Abstract Quorum sensing in bacteria is a cell density-dependent phenomenon in which, a community of cells communicate with each other using signalling molecules belonging to various families of which N-acyl homoserine lactone (AHL) is one. AHL acts via ligand–receptor interaction where receptors of AHL differ from species to species, and possess great degree of similarity in conformation at the active site. A macromolecule, LasR, is a receptor protein that binds to N-(3-oxododecanoyl)-l-homoserinelactone...
Sat Jul 04, 2020 08:33
Abstract Bradysia difformis is one of the most damaging pests in mushroom production in China. In this study, eight Bacillus thuringiensis strains were analyzed for insecticidal activity in B. difformis. The strain JW-1 showed the highest insecticidal activity against B. difformis larvae, but did not inhibit the mycelial growth of Pleurotus ostreatus and P. geesteranus. The 16S rRNA gene (1397 bp) and cyt2 gene (792 bp) were obtained from strain JW-1. The phylogenetic tree based...
Fri Jul 03, 2020 03:00
Abstract The gut microbiota is crucial in the pathogenesis of type 2 diabetes mellitus (T2DM). However, the metabolism of T2DM patients is not well-understood. We aimed to identify the differences on composition and function of gut microbiota between T2DM patients with obesity and healthy people. In this study, 6 T2DM patients with obesity and 6 healthy volunteers were recruited, and metagenomic approach and bioinformatics analysis methods were used to understand the composition...
Sat Jul 04, 2020 03:00
Abstract Root colonization of beneficial rhizobacteria is critical for their beneficial effects. Quorum sensing (QS) has been reported to affect the colonization of many plant pathogens. However, how QS signals regulate root colonization of beneficial rhizobacteria is unclear. In this study, the QS signal AI-2 synthetase-encoding gene luxS was completely deleted from the genome of the plant beneficial rhizobacterium Bacillus velezensis SQR9, and bioluminescence...
Sat Jul 04, 2020 03:00
Abstract Intertidal red algae Hypnea valentiae associated Bacillus amyloliquefaciens MTCC 12716 revealed potential inhibitory effects on the growth of drug-resistant pathogens. In the genome of B. amyloliquefaciens MTCC 12716, biosynthetic gene clusters encoding antibacterial metabolites were predicted, which might be expressed and contributed to the broad-spectrum anti-infective activity. Three homologue members of the 24-membered macrocyclic lactone...
Fri Jul 03, 2020 03:00
Abstract Neural tube defects (NTD) are among the most common congenital anomalies, affecting about 1:1000 births. In most cases, the etiology of NTD is multifactorial and the genetic variants associated with them remain largely unknown. There is extensive evidence from animal models over the past two decades implicating SHROOM3 in neural tube formation; however, its exact role in human disease has remained elusive. In this report, we present the first case of a human fetus with a homozygous...
Fri Jul 03, 2020 18:33
Abstract Megacystis‐Microcolon‐Intestinal‐Hypoperistalsis‐syndrome(MMIHS) is a severe congenital visceral myopathy characterized by an abdominal distension due to a large non‐obstructed urinary bladder, a microcolon and intestinal hypo‐ or aperistalsis. Most of the patients described to date carry a sporadic heterozygous variant in ACTG2 . More recently, recessive forms have been reported and mutations in MYH11 , LMOD1, MYLK and MYL9 have been described at the molecular level. In the...
Fri Jul 03, 2020 18:30
Abstract Ciliopathies are a heterogeneous group of disorders, related to abnormal ciliary function. Severe biliary ciliopathy, caused by bi‐allelic mutations in TTC26 , has been recently described in the context of a syndrome of polydactyly and severe neonatal cholestasis, with brain, kidney and heart involvement. Pituitary involvement has not been previously reported for patients with this condition. Pituitary stalk interruption syndrome (PSIS) is a congenital anomaly of the pituitary...
Thu Jul 02, 2020 21:24
Sulforaphane (SFN) is a kind of natural isothiocyanate, which exists in cruciferous plants. Only few studies were about the anti-inflammatory effects of sulforaphane in ulcerative colitis. In this study, our p...
