Related ArticlesWEE1 inhibition enhances sensitivity to hypoxia/reoxygenation in HeLa cells. J Radiat Res. 2019 Oct 23;60(5):714-718 Authors: Goto T, Homma H, Kaida A, Miura M Abstract Hypoxia/reoxygenation (H/R) treatment reportedly induces DNA damage response (DDR), including DNA double-strand break (DSB) repair and G2 arrest, resulting in reduction of clonogenic survival. Because WEE1 plays a key role in the G2/M checkpoint along with CHK1/2, we...
Sat Mar 07, 2020 13:19
Related ArticlesResponse of head and neck epithelial cells to a DNA damage-differentiation checkpoint involving polyploidization. Head Neck. 2018 11;40(11):2487-2497 Authors: Sanz-Gómez N, Freije A, Ceballos L, Obeso S, Sanz JR, García-Reija F, Morales-Angulo C, Gandarillas A Abstract BACKGROUND: Squamous epithelia of the head and neck undergo continuous cell renewal and are continuously exposed to mutagenic hazard, the main cause of cancer. How they...
Sat Mar 07, 2020 13:19
Related ArticlesVorinostat upregulates MICA via the PI3K/Akt pathway to enhance the ability of natural killer cells to kill tumor cells. Eur J Pharmacol. 2020 Mar 02;:173057 Authors: Xia C, He Z, Cai Y, Liang S Abstract Vorinostat has good therapeutic efficacy against primary cutaneous T-cell lymphoma in the refractory stage. However, the molecular mechanism by which it inhibits solid tumors has not been clarified. To investigate the tumor inhibitory...
Fri Mar 06, 2020 22:07
Related ArticlesLocally acting transcription factors regulate p53-dependent cis-regulatory element activity. Nucleic Acids Res. 2020 Mar 05;: Authors: Catizone AN, Uzunbas GK, Celadova P, Kuang S, Bose D, Sammons MA Abstract The master tumor suppressor p53 controls transcription of a wide-ranging gene network involved in apoptosis, cell cycle arrest, DNA damage repair, and senescence. Recent studies revealed pervasive binding of p53 to cis-regulatory...
Fri Mar 06, 2020 22:07
Related ArticlesCucurbitacin D Overcomes Gefitinib Resistance by Blocking EGF Binding to EGFR and Inducing Cell Death in NSCLCs. Front Oncol. 2020;10:62 Authors: Hong SH, Ku JM, Lim YS, Lee SY, Kim JH, Cheon C, Ko SG Abstract In this study, the mechanism of the anticancer effect through which cucurbitacin D (CuD) can overcome gefitinib resistance in NSCLC was investigated. Cell viability was measured by 3-(4,5-dimethylthiazol-2-yl)-2-5-diphenyltetrazolium...
Fri Mar 06, 2020 22:07
Related ArticlesPathobiological Mechanisms of Endothelial Dysfunction Induced by tert-Butyl Hydroperoxide via Apoptosis, Necrosis and Senescence in a Rat Model. Int J Med Sci. 2020;17(3):368-382 Authors: Yeh YC, Liu TJ, Lai HC Abstract Background: Endothelial dysfunction is one of the underlying causes for vascular diseases. tert-Butyl hydroperoxide (t-BHP), a short-chain lipid hydroperoxide analog, has been reported to cause adverse effects in different...
Fri Mar 06, 2020 22:07
Related ArticlesAqueous Ocimum gratissimum extract induces cell apoptosis in human hepatocellular carcinoma cells. Int J Med Sci. 2020;17(3):338-346 Authors: Huang CC, Hwang JM, Tsai JH, Chen JH, Lin H, Lin GJ, Yang HL, Liu JY, Yang CY, Ye JC Abstract Treatment of advanced hepatocellular carcinoma (HCC) has exhibited a poor overall survival rate of only six to ten months, and the urgency of the development of more effective novel agents is ever present....
