Abstract The study by Burley and colleagues concluded that a PCO2 stimulus of at least 3‐minutes, and a 30‐60 second data average in the final minute of the PCO2 stimulus, was the best approach to accurately quantify cerebrovascular and ventilatory reactivity to this magnitude of hypercapnia. This article is protected by copyright. All rights reserved
Sat Mar 07, 2020 07:31
New Findings What is the topic of this review? Activation of brown adipose tissue is a promising strategy to increase energy consumption and reduce fat mass. G protein‐coupled receptors are key druggable targets and their identification in brown adipose tissue is leading to novel ways to activate this tissue. What advances does it highlight? GPR120 is a fatty acid receptor highly expressed in brown adipose tissue. Its activation by selective ligands increases brown...
Sat Mar 07, 2020 07:31
Related ArticlesThe relationship between self-reported habitual snoring and hyperuricemia among Chinese urban adults: a cross-sectional study. Sleep Med. 2019 Dec 11;68:207-212 Authors: Xiong X, He F, Sun G, Li Y, Shi Y, Ge X, Zheng S, Xu R Abstract BACKGROUND: Growing evidence suggests an independent relationship between habitual snoring and metabolic abnormalities. Currently, there are few data available on the association between snoring and hyperuricemia....
Sat Mar 07, 2020 14:49
Related ArticlesVelopharyngeal insufficiency in patients without a cleft palate: important considerations for the ENT surgeon. J Laryngol Otol. 2020 Mar 06;:1-4 Authors: Mushi E, Mahdi N, Upile N, Hevican C, McKernon S, van Eeden S, De S Abstract BACKGROUND: Velopharyngeal insufficiency is the inability to close the velopharyngeal port during speech and swallowing, leading to hypernasal speech and food regurgitation. OBJECTIVE: This study aimed...
Sat Mar 07, 2020 14:49
Key points Ipsilateral‐projecting corticobulbar pathways, originating primarily from secondary motor areas, innervate the proximal and even distal portions, but branch more extensively at the spinal cord It is currently unclear to what extent these ipsilateral secondary motor areas and subsequent cortical projections may contribute to hand function following stroke‐induced damage to one hemisphere In this study, we provide both structural and functional evidence that individuals increasingly...
Sat Mar 07, 2020 14:36
Abstract NMDA receptors (NMDARs) are glutamate‐gated ion channels that contribute to nearly all brain processes. Not surprisingly then, genetic variations in the genes encoding NMDAR subunits can be associated with neurodevelopmental, neurological, and psychiatric disorders. These disease‐associated variants (DAVs) present challenges, such as defining how DAV‐induced alterations in receptor function contribute to disease progression and how to treat the affected individual clinically. As a starting...
Sat Mar 07, 2020 14:36
Key points The major electrophysiological hallmark of absence seizures are spike and wave discharges, consisting of a sharp spike‐ and a slow wave component. In a widely accepted scheme, these components are functionally coupled and reflect an iterative progression of neuronal excitation during the spike and post‐excitatory silence during the wave. In a genetic rat model of absence epilepsy, local pharmacological inhibition of the centromedian thalamus (CM) selectively suppressed the spike...
Sat Mar 07, 2020 14:36
Publication date: Available online 7 March 2020Source: Seminars in Ultrasound, CT and MRIAuthor(s): Colleen M. Costelloe, Behrang Amini, John E. Madewell
Sat Mar 07, 2020 14:35
Abstract Purpose There have been no large-scale studies on whether metformin therapy might have a potential benefit for lowering mortality. Thus, this study aimed to investigate the association between prior metformin therapy and the development of sepsis as well as the association between prior metformin therapy and 30-day mortality in sepsis patients. Methods ...