Fri Jul 03, 2020 03:00
Related Articles [A review of psychophysical olfactory tests in children]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2020 Jun 07;55(6):645-648 Authors: Liu L, Li ZL, Lyu ZG, Zou LQ PMID: 32610413 [PubMed - in process]
Sat Jul 04, 2020 04:18
Related Articles [Advances in the application of molecular testing in preoperative diagnosis of differentiated thyroid cancer]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2020 Jun 07;55(6):641-644 Authors: Ye ZH, Guo MG PMID: 32610412 [PubMed - in process]
Sat Jul 04, 2020 04:18
Related Articles [Application and research progress of 3D printing in otorhinolaryngology and skull base surgery]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2020 Jun 07;55(6):635-640 Authors: Liu Q, Zhang H, Hang W, Liu G PMID: 32610411 [PubMed - in process]
Sat Jul 04, 2020 04:18
Related Articles [Research progress on the predictive factors for the outcomes of adenotonsillectomy in children with obstructive sleep apnea syndrome]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2020 Jun 07;55(6):630-634 Authors: Gao SS, Guo YL, Xu ZF PMID: 32610410 [PubMed - in process]
Sat Jul 04, 2020 04:18
Related Articles [A case of neck abscess caused by Nocardia infection]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2020 Jun 07;55(6):627-629 Authors: Liang JF, He BC, Li M, Nong DX PMID: 32610409 [PubMed - in process]
Sat Jul 04, 2020 04:18
Related Articles [Stapediovestibular dislocation caused by penetrating tympanic membrane injury: a case report]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2020 Jun 07;55(6):623-626 Authors: Fan XL, Zhu DD, Li L, Chen X, Wang YT, Wen XJ, Ma XY, Ding WJ PMID: 32610408 [PubMed - in process]
Sat Jul 04, 2020 04:18
Related Articles [Angiographic embolization treatment of tonsillar artery pseudoaneurysm causing recurrent hemorrhages after tonsillectomy: a case report]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2020 Jun 07;55(6):620-622 Authors: Dong FL, Su LZ, Luo ZY, Jiang XZ PMID: 32610407 [PubMed - in process]
Sat Jul 04, 2020 04:18
Related Articles [Study on the matching feature of current parameters for inducing contraction of orbicularis oris muscle by artificial facial nerve in rabbit with peripheral facial paralysis]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2020 Jun 07;55(6):615-619 Authors: Xu DY, Sun YJ, Zhao NJ, Luo D, Zhao YX, Li KY Abstract Objective: To explore the optimal matching of the current parameters about artificial facial nerve (AFN) for inducing...
Sat Jul 04, 2020 04:18
Related Articles [Clinical study of butterfly cartilage myringoplasty for anterior quadrant tympanic perforation under endoscope]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2020 Jun 07;55(6):611-614 Authors: Li Y, Liu HQ, Sheng Y, Yan J, Xu YL, Liang JM, Wu BJ, Zhang Q, Ren XY Abstract Objective: To evaluate the results of butterfly cartilage myringoplasty for anterior quadrant tympanic perforation under endoscope. Methods: Thirty-eight...
Sat Jul 04, 2020 04:18
Related Articles [Expression and cellular provenance of interleukin 17A in non-eosinophilic chronic rhinosinusitis with nasal polyps]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2020 Jun 07;55(6):604-610 Authors: Chen XH, Chang LH, Huang JC, Li X, Lai XP, Wu XF, Huang ZZ, Wang ZY, Bao HW, Zhang GH Abstract Objective: To investigate the expression and cellular provenance of interleukin 17A (IL-17A) in non-eosinophilic chronic rhinosinusitis...
Sat Jul 04, 2020 04:18
Related Articles [Transnasal endoscopic surgery of choanal atresia after radiotherapy for nasopharyngeal carcinoma]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2020 Jun 07;55(6):599-603 Authors: Zeng L, Ye J, Luo WG, Jiang HQ Abstract Objective: To discuss the effect of endoscopic dilatation and plasty for choanal atresia after radiotherapy for nasopharyngeal carcinoma. Methods: Nineteen patients with choanal atresia who were admitted...
Sat Jul 04, 2020 04:18
Related Articles [Characteristics and prognosis of ear fullness feeling in patients with all-frequency sudden deafness]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2020 Jun 07;55(6):593-598 Authors: Zhou E, Liu B, Tan ZQ, Liu XB, Bu MX, Pei WQ, Cao X, Xiao XP Abstract Objective: The characteristics and prognosis of ear fullness feeling in patients with all-frequency sudden deafness were explored. Method: 104 patients (104 ears) with unilateral...
