The published online version of this paper contains mistake. The authors first and last names have been interchanged. The correct version is given above.
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Abstract A PCR-independent in vitro site-directed mutagenesis method was established. Cas12a from Francisella novicida (FnCas12a) linearizes the plasmid with single digestion. T5 exonuclease removes the target nucleotide. A short single- or double-stranded mutagenic oligonucleotide introduces the mutation. This rapid and simple mutagenesis method is referred to as FnCas12a and T5 exonuclease mediated site-directed mutagenesis system (CT5-SDM). The platform...
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Related ArticlesHaptic vs sensorimotor training in the treatment of upper limb dysfunction in multiple sclerosis: A multi-center, randomised controlled trial. J Neurol Sci. 2020 Feb 19;412:116743 Authors: Solaro C, Cattaneo D, Basteris A, Carpinella I, De Luca A, Mueller M, Bertoni R, Ferrarin M, Sanguineti V Abstract BACKGROUND: In multiple sclerosis (MS) exercise improves upper limb functions, but it is unclear what training types are more effective....
Sun Mar 08, 2020 14:58
Related ArticlesCombination therapy with mTOR kinase inhibitor and dasatinib as a novel therapeutic strategy for vestibular schwannoma. Sci Rep. 2020 Mar 06;10(1):4211 Authors: Sagers JE, Beauchamp RL, Zhang Y, Vasilijic S, Wu L, DeSouza P, Seist R, Zhou W, Xu L, Ramesh V, Stankovic KM Abstract Neurofibromatosis type 2 (NF2) is an inherited disorder characterized by bilateral vestibular schwannomas (VS) that arise from neoplastic Schwann cells (SCs)....
Sun Mar 08, 2020 13:01
Related ArticlesA fast robust optimizer for intensity modulated proton therapy using GPU. J Appl Clin Med Phys. 2020 Mar 06;: Authors: Xu Y, Chen J, Cao R, Liu H, Xu XG, Pei X Abstract Robust optimization has been shown to be effective for stabilizing treatment planning in intensity modulated proton therapy (IMPT), but existing algorithms for the optimization process is time-consuming. This paper describes a fast robust optimization tool that takes advantage...
Sat Mar 07, 2020 15:21
Related ArticlesDevelopment of an Isocentric Rotating Chair Positioner to Treat Patients of Head and Neck Cancer at Upright Seated Position with Multiple Nonplanar Fields in a Fixed Carbon-Ion Beamline. Med Phys. 2020 Mar 05;: Authors: Zhang X, Hsi WC, Yang F, Wang Z, Sheng Y, Sun J, Yang C, Zhou R Abstract PURPOSE: An isocentric rotating chair for a positioner was developed as a non-gantry solution to provide multiple nonplanar radiation fields with...
Sat Mar 07, 2020 13:23
Related ArticlesPerioperative Antibiotics in Clean-Contaminated Head and Neck Surgery: A Systematic Review and Meta-Analysis. Adv Ther. 2020 Mar 05;: Authors: Vander Poorten V, Uyttebroek S, Robbins KT, Rodrigo JP, de Bree R, Laenen A, F Saba N, Suarez C, Mäkitie A, Rinaldo A, Ferlito A Abstract BACKGROUND: The optimal evidence-based prophylactic antibiotic regimen for surgical site infections following major head and neck surgery remains a matter of...
Sat Mar 07, 2020 13:23
Related ArticlesA three-dimensional printed photopolymer resin implant for orbital rehabilitation for evisceration. Arq Bras Oftalmol. 2019;82(6):471-475 Authors: Kormann RB, Mörschbächer R, Moreira H, Akaishi P Abstract PURPOSE: To evaluate the biocompatibility of three-dimensional (3D) printed orbital spheres for evisceration. MATERIALS: A total of 10 consecutive patients (eight females and two males; mean age, 46.8 ± 14.2 years) underwent...
Sat Mar 07, 2020 13:23
Related ArticlesProton therapy for non-squamous cell carcinoma of the head and neck: planning comparison and toxicity. J Radiat Res. 2019 Oct 23;60(5):612-621 Authors: Iwata H, Toshito T, Hayashi K, Yamada M, Omachi C, Nakajima K, Hattori Y, Hashimoto S, Kuroda Y, Okumura Y, Mizoe JE, Ogino H, Shibamoto Y Abstract To investigate optimal treatment planning using proton beams for non-squamous cell carcinoma of the head and neck (NSCHN), the dose distributions...