Fri Mar 06, 2020 22:07
Related ArticlesPEITC triggers multiple forms of cell death by GSH-iron-ROS regulation in K7M2 murine osteosarcoma cells. Acta Pharmacol Sin. 2020 Mar 04;: Authors: Lv HH, Zhen CX, Liu JY, Shang P Abstract Phenethyl isothiocyanate (PEITC) is an isothiocyanate that largely exists in cruciferous vegetables and exhibits chemopreventive and chemotherapeutic potential against various cancers. However, it is little known about the molecular mechanisms...
Fri Mar 06, 2020 22:07
Related ArticlesSynergistic Effect of Alectinib and Everolimus on ALK-positive Anaplastic Large Cell Lymphoma Growth Inhibition. Anticancer Res. 2020 Mar;40(3):1395-1403 Authors: Kim D, Koh Y, Yoon SS Abstract BACKGROUND/AIM: The aim of the study was to examine the efficacy of the combination of anaplastic lymphoma kinase (ALK) inhibitors with other inhibitors for the treatment of ALK-positive lymphomas. This approach is predicted to be an alternative...
Fri Mar 06, 2020 22:07
Related ArticlesHuman Glioma Cells Acquire Temozolomide Resistance After Repeated Drug Exposure Via DNA Mismatch Repair Dysfunction. Anticancer Res. 2020 Mar;40(3):1315-1323 Authors: Yamashiro K, Nakao K, Ohba S, Hirose Y Abstract BACKGROUND/AIM: Temozolomide (TMZ) induces prolonged arrest of human glioma cells in the G2/M phase and inhibition of the G2 checkpoint intensifies the effect of TMZ. These findings suggest that the G2 checkpoint is linked...
Fri Mar 06, 2020 22:07
Related ArticlesTroglitazone, a Selective Ligand for PPARγ, Induces Cell-cycle Arrest in Human Oral SCC Cells. Anticancer Res. 2020 Mar;40(3):1247-1254 Authors: Saito M, Fujita Y, Kuribayashi N, Uchida D, Komiyama Y, Fukumoto C, Hasegawa T, Kawamata H Abstract AIM: We attempted to clarify the role of Peroxisome proliferator-activated receptor γ (PPARγ) and its ligand, troglitazone (TRO) on oral squamous cell carcinoma (SCC). MATERIALS AND...
Fri Mar 06, 2020 22:07
Related ArticlesCXCR4 signaling directs Igk recombination and the molecular mechanisms of late B lymphopoiesis. Nat Immunol. 2019 10;20(10):1393-1403 Authors: Mandal M, Okoreeh MK, Kennedy DE, Maienschein-Cline M, Ai J, McLean KC, Kaverina N, Veselits M, Aifantis I, Gounari F, Clark MR Abstract In B lymphopoiesis, activation of the pre-B cell antigen receptor (pre-BCR) is associated with both cell cycle exit and Igk recombination. Yet how the pre-BCR...
Fri Mar 06, 2020 22:07
Related ArticlesNew Aspects of VEGF, GABA, and Glutamate Signaling in the Neocortex of Human Temporal Lobe Pharmacoresistant Epilepsy Revealed by RT-qPCR Arrays. J Mol Neurosci. 2020 Mar 06;: Authors: Castro-Torres RD, Ureña-Guerrero ME, Morales-Chacón LM, Lorigados-Pedre L, Estupiñan-Díaz B, Rocha L, Orozco-Suárez S, Rivera-Cervantes MC, Alonso-Vanegas M, Beas-Zárate C Abstract In the epilepsy spectrum, temporal lobe epilepsy (TLE) is the most common...
Sun Mar 08, 2020 12:36
Related Articles[Epilepsy in old age]. Nervenarzt. 2020 Mar 06;: Authors: Siebenbrodt K, Strzelczyk A, Rosenow F Abstract In an aging society, epilepsy in old age will become a more and more relevant disease. The diagnosis is often difficult because of the frequent occurrence of focal seizures in old age, which are easily overlooked. The diagnosis is often delayed, particularly in older patients who, for example also suffer from dementia. The causes...
