Κυριακή 8 Μαρτίου 2020


Standardizing the cerebrovascular response to hypercapnia – increasing the flow of data!
Abstract The study by Burley and colleagues concluded that a PCO2 stimulus of at least 3‐minutes, and a 30‐60 second data average in the final minute of the PCO2 stimulus, was the best approach to accurately quantify cerebrovascular and ventilatory reactivity to this magnitude of hypercapnia. This article is protected by copyright. All rights reserved
Experimental Physiology
Sat Mar 07, 2020 07:31
Elucidation of the roles of brown and BRITE fat genes: GPR120 is a Modulator of Brown Adipose Tissue Function
New Findings What is the topic of this review? Activation of brown adipose tissue is a promising strategy to increase energy consumption and reduce fat mass. G protein‐coupled receptors are key druggable targets and their identification in brown adipose tissue is leading to novel ways to activate this tissue. What advances does it highlight? GPR120 is a fatty acid receptor highly expressed in brown adipose tissue. Its activation by selective ligands increases brown...
Experimental Physiology
Sat Mar 07, 2020 07:31
The relationship between self-reported habitual snoring and hyperuricemia among Chinese urban adults: a cross-sectional study.
Related ArticlesThe relationship between self-reported habitual snoring and hyperuricemia among Chinese urban adults: a cross-sectional study. Sleep Med. 2019 Dec 11;68:207-212 Authors: Xiong X, He F, Sun G, Li Y, Shi Y, Ge X, Zheng S, Xu R Abstract BACKGROUND: Growing evidence suggests an independent relationship between habitual snoring and metabolic abnormalities. Currently, there are few data available on the association between snoring and hyperuricemia....
pubmed: snoring
Sat Mar 07, 2020 14:49
Velopharyngeal insufficiency in patients without a cleft palate: important considerations for the ENT surgeon.
Related ArticlesVelopharyngeal insufficiency in patients without a cleft palate: important considerations for the ENT surgeon. J Laryngol Otol. 2020 Mar 06;:1-4 Authors: Mushi E, Mahdi N, Upile N, Hevican C, McKernon S, van Eeden S, De S Abstract BACKGROUND: Velopharyngeal insufficiency is the inability to close the velopharyngeal port during speech and swallowing, leading to hypernasal speech and food regurgitation. OBJECTIVE: This study aimed...
The Journal of laryngology and otology http://goo.gl/Tl02xD
Sat Mar 07, 2020 14:49
Limited capacity for ipsilateral secondary motor areas to support hand function post‐stroke
Key points Ipsilateral‐projecting corticobulbar pathways, originating primarily from secondary motor areas, innervate the proximal and even distal portions, but branch more extensively at the spinal cord It is currently unclear to what extent these ipsilateral secondary motor areas and subsequent cortical projections may contribute to hand function following stroke‐induced damage to one hemisphere In this study, we provide both structural and functional evidence that individuals increasingly...
The Journal of Physiology
Sat Mar 07, 2020 14:36
From bedside‐to‐bench: What disease‐associated variants are teaching us about the NMDA receptor
Abstract NMDA receptors (NMDARs) are glutamate‐gated ion channels that contribute to nearly all brain processes. Not surprisingly then, genetic variations in the genes encoding NMDAR subunits can be associated with neurodevelopmental, neurological, and psychiatric disorders. These disease‐associated variants (DAVs) present challenges, such as defining how DAV‐induced alterations in receptor function contribute to disease progression and how to treat the affected individual clinically. As a starting...
The Journal of Physiology
Sat Mar 07, 2020 14:36
Spike‐wave discharges in absence epilepsy: Segregation of electrographic components reveals distinct pathways of seizure activity
Key points The major electrophysiological hallmark of absence seizures are spike and wave discharges, consisting of a sharp spike‐ and a slow wave component. In a widely accepted scheme, these components are functionally coupled and reflect an iterative progression of neuronal excitation during the spike and post‐excitatory silence during the wave. In a genetic rat model of absence epilepsy, local pharmacological inhibition of the centromedian thalamus (CM) selectively suppressed the spike...
The Journal of Physiology
Sat Mar 07, 2020 14:36
How the metabolic machinery of maximally exercising muscle fails
The Journal of Physiology
Sat Mar 07, 2020 02:46
Risks and Benefits of Gadolinium-Based Contrast Enhanced MRI
Publication date: Available online 7 March 2020Source: Seminars in Ultrasound, CT and MRIAuthor(s): Colleen M. Costelloe, Behrang Amini, John E. Madewell
Seminars in Ultrasound, CT and MRI
Sat Mar 07, 2020 14:35
Association between prior metformin therapy and sepsis in diabetes patients: a nationwide sample cohort study
Abstract Purpose There have been no large-scale studies on whether metformin therapy might have a potential benefit for lowering mortality. Thus, this study aimed to investigate the association between prior metformin therapy and the development of sepsis as well as the association between prior metformin therapy and 30-day mortality in sepsis patients. Methods ...