Sat Mar 07, 2020 02:00
Publication date: Available online 6 March 2020Source: Medical HypothesesAuthor(s): V.E. Zakhvataev
Sat Mar 07, 2020 14:04
Publication date: Available online 6 March 2020Source: Medical HypothesesAuthor(s): A. Pace, G. Iannella, V. Rossetti, A. Colizza, G. Magliulo
Sat Mar 07, 2020 14:04
Publication date: Available online 6 March 2020Source: Medical HypothesesAuthor(s): David Brown
Sat Mar 07, 2020 14:04
Publication date: Available online 6 March 2020Source: Medical HypothesesAuthor(s): Y. Hu, X.Y. Yang, J.H. Zhang
Fri Mar 06, 2020 22:15
Publication date: Available online 6 March 2020Source: Hearing ResearchAuthor(s): Thibault Vicente, Mathieu Lavandier
Sat Mar 07, 2020 13:49
Publication date: Available online 6 March 2020Source: Hearing ResearchAuthor(s): Tomoyo Isoguchi Shiramatsu, Hirokazu Takahashi
Sat Mar 07, 2020 13:49
Publication date: Available online 6 March 2020Source: Hearing ResearchAuthor(s): Daniël O.J. Reijntjes, Christine Köppl, Sonja J. Pyott
Sat Mar 07, 2020 13:49
Publication date: Available online 6 March 2020Source: Hearing ResearchAuthor(s): Sungsu Lee, Anna Dondzillo, Samuel P. Gubbels, Yehoash Raphael
Fri Mar 06, 2020 13:32
Sat Mar 07, 2020 02:00
Abstract The recently adopted terminology of “Noninvasive follicular thyroid neoplasm with papillary-like nuclear features” (NIFTP) reflects the indolent behavior of these tumors. In contrast to conventional papillary thyroid carcinomas, NIFTP can be managed conservatively. The purpose of this study was to investigate changes in surgical and pathologic practice patterns at our institution since the introduction of the NIFTP diagnosis in 2016. A retrospective analysis of all thyroid...
Sat Mar 07, 2020 02:00
Abstract Neuroendocrine neoplasms comprise a heterogeneous group of tumors, categorized into neuroendocrine tumors (NETs) and neuroendocrine carcinomas (NECs) depending on tumor differentiation. NECs and high-grade NETs (G3) confer a poor prognosis, demanding novel treatment strategies such as immune checkpoint inhibition in tumors with microsatellite instability (MSI). To study any possible intratumoral heterogeneity of MSI, a tissue microarray (TMA) containing 199 NETs and 40...
Fri Mar 06, 2020 02:00
Publication date: Available online 6 March 2020Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Shupei Liu, Bingjie Mai, Mengqi Jia, Dewu Lin, Jingdan Zhang, Quanhong Liu, Pan Wang
Sat Mar 07, 2020 13:09
Abstract Ollier disease (OD) and Maffucci syndrome (MS) are characterized by multiple enchondromas. Patients with MS also have benign vascular overgrowths that become malignant in 8.5% of cases. OD is characterized by multiple enchondromas, typically unilateral in distribution with a predilection for the appendicular skeleton. MS is characterized by multiple enchondromas bilaterally distributed in most of the cases. Both disorders feature multiple swellings on the extremity, deformity around the...
Sat Mar 07, 2020 13:03
Abstract The genetic basis of congenital heart malformations associated with disruption of left–right (L–R) asymmetry is broad and heterogenous, with variants in over 25 genes implicated thus far. Of these, deleterious variants in the Growth/Differentiation Factor 1 (GDF1) gene have been shown to cause heterotaxy with varied complex heart malformations of left–right patterning, in 23 individuals reported to date, either in monoallelic or biallelic state. We report three unrelated individuals exhibiting...
Sat Mar 07, 2020 13:03
Abstract Autosomal dominant (de novo) mutations in PBX1 are known to cause congenital abnormalities of the kidney and urinary tract (CAKUT), with or without extra‐renal abnormalities. Using trio exome sequencing, we identified a PBX1 p.(Arg107Trp) mutation in a deceased one‐day‐old neonate presenting with CAKUT, asplenia, and severe bilateral diaphragmatic thinning and eventration. Further investigation by droplet digital PCR revealed that the mutation had occurred post‐zygotically in the father,...