Sun Mar 08, 2020 12:36
42 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: epilepsy treatment These pubmed results were generated on 2020/03/07PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Sat Mar 07, 2020 15:00
42 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: epilepsy treatment These pubmed results were generated on 2020/03/07PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Sat Mar 07, 2020 13:19
Related ArticlesWhy do seizures impair consciousness and how can we reverse this? Curr Opin Neurol. 2020 Apr;33(2):173-178 Authors: Lambert I, Bartolomei F Abstract PURPOSE OF REVIEW: Consciousness disorders occurring during seizures are a major source of disability in people with epilepsy. The purpose of this review is to show recent developments in the assessment and understanding of consciousness disorders in epilepsy. RECENT FINDINGS: The...
Fri Mar 06, 2020 22:21
Related ArticlesMortality in infantile spasms: A hospital-based study. Epilepsia. 2020 Mar 05;: Authors: Harini C, Nagarajan E, Bergin AM, Pearl P, Loddenkemper T, Takeoka M, Morrison PF, Coulter D, Harappanahally G, Marti C, Singh K, Yuskaitis C, Poduri A, Libenson MH Abstract OBJECTIVE: To determine risk factors and causes for mortality during childhood in patients with infantile spasms (IS). We describe the overall goals of care for those who died....
Fri Mar 06, 2020 22:21
Related ArticlesTwo Cases of Late-Onset Anti-NMDAr Auto-Immune Encephalitis After Herpes Simplex Virus 1 Encephalitis. Front Neurol. 2020;11:38 Authors: Dorcet G, Benaiteau M, Bost C, Mengelle C, Bonneville F, Martin-Blondel G, Pariente J Abstract Context: Encephalitis due to herpes simplex virus 1 (HSV-1) was described as a potential trigger for the development of anti-N-methyl-D-aspartate receptor (NMDAr) auto-immune encephalitis (AIE) within a few...
Fri Mar 06, 2020 22:21
Related ArticlesEpilepsia Partialis Continua as an Early Sign of Anti-Myelin Oligodendrocyte Glycoprotein Antibody-positive Encephalitis. Intern Med. 2020 Mar 05;: Authors: Katsuse K, Shimizu G, Saito Sato N, Hatano K, Yagi S, Kimura T, Irie K, Ichi S, Takahashi T, Hashida H Abstract Anti-myelin oligodendrocyte glycoprotein (MOG) antibodies have been associated with steroid-responsive cortical encephalitis and comorbid generalized epilepsy. A 44-year-old...
Fri Mar 06, 2020 22:21
Related ArticlesClinical characteristics of anti-N-methyl-D-aspartate receptor encephalitis in children. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2020 Jan 28;45(1):47-54 Authors: Zheng J, Shen J, Wang A, Liu L, Xiong J, Li X, Xiao Y, Li J, Mao D, Liu L Abstract OBJECTIVES: To analyze the clinical characteristics and prognosis of children with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis and to provide a basis for early clinical identification...
Fri Mar 06, 2020 22:21
Related Articles[Effect of α-asarone on the Function and Expression of P-glycoprotein in Rat Brain Microvascular Endothelial Cells]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2020 Feb 28;42(1):1-6 Authors: Yuan SY, Sun J, Liu JM Abstract Objective To investigate the effect of α-asarone on the function and expression of P-glycoprotein(P-gp)in rat brain microvascular endothelial cells(rBMECs). Methods rBMECs were exposed to L-glutamate(100 μmol/L) for 30 mins...
Fri Mar 06, 2020 22:21
Related ArticlesT-Type Channel Druggability at a Crossroads. ACS Chem Neurosci. 2019 03 20;10(3):1124-1126 Authors: Weiss N, Zamponi GW Abstract Low-voltage activated T-type calcium channels mediate essential functions in the nervous system, and alteration of channel activity is causally linked to a number of neurological conditions. Therefore, T-type channels hold great promise as pharmacological targets for new medicines. In this Viewpoint, we discuss...
