pharmacotherapy, Volume 129Author(s): Mohammad Yunus Ansari, Nashrah Ahmad, Tariq M Haqqi

Biomedicine & Pharmacotherapy

Fri Jul 03, 2020 16:00

Noncoding RNAs in peritoneal fibrosis: Background, Mechanism, and Therapeutic Approach

Publication date: September 2020Source: Biomedicine & Pharmacotherapy, Volume 129Author(s): Yanhong Guo, Liuwei Wang, Rong Gou, Lin Tang, Peipei Liu

Biomedicine & Pharmacotherapy

Fri Jul 03, 2020 16:00

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 Brachytherapy

A semiautomatic segmentation method for interstitial needles in intraoperative 3D transvaginal ultrasound images for high-dose-rate gynecologic brachytherapy of vaginal tumors

Publication date: Available online 3 July 2020Source: BrachytherapyAuthor(s): Jessica Robin Rodgers, William Thomas Hrinivich, Kathleen Surry, Vikram Velker, David D'Souza, Aaron Fenster

Brachytherapy

Sat Jul 04, 2020 15:40

Overall survival comparison between androgen deprivation therapy (ADT) plus external beam radiation therapy (EBRT) vs ADT plus EBRT with brachytherapy boost in clinically node-positive prostate cancer

Publication date: Available online 3 July 2020Source: BrachytherapyAuthor(s): Benjamin W. Fischer-Valuck, Yuan James Rao, Randall J. Brenneman, Pretesh R. Patel, Christopher P. Filson, Ashesh B. Jani, Yuan Liu, Subir Goyal, Karen Xu, Aaron Weiss, Omer Kucuk, Cara Cimmino, Stephen Szabo, Peter Rossi, Brian C. Baumann, John Pattaras, Bruce Hershatter, Sagar A. Patel

Brachytherapy

Fri Jul 03, 2020 18:56

Techniques for and uncertainties of MRI-based reconstruction of titanium tandem and ring brachytherapy applicators

Publication date: Available online 3 July 2020Source: BrachytherapyAuthor(s): Irina Malajovich, Shibu Anamalayil, Otilia Valentina Dolney, Boon-Keng Kevin Teo, William Tristram Arscott, Neil K. Taunk

Brachytherapy

Fri Jul 03, 2020 18:56

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 Clinical Therapeutics

Population Pharmacokinetics of Erlotinib in Patients With Non–small Cell Lung Cancer: Its Application for Individualized Dosing Regimens in Older Patients

Publication date: Available online 4 July 2020Source: Clinical TherapeuticsAuthor(s): Evelina Cardoso, Monia Guidi, Nihel Khoudour, Pascaline Boudou-Rouquette, Elizabeth Fabre, Camille Tlemsani, Jennifer Arrondeau, François Goldwasser, Michel Vidal, Marie Paule Schneider, Anna Dorothea Wagner, Nicolas Widmer, Benoit Blanchet, Chantal Csajka

Clinical Therapeutics

Sat Jul 04, 2020 14:50

Review of Transcranial Magnetic Stimulation in Epilepsy

Publication date: Available online 3 July 2020Source: Clinical TherapeuticsAuthor(s): Melissa Tsuboyama, Harper L. Kaye, Alexander Rotenberg

Clinical Therapeutics

Fri Jul 03, 2020 22:40

Comparison of Therapies for Secondary Prophylaxis of Esophageal Variceal Bleeding in Cirrhosis: a Network Meta-analysis of Randomized Controlled Trials

Publication date: Available online 2 July 2020Source: Clinical TherapeuticsAuthor(s): Zhiwei Miao, Jun Lu, Jing Yan, Lidan Lu, Bai Ye, Mingjia Gu

Clinical Therapeutics

Fri Jul 03, 2020 22:40

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 Latest Results for Investigational New Drugs

Extrahepatic metabolism of ibrutinib

Summary Ibrutinib is a first-in-class Bruton’s kinase inhibitor used in the treatment of multiple lymphomas. In addition to CYP3A4-mediated metabolism, glutathione conjugation can be observed. Subsequently, metabolism of the conjugates and finally their excretion in feces and urine occurs. These metabolites, however, can reach substantial concentrations in human subjects, especially when CYP3A4 is inhibited. Ibrutinib has unexplained nephrotoxicity and high metabolite concentrations...

