Publication date: Available online 7 March 2020Source: Acta Otorrinolaringológica EspañolaAuthor(s): María del Carmen Martínez Pacheco, José Miguel Sequí Canet, Médard Donzo Tobele
Sun Mar 08, 2020 16:24
Publication date: Available online 7 March 2020Source: Acta Otorrinolaringológica EspañolaAuthor(s): Antonia Lagos, Pablo Villarroel, Francisco García-Huidobro, Valentina Delgado, Bárbara Huidobro, Jorge Caro, José San Martín
Sun Mar 08, 2020 16:24
Abstract ENT involvement is common in ANCA‐associated vasculitis (AAV), particularly in GPA and EGPA. Early recognition and treatment is important for good outcomes, yet evidence suggests that UK ENT surgeons may not consistently recognise the early features of AAV, despite a similar incidence to vestibular schwannoma. AAV is a rapidly advancing field, with significant developments in the understanding of its pathogenesis, classification and treatment over the past decade. Relevant vasculitis mimics...
Sat Mar 07, 2020 22:19
Abstract Objectives It is well established that sequential bilateral implantation offers functional benefits in speech in noise and sound localisation, although it can be challenging to get long‐term unilateral users to adapt to the second implant. The aim of this study was to investigate programming differences between the two cochlear implants that can impact on performance outcomes. Design Cohort Study Participants Sixteen older children who received sequential implants...
Sat Mar 07, 2020 09:12
Abstract Success rate in tympanoplasty can deteriorate with time after initial graft healing. Early successful repair of tympanic membrane does not necessarily guarantee permanent closure. It might be prudent to have long‐term follow up after tympanoplasty in a select group of patients. Potential risks factors for delayed failure include a continued smoking history, bilateral perforations and tympanosclerosis at time of surgery or its development post‐operatively. The...
Sat Mar 07, 2020 02:07
Abstract Objective To investigate the influence of family environment on the development of speech and language in preschool children after cochlear implantation. Methods A total of 88 prelingually deaf children, aged from 2 to 5 years, who received cochlear implantation were included in this study. All families completed a self‐report family environment questionnaire (FES). The deaf children's linguistic progress was assessed by Categories of Auditory Performance (CAP) and Speech...
Sat Mar 07, 2020 02:07
Conditions: Parathyroid Adenoma; Parathyroid Neoplasms; Parathyroid Hyperplasia; Parathyroid Cancer; Hypercalcemia; Primary HyperparathyroidismIntervention: Device: NIRAF Detection TechnologySponsors: Vanderbilt-Ingram Cancer Center; National Cancer Institute (NCI)Recruiting
Fri Mar 06, 2020 18:24
Conditions: Diabetes Mellitus, Type 2; Thyroid Nodule (Benign)Interventions: Drug: METFORMIN; Drug: SitagliptinSponsor: Centre Hospitalier Universitaire de Pointe-a-PitreNot yet recruiting
Fri Mar 06, 2020 18:24
Condition: Head and Neck Squamous Cell CarcinomaInterventions: Drug: Experimental: Stage 1L: HLX10 Plus HLX07; Drug: Experimental: Stage 1H: HLX10 Plus HLX07Sponsor: Shanghai Henlius BiotechNot yet recruiting
Fri Mar 06, 2020 18:24
Purpose of review Chordomas of the clival region are challenging tumors to treat due to their location and infiltrative behavior. The primary goal of treatment remains a gross total resection (GTR). Advances in surgical techniques, especially the adoption of endoscopic endonasal techniques, provide improved rates of surgical resection while minimizing secondary surgical morbidities. Recent findings Advances in the management of clival chordomas include further development of endoscopic endonasal...
Fri Mar 06, 2020 14:15
Purpose of review To describe and popularize the transmanubrial osteomuscular-sparing approach (TOSA) outside its original thoracic surgical field of application, based on the consideration that it could be of interest for the management of a number of head and neck cases in both elective and emergent scenarios. Recent findings The main advantages of TOSA compared with transclavicular techniques are its superb exposure of anatomic structures located at the level of the cervicothoracic junction,...