Sat Mar 07, 2020 13:23
Related ArticlesTransoral surgery using the Flex Robotic System: Initial experience in the United States. Head Neck. 2018 11;40(11):2482-2486 Authors: Persky MJ, Issa M, Bonfili JR, Goyal N, Goldenberg D, Duvvuri U Abstract BACKGROUND: This multicenter, retrospective review documents the initial experience using the Flex system for transoral surgery in 2 United States academic centers. METHODS: All patients who underwent transoral robotic surgery...
Sat Mar 07, 2020 13:23
Related ArticlesThe Use of Both Therapeutic and Prophylactic Vaccines in the Therapy of Papillomavirus Disease. Front Immunol. 2020;11:188 Authors: Garbuglia AR, Lapa D, Sias C, Capobianchi MR, Del Porto P Abstract Human papillomavirus (HPV) is the most common sexually transmitted virus. The high-risk HPV types (i.e., HPV16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59) are considered to be the main etiological agents of genital tract cancers, such as...
Fri Mar 06, 2020 23:36
Related ArticlesA Case of Late Diagnosis of Acute Aortic Dissection Involving the Carotid Arteries in a Patient Presenting with Signs of Acute Ischemic Stroke. Am J Case Rep. 2020 Mar 05;21:e919271 Authors: Bressler M, Klein E, Shayowitz M, Gupta K, Delman A Abstract BACKGROUND Acute aortic dissection (AAD) is a rare but life-threatening condition with high mortality. The Stanford classification of aortic dissection includes type A, which originates...
Fri Mar 06, 2020 23:36
Publication date: April 2020Source: Archives of Oral Biology, Volume 112Author(s):
Sun Mar 08, 2020 12:31
Sun Mar 08, 2020 12:30
Abstract About every second allergic person in Germany suffers from a so‐called "early bloomer allergy", a little scientific description of the tree pollen allergy [2]. And almost every allergic person knows the specific tree, which he or she is allergic to, the hazel, the alder, the birch, the ash, the plane tree, and finally the most German of all the trees, the oak.
Sun Mar 08, 2020 12:30
Abstract Background Bronchial asthma is a chronic disease characterized by inflammation, obstruction and hyperresponsiveness of the airways. There is currently no curative therapy for asthma. Type 2 helper T cell response plays a critical role in the pathogenesis of the disease. Protein S is a glycoprotein endowed with anticoagulant, anti‐inflammatory and anti‐apoptotic properties. Whether protein S can suppress bronchial asthma and be useful for its therapy is unknown. Methods To...
Sun Mar 08, 2020 12:30
Sun Mar 08, 2020 12:30
Abstract Background Allergic rhinoconjunctivitis is a public health problem. Allergen Immunotherapy is an effective and safe treatment, that modifies the natural course of allergic disease and induces long‐term tolerance. Objective To correlate basophil and antibody biomarkers of subcutaneous immunotherapy to clinical outcomes and cellular changes in target tissue. Methods Adults suffering from allergic rhinoconjunctivitis due to grass pollen allergy were randomized to...
Sat Mar 07, 2020 21:30
Abstract Background Adolescence represents a vulnerable time for individuals with asthma and allergic conditions. They suffer an unexpected degree of morbidity. This systematic review aimed to understand the challenges faced by adolescents and young adults with these conditions. Methods A systematic literature search was undertaken across eight databases. References were checked by two reviewers for inclusion. Study data were extracted and their quality was assessed in duplicate....
Fri Mar 06, 2020 15:52
Fri Mar 06, 2020 15:52
Related ArticlesAPPLICATION OF THE MCNP6.1 CODE TO ESTIMATE THE DIRECTIONAL DEPENDENCE OF RADIATION PROTECTION FACTOR VALUES FOR A SIMPLE SURROGATE VEHICLE. Radiat Prot Dosimetry. 2020 Mar 06;: Authors: McHale SR, Decker AW, Huff BK Abstract Radiation protection factor (RPF) values are relevant to various US defense and civil support organizations. An equation was developed to quantify the angular-dependent protection of a shielding configuration...
Sun Mar 08, 2020 12:24
Related ArticlesASSESSMENT OF AMBIENT NEUTRON DOSE EQUIVALENT IN SPATIALLY FRACTIONATED RADIOTHERAPY WITH PROTONS USING PHYSICAL COLLIMATORS. Radiat Prot Dosimetry. 2020 Mar 07;: Authors: Charyyev S, Wang CC Abstract New technique is trending in spatially fractionated radiotherapy with protons to utilize the spot scanning together with a physical collimator to obtain minibeams. The primary goal of this study is to quantify ambient neutron dose equivalent...