Latest Results for Investigational New Drugs

Sat Jul 04, 2020 03:00

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 Radiotherapy and Oncology

A deep learning MR-based radiomic nomogram may predict survival for nasopharyngeal carcinoma patients with stage T3N1M0

Publication date: Available online 4 July 2020Source: Radiotherapy and OncologyAuthor(s): Lian-Zhen Zhong, Xue-Liang Fang, Di Dong, Hao Peng, Meng-Jie Fang, Cheng-Long Huang, Bing-Xi He, Li Lin, Jun Ma, Ling-Long Tang, Jie Tian

Radiotherapy and Oncology

Sun Jul 05, 2020 15:12

Prostate intrafraction motion during the preparation and delivery of MR-guided radiotherapy sessions on a 1.5T MR-Linac

Publication date: Available online 3 July 2020Source: Radiotherapy and OncologyAuthor(s): D.M. de Muinck Keizer, L.G.W. Kerkmeijer, T. Willigenburg, A.L.H.M.W. van Lier, M.D. den Hartogh, J.R.N. van der Voort van Zyp, E.N. de Groot-van Breugel, B.W. Raaymakers, J.J.W. Lagendijk, J.C.J. de Boer

Radiotherapy and Oncology

Fri Jul 03, 2020 19:04

4D CT analysis of organs at risk (OARs) in stereotactic radiotherapy

Publication date: Available online 3 July 2020Source: Radiotherapy and OncologyAuthor(s): Valerio Nardone, Francesca Maria Giugliano, Alfonso Reginelli, Angelo Sangiovanni, Maria Mormile, Luciano Iadanza, Salvatore Cappabianca, Cesare Guida

Radiotherapy and Oncology

Fri Jul 03, 2020 19:04

Involved node radiation therapy in the combined modality treatment for early-stage Hodgkin lymphoma: Analysis of relapse location and long-term outcome

Publication date: Available online 3 July 2020Source: Radiotherapy and OncologyAuthor(s): Karin Nielsen, Maja Vestmoe Maraldo, Anne Kiil Berthelsen, Annika Loft, Peter de Nully Brown, Ivan Richter Vogelius, Peter Meidahl Petersen, Lena Specht

Radiotherapy and Oncology

Fri Jul 03, 2020 19:04

Measurement of circulating free DNA in squamous cell carcinoma of the anus and relation to risk factors and recurrence

Publication date: Available online 3 July 2020Source: Radiotherapy and OncologyAuthor(s): Anna Cecilie Lefèvre, Camilla Kronborg, Brita Singers Sørensen, Søren Rasmus Palmelund Krag, Eva Serup-Hansen, Karen-Lise Garm Spindler

Radiotherapy and Oncology

Fri Jul 03, 2020 19:04

Magnetic resonance-based synthetic computed tomography images generated using generative adversarial networks for nasopharyngeal carcinoma radiotherapy treatment planning

Publication date: Available online 3 July 2020Source: Radiotherapy and OncologyAuthor(s): Yinglin Peng, Shupeng Chen, An Qin, Meining Chen, Xingwang Gao, Yimei Liu, Jingjing Miao, Huikuan Gu, Chong Zhao, Xiaowu Deng, Zhenyu Qi

Radiotherapy and Oncology

Fri Jul 03, 2020 19:04

Impact of Invasive Nodal Staging on Regional and Distant Recurrence Rates after SBRT for Inoperable Stage I NSCLC

Publication date: Available online 3 July 2020Source: Radiotherapy and OncologyAuthor(s): William R Kennedy, Pamela P Samson, Prashant Gabani, John Nikitas, Jeffrey D Bradley, Michael C Roach, Clifford G Robinson

Radiotherapy and Oncology

Fri Jul 03, 2020 19:04

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 ScienceDirect Publication: International Immunopharmacology

Cytotoxicity of Saikosaponin A targets HEKa cell through apoptosis induction by ROS accumulation and inflammation suppression via NF-κB pathway

Publication date: September 2020Source: International Immunopharmacology, Volume 86Author(s): Meng Liu, Guanfei Zhang, Saima Naqvi, Fan Zhang, Tong Kang, Qiqi Duan, Ziyang Wang, Shengxiang Xiao, Yan Zheng

ScienceDirect Publication: International Immunopharmacology

Sun Jul 05, 2020 19:00

Canine immunoglobulin F(ab′)₂ fragments protect cats against feline parvovirus virus infection