Fri Mar 06, 2020 14:15
Purpose of review A strong association between diabetes mellitus and carcinogenesis has been reported in different organs. The purpose of this review is to summarize the new evidences in relation to diabetes mellitus and its association with the development, prognosis, and therapeutic strategies of head and neck squamous cell carcinomas (HNSCC). Recent findings Recent publications suggest that glycemic metabolism is altered in HNSCC. Elevated blood glucose levels, before or around the time...
Fri Mar 06, 2020 14:15
Purpose of review Medullary thyroid carcinoma (MTC) represents a wide spectrum of tumours with differing biology, behaviour and natural history. The only current available curative treatment is surgery in the form of thyroidectomy with or without ipsilateral or bilateral neck dissection. There is a lack of consensus in the available published guidelines on the optimum extent of initial surgery, and there is significant variation in clinical practice. This review focuses on the most recently published...
Fri Mar 06, 2020 14:15
Purpose of review The vessel-depleted neck is the ultimate challenge for the head and neck reconstructive surgeon. In patients who have had previous neck dissections or radiotherapy, the arterial and venous options for future reconstruction can be very limited, and it is important for the surgeon to consider alternative options for vessels. Recent findings Appropriate preoperative planning is crucial in these patients with a thorough history including previous operation notes, details of...
Fri Mar 06, 2020 14:15
Purpose of review Anaplastic thyroid cancer (ATC) is a rare but aggressive form of thyroid cancer that is associated with significant morbidity and mortality. Because ATC is locally invasive, airway management is a critical component of treating these patients. Timely decisions regarding airway interventions can contribute to symptom relief and supportive care for patients. Over the last decade, there has been a paradigm shift in our recommendations for airway management. The purpose of this review...
Fri Mar 06, 2020 14:15
Purpose of review The 8th edition tumor, node, metastasis (TNM) classification (TNM-8) introduced a new classification for human papillomavirus (HPV)-mediated oropharyngeal carcinoma (HPV+ OPC). This review summarizes its potential therapeutic implications focusing on literature published since 2018. Recent findings The following are active research areas involved in clinical care and therapy relevant to TNM-8: tumor HPV testing and its clinical implications; stage I disease: treatment selection...
Fri Mar 06, 2020 14:15
Purpose of review To review, the surgical approaches available on diagnosing a patient with salivary gland malignancy in the infratemporal fossa (ITF). To comment on patient evaluation and method of treatment selection. To identify and report on patient outcome data and make recommendations on future needs. Recent findings There is a need to define the anatomic boundaries contents of the ITF, masticator space, parapharyngeal space (PPS), pterygopalatine fossa, ventral skull base, and paramedian...
Fri Mar 06, 2020 14:15
Purpose of review Electrochemotherapy (ECT) is increasingly used in different settings in head and neck cancer patients when conventional treatment options are not available. Recent findings Recent improvements of electroporation and ECT include new advanced electrode probes, the combination with intratumorally injected supraphysiological doses of calcium and an update of the standard operating procedures. Summary ECT is a treatment modality that combines administration of a chemotherapeutic...
Fri Mar 06, 2020 14:15
Purpose of review Perineural invasion (PNI) is a pathological feature frequently observed in head and neck squamous cell carcinoma (HNSCC). The difficulties of pathological standardization and the lack of a simple validated experimental model to study PNI render its analysis complex. Here, we aim to summarize the recent advances in the understanding of the biology of PNI in HNSCC and their potential clinical implications. Recent findings PNI is a multistep process leading to a dialogue between...
Fri Mar 06, 2020 14:15
Purpose of review The present review describes the latest development of 3D virtual surgical planning (VSP) and computer aided design (CAD) for reconstruction of maxillary defects with an aim of fully prosthetic rehabilitation. The purpose is to give an overview of different methods that use CAD in maxillary reconstruction in patients with head and neck cancer. Recent findings 3D VSP enables preoperative planning of resection margins and osteotomies. The current 3D VSP workflow is expanded...
