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Objectives Reducing avoidable radiation exposure during medical procedures is a top priority. The purpose of this study was to quantify, for the first time, the percentage of avoidable radiation during fluoroscopically guided cardiovascular interventions using eye tracking technologies. Materials and Methods Mobile eye tracking glasses were used to measure precisely when the operators looked at a fluoroscopy screen during the interventions. A novel machine learning algorithm and image...
Fri Mar 06, 2020 02:00
Objectives To reduce the number of false-positive diagnoses in the screening of women with extremely dense breasts using magnetic resonance imaging (MRI), we aimed to predict which BI-RADS 3 and BI-RADS 4 lesions are benign. For this purpose, we use computer-aided diagnosis (CAD) based on multiparametric assessment. Materials and Methods Consecutive data were used from the first screening round of the DENSE (Dense Tissue and Early Breast Neoplasm Screening) trial. In this trial, asymptomatic...
Fri Mar 06, 2020 02:00
Objectives In late December, 2019, an outbreak of coronavirus disease (COVID-19) in Wuhan, China was caused by a novel coronavirus, newly named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We aimed to quantify severity of COVID-19 infection on High-Resolution CT and to determine its relationship with clinical parameters. Materials and Methods From Jan 11, 2020, to Feb 5, 2020, the clinical, laboratory and HRCT features of 42 patients (26-75 years, 25 males) with COVID-19...
Tue Mar 03, 2020 02:00
Objectives Using maximum diameter of an abdominal aortic aneurysm (AAA) alone for management can lead to delayed interventions or unnecessary urgent repairs. Abdominal aortic aneurysm stiffness plays an important role in its expansion and rupture. In vivo aortic magnetic resonance elastography (MRE) was developed to spatially measure AAA stiffness in previous pilot studies and has not been thoroughly validated and evaluated for its potential clinical value. This study aims to evaluate noninvasive...
Tue Mar 03, 2020 02:00
British Journal of Cancer, Published online: 09 March 2020; doi:10.1038/s41416-020-0778-xMitochondrial division inhibitor (mdivi-1) decreases oxidative metabolism in cancer
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British Journal of Cancer, Published online: 09 March 2020; doi:10.1038/s41416-020-0764-3A common polymorphism in the retinoic acid pathway modifies adrenocortical carcinoma age-dependent incidence
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British Journal of Cancer, Published online: 09 March 2020; doi:10.1038/s41416-020-0769-yImatinib in combination with phosphoinositol kinase inhibitor buparlisib in patients with gastrointestinal stromal tumour who failed prior therapy with imatinib and sunitinib: a Phase 1b, multicentre study
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British Journal of Cancer, Published online: 09 March 2020; doi:10.1038/s41416-020-0776-zPhase 1 study of the pan-HER inhibitor dacomitinib plus the MEK1/2 inhibitor PD-0325901 in patients with KRAS-mutation-positive colorectal, non-small-cell lung and pancreatic cancer
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Objectives: The motivation for this research is to determine whether a listening-while-balancing task would be sensitive to quantifying listening effort in middle age. The premise behind this exploratory work is that a decrease in postural control would be demonstrated in challenging acoustic conditions, more so in middle-aged than in younger adults. Design: A dual-task paradigm was employed with speech understanding as one task and postural control as the other. For the speech perception...
Fri Mar 06, 2020 02:00
Objectives: Vestibular reflexes have traditionally formed the cornerstone of vestibular evaluation, but perceptual tests have recently gained attention for use in research studies and potential clinical applications. However, the unknown reliability of perceptual thresholds limits their current importance. This is addressed here by establishing the test-retest reliability of vestibular perceptual testing. Design: Perceptual detection thresholds to earth-vertical, yaw-axis rotations were collected...