Publication date: September 2020Source: International Immunopharmacology, Volume 86Author(s): Zhihua Pei, Mingjie Sun, Xuezhu Zhang, Yan Yan, Fanru Meng, Ruo Mo, Haijun Wang, Junzheng Wang, Kai Wang, Guixue Hu

ScienceDirect Publication: International Immunopharmacology

Sun Jul 05, 2020 19:00

Protective role of microRNA-27a upregulation and HSP90 silencing against cerebral ischemia-reperfusion injury in rats by activating PI3K/AKT/mTOR signaling pathway

Publication date: September 2020Source: International Immunopharmacology, Volume 86Author(s): Ensheng Zhang, Qian Chen, Jing Wang, Dong Li, Zhenxia Wan, Xiuli Ju

ScienceDirect Publication: International Immunopharmacology

Sun Jul 05, 2020 19:00

Damage-associated molecular patterns in tumor radiotherapy

Publication date: September 2020Source: International Immunopharmacology, Volume 86Author(s): Milad Ashrafizadeh, Bagher Farhood, Ahmed Eleojo Musa, Shahram Taeb, Masoud Najafi

ScienceDirect Publication: International Immunopharmacology

Sat Jul 04, 2020 21:56

Comprehensive analyses of the heterogeneity and prognostic significance of tumor-infiltrating immune cells in non-small-cell lung cancer: Development and validation of an individualized prognostic model

Publication date: September 2020Source: International Immunopharmacology, Volume 86Author(s): Zhaofei Pang, Xiaowei Chen, Yu Wang, Yadong Wang, Tao Yan, Jun Wan, Jiajun Du

ScienceDirect Publication: International Immunopharmacology

Fri Jul 03, 2020 18:06

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 ScienceDirect Publication: Photodiagnosis and Photodynamic Therapy

Visible Light Plasmon Excitation of Silver Nanoparticles Against Antibiotic-Resistant <em>Pseudomonas aeruginosa</em>

Publication date: Available online 5 July 2020Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Rafael T.P. da Silva, Marcos V. Petri, Estela Y. Valencia, Pedro H.C. Camargo, Susana I.C. de Torresi, Beny Spira

ScienceDirect Publication: Photodiagnosis and Photodynamic Therapy

Sun Jul 05, 2020 17:05

Effectiveness of mechanical debridement with and without adjunct antimicrobial photodynamic for treating peri-implant mucositis among prediabetic cigarette-smokers and non-smokers

Publication date: Available online 4 July 2020Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Ahmed Saleh Saeed Al Hafez, Navin Ingle, Alathra Abdullah alshayeb, Hamed Mohammad Tashery, Abdulrahman Abdullah Mohammad Alqarni, Salma Hamed Alshamrani

ScienceDirect Publication: Photodiagnosis and Photodynamic Therapy

Sun Jul 05, 2020 17:05

Modified photodynamic therapy to minimize pain in the treatment of condylomata acuminata: a prospective, randomized, self-controlled study

Publication date: Available online 4 July 2020Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Haiyan Zhang, Lei Shi, Yunfeng Zhang, Peiru Wang, Guolong Zhang, Yajing Cao, Zhongxia Zhou, Xiuli Wang

ScienceDirect Publication: Photodiagnosis and Photodynamic Therapy

Sun Jul 05, 2020 17:05

Ultraviolet-based Biophotonic Technologies and COVID-19

Publication date: Available online 3 July 2020Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Viroj Wiwanitkit

ScienceDirect Publication: Photodiagnosis and Photodynamic Therapy

Sat Jul 04, 2020 21:08

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Antimicrobial photodynamic therapy reduces gene expression of <em>Candida albicans</em> in biofilms

Publication date: September 2020Source: Photodiagnosis and Photodynamic Therapy, Volume 31Author(s): Cláudia Carolina Jordão, Tábata Viana de Sousa, Marlise Inêz Klein, Luana Mendonça Dias, Ana Cláudia Pavarina, Juliana Cabrini Carmello

ScienceDirect Publication: Photodiagnosis and Photodynamic Therapy

Fri Jul 03, 2020 17:28

Tissue Characterization Utilizing Hyperspectral Imaging for Liver Thermal Ablation

Publication date: Available online 2 July 2020Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Mohamed Hisham Aref, Ibrahim H. Aboughaleb, Yasser H. El-Sharkawy

ScienceDirect Publication: Photodiagnosis and Photodynamic Therapy

Fri Jul 03, 2020 17:28

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