Sat Jul 04, 2020 04:18
Related Articles [Application of tracheotomy in the treatment of severe cases of COVID-19]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2020 Jun 07;55(6):576-579 Authors: Deng ZF, Zhu T, Ding YJ, Zhou CL, Kang Y, Qu JN, Hua QQ, Xu Y Abstract Objective: To discuss the the effects, indications and protective measures of tracheotomy for severe cases of coronavirus disease 2019 (COVID-19) patients. Methods: A retrospectively analysis was conducted...
Sat Jul 04, 2020 04:18
This article has an online data supplement.
Fri Jul 03, 2020 03:00
A 2-year-old male, with a history significant for congenital cytomegalovirus, failure to thrive, pericardial effusion and chronic pulmonary hypertension of unknown etiology, reactive airway disease, and enteropathy with total parenteral nutrition-dependence, was initially evaluated for recurrent sinopulmonary infections and chronic mucocutaneous candidiasis (CMC). Two colonoscopies revealed pan-gastrointestinal inflammation, with suspicion that his enteropathy was related to an underlying immunodeficiency.
Fri Jul 03, 2020 03:00
Asthma is a heterogeneous disease with emerging phenotypes and endotypes. Currently, five distinct biologics are Food and Drug Administration (FDA)-approved as add-on therapy for difficult-to-control Type 2-high asthma. As allergy specialists manage a spectrum of diseases for which biologics may be appropriate, it is important to understand their prescribing patterns.
Fri Jul 03, 2020 03:00
New Findings What is the central question of this study? To characterize cerebral blood flow (CBF) regulation following a single SCUBA dive to a depth of 18 m sea water with a 47‐minute bottom time. What is the main finding and its importance? Acute alterations in CBF regulation at rest, including; extra‐cranial vasodilation, reductions in shear patterns, and elevations in intra‐cranial blood velocity were observed at rest following a single SCUBA dive. These subtle changes in...
Fri Jul 03, 2020 13:52
Abstract Activation of the nuclear factor (erythroid‐derived 2)‐like 2 (NFE2L2 or NRF2) transcription factor is a critical and evolutionarily conserved cellular response to oxidative stress, metabolic stress, and xenobiotic insult. Deficiency of NRF2 results in hypersensitivity to a variety of stressors, whereas its aberrant activation contributes to several cancer types, most commonly squamous cell carcinomas of the esophagus, oral cavity, bladder, and lung. Between 10 and 35% of patients with...
Fri Jul 03, 2020 16:48
Abstract The histone demethylase KDM4B functions as a key co‐activator for the androgen receptor (AR) and plays a vital in multiple cancers through controlling gene expression by epigenetic regulation of H3K9 methylation marks. Constitutively active androgen receptor confers anti‐androgen resistance in advanced prostate cancer. However, the role of KDM4B in resistance to next generation anti‐androgens, and the mechanisms of KDM4B regulation, are poorly defined. Here we found that KDM4B is overexpressed...
Fri Jul 03, 2020 11:04
Squamous cell carcinoma (SCC) of the parotid gland is a rare aggressive malignancy with a poor prognosis. The clinical behaviour, histopathological characteristics, and treatment strategies for parotid SCC still need to be comprehensively demonstrated. In this study, a retrospective review of patients diagnosed with parotid SCC was performed, covering the past two decades. Twenty-nine patients with primary parotid SCC and 10 patients with recurrent parotid SCC were identified. The clinicopathological...
Fri Jul 03, 2020 03:00
Abstract The EFSA Panel on Plant Health performed a pest categorisation of the species within the Andean Potato Weevil (APW ) complex (Coleoptera: Curculionidae) for the EU . The complex consists of 14 species, 12 belong to the genus Premnotrypes, plus Phyrdenus muriceus and Rhigopsidius tucumanus . These weevils co‐occur in the Andean region, usually above 2,100 m. Eggs are deposited in plant debris close to potato plants. Upon hatching larvae immediately bore into potato tubers where they complete...
