There are many approaches to improving the well-being of medical students such as having a wellness curriculum including emphasizing the importance of keeping a balance in life between work and other activities, encouraging mindfulness and other stress reduction techniques, getting adequate sleep and exercise, and learning about the signs of burnout and depression. It is also important to have mentoring services and discussion groups available and to offer counseling for monetary management. Mental...
Sat Mar 07, 2020 02:00
Progressive supranuclear palsy (PSP) is rare neurodegenerative disorder characterized by deposition of fibrillar aggregates of 4R tau-protein in neurons and glial cells. This disorder is underdiagnosed due to the overlap of the clinical syndrome with other related conditions. The clinical manifestations include cognitive impairment associated with behavioral changes, akinetic rigid syndrome, and prominent oculomotor dysfunction. We present the 18F-FDG and 18F-THK5351 PET images of a 71-year-old man...
Sat Mar 07, 2020 02:00
A 45-year-old man with suspected colonic malignancy was referred to 18F-FDG PET/CT for staging. PET/CT images showed segmental increased FDG uptake along the intestine with thickening of colonic wall, where no mass was obviously seen. Subsequently, left hemicolectomy and resection of partial small intestine were done. Histopathology of the resected specimen confirmed the diagnosis of inflammatory pseudotumor involving colon and small intestine. No recurrence was detected on follow-up CT images after...
Sat Mar 07, 2020 02:00
An 81-year-old man with prostate adenocarcinoma (Gleason 4 + 3 = 7) treated with brachytherapy and intermittent androgen deprivation therapy was referred for serial 68Ga–prostate-specific membrane antigen (PSMA-HBED-CC) PET/CT scans for rising prostate-specific antigen. Findings were suggestive of local prostatic recurrence and nodal metastases. An incidental PSMA-avid focus was noted in the anterior wall of an infrarenal aortic aneurysm, with a contrast-enhanced hyperdense region surrounded by a...
Sat Mar 07, 2020 02:00
Purpose This article demonstrates the use of a new SPECT/CT acquisition protocol in patients with differentiated thyroid cancer (DTC). Methods SPECT/CT scans (FASpecT/CT) with fewer angle acquisitions were retrospectively reviewed in 30 DTC patients treated with radioiodine at University Hospital, San Antonio, Tex, from July 2017 to March 2019. This FASpecT/CT of 12 versus 60 to 64 sampled views for convention SPECT was made possible by iterative reconstruction. Results The...
Sat Mar 07, 2020 02:00
Management of patients with thyroglobulin elevated and negative iodine scan is still a challenge with limited options left as the disease stops concentrating iodine. The minimally invasive surgery is the best option for residual/recurrent locoregional disease in postsurgical setup requiring accurate presurgical localization. Intraoperative gamma probe using low-dose tracer has shown its utility in radioguided surgery. The authors present a 46-year-old man with thyroglobulin elevated and negative...
Sat Mar 07, 2020 02:00
The aim of this study was to investigate predictors of lymph node metastasis (LNM) in early gastric signet-ring cell carcinoma (SRCC) and determine clinicopathologic and prognostic differences of different histologic subtypes. We retrospectively analyzed 13,661 gastric cancer patients; 231 were eligible for inclusion. Data for clinical, endoscopic, and histopathologic characteristics and prognoses were collected. Patients were followed up regarding postresection survival; overall and disease-specific...
Fri Mar 06, 2020 02:00
Synovial sarcoma (SS), an aggressive soft tissue sarcoma with a predilection for the extremities of young adults, harbors the pathognomonic t(X;18)(p11;q11) translocation, resulting in SS18-SSX rearrangements. SS includes monophasic, biphasic, and poorly differentiated variants, which show considerable histologic overlap with a range of other tumor types, making the diagnosis challenging on limited biopsies. Immunohistochemistry (IHC) is routinely used in the differential diagnosis; however, presently...
Tue Mar 03, 2020 02:00
Papillary fibroelastoma (PFE) is an increasingly recognized cardiac tumor. Despite its prevalence, controversy exists as to whether it represents a reactive or neoplastic process due to histopathologic similarities with Lambl excrescences (LEs), an accepted reactive phenomenon. Recently, KRAS mutations were reported in a small collection of PFEs, but the incidence of mutations and conditions in which they arise in are unknown. Furthermore, the relationship between PFE and LE has yet to be investigated....