Fri Mar 06, 2020 14:15
Purpose of review The progressive growth of endoscopic and robotic-assisted procedures provided the tools for development of remote approaches to the neck, which could avoid a visible large neck scar usually necessary for neck dissections. This review explores the current experience with robotic neck dissection, looking for pros and cons in surgical, oncologic and aesthetic outcomes. Recent findings Robotic neck dissection was shown to be feasible and well tolerated, with adequate oncological...
Fri Mar 06, 2020 14:15
Purpose of review To overview the array of differential diagnoses among lipomatous tumours of the head and neck with special focus on their evaluation, three-dimensional assessment, and their available treatments. Recent findings The head and neck is an infrequent localization for lipomatous tumours, even though they represent the most common mesenchymal lesions. Lipoma, spindle cell/pleomorphic lipoma (SC/PL), atypical lipomatous tumour/well differentiated liposarcoma (ALT/WDLPS), de-differentiated...
Fri Mar 06, 2020 14:15
Sat Mar 07, 2020 02:00
Abstract Purpose Granulomatous inflammation is a common cause of subacute cervicofacial lymphadenitis in children. Nontuberculous mycobacterial (NTM) infections and cat-scratch disease (CSD) are the most frequent causes. Optimal treatment, which may include surgery, antibiotic treatment or wait-and-see approach, is debatable. The goal of this study was to compare the short- and long-term outcome of various surgical procedures. ...
Fri Mar 06, 2020 02:00
Abstract Objective To assess the change in health-related quality of life (HRQoL) in patients undergoing mastoid cavity obliteration. Methods Patients who had undergone canal wall-down mastoidectomy for chronic otitis media with creation of a persistent mastoid cavity and underwent revision tympanomastoid surgery including mastoid cavity obliteration using...
Fri Mar 06, 2020 02:00
Abstract Purpose To show the different effects of expansion sphincter pharyngoplasty (ESP) and barbed reposition pharyngoplasty (BRP) on muscle tension and muscle fiber tearing using a comparative experimental stress test with a frog thigh muscle model. Methods Frog thigh muscle was used for this experimental study. A Barbed suture was used to simulate the...
Fri Mar 06, 2020 02:00
Fri Mar 06, 2020 02:00
Abstract Hidradenitis Suppurativa (HS) is a chronic inflammatory dermatosis in which B cells play a prominent but unclear role. Our understanding of the role of B‐cells in innate and adaptive immunity (including antibody production, antigen presentation and effector functions) is rapidly evolving; and these novel findings requiring integration into the pathophysiologic model of HS. B‐cells are transiently present in normal human skin and have functions in the maintenance of innate cutaneous immunity....
Sun Mar 08, 2020 02:26
Abstract Mouse dorsal coat hair types, guard, awl, auchene and zigzag, develop in three consecutive waves. To date, it is unclear if these hair types are determined genetically through expression of specific factors or can change based on their mesenchymal environment. We undertook a novel approach to this question by studying individual hair type in 67 Collaborative Cross (CC) mouse lines and found significant variation in the proportion of each type between strains. Variation in the proportion...
Sat Mar 07, 2020 21:02
This study aims to examine the availability of subscales in the Tinnitus Handicap Inventory (THI) originally proposed by Newman and the possibility of other useful subscales. We also examine whether each item ...
Sat Mar 07, 2020 02:00
Abstract Background International thyroid nodule and cancer management guidelines generally fail to take into account potential limitations in diagnostic and treatment resources. Methods Thyroid cancer specialists from the African Head and Neck Society and American Head & Neck Society Endocrine Section developed guidelines for diagnosis and management of thyroid nodules and cancer in low resource settings. Recommendations were based on literature review and expert opinion, with...
Sat Mar 07, 2020 12:55
Abstract Background Relationships between health insurance coverage and radiotherapy (RT) interruption rates in patients with head and neck (H&N) cancer remain unclear. Methods We performed a retrospective cohort study at our academic center. Days of RT interruption for individual patients were tabulated, analyzed for explanatory variables, and geographically mapped. Results 894 of 7526 (11.9%) scheduled treatment days were interrupted, impacting 149 of 216 (69%) patients....