Fri Mar 06, 2020 02:00
Objectives: Cochlear implants (CIs) are remarkable in allowing individuals with severe to profound hearing loss to perceive speech. Despite these gains in speech understanding, however, CI users often struggle to perceive elements such as vocal emotion and prosody, as CIs are unable to transmit the spectro-temporal detail needed to decode affective cues. This issue becomes particularly important for children with CIs, but little is known about their emotional development. In a previous study,...
Fri Mar 06, 2020 02:00
Objective: This study aimed to (1) investigate the effect of pulse polarity on neural response of the electrically stimulated cochlear nerve in children with cochlear nerve deficiency (CND) and children with normal-sized cochlear nerves and (2) compare the size of the pulse polarity effect between these two subject groups. Design: The experimental and control group included 31 children with CND and 31 children with normal-sized cochlear nerves, respectively. For each study participant, evoked...
Tue Mar 03, 2020 02:00
Abstract Introduction Maxillectomy following tumors or, more rarely, traumatic injuries may result in maxillary defects that may determine physical dysfunctions and functional impairment of speech and swallowing. The aim of our study was to present our experience in the management of post-maxillectomy patients by the use of obturator prostheses that were obtained by 3D digital casts via an intraoral scanner. ...
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A 71-year-old man with pathologically confirmed rectal cancer underwent 18F-FDG PET/CT before radical operation, which showed multiple nodules with low uptake in bilateral pleura and 1 solitary pulmonary nodule with slight uptake in left lung. The subpleural nodule was diagnosed as benign lesion through the biopsy. 68Ga-labeled fibroblast-activation-protein inhibitor PET/CT was performed for further evaluation, which showed low uptake in bilateral subpleural nodules but focally increased uptake in...
Sat Mar 07, 2020 02:00
18F-FDG PET/CT was performed on a 48-year-old woman with leukocytosis (white blood cell count 57.10 × 109/L, 84.0% neutrophils) and monoclonal gammopathy to investigate the possibility of reactive neutrophilia secondary to plasmacytoma. On the background of skeletal “superscan,” the maximum intensity projection image of PET demonstrated the highest metabolic region in the left sacrum, which was confirmed as an osteolytic lesion by CT. Biopsy of the sacral lesion revealed a plasma cell myeloma, indicating...
Sat Mar 07, 2020 02:00
This 68-year-old woman with a 9-year history of skin sarcoidosis presented with abdominal pain, bloating, and diarrhea. Following positive occult fecal blood, a diagnosis of ascending colon sarcoidosis was pathologically confirmed after colonoscopy. FDG PET/CT was performed for sarcoid staging, and the ascending colon demonstrated the only focal site of active sarcoidosis (SUVmax = 10). Received for publication September 6, 2019; revision accepted January 16, 2020. Conflicts of interest and...
Sat Mar 07, 2020 02:00
We present a 60-year-old man with known prostate cancer treated with robot-assisted radical prostatectomy. Prostate-specific antigen levels did not decline accordingly, and a second 68Ga-PSMA PET/CT demonstrated a new focus with high 68Ga-PSMA uptake in the pancreatic tail. A subsequent CT scan did not display the lesion as a typical pancreatic tumor, and a spleen scintigraphy was also negative excluding an ectopic intrapancreatic accessory spleen. 68Ga-DOTATOC PET/CT showed uptake in the same area...
Sat Mar 07, 2020 02:00
A 78-year-old woman with chest pain and a history of pacemaker implantation for arrhythmia underwent myocardial perfusion imaging by means of 13N-NH3 cardiac PET/CT. 13N-NH3 cardiac PET showed no signs of ischemia or infarction. Incidentally, a nodule with increased 13N-NH3 activity was observed in the right breast. Histopathologic examination revealed invasive ductal carcinoma. Received for publication November 25, 2019; revision accepted January 14, 2020. Conflicts of interest and sources...
Sat Mar 07, 2020 02:00
In illicit drug use, “skin popping” refers to the method of administering drugs by injecting it into the subcutaneous tissue. “Skin popping” can lead to acute and chronic skin manifestations caused by the drug itself and/or by the various adulterants and fillers commonly added to drug substances. Chronic skin manifestations include a foreign-body reaction with formation of granulomas at the site of injection. We present the 18F-FDG PET/CT findings of extensive subcutaneous granulomas in a 58-year-old...