Fri Mar 06, 2020 22:21
Related ArticlesTreatment options after first-line immunotherapy in metastatic NSCLC. Expert Rev Anticancer Ther. 2020 Mar 06;: Authors: Santos ES, Schmidt CE Abstract INTRODUCTION: The recent approvals of checkpoint inhibitors as single agents or in combination with chemotherapy with programmed death ligand 1 expression of < or ≥ 1% has challenged clinicians when it is time to begin a metastatic lung cancer patient in second line therapy. The advantages...
Sat Mar 07, 2020 16:05
Related ArticlesNon-clinical efficacy, safety, and stable clinical cell processing of iPSC-derived anti-GPC3 CAR-expressing NK/ILC cells. Cancer Sci. 2020 Mar 04;: Authors: Ueda T, Kumagai A, Iriguchi S, Yasui Y, Miyasaka T, Nakagoshi K, Nakane K, Saito K, Takahashi M, Sasaki A, Yoshida S, Takasu N, Seno H, Uemura Y, Tamada K, Nakatsura T, Kaneko S Abstract The use of allogeneic, pluripotent stem-cell-derived immune cells for cancer immunotherapy has...
Fri Mar 06, 2020 22:39
Related ArticlesInter-α-inhibitor Ameliorates Endothelial Inflammation in Sepsis. Lung. 2019 06;197(3):361-369 Authors: Stober VP, Lim YP, Opal S, Zhuo L, Kimata K, Garantziotis S Abstract PURPOSE: Vascular endothelial cells demonstrate severe injury in sepsis, and a reduction in endothelial inflammation would be beneficial. Inter-α-Inhibitor (IαI) is a family of abundant plasma proteins with anti-inflammatory properties and has been investigated in...
Fri Mar 06, 2020 22:39
Related ArticlesCorrigendum: Autonomic Nervous System Correlates of Speech Categorization Revealed Through Pupillometry. Front Neurosci. 2020;14:132 Authors: Lewis GA, Bidelman GM Abstract [This corrects the article DOI: 10.3389/fnins.2019.01418.].PMID: 32140097 [PubMed - in process]
Sat Mar 07, 2020 13:51
Related ArticlesLong-Term Home-Use of Sensory-Motor-Integrated Bidirectional Bionic Prosthetic Arms Promotes Functional, Perceptual, and Cognitive Changes. Front Neurosci. 2020;14:120 Authors: Schofield JS, Shell CE, Beckler DT, Thumser ZC, Marasco PD Abstract Cutaneous sensation is vital to controlling our hands and upper limbs. It helps close the motor control loop by informing adjustments of grasping forces during object manipulations and provides...
Sat Mar 07, 2020 13:51
Related ArticlesWireless Electrical Stimulators and Sensors Network for Closed Loop Control in Rehabilitation. Front Neurosci. 2020;14:117 Authors: Andreu D, Sijobert B, Toussaint M, Fattal C, Azevedo-Coste C, Guiraud D Abstract This paper presents a wireless distributed Functional Electrical Stimulation (FES) architecture. It is based on a set of, potentially heterogeneous, distributed stimulation and measurement units managed by a wearable controller....
Sat Mar 07, 2020 13:51
Related ArticlesCorrigendum: Effects of Second Language Learning on the Plastic Aging Brain: Functional Connectivity, Cognitive Decline, and Reorganization. Front Neurosci. 2020;14:108 Authors: Bubbico G, Chiacchiaretta P, Parenti M, di Marco M, Panara V, Sepede G, Ferretti A, Perrucci MG Abstract [This corrects the article DOI: 10.3389/fnins.2019.00423.].PMID: 32140094 [PubMed - in process]
Sat Mar 07, 2020 13:51
Related ArticlesBoosting Throughput and Efficiency of Hardware Spiking Neural Accelerators Using Time Compression Supporting Multiple Spike Codes. Front Neurosci. 2020;14:104 Authors: Xu C, Zhang W, Liu Y, Li P Abstract Spiking neural networks (SNNs) are the third generation of neural networks and can explore both rate and temporal coding for energy-efficient event-driven computation. However, the decision accuracy of existing SNN designs is contingent...