Sat Mar 07, 2020 00:49
Abstract Background Single‐modality treatment (surgery or radiotherapy [RT]) is a curative treatment option for early‐stage oropharyngeal carcinoma (OPC) with comparable (excellent) oncological outcomes. This study aimed to compare self‐reported swallowing function. Methods Participants with a T1‐2N0‐2bM0 OPC who were offered single‐modality treatment and were recruited to the Head and Neck 5000 study were included. Prospectively collected self‐reported swallowing function was compared...
Sat Mar 07, 2020 00:49
Abstract Introduction Human papillomavirus (HPV) is among the reported etiologies of laryngeal squamous cell carcinoma (LSCC). Understanding the impact of HPV on LSCC may help reduce its incidence. This study investigates the association between HPV and LSCC as well as the roles for different immunohistochemical stains in HPV detection. Methods A total of...
Sat Mar 07, 2020 02:00
Related ArticlesLong-term outcome of surgical excision for treatment of cervicofacial granulomatous lymphadenitis in children. Eur Arch Otorhinolaryngol. 2020 Mar 06;: Authors: Neven Q, Van der Linden D, Hainaut M, Schmitz S Abstract PURPOSE: Granulomatous inflammation is a common cause of subacute cervicofacial lymphadenitis in children. Nontuberculous mycobacterial (NTM) infections and cat-scratch disease (CSD) are the most frequent causes. Optimal...
Sun Mar 08, 2020 13:54
Related ArticlesMastoid cavity obliteration leads to a clinically significant improvement in health-related quality of life. Eur Arch Otorhinolaryngol. 2020 Mar 06;: Authors: Weiss NM, Bächinger D, Botzen J, Großmann W, Mlynski R Abstract OBJECTIVE: To assess the change in health-related quality of life (HRQoL) in patients undergoing mastoid cavity obliteration. METHODS: Patients who had undergone canal wall-down mastoidectomy for chronic otitis...
Sun Mar 08, 2020 13:54
Related ArticlesLateral pharyngoplasty techniques for obstructive sleep apnea syndrome: a comparative experimental stress test of two different techniques. Eur Arch Otorhinolaryngol. 2020 Mar 06;: Authors: Iannella G, Magliulo G, Di Luca M, De Vito A, Meccariello G, Cammaroto G, Pelucchi S, Bonsembiante A, Maniaci A, Vicini C Abstract PURPOSE: To show the different effects of expansion sphincter pharyngoplasty (ESP) and barbed reposition pharyngoplasty...
Sun Mar 08, 2020 13:54
Related ArticlesA Call for Improved Otoscopy Training. Eur Arch Otorhinolaryngol. 2020 Mar 06;: Authors: Hakimi AA, Lalehzarian AS, Lalehzarian SP, Azhdam AM, Nedjat-Haiem S, Boodaie BD PMID: 32144567 [PubMed - as supplied by publisher]
Sun Mar 08, 2020 13:54
Related ArticlesReply to the letter to the editor concerning 'The of elevation of the mucosal flap without additional anterior canal wall incisions for repairing anterior perforations using endoscopic cartilage tympanoplasty'. Eur Arch Otorhinolaryngol. 2020 Mar 06;: Authors: Gülşen S, Arıcı M PMID: 32144566 [PubMed - as supplied by publisher]
Sun Mar 08, 2020 13:54
Related ArticlesEffects of submucosal PRP injection on wound healing in endonasal surgeries: an experimental study. Eur Arch Otorhinolaryngol. 2020 Mar 06;: Authors: Yildirim U, Kemal O, Aksoy A, Karaca E, Terzi O, Atmaca S Abstract PURPOSE: To investigate the effects of submucosal platelet-rich plasma (PRP) injection on nasal mucosal wound healing after endoscopic sinus surgery. METHODS: 24 New Zealand white rabbits were randomly divided into...