Fri Jul 03, 2020 11:04
Abstract The qualified presumption of safety (QPS ) was developed to provide a generic safety evaluation for biological agents to support EFSA 's Scientific Panels. It is based on an assessment of the taxonomic identity, the body of knowledge, safety concerns and antimicrobial resistance. Safety concerns identified for a taxonomic unit (TU ) are where possible to be confirmed at strain or product level, reflected by ‘qualifications’. No new information was found that would change the previously...
Thu Jul 02, 2020 17:19
Caecilians are limbless amphibians that can be easily mistaken for snakes. Though caecilians are only distantly related to their reptilian cousins, researchers describe specialized glands found along the teeth of the ringed caecilian (Siphonops annulatus), which have the same biological origin and possibly similar function to the venom glands of snakes. As such, caecilians may represent the oldest land-dwelling vertebrate animal with oral venom glands.
Fri Jul 03, 2020 21:12
This work addresses an unmet clinical need, that of glaucoma monitoring through intraocular pressure (IOP) interrogation in patients with artificial corneas (keratoprost hesis). We demonstrate direct integration of a low‐drift, fiber‐optic Fabry‐Perot pressure sensor embedded in the keratoprosthesis via rapid, non‐contact micromagnetic fiber alignment. IOP interrogation is achieved by using white‐light interferometry, which provides sub‐mmHg IOP sensitivity. Further details can be found in the...
Thu Jul 02, 2020 21:31
Almost all land plants employ an army of molecular editors who correct errors in their genetic information. Researchers have now transferred one of these proofreaders from the moss Physcomitrium patens (previously known as Physcomitrella patens) into a flowering plant. Surprisingly, it performs its work there as reliably as in the moss itself.
Thu Jul 02, 2020 21:40
Cyanobacteria hardly need any nutrients and use the energy of sunlight. Bathers are familiar with these microorganisms as they often occur in waters. A group of researchers has discovered that the multicellular species Phormidium lacuna can be genetically modified by natural transformation and could thus produce substances such as ethanol or hydrogen.
Thu Jul 02, 2020 18:36
Here, standardized protocols are presented to assess induction of the heat shock response (HSR) in Caenorhabditis elegans using RT-qPCR at the molecular level, fluorescent reporters at the cellular level, and thermorecovery at the organismal level.
Fri Jul 03, 2020 21:42
Publication date: Available online 3 July 2020Source: Allergologia et ImmunopathologiaAuthor(s): Fernando Álvez
Fri Jul 03, 2020 21:15
Publication date: Available online 3 July 2020Source: Allergologia et ImmunopathologiaAuthor(s): Amit Raj Sharma, Gitika Batra, Mukesh Kumar, Abhishek Mishra, Rubal Singla, Ashutosh Singh, Rahul Soloman Singh, Bikash Medhi
Fri Jul 03, 2020 21:15
Since its first documentation, a novel coronavirus (SARS-CoV-2) infection has emerged worldwide, with the consequent declaration of a pandemic disease (COVID-19). Severe forms of acute respiratory failure can ...
Thu Jul 02, 2020 03:00
Publication date: Available online 2 July 2020Source: Magnetic Resonance ImagingAuthor(s): Marion E. Scoggins, Banu K. Arun, Rosalind P. Candelaria, Mark J. Dryden, Wei Wei, Jong Bum Son, Jingfei Ma, Basak E. Dogan
Fri Jul 03, 2020 20:43
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00863
Fri Jul 03, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01394
Thu Jul 02, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00037
Thu Jul 02, 2020 07:00
Antimicrobial stewardship (AMS) describes activities concerned with safe-guarding antibiotics for the future, reducing drivers for the major global public health threat of antimicrobial resistance (AMR), where...
Thu Jul 02, 2020 03:00
Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) and comorbid asthma have more severe disease and are difficult to treat. However, the molecular endotypes associated with CRSwNP with comorbid as...
Fri Jul 03, 2020 03:00
Related Articles Oral cancer and dentists in Primary Care: difficulties, behavior and expectation in Brazil. Minerva Stomatol. 2020 Jun;69(3):183-189 Authors: Galante ML, Pedroso da Silva D, Gabriel M, Campos de Almeida Carrer F Abstract BACKGROUND: Oral cancer affects thousands of people around the world, and the later the diagnosis is performed, the worse are prognosis and survival. In Brazil, primary care is the preferred gateway to the Unified...