Sat Mar 07, 2020 13:51
Related ArticlesSomatostatin, Olfaction, and Neurodegeneration. Front Neurosci. 2020;14:96 Authors: Saiz-Sanchez D, Ubeda-Bañon I, Flores-Cuadrado A, Gonzalez-Rodriguez M, Villar-Conde S, Astillero-Lopez V, Martinez-Marcos A Abstract Alzheimer's and Parkinson's diseases are the most prevalent neurodegenerative disorders in aging. Hyposmia has been described as an early symptom that can precede cognitive and motor deficits by decades. Certain regions...
Sat Mar 07, 2020 13:51
Related ArticlesOptimal Stereoacuity Reveals More Than Critical Time in Patients With Intermittent Exotropia. Front Neurosci. 2020;14:133 Authors: Wu H, Li X, Tang Y, Xu Q, Zhang X, Zhou L, Lan W, Zhang B, Yang Z Abstract Synopsis: Both optimal stereoacuity and integration time to achieve that are impaired in patients with intermittent exotropia. The deterioration of stereoacuity is more revealing since it correlates well with exotropia control score....
Fri Mar 06, 2020 21:54
Related ArticlesEvolution and Comparative Physiology of Luqin-Type Neuropeptide Signaling. Front Neurosci. 2020;14:130 Authors: Yañez-Guerra LA, Elphick MR Abstract Luqin is a neuropeptide that was discovered and named on account of its expression in left upper quadrant cells of the abdominal ganglion in the mollusc Aplysia californica. Subsequently, luqin-type peptides were identified as cardio-excitatory neuropeptides in other molluscs and a cognate...
Fri Mar 06, 2020 21:54
Related ArticlesCase-Control Study of the Effects of Gut Microbiota Composition on Neurotransmitter Metabolic Pathways in Children With Attention Deficit Hyperactivity Disorder. Front Neurosci. 2020;14:127 Authors: Wan L, Ge WR, Zhang S, Sun YL, Wang B, Yang G Abstract Background: Attention-deficit/hyperactivity disorder (ADHD) is a neuropsychiatric condition that may be related to an imbalance of neural transmitters. The gut microbiota is the largest...
Fri Mar 06, 2020 21:54
Related ArticlesEffects of Cigarette Smoke on the Nasal Respiratory and Olfactory Mucosa in Allergic Rhinitis Mice. Front Neurosci. 2020;14:126 Authors: Ueha R, Ueha S, Kondo K, Nishijima H, Yamasoba T Abstract Objective: Cigarette smoke (CS) exposure reportedly enhances allergic airway inflammation. However, some studies have shown an association between current cigarette smoke exposure and a low risk for allergic rhinitis. Thus, the impact of CS exposure...
Fri Mar 06, 2020 21:54
Related ArticlesAcoustic Change Responses to Amplitude Modulation in Cochlear Implant Users: Relationships to Speech Perception. Front Neurosci. 2020;14:124 Authors: Han JH, Dimitrijevic A Abstract Objectives: The ability to understand speech is highly variable in people with cochlear implants (CIs) and to date, there are no objective measures that identify the root of this discrepancy. However, behavioral measures of temporal processing such as the...
Fri Mar 06, 2020 21:54
Related ArticlesSocial Jetlag and Its Association With Screen Time and Nighttime Texting Among Adolescents in Sweden: A Cross-Sectional Study. Front Neurosci. 2020;14:122 Authors: Hena M, Garmy P Abstract The discrepancy between social and biological clock due to sleep and wake up time difference across weekdays and weekends is referred as social jetlag. The overall aim of this study is to test whether there is an association between both screen time...
Fri Mar 06, 2020 21:54
Related ArticlesNeurons and Glia Cells in Marine Invertebrates: An Update. Front Neurosci. 2020;14:121 Authors: Ortega A, Olivares-Bañuelos TN Abstract The nervous system (NS) of invertebrates and vertebrates is composed of two main types of cells: neurons and glia. In both types of organisms, nerve cells have similarities in biochemistry and functionality. The neurons are in charge of the synapse, and the glial cells are in charge of important functions...
Fri Mar 06, 2020 21:54
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