Sun Mar 08, 2020 13:54
Related ArticlesCorrection to: Efficacy and safety of delivery of topical medication on to the frontal sinus at different head positions after frontal sinusotomy. Eur Arch Otorhinolaryngol. 2020 Mar 06;: Authors: Wu YX, Wang M, Li H, Xing ZM, Shi MH, Huang SE, Liu Y, Geng CL Abstract In the original publication of the article, under the experimental protocol of the section "Clinical head position study in postoperative CRS patients", the following sentence...
Sun Mar 08, 2020 13:54
Related ArticlesCorrection to: Safety of the "Saxophone®" electrode in parotid surgery for continuous intraoperative neuromonitoring of the facial nerve: results of a pro- and retrospective cohort study. Eur Arch Otorhinolaryngol. 2020 Mar 06;: Authors: Stankovic P, Wittlinger J, Georgiew R, Dominas N, Reimann K, Hoch S, Wilhelm T, Günzel T Abstract In the original publication of the article, first name and last names of all authors were swapped.PMID:...
Sun Mar 08, 2020 13:54
Related ArticlesOutcomes for a clinically representative cohort of hearing-impaired adults using the Nucleus® CI532 cochlear implant. Eur Arch Otorhinolaryngol. 2020 Mar 05;: Authors: Hey M, Neben N, Stöver T, Baumann U, Mewes A, Liebscher T, Schüssler M, Aschendorff A, Wesarg T, Büchner A, Greenham P, Hoppe U Abstract PURPOSE: Hearing performance data was collected from a large heterogeneous group of subjects implanted with the Cochlear™ Nucleus® CI532...
Sat Mar 07, 2020 13:51
J Neurol Surg BDOI: 10.1055/s-0040-1702218 Background Skull base chordomas are a major therapeutic challenge. The surgical management involves selecting an approach that will offer the patient the best chance of largest/complete removal while minimizing morbidity and mortality. Methods Medical records and imaging review of two skull base chordomas involving the middle fossa and posterior fossa that were successfully treated with an endoscope-assisted middle fossa approach. ...
Fri Mar 06, 2020 01:00
J Neurol Surg BDOI: 10.1055/s-0040-1701530 Objective This study aims to determine the topographic localization of the stylomastoid foramen (SF) and its morphometric relationship with the surrounding bony landmarks. Design A descriptive anatomical study. Setting Anatomy Laboratory of the Faculty of Medicine. Participants Measurements were performed on 53 dry temporal bones. Main Outcome Measures On the inferior and lateral aspects of photographic...
Fri Mar 06, 2020 01:00
To evaluate the graft success rate and postoperative hearing gain for marginal perforations using endoscopic cartilage myringoplasty with the removal of a small rim of the external auditory canal (EAC).
Fri Mar 06, 2020 02:00
We observed several cases of hypotension associated with high-dose dacarbazine. We conducted a retrospective observational analysis of all patients treated with high-dose dacarbazine from January 2018 to August 2019 in Oscar Lambret Center, Lille, France. In our study, a total of 23 patients in outpatient care were analyzed, they underwent 57 treatment cycles. We observed 8 episodes of hypotension in 7 of the 23 consecutive treated patients (30.4%). We discuss herein several hypotheses explaining...
Wed Mar 04, 2020 02:00
Immune checkpoint inhibitors have become the mainstay of treatment for metastatic melanoma. This article presents a new case of acquired generalised lipodystrophy (AGL) during anti-programmed cell death-1 (anti-PD-1) therapy and a systematic review of the literature with an aim to further understand the pathogenesis. A comprehensive search was conducted using PubMed, Embase, MEDLINE and Cochrane Central databases. We identified four cases of lipodystrophy associated with anti-PD-1 immunotherapy,...
Wed Mar 04, 2020 02:00
It wasn’t very long ago that it seemed like every woman walking around the fancy shops in Manhattan looked eerily similar to every other one: they were all proudly sporting the same nose! In 1957, the Goldman tip was popularized. It is a vertical dome division endonasal approach that narrows the tip of the nose and causes a slightly upward projection. This results in a pert, adorable nose popularized by many American television stars in the 1960s and therefore coveted widely. The Diamond nose has...