Sun Mar 08, 2020 12:24
Related ArticlesPATIENT-SPECIFIC DOSIMETRY USING IN-HOUSE DEVELOPED OSL DISC DOSEMETERS. Radiat Prot Dosimetry. 2020 Mar 05;: Authors: Kumar P, Sharma SD, Dhabekar B, Mishra DR, Rawat NS, Kadam S, Chaudhari S, Chandola RM, Agrawal S Abstract Circular discs of diameter 5 mm were made from three indigenously developed optically stimulated luminescent (OSL) phosphors for medical dosimetry. Dosimetric characteristics of these discs were evaluated for their...
Sat Mar 07, 2020 14:17
Related ArticlesEFFECTIVE DOSE FOR RADIOLOGICAL PROCEDURES IN AN EMERGENCY DEPARTMENT: A CROSS-SECTIONAL STUDY. Radiat Prot Dosimetry. 2020 Mar 05;: Authors: Naseri M, Shahsavan M, Salahshour F, Peiman S, Allameh SF, Farzanehfar S, Emami-Ardekani AR, Pouraliakbar H, Abbasi M Abstract The extent of radiation exposure in emergency settings is not well documented; here, the corresponding effective dose (ED) is provided. In 500 patients admitted in row to...
Sat Mar 07, 2020 14:17
Related Articles68Ga-PSMA PET/CT in radioactive iodine-refractory differentiated thyroid cancer and first treatment results with 177Lu-PSMA-617. EJNMMI Res. 2020 Mar 06;10(1):18 Authors: de Vries LH, Lodewijk L, Braat AJAT, Krijger GC, Valk GD, Lam MGEH, Borel Rinkes IHM, Vriens MR, de Keizer B Abstract BACKGROUND: Differentiated thyroid carcinoma (DTC) is the most common type of thyroid cancer. Treatment with surgery, radioactive iodine (RAI), and...
Sun Mar 08, 2020 12:09
Related ArticlesRORγt may Influence the Microenvironment of Thyroid Cancer Predicting Favorable Prognosis. Sci Rep. 2020 Mar 05;10(1):4142 Authors: Cunha LL, Morari EC, Nonogaki S, Bufalo NE, da Assumpção LVM, Soares FA, Vassallo J, Ward LS Abstract We aimed to investigate the role of RORγt (Retinoic acid-related orphan receptor gamma) in the tumor microenvironment of differentiated thyroid carcinoma. We retrospectively analyzed 56 patients (48 papillary...
Sat Mar 07, 2020 13:40
Related ArticlesRisk Factors for the Relapse of Graves' Disease Treated With Antithyroid Drugs: a Systematic Review and Meta-Analysis. Clin Ther. 2020 Mar 02;: Authors: Shi H, Sheng R, Hu Y, Liu X, Jiang L, Wang Z, Cui D Abstract PURPOSE: Antithyroid drugs (ATDs) are the first-line treatment for Graves' disease (GD). A common problem with ATD treatment is the high relapse rate after drug withdrawal. The goal of this study was to analyze the influencing...
Sat Mar 07, 2020 13:40
Related ArticlesVenous thromboembolism following 672,495 primary total shoulder and elbow replacements: Meta-analyses of incidence, temporal trends and potential risk factors. Thromb Res. 2020 Feb 20;189:13-23 Authors: Kunutsor SK, Barrett MC, Whitehouse MR, Blom AW Abstract BACKGROUND: There is wide variability in reported venous thromboembolism (VTE) incidence following total shoulder replacement (TSR) or total elbow replacement (TER). It is uncertain...
Fri Mar 06, 2020 22:25
Related ArticlesOptic Disc Measures in Obstructive Sleep Apnoea: A Community-based Study of Middle-aged and Older Adults. J Glaucoma. 2020 Mar 03;: Authors: Lee SS, Sanfilippo PG, Hunter M, Yazar S, James A, Mackey DA Abstract PRéCIS:: This study found an association between thinner superotemporal retinal nerve fiber layer and obstructive sleep apnoea. However, the lack of association of sleep apnoea with other disc measures does not support a link with...
