Severe acute kidney injury (AKI), especially when caused or accompanied by sepsis, is associated with prolonged hospitalization, progression to chronic kidney disease (CKD), financial burden, and high mortalit...
Fri Mar 06, 2020 02:00
High-frequency oscillatory ventilation (HFOV) may theoretically provide lung protective ventilation. The negative clinical results may be due to inadequate mean airway pressure (mPaw) settings in HFOV. Our obj...
Fri Mar 06, 2020 02:00
Former white and middle-class cocaine and cannabis dealers talk about their often contradictory “careers in dope.” When anthropologists and sociologists study illegal drug dealing (or anything else), we tend to be wary of such economic orthodoxy as “self-interest.” Our analyses rely, instead, on culture or subcultures or deviance with attention to how social inequalities give rise to patterns of behavior. Drawing a line of cocaine. danielfoster437/Flickr (CC BY-NC-SA 2.0) Deeper dynamics of...
Fri Mar 06, 2020 19:30
What might a letter of complaint to a university truth commission reveal about Brazil’s political climate and the multiple lives of documents? The letter wobbled in brief, nervous tremors between Pedro’s mature hands—the left one adorned with a large, silver watch. He moved slightly in his chair to greet the new arrivals, making sure that the attendees promptly took their seats around the oval table to begin an already late meeting. They were gathering to discuss the future projects on which...
Fri Mar 06, 2020 16:30
Journal Name: Biological ChemistryIssue: Ahead of print
Sun Mar 08, 2020 12:32
Journal Name: Biological ChemistryIssue: Ahead of print
Sun Mar 08, 2020 12:32
Journal Name: Biological ChemistryIssue: Ahead of print
Sat Mar 07, 2020 12:20
Understanding adaptation involves establishing connections between selective agents and beneficial population responses. However, relatively little attention has been paid to seasonal adaptation, in part, beca...
Fri Mar 06, 2020 02:00
We report a female toddler who presented repetitively with a chief complaint of motile white worms seen in her diapers. Symptoms of perianal itching and visualization of visible motile worms persisted for 6 months despite being treated with multiple courses of albendazole causing a lot of frustration and distress to the caregivers. The characteristics of the worms by inspection along with the presence of 3 pet dogs are consistent with Dipylidium caninum.
Sat Mar 07, 2020 22:20
Abstract With the predicted increase in extreme weather events as a result of global climate change, animals living in dry or seasonally dry habitats are likely to experience dramatic fluctuations in water availability from season to season and year to year. Understanding how animals respond to short-term changes in water availability is paramount for future conservation and management of water-dependent wild populations. We investigated how short-term changes to the availability...
Sat Mar 07, 2020 02:00
Abstract The proximate and ultimate mechanisms underlying scaling relationships as well as their evolutionary consequences remain an enigmatic issue in evolutionary biology. Here I investigate the evolution of wing allometries in the Schizophora, a group of higher Diptera that radiated about 65 million years ago, by studying static allometries in five species using multivariate approaches. Despite the vast ecological diversity observed in contemporary members of the Schizophora and independent...
Sat Mar 07, 2020 21:01
Abstract Osteocytes, cells embedded within the bone mineral matrix, inform on key aspects of vertebrate biology. In particular, a relationship between volumes of the osteocytes and bone growth and/or genome size has been proposed for several tetrapod lineages. However, the variation in osteocyte volume across different scales is poorly characterised, and mostly relies on incomplete, two‐dimensional information. In this study, we characterise the variation of osteocyte volumes in ray‐finned fishes...
Sat Mar 07, 2020 09:12
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b11809
Fri Mar 06, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b11875
Fri Mar 06, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c02031
Fri Mar 06, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c00905
Fri Mar 06, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b13694
Fri Mar 06, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c01576
Fri Mar 06, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c01757
Fri Mar 06, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b12171
Fri Mar 06, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b12873
Fri Mar 06, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c02356
Fri Mar 06, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c00363
Fri Mar 06, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c01318
Fri Mar 06, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b13960
Fri Mar 06, 2020 07:00
Abstract Transcranial photobiomodulation is an innovative method for the stimulation of neural activity which consists of the exposure of neural tissue to low-level light irradiance. In the present study, light-emitting diodes (LEDs) were used as light source due to their practicality and low cost. The objective was to analyze the effects of transcranial photobiomodulation using 945-nm LED in university students with anxiety and depression. Sample was composed of 22 individuals...