Sat Mar 07, 2020 02:00
Peripheral primitive neuroectodermal tumor (PNET) is a group of malignant tumors composed of small round cells. Peripheral PNET usually originates in the skeletal system. However, the presence of PNET lesion in prostate is extremely rare. We report a case of a 40-year-old man who presented with dysuria for more than 2 months. Pelvic MRI indicated prostatic malignant tumor, and 18F-DCFPyL PET/CT showed an isolated prostatic mass with high uptake of 18F-DCFPyL. Although 18F-DCFPyL is very specific...
Sat Mar 07, 2020 02:00
We present a case of secondary central nervous system relapse of lymphoma detected initially on PET/CT without corresponding findings on MRI. A 60-year-old lymphoma patient demonstrated an FDG-avid focus in left cerebellar hemisphere on restaging PET/CT. MRI brain showed no corresponding abnormality, and expectant management ensued. Six months later, she represented with metabolic progression of previously seen FDG-avid focus in left cerebellar hemisphere, now also manifesting as an enhancing mass...
Sat Mar 07, 2020 02:00
Splenogonadal fusion (SGF) is a rare congenital malformation, which can be of a continuous or discontinuous type. It is characterized by splenic tissue fused with gonadal tissue. Because it lacks characteristic features, very few cases of SGF have been diagnosed preoperatively. Herein, we present a case with left side SGF who was diagnosed by 99mTc-nanocolloid spleen scintigraphy. Received for publication November 14, 2019; revision accepted January 7, 2020. Conflicts of interest and sources...
Sat Mar 07, 2020 02:00
A 17-year-old boy presented with fatigue, hypoxia, palpitations, and anemia (hemoglobin 3.5 g/dL). The search for the etiology of the bleeding began with a Meckel scan. A photopenic region in the gastric body and a region of abnormal tracer uptake in the right midabdomen were unexpected findings. Further investigation with ultrasound and computed tomography revealed a gastric mass, which proved to be a gastrointestinal stromal tumor at pathology. The right-sided tracer uptake resulted from stasis...
Sat Mar 07, 2020 02:00
We report a rare case of a 60-year-old man with diffuse metastases in bilateral penile corpus cavernosum after radical nephrectomy for left renal carcinoma. 18F-FDG PET/CT demonstrated diffuse hypermetabolic lesions in bilateral penile corpus cavernosum, hypermetabolic tumor recurrences in left renal operation region, and left pulmonary metastasis. Biopsy confirmed penile metastasis from renal clear cell carcinoma. Diffuse penile metastatic carcinoma from renal cancer is extremely rare and associated...
Sat Mar 07, 2020 02:00
An 85-year-old asymptomatic man with suspected biochemical recurrence of prostate cancer underwent an 18F-fluciclovine PET/CT scan, which revealed a solitary suspicious tracer uptake in the dorsal right corporal body of the proximal pendulous penis. The patient underwent ultrasound-guided fine-needle aspiration of the penile lesion, which revealed metastatic prostate cancer. The patient had definitive external beam radiation therapy 3 years before the examination. At the time of scan, the prostatic-specific...
Sat Mar 07, 2020 02:00
A 66-year-old man with castration-resistant prostate cancer was evaluated with 18F–prostate-specific membrane antigen (PSMA) 1007 PET/CT, which revealed extensive PSMA-positive skeletal metastases in the skull, thorax, spine, pelvis, and extremities. He was then treated 177Lu-PSMA-617 therapy. Twenty-four-hour SPECT/CT revealed additional activity not seen with 18F-PSMA adjacent to his left eye. The lesion was biopsied after the first cycle due to pain. This activity was not visible on SPECT/CT after...