Fri Mar 06, 2020 22:25
Related ArticlesModelling the Upper Airway; A Precursor to Personalised Surgical Interventions for the Treatment of Sleep Apnoea. J Biomed Mater Res A. 2020 Mar 05;: Authors: Hingley L, Jeiranikhameneh A, Beirne S, Peoples G, Jones A, Sayyar S, Eastwood P, Lewis R, Wallace G, MacKay S Abstract An accurate benchtop model was developed to mimic the different forms of human upper airway collapse in adult sleep apnoea patients. This was done via modelling...
Fri Mar 06, 2020 22:25
Related ArticlesInadequate sleep as a contributor to impaired glucose tolerance: A cross-sectional study in children, adolescents, and young adults with circadian rhythm sleep-wake disorder. Pediatr Diabetes. 2020 Mar 05;: Authors: Toyoura M, Miike T, Tajima S, Matsuzawa S, Konishi Y Abstract BACKGROUND: Sleep deprivation and circadian disruption are associated with decreased insulin sensitivity and hyperglycemia. It is uncertain whether circadian sleep-wake...
Fri Mar 06, 2020 22:25
Related ArticlesSympathetic overdrive in the metabolic syndrome: meta-analysis of published studies. J Hypertens. 2020 Apr;38(4):565-572 Authors: Quarti Trevano F, Dell'Oro R, Biffi A, Seravalle G, Corrao G, Mancia G, Grassi G Abstract OBJECTIVE: The microneurographic technique has shown that sympathetic overactivity may characterize patients with the metabolic syndrome. However, technical and methodological limitations of the studies prevented to draw...
Fri Mar 06, 2020 22:25
Related Articles[GG Genotype at rs1275988 and rs2586886 Loci of TWIK-related Acid-sensitive K + Channel-1 Gene is A Potential Risk Factor for Severe Obstructive Sleep Apnea]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2020 Feb 28;42(1):16-23 Authors: Zhang L, Shi T, Yao XG, Li M, Mulalibike H, Li XF, Wen L, Yao L, He YY, Wang YC, Hong J, Li NF Abstract Objective To explore the mechanism of obstructive sleep apnea(OSA) by assessing the association between human...
Fri Mar 06, 2020 22:25
Related ArticlesRisk factors of obstructive sleep apnea syndrome in children. J Otolaryngol Head Neck Surg. 2020 Mar 04;49(1):11 Authors: Xu Z, Wu Y, Tai J, Feng G, Ge W, Zheng L, Zhou Z, Ni X Abstract BACKGROUND: The known risk factors of childhood OSAS include tonsillar and adenoidhypertrophy, obesity, craniofacial anomalies, neuromuscular disorders and African-American (AA) ancestry. Whether other factors such as allergic rhinitis (AR), premature,...
Fri Mar 06, 2020 22:25
Related ArticlesA Simplified Screening Questionnaire for Detecting Severe OSA in Chronic Obstructive Airway Disease in Asian Population. COPD. 2020 Mar 05;:1-6 Authors: Wang TY, Tsai MH, Ni YL, Lin TY, Huang SY, Lo YL Abstract The aim of this study was to develop a simplified screening questionnaire to detect the existence of severe obstructive sleep apnea (OSA) in chronic obstructive pulmonary disease (COPD) patients to reduce mortality and hospitalization...
Fri Mar 06, 2020 22:25
Related ArticlesImpact of Lung Function and SDB on Incident Myocardial Infarction and Heart Failure: A Community-based Study. Lung. 2019 06;197(3):339-347 Authors: Li R, Zhang J, Gao Y, Li J, Yan B, Wang G Abstract PURPOSE: To investigate whether lung function, especially when complicated with SDB, has an increased risk for myocardial infarction (MI) and congestive heart failure (CHF). METHODS: A prospective study was performed within the Sleep...
Fri Mar 06, 2020 22:25
Children and adolescents form a distinct patient group, whose experiences are relatively under-represented in research. Surveys have shown that healthcare professionals (HCPs) do not always communicate with th...
Sat Mar 07, 2020 02:00
Precarious employment has become an urgent public health issue at a global scale with potential consequences for quality of life and health of employees, especially in vulnerable groups such as migrants. The p...
Sat Mar 07, 2020 02:00
Colorectal cancer, a prevalent malignancy worldwide, is associated with numerous modifiable and non-modifiable risk factors that play a role in the early detection and successful treatment of cancer. Despite i...
Fri Mar 06, 2020 02:00
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