Sat Mar 07, 2020 04:10
Over the past several decades, in the United States and around the world, we have witnessed a transformation in racial and cultural demographics and awareness. Within the United States, we have experienced population growth with significant increases seen in Hispanics, Asians, Indo-Asians, and patients of African descent. Greater social acceptance of cosmetic procedures and improved economics combined with this change in cultural demographics has resulted in an increase in individuals of diverse...
Sat Mar 07, 2020 04:10
Abstract The aim of this study was to investigate the adequacy of the reporting of cochlear implant device failures. Data from a parallel study involving over 6300 children [1] was used to calculate the instantaneous failure rate for explantations. We found that this is comparable to what manufacturers term ‘Cumulative Failure Percentage’ (CFP). This finding raises concerns about the information provided by manufacturers on the reliability of their implants.
Sat Mar 07, 2020 02:00
Publication date: Available online 6 March 2020Source: Operative Techniques in Otolaryngology-Head and Neck SurgeryAuthor(s): Robert T. Sataloff, Rakesh Chandra, Edward W. Fisher, David Goldenberg, Ehab Y. Hanna, Jonas Johnson, David W. Kennedy, Dennis H. Kraus, John H. Krouse, Michael Link, Lawrence R. Lustig, Jr Bert W. O'Malley, Jay F. Piccirillo, Robert Ruben, Sandra Schwartz, Samuel H. Selesnick, Raj Sindwani, Richard J. Smith, Michael G. Stewart, James Tysome
Sat Mar 07, 2020 14:26
Publication date: Available online 5 March 2020Source: Operative Techniques in Otolaryngology-Head and Neck SurgeryAuthor(s): Lauren E. Miller, Jacqueline J. Greene
Fri Mar 06, 2020 14:13
Publication date: Available online 6 March 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Juha Tapio Silvola
Fri Mar 06, 2020 19:21
Publication date: Available online 5 March 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Aileen Wertz, Linda Carroll, Karen B. Zur
Fri Mar 06, 2020 19:21
Objectives Our objectives were to analyze the recent trends in applicants of otolaryngology‐head and neck surgery (Oto‐HNS) residency programs, including evolutions in sex and racial/ethnic distribution within the applicant pool and subsequent residency cohort. Methods Retrospective database and literature review. Data regarding applicants to Oto‐HNS programs as well as Oto‐HNS residents in the United States from 2008 to 2017 were analyzed from the Electronic Residency Application Service,...
Sat Mar 07, 2020 10:32
Objectives/Hypothesis To assess the ability of specific positron emission tomography/computed tomography (PET/CT) and magnetic resonance imaging (MRI) features to detect extracapsular extension (ECE) in head and neck squamous cell carcinoma (HNSCC) patients. Study Design Retrospective study in a tertiary certified university cancer institute. Methods We performed a review of patients with advanced HNSCC at Bern University Hospital between 2014 and 2018. Patients with pretherapeutic...
Fri Mar 06, 2020 22:20
Objectives/Hypothesis To evaluate whether antithrombotic status impacts the incidence of perioperative or postoperative bleeding in direct microlaryngoscopy (DML). Study Design Retrospective chart review. Methods Patients undergoing DML in a single surgeon's practice from September 2012 to September 2017 were studied. Included patients underwent DML with or without biopsy, balloon dilation, microsurgery, laser ablation, or vocal fold injection. Patients were stratified based...
Fri Mar 06, 2020 22:20
EWSR1‐PATZ1 is a rare gene fusion recently recognized to occur in round and spindle cell sarcomas. To date, fewer than 20 cases have been described in the literature. However, no dedicated case reports have detailed its presentation in the head and neck region. We recently cared for a 52‐year‐old woman with an isolated, single right level 5A cervical mass. Excisional biopsy at an external hospital revealed pathology results consistent with EWSR1‐PATZ1 polyphenotypic round and spindle cell sarcoma....
Fri Mar 06, 2020 22:20
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