Sat Mar 07, 2020 02:00
Abstract Purpose This study aimed to explore the differences in VERDICT parameters for normal prostatic tissues among different regions and age groups. Materials and methods In total, 31 male volunteers were included in the study. Vascular, extracellular and restricted diffusion for cytometry in tumors (VERDICT) model parameters (fIC, intracellular volume...
Sat Mar 07, 2020 02:00
Abstract The aim of this study was to clarify the effect of the spore-forming and lactic acid-producing probiotic strain, Bacillus coagulans SANK 70258, on human colonic microbiota of healthy subjects and ulcerative colitis patients. A model culture system was employed to construct the in vitro human colonic microbiota, to retain the bacterial species richness and simulate the patient’s disordered composition, from the fecal inoculum. Bacterial 16S rRNA...
Sat Mar 07, 2020 02:00
Abstract Corynebacterium glutamicum is widely used to produce amino acids and is a chassis for the production of value-added compounds. Effective genome engineering methods are crucial to metabolic engineering and synthetic biology studies of C. glutamicum. Herein, a homing endonuclease I-SceI-mediated genome engineering strategy was established for the model strain C. glutamicum ATCC 13032. A vegetative R6K replicon-based, suicide plasmid was employed....
Sat Mar 07, 2020 02:00
Abstract Background Oral health is associated with diabetes, but the chances of experiencing acute or chronic diabetes complications as per this association is unknown in Canada’s most populous province, Ontario. This study assesses the impact of self-reported oral health on the likelihood of experiencing acute and chronic complications among a cohort of previously diagnosed diabetics. ...
Sat Mar 07, 2020 02:00
Summary Background Metformin use is associated with reduced cancer risk in epidemiological studies and has preclinical anti-cancer activity in ovarian cancer models. The primary objective of this phase I study was to determine the recommended phase II dose (RP2D) of metformin in combination with carboplatin/paclitaxel in patients with ovarian cancer. Secondary objectives were to describe safety and pharmacokinetics. Methods In this single-center trial the RP2D of metformin in...
Sat Mar 07, 2020 02:00
Abstract Sperm morphology, as an indicator of fertility, is a critical tool in semen analysis. In this study, a smartphone-based hybrid system that fully automates the sperm morphological analysis is introduced with the aim of eliminating unwanted human factors. Proposed hybrid system consists of two progressive steps: automatic segmentation of possible sperm shapes and classification of normal/ab-normal sperms. In the segmentation step, clustering techniques with/without group...
Fri Mar 06, 2020 02:00
Abstract Rationale Is it possible to have a psychedelic experience from a placebo alone? Most psychedelic studies find few effects in the placebo control group, yet these effects may have been obscured by the study design, setting, or analysis decisions. Objective We examined individual variation in placebo effects in a naturalistic environment resembling...
Sat Mar 07, 2020 02:00
Abstract Tissue reactions and stochastic effects after exposure to ionising radiation are variable between individuals but the factors and mechanisms governing individual responses are not well understood. Individual responses can be measured at different levels of biological organization and using different endpoints following varying doses of radiation, including: cancers, non-cancer diseases and mortality in the whole organism; normal tissue reactions after exposures; and, cellular...
Sat Mar 07, 2020 02:00
Abstract Grau and Pury (Review of Philosophy and Psychology, 5, 155–168, 2014) reported that people’s views about love are related to their views about reference. This surprising effect was however not replicated in Cova et al.’s (in press) replication study. In this article, we show that the replication failure is probably due to the replication’s low power and that a metaanalytic reanalysis of the result in Cova et al. suggests that the effect reported in Grau and Pury is real....
Sat Mar 07, 2020 02:00
Related ArticlesPhotochemical aqueous-phase reactions induce rapid daytime formation of oxygenated organic aerosol on the North China Plain. Environ Sci Technol. 2020 Mar 04;: Authors: Kuang Y, He Y, Xu W, Yuan B, Zhang G, Ma Z, Wu C, Wang C, Wang S, Zhang S, Tao J, Ma N, Su H, Cheng Y, Shao M, Sun Y Abstract Secondary organic aerosol (SOA) constitutes a large fraction of organic aerosol worldwide, however, the formation mechanisms in polluted environments...