Sat Mar 07, 2020 02:00
The gallbladder is generally located at the anterolaterally situated gallbladder fossa on the undersurface of the liver, whereas choledochal cyst, as a dilation of the common bile duct, is located more posteromedially. We reported an ectopically located gallbladder, which appeared to be a choledochal cyst on hepatobiliary scintigraphy in a 10-year-old girl. Received for publication December 30, 2019; revision accepted January 2, 2020. Conflicts of interest and sources of funding: none declared....
Sat Mar 07, 2020 02:00
Isolated pancreatic metastasis from lung cancer is rare. We present a case of isolated pancreatic metastasis from squamous cell lung cancer. The pancreatic tumor showed hypovascularity on enhanced MRI and intense FDG uptake on FDG PET/CT mimicking primary pancreatic ductal adenocarcinoma. This case indicates pancreatic metastasis should be considered as a differential diagnosis in patients with a history of extrapancreatic cancer and hypermetabolic pancreatic lesion. Received for publication...
Sat Mar 07, 2020 02:00
FDG PET/CT was performed for staging in a 15-year-old adolescent girl with cholangiocarcinoma, which showed only mild activity in the tumor but more impressive FDG activity in right femoral fibrous cortical defect without any other hypermetabolic lesions elsewhere. Pathological examination of the resected cholangiocarcinoma revealed significant neuroendocrine differentiation, which lead to subsequent 68Ga-DOTATATE PET/CT study. Unexpectedly, the same femoral fibrous cortical defect also had increased...
Sat Mar 07, 2020 02:00
Suggestions to improve the well-being in medical students include establishing learning communities, having pass-fail grading at least in the freshman and sophomore years, giving the students some control over their learning environment (such as with evaluations and serving on the curriculum committee), encouraging more protected time and more money for faculty teaching and mentoring, and eliminating mistreatment of medical students. Also, the Medical Student and Physician Well-Being Index should...
Sat Mar 07, 2020 02:00
A 4-day-old female neonate with raised cord blood thyroid-stimulating hormone (127 μIU/mL) underwent 99mTc thyroid scan to rule out thyroid dysgenesis. The images revealed midline focus of lingual thyroid as the only functioning thyroid tissue. In addition, bilateral focal and symmetrical breast uptake was seen without clinically palpable breast nodule on either side. Transplacental transfer of maternal hormones leading to stimulation of neonatal breasts explains this unusual scan finding. One should...
Sat Mar 07, 2020 02:00
We present a case with an unexpected nodule in the thymus showing increased 18F-FDG uptake on PET/CT. The nodule was surgically removed. Histopathologic examination revealed granuloma in the thymus. This case indicates physicians and radiologists must be aware that although thymic granuloma is rare, it should be included in the differential diagnosis of the thymic lesions with 18F-FDG accumulation along with neoplastic and nonneoplastic conditions. Received for publication October 27, 2019; revision...
Sat Mar 07, 2020 02:00
We present a paraspinal amyloidoma found incidentally in a 77-year-old man during lymphoma workup by 18F-FDG PET/CT. A solitary FDG-avid paraspinal lesion was seen at T11–T12. MRI showed T2 hypointensity and enhancement. Lymphoma was considered the primary differential due to FDG uptake, but biopsy revealed nodules of extracellular acellular homogeneous material with apple-green birefringence on Congo red stain consistent with amyloidoma. Spinal amyloidoma is rare with few cases reported so far in...
Sat Mar 07, 2020 02:00
PRRT (peptide receptor radionuclide therapy) with 177Lu-DOTATATE for neuroendocrine tumor has some well-known adverse effects, concerning specially the bone marrow and kidneys. Hepatotoxicity has been rarely reported, and there are no data regarding hepatic steatosis secondary to PRRT. We reviewed upper abdomen CT and MRI and applied radiologic criteria for the diagnosis of hepatic steatosis on 62 patients treated between the years of 2010 and 2017. Two patients already showed radiologic signs of...
Sat Mar 07, 2020 02:00
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