Tue Mar 03, 2020 02:00
No abstract available
Thu Mar 05, 2020 02:00
No abstract available
Wed Mar 04, 2020 02:00
Abstract: A 36-year-old apparently healthy man presented with acute onset of diplopia. Examination demonstrated left sixth nerve palsy with 3 retinal hemorrhages noted in one eye. Gadolinium-enhanced high-resolution skull base MRI revealed left sixth nerve enhancement involving the cisternal segment. Complete blood count, cerebrospinal fluid analysis, bone marrow biopsy, and flow cytometry confirmed acute T-cell lymphoblastic leukemia with central nervous system involvement. This case demonstrates...
Wed Mar 04, 2020 02:00
No abstract available
Wed Mar 04, 2020 02:00
Background: Severe, permanent vision loss is a feared sequela of untreated or refractory idiopathic intracranial hypertension (IIH). For patients with progressive vision loss despite maximally tolerated medical treatment, optic nerve sheath decompression (ONSD) remains a viable and effective option to protect vision. Our objective is to introduce a modified transconjunctival technique for ONSD and determine its safety, efficacy, and efficiency in patients with IIH. Methods: We performed...
Wed Mar 04, 2020 02:00
No abstract available
Wed Mar 04, 2020 02:00
Background: Compression of the optic chiasm typically leads to bitemporal hemianopia. This implies that decussating nasal fibers are selectively affected, but the precise mechanism is unclear. Stress on nasal fibers has been investigated using finite element modeling but requires accurate anatomical data to generate a meaningful output. The precise shape of the chiasm is unclear: A recent photomicrographic study suggested that nasal fibers decussate paracentrally and run parallel to each other...
Wed Mar 04, 2020 02:00
Publication date: Available online 7 March 2020Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): K. Liu, H. Sun, L. Zhang, B. Li, S. Chakraborty, X. Wang
Sun Mar 08, 2020 23:37
New way to reduce the length and bulk of a two-perforator anterolateral thigh flap: a technical note
Publication date: Available online 6 March 2020Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): P. Alam, F. Dylgjeri, P.A. Brennan
Sat Mar 07, 2020 20:45
Publication date: Available online 5 March 2020Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): Z.S. Shaikh, N. Ahmed, V. Beale, K. Moar
Fri Mar 06, 2020 11:44
Publication date: Available online 5 March 2020Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): L.G. Mercuri
Fri Mar 06, 2020 11:44
Publication date: Available online 5 March 2020Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): B. Gupta, N. Ahmed, A.J. Sidebottom
Fri Mar 06, 2020 11:44
Publication date: April 2020Source: Cancer Epidemiology, Volume 65Author(s): Emmanuel Desandes, Laure Faure, Sandra Guissou, Stéphanie Goujon, Claire Berger, Véronique Minard-Colin, Arnaud Petit, Gudrun Schleiermacher, Claire Poulalhon, Brigitte Lacour, Jacqueline Clavel
Sun Mar 08, 2020 22:14
Publication date: April 2020Source: Cancer Epidemiology, Volume 65Author(s): Jake Tempo, Callum Logan, Michael O’Callaghan, Arman Kahokehr, Ganessan Kichenadasse, Katina D’Onise, Darren Foreman
Sat Mar 07, 2020 15:11
Publication date: April 2020Source: Cancer Epidemiology, Volume 65Author(s): Marjolein Hermens, Anne M. van Altena, Johan Bulten, Albert G. Siebers, Ruud L.M. Bekker
Fri Mar 06, 2020 14:47
Publication date: April 2020Source: Cancer Epidemiology, Volume 65Author(s): Romain Fantin, Carolina Santamaría-Ulloa, Cristina Barboza-Solís
Fri Mar 06, 2020 14:47
Publication date: April 2020Source: Cancer Epidemiology, Volume 65Author(s): Peter Murchie, Wei Lynn Khor, Rosalind Adam, Magdalena Esteva, Emmanouil Smyrnakis, Davorina Petek, Hans Thulesius, Peter Vedsted, David McLernon, Michael Harris
Fri Mar 06, 2020 14:47
Chloroplast genomes (plastomes) are frequently treated as highly conserved among land plants. However, many lineages of vascular plants have experienced extensive structural rearrangements, including inversions and modifications to the size and content of genes. Cacti are one of these lineages, containing the smallest plastome known for an obligately photosynthetic angiosperm, including the loss of one copy of the inverted repeat (~25 kb) and the ndh genes suite, but only a few cacti from the subfamily...