Sat Mar 07, 2020 01:07
Oncogenesis, Published online: 06 March 2020; doi:10.1038/s41389-020-0212-5Transcription co-activator P300 activates Elk1-aPKC-ι signaling mediated epithelial-to-mesenchymal transition and malignancy in hepatocellular carcinoma
Fri Mar 06, 2020 02:00
Oncogenesis, Published online: 05 March 2020; doi:10.1038/s41389-020-0216-1Cdc37 suppression induces plasma cell immaturation and bortezomib resistance in multiple myeloma via Xbp1s
Thu Mar 05, 2020 02:00
Fri Mar 06, 2020 02:00
Neuroblastoma is the most common type of extracranial solid tumor during childhood. Clinical presentation includes ipsilateral ptosis, myosis, anhydrosis and enophthalmos. The case of a 2.5-year-old boy who had a complaint of constriction of the left pupil for 3 days is presented. In the physical examination, the pupil of the OD was moderately dilated; there was myosis on the OS and ptosis on the left eyelid. Horner syndrome was considered due to these findings. History of the patient revealed that...
Sun Mar 01, 2020 02:00
Purpose: Orbital myositis occurs in typical and atypical forms. This review summarizes and updates the current state of knowledge of all forms of inflammation affecting extraocular muscle, excluding thyroid-associated orbitopathy. Methods: A comprehensive literature review of orbital myositis was performed. Results: Orbital myositis typically occurs in an idiopathic acute form, with painful diplopia due to inflammation in 1 or more extraocular muscles of young adult females, which usually...
Sun Mar 01, 2020 02:00
Purpose: The aim of this systematic review is to provide 1) an understanding of the components of quality of life (QOL) questionnaires and 2) an up-to-date insight of the types of QOL questionnaires available, strengths and limitations based on current literature. Methods: A literature search was conducted from 18 to 21 of February 2019 using 6 major databases: Cochrane Library, Ovid Medline, PubMed, Scopus, Taylor and Francis, and Web of Science. All papers were skimmed by title and abstract...
Sun Mar 01, 2020 02:00
No abstract available
Sun Mar 01, 2020 02:00
Purpose: Extrusion is the most common cause of failure in conventional Lester Jones tubes (LJTs). StopLoss Jones tubes (SLJTs) with distal flange are designed to reduce this complication. This study compared the survival of SLJTs with their prior LJTs and control patients with LJTs-only. Methods: Retrospective review of consecutive LJT or SLJT insertion between January 2014 and December 2016. Results: Twenty-eight eyes of 23 patients had 31 SLJTs. Before their SLJTs, these patients had...
Sun Mar 01, 2020 02:00
A 52-year-old woman with a 7-month history of a left lateral upper eyelid nodule presented with an acute, 1-day history of left upper eyelid swelling and erythema associated with chemosis, epiphora, and pain. Magnetic resonance (MR) imaging revealed a well-circumscribed cystic mass indistinguishable from the left lacrimal gland containing a fluid–fluid level. Surgery confirmed an abscess within the lacrimal gland; histopathologic examination revealed a dilated lacrimal duct with an inflammatory exudate...
Sun Mar 01, 2020 02:00
Purpose: Intravenous ketorolac (IVK) is an effective agent to reduce postoperative pain without the risks inherent to opioid analgesics. However, many clinicians avoid using this agent due to concerns regarding hemorrhagic complications. This study was performed to assess the efficacy and safety of IVK in the setting of orbital surgery. Methods: In a single dose prospective study, patients either received IVK immediately before orbital surgery (n = 50) or acted as controls (n = 50). Postoperative...
Sun Mar 01, 2020 02:00
Focal eosinophilic myositis (FEM) is a rare disease that is even more uncommon in affecting the periocular area. The authors are reporting the first case of FEM occurring in the lower eyelid of a 45-year-old Caucasian female who presented with localized painful area of glossy induration and peau d’orange skin lesion. Magnetic resonance image shows significant hyperintense thickening of the pre-septal orbicularis muscle region on T2-weighted images. Incisional biopsy of the induration revealed marked...