Sat Mar 07, 2020 01:11
Abstract Lateral meningocele syndrome (LMS) is due to specific pathogenic variants in the last exon of NOTCH3 gene. Besides the lateral meningoceles, this condition presents with dysmorphic features, short stature, congenital heart defects, and feeding difficulties. Here, we report a girl with neurosensorial hearing loss, severe gastroesophageal reflux disease, congenital heart defects, multiple renal cysts, kyphosis and left‐convex scoliosis, dysmorphic features, and mild developmental delay....
Sat Mar 07, 2020 01:11
Abstract Processing of Precursor RNA 1 (POP1) is a core protein component shared by two essential closely related eukaryotic ribonucleoprotein complexes: RNase MRP (the mitochondrial RNA processing ribonuclease) and RNase P. Recently, five patients harboring mutations in POP1 have been reported with severe spondylo‐epi‐metaphyseal dysplasia and extremely short stature. We report a unique clinical phenotype resulting from the novel homozygous R211Q POP1 mutation in three patients from one family,...
Sat Mar 07, 2020 01:11
Abstract Congenital heart defects (CHDs) are caused by a disruption in heart morphogenesis, which is dependent, in part, on a network of transcription factors (TFs) that regulate myocardial development. Heterozygous sequence variants in the basic helix–loop–helix TF gene heart and neural crest derivatives expressed 2 (HAND2) have been reported among some patients with CHDs; however, HAND2 has not yet been established as a Mendelian disease gene. We report a 31‐month‐old male with unicommissural...
Sat Mar 07, 2020 01:11
Publication date: Available online 6 March 2020Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Maria F. Giannoni, Fabrizio D'Abate, Arnaldo Ippoliti
Sat Mar 07, 2020 11:56
Publication date: May 2020Source: World Neurosurgery, Volume 137Author(s): Yu-fei Liu, Ling-yu Liu, Shi-lin Xia, Tao Li, Jun Li
Sat Mar 07, 2020 11:51
Publication date: May 2020Source: World Neurosurgery, Volume 137Author(s): Matthew A. Boissaud-Cooke, Kush Bhatt, David A. Hilton, Samiul Muquit
Sat Mar 07, 2020 11:51
Publication date: May 2020Source: World Neurosurgery, Volume 137Author(s): Brian Y.L. Chan, Khurshid Z. Merchant, Jennifer G.C. Teo, Kenneth T.E. Chang, David C.Y. Low, Sharon Y.Y. Low
Sat Mar 07, 2020 11:51
Publication date: May 2020Source: World Neurosurgery, Volume 137Author(s): Tomotaka Ohshima, Aichi Niwa, Reo Kawaguchi, Naoki Matsuo, Shigeru Miyachi
Sat Mar 07, 2020 11:51
Publication date: May 2020Source: World Neurosurgery, Volume 137Author(s): Ozal Beylerli, Ilgiz Gareev, Valentin Pavlov, Xin Chen, Shiguang Zhao
Sat Mar 07, 2020 11:51
Publication date: May 2020Source: World Neurosurgery, Volume 137Author(s): Yu-Hsiang Lan, Ying-Ching Li, Cheng-Nen Chang, Bo Zhang, Yu-Jen Lu
Fri Mar 06, 2020 16:43
Publication date: May 2020Source: World Neurosurgery, Volume 137Author(s): Russell J. Andrews
Fri Mar 06, 2020 16:43
Publication date: May 2020Source: World Neurosurgery, Volume 137Author(s): Hong-Xiang Zheng, Tee-Tau Eric Nyam, Che-An Liu, Yao-Lin Lee, Jinn-Rung Kuo, Kuan-Chin Sung
Fri Mar 06, 2020 16:43
Abstract Purpose Neuroblastoma is a malignant solid tumor that originates from the sympathetic nervous system in early childhood. Temozolomide is used for treatment in high-risk groups with low treatment response of neuroblastomas. TRPA1 channels in neuroblastoma cells are calcium permeable channels that can be activated by reactive oxygen species (ROT). In this study, we aimed to evaluate the level of activity of temozolomide and selenium...
Sat Mar 07, 2020 02:00
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