Sun Mar 08, 2020 02:00
Humans are sexually dimorphic: on average men significantly differ from women in body build and composition, craniofacial structure, and voice pitch, likely mediated in part by developmental testosterone exposure. Hypotheses which attempt to explain the evolution of dimorphism in humans, such as the immunocompetence handicap hypothesis and the male-male competition hypothesis, assume that more dimorphic (i.e. masculine) men have historically achieved greater mating success, resulting in greater reproductive...
Sun Mar 08, 2020 02:00
During range expansions, epigenetic mechanisms may mediate phenotypic responses to environmental cues, enabling organisms to adjust to novel conditions at novel sites. Here, we predicted that the number of CpG sites within the genome, one form of epigenetic potential, would be important for success during range expansions because DNA methylation can modulate gene expression and hence facilitate adaptive plasticity. Previously, we found that this same form of epigenetic potential was higher in introduced...
Sun Mar 08, 2020 02:00
Mitochondria are the centre of energy metabolism in eukaryotic cells and its genes are thus key to the evolution of molecular mechanisms that metabolize cellular energy. Intertidal zone is one of the most stressful environments with extreme shifts in temperature, salinity, pH and oxygen concentrations. Marine molluscs, particularly chitons belong to the ecologically dominant organisms in this extreme environment, symbolizing an ideal model to understand mitochondrial stress adaptation. Here, we used...
Sun Mar 08, 2020 02:00
Plasticity and Artificial Selection for Developmental Mode in a Poecilogonous Sea Slug [NEW RESULTS]
Developmental mode describes the means by which larvae are provisioned with the nutrients they need to proceed through development, and typically results in a trade-off between offspring size and number. The sacoglossan sea slug Alderia willowi exhibits intraspecific variation for developmental mode (= poecilogony) that is environmentally modulated with populations producing more yolk-feeding (lecithotrophic) larvae during the summer, and more planktonic feeding (planktotrophic) larvae in the winter....
Sun Mar 08, 2020 02:00
In the evolutionary biology literature, it is generally assumed that in deterministic haploid selection models, in the absence of variation-generating mechanisms such as mutation, no polymorphic equilibrium can be stable. However, results corroborating this claim are scarce and almost always depend upon additional assumptions. Using ideas from game theory, we establish a condition on the fitness parameters of haplotypes formed by two loci such that a monomorphism is a global attractor. Further, we...
Sun Mar 08, 2020 02:00
Numerous studies of emerging species have identified genomic "islands" of elevated differentiation against a background of relative homogeneity. The causes of these islands remain unclear, however, with some signs pointing toward "speciation genes" that locally restrict gene flow and others suggesting selective sweeps that have occurred within nascent species after speciation. Here, we examine this question through the lens of recently obtained genome sequence data for five species of southern capuchino...
Sun Mar 08, 2020 02:00
Since all forms of mimicry are based on perceptual deception, the sensory ecology of the intended receiver is of paramount importance to test the necessary precondition for mimicry to occur, i.e. model-mimic misidentification, and to gain insight in the origin and evolutionary trajectory of the signals. Here we test the potential for aggressive mimicry by a group of coral reef fishes, the color polymorphic Hypoplectrus hamlets, from the point of view of their most common prey, small epibenthic gobies...
Sun Mar 08, 2020 02:00
One of the most widely-used measures for protein evolution is the ratio of nonsynonymous distance (dN) to synonymous distance (dS). Under the assumption that synonymous substitutions in the coding region are selectively neutral, the dN/dS ratio can be used to test the adaptive evolution if dN/dS>1 statistically significantly. However, due to selective constraints imposed on amino acid sites, most encoding genes demonstrate dN/dS<1. As a result, dN/dS of a gene is less than 1, even some sites...
Sun Mar 08, 2020 02:00
Since December 2019, coronavirus disease 2019 (COVID-19) emerged in Wuhan, Central China and rapidly spread throughout China. Up to March 3, 2020, SARS-CoV-2 has infected more than 89,000 people in China and other 66 countries across six continents. In this study, we used 10 new sequenced genomes of SARS-CoV-2 and combined 136 genomes from GISAID database to investigate the genetic variation and population demography through different analysis approaches (e.g. Network, EBSP, Mismatch, and neutrality...
Sat Mar 07, 2020 02:00
The evolution and diversification of Archaea is central to the history of life on Earth. Cultivation-independent approaches have revealed the existence of at least ten archaeal lineages whose members have small cell and genome sizes and limited metabolic capabilities and together comprise the tentative DPANN archaea. However, the phylogenetic diversity of DPANN and the placement of the various lineages of this group in the archaeal tree remain debated. Here, we reconstructed additional metagenome...
Sat Mar 07, 2020 02:00
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