Sun Mar 01, 2020 02:00
Purpose: Canthotomy is frequently used to mobilize extra tissue when repairing larger lower eyelid defects. The aim of this study was to explore the effect of canthotomy on blood perfusion and oxygen tension. Methods: Eight pigs underwent a wedge resection of the lower eyelid and canthotomy (with cantholysis involving the lateral palpebral artery). The wedge resection was performed 8, 6, and 4 mm from the canthotomy. Perfusion and oxygen tension were monitored in the eyelid between the wedge...
Sun Mar 01, 2020 02:00
Purpose: To compare bony orbital volumes in young skulls with those of older skulls to elucidate aging-associated changes of the orbit. Methods: One hundred Caucasian male skulls from the Hamann-Todd collection of the Cleveland Museum of Natural History were studied. There were 50 young skulls (age range, 19–33 years) and 50 senescent skulls (age range, 79–96 years). Volcanic sand was used to fill each orbit in an identical fashion and weighed as a proxy for volume. Digital calipers were...
Sun Mar 01, 2020 02:00
A 56-year-old man presented with a periorbital subcutaneous mass and ipsilateral visually significant orbital inflammation that was refractory to broad-spectrum antibiotics. Orbitotomy with biopsy revealed the diagnosis of metastatic lung cancer, and the patient was initiated on systemic chemotherapy and adjuvant radiation. This is the first report of pulmonary adenocarcinoma metastatic simultaneously to the periocular cutaneous and intraorbital soft tissues. Atypical periorbital and orbital inflammation...
Sun Mar 01, 2020 02:00
Purpose: To compare serum angiotensin-converting enzyme (sACE) titers in patients with newly diagnosed sarcoid-like dacryoadenitis and nongranulomatous dacryoadenitis. Study Design: Retrospective comparative case series. Patients and Methods: Clinical details and presenting sACE titers were reviewed for patients with newly diagnosed sarcoid-like dacryoadenitis (SLD) and nongranulomatous dacryoadenitis (NGD). All sACE titers were expressed as a percentage of the upper end of normal range...
Sun Mar 01, 2020 02:00
The management of metastatic melanoma to the orbit may involve a variety of therapeutic modalities including external-beam radiation, chemotherapy, and varying degrees of surgical resection or debulking. Pembrolizumab is an immunotherapeutic agent that has demonstrated efficacy in the treatment of metastatic melanoma. The authors present a case of metastatic melanoma to the orbit demonstrating profound pseudoprogression within hours of beginning pembrolizumab therapy, with associated mass effect...
Sun Mar 01, 2020 02:00
Purpose: Large upper eyelid defects can be repaired by rotational full-thickness lower eyelid flaps. The aim was to measure the blood perfusion in such flaps, and how it is affected by the length of the flaps, and the degree of rotation and stretching. Methods: Nine patients underwent the Quickert procedure for entropion repair in which a full-thickness eyelid flap of approximate width 0.5 cm and length 2 cm was dissected in the lower eyelid. This generates a full-thickness eyelid flap similar...
Sun Mar 01, 2020 02:00
Pediatric-type follicular lymphoma is an uncommon B-cell lymphoma that primarily involves the lymph nodes of the head and neck of children and young adults. Ocular involvement is rare, with only 5 well-documented cases in the literature, all occurring in the conjunctiva. The authors describe a 20-year-old African American man with enlarging bilateral medial conjunctival nodules. Excisional biopsy of the larger left conjunctival lesion, clinically presumed to be pyogenic granuloma, revealed pediatric-type...
Sun Mar 01, 2020 02:00
Purpose: Self-inflicted facial gunshots (SIGSWs) typically result in a spectrum of severe injuries to facial structures, including the orbit and globe. Roughly three-quarters of those who arrive to the hospital will survive their injuries, and recidivism is typically low. Therefore, effective management is paramount to preserve vision, and long-term quality of life. The objective of this study is to characterize the common injuries to the orbit, globe, and periocular structures following SIGSWs,...
Sun Mar 01, 2020 02:00
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