Fri Jul 03, 2020 18:44
Related Articles Etiology and characteristics of halitosis in patients of a halitosis center in Northern Italy. Minerva Stomatol. 2020 Jun;69(3):174-182 Authors: Romano F, Pigella E, Guzzi N, Manavella V, Campanelli L, Aimetti M Abstract BACKGROUND: As there are few studies in Europe describing characteristics of breath malodor for large groups of patients, this retrospective study was designed to analyse the etiology of halitosis among patients...
Fri Jul 03, 2020 18:44
Related Articles Relationship between upper lateral incisors anomalies and palatal displaced canine: a case-control retrospective study. Minerva Stomatol. 2020 Jun;69(3):159-164 Authors: Cassetta M, Guarnieri R, Altieri F, Brandetti G, Padalino G, Di Giorgio R, Barbato E Abstract BACKGROUND: An observational case-control study was designed to retrospectively assess the association among sex, skeletal and dental variables and the and the palatal...
Fri Jul 03, 2020 18:44
Related Articles Comparison of two digital intraoral radiography imaging systems as a function of contrast resolution and exposure time. Minerva Stomatol. 2020 Jun;69(3):148-152 Authors: Aydin KC, Demirel O, Özcan M Abstract BACKGROUND: To compare the image quality of two different digital imaging systems; one photostimulable phosphor plate system (PSP) and a direct digital radiography system with CMOS imaging sensor; via evaluating contrast...
Fri Jul 03, 2020 18:44
Related Articles Quantitative assessment of CD15 positive tissue eosinophils in Oral Squamous Cell Carcinoma: effects on mast cells and tumor angiogenesis. Minerva Stomatol. 2020 Jun;69(3):133-140 Authors: Sethi A, Shetty DC, Rathore AS, Tandon A, Juneja S, Gulati N Abstract BACKGROUND: The present study determines to correlate eosinophil, mast cell and microvessel densities with the histopathological grades and clinical staging of Oral Squamous...
Fri Jul 03, 2020 18:44
Abstract Multiple long-bone fractures, particularly bilateral fractures, are of moderate specificity for inflicted injury (physical abuse) in infants and young children. Bilateral healing fractures of the fibulae are rare and, depending on age, raise the suspicion of inflicted injury. We report healing undisplaced fractures of both fibulae, in almost identical positions, in a pre-ambulant infant. The caregivers reported that the infant repeatedly banged his legs against the metal...
Fri Jul 03, 2020 03:00
Abstract Forearm fractures are common injuries in pediatric patients. We present a case of median nerve tethering as a complication of both-bone forearm fracture in a child, with an emphasis on MRI as an appropriate and important complement to clinical and electrodiagnostic examination. Early intervention is essential because delayed surgical management of median nerve tethering can result in poor clinical outcomes as a result of irreversible muscle denervation. In this case,...
Fri Jul 03, 2020 03:00
Abstract Background Neck computed tomography (CT) angiography is commonly ordered for pediatric patients with soft palate trauma to exclude vascular injury. Debate exists regarding what type of imaging is indicated in this setting, particularly amid growing concern that standard neck CT angiography results in considerable radiation exposure. Objective ...
Fri Jul 03, 2020 03:00
Abstract During the outbreak of the COVID-19 pandemic, guidelines have been issued by international, national and local authorities to address management and the need for preparedness. Children with COVID-19 differ from adults in that they are less often and less severely affected. Additional precautions required in the management of children address their increased radiosensitivity, need for accompanying carers, and methods for dealing with children in a mixed adult-paediatric...
Fri Jul 03, 2020 03:00
Abstract Purpose To assess the feasibility of thoracoscopic transdiaphragmatic approach for biopsy of all lung lobes and to determine the optimal intercostal space (ICS) for biopsy of each lung lobe. Methods Ten rabbits were positioned in dorsal recumbency. Total thoracoscopy lung biopsy was made combined transdiaphragmatic approach and right ICS approaches. A camera port was made in the transdiaphragmatic approach and the instrument port was made of ICS 7 and ICS 9. A pre tied loop ligature...
Fri Jul 03, 2020 17:46
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