Latest Results for Journal of Anesthesia
Sat Mar 07, 2020 02:00
Catheter-related bladder discomfort in gynecologic surgery
Latest Results for Journal of Anesthesia
Sat Mar 07, 2020 02:00
Tidal variations of background ionizing radiation and circadian timing of the suprachiasmatic nucleus clock
Publication date: Available online 6 March 2020Source: Medical HypothesesAuthor(s): V.E. Zakhvataev
ScienceDirect Publication: Medical Hypotheses
Sat Mar 07, 2020 14:04
Vestibular drop attack: a potential origin from perilymphatic fistula?
Publication date: Available online 6 March 2020Source: Medical HypothesesAuthor(s): A. Pace, G. Iannella, V. Rossetti, A. Colizza, G. Magliulo
ScienceDirect Publication: Medical Hypotheses
Sat Mar 07, 2020 14:04
Preeclampsia, hypertension, and a possible treatment for preeclampsia
Publication date: Available online 6 March 2020Source: Medical HypothesesAuthor(s): David Brown
ScienceDirect Publication: Medical Hypotheses
Sat Mar 07, 2020 14:04
Etomidate plus fentanyl for anesthesia in pediatric strabotomy
Publication date: Available online 6 March 2020Source: Medical HypothesesAuthor(s): Y. Hu, X.Y. Yang, J.H. Zhang
ScienceDirect Publication: Medical Hypotheses
Fri Mar 06, 2020 22:15
Further validation of a binaural model predicting speech intelligibility against envelope-modulated noises
Publication date: Available online 6 March 2020Source: Hearing ResearchAuthor(s): Thibault Vicente, Mathieu Lavandier
Hearing Research
Sat Mar 07, 2020 13:49
Mismatch-negativity (MMN) in animal models: Homology of human MMN?
Publication date: Available online 6 March 2020Source: Hearing ResearchAuthor(s): Tomoyo Isoguchi Shiramatsu, Hirokazu Takahashi
Hearing Research
Sat Mar 07, 2020 13:49
Volume gradients in inner hair cell-auditory nerve fiber pre- and postsynaptic proteins differ across mouse strains
Publication date: Available online 6 March 2020Source: Hearing ResearchAuthor(s): Daniël O.J. Reijntjes, Christine Köppl, Sonja J. Pyott
Hearing Research
Sat Mar 07, 2020 13:49
Practical aspects of inner ear gene delivery for research and clinical applications
Publication date: Available online 6 March 2020Source: Hearing ResearchAuthor(s): Sungsu Lee, Anna Dondzillo, Samuel P. Gubbels, Yehoash Raphael
Hearing Research
Fri Mar 06, 2020 13:32
Images in Endocrine Pathology: High-Grade Intrathyroidal Parathyroid Carcinoma with Crooke’s Hyalinization
Endocrine Pathology
Sat Mar 07, 2020 02:00
Practice Paradigms Before and After Introduction of the Diagnosis-Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP): an Institutional Experience
Abstract The recently adopted terminology of “Noninvasive follicular thyroid neoplasm with papillary-like nuclear features” (NIFTP) reflects the indolent behavior of these tumors. In contrast to conventional papillary thyroid carcinomas, NIFTP can be managed conservatively. The purpose of this study was to investigate changes in surgical and pathologic practice patterns at our institution since the introduction of the NIFTP diagnosis in 2016. A retrospective analysis of all thyroid...
Endocrine Pathology
Sat Mar 07, 2020 02:00
Homogeneous MMR Deficiency Throughout the Entire Tumor Mass Occurs in a Subset of Colorectal Neuroendocrine Carcinomas
Abstract Neuroendocrine neoplasms comprise a heterogeneous group of tumors, categorized into neuroendocrine tumors (NETs) and neuroendocrine carcinomas (NECs) depending on tumor differentiation. NECs and high-grade NETs (G3) confer a poor prognosis, demanding novel treatment strategies such as immune checkpoint inhibition in tumors with microsatellite instability (MSI). To study any possible intratumoral heterogeneity of MSI, a tissue microarray (TMA) containing 199 NETs and 40...
Endocrine Pathology
Fri Mar 06, 2020 02:00
Synergistic antimicrobial effects of photodynamic antimicrobial chemotherapy and gentamicin on <em>Staphylococcus aureus</em> and multidrug-resistant <em>Staphylococcus aureus</em>
Publication date: Available online 6 March 2020Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Shupei Liu, Bingjie Mai, Mengqi Jia, Dewu Lin, Jingdan Zhang, Quanhong Liu, Pan Wang
ScienceDirect Publication: Photodiagnosis and Photodynamic Therapy
Sat Mar 07, 2020 13:09
Natural history of Ollier disease and Maffucci syndrome: Patient survey and review of clinical literature
Abstract Ollier disease (OD) and Maffucci syndrome (MS) are characterized by multiple enchondromas. Patients with MS also have benign vascular overgrowths that become malignant in 8.5% of cases. OD is characterized by multiple enchondromas, typically unilateral in distribution with a predilection for the appendicular skeleton. MS is characterized by multiple enchondromas bilaterally distributed in most of the cases. Both disorders feature multiple swellings on the extremity, deformity around the...
American Journal of Medical Genetics Part A
Sat Mar 07, 2020 13:03
A founder truncating variant in GDF1 causes autosomal‐recessive right isomerism and associated congenital heart defects in multiplex Arab kindreds
Abstract The genetic basis of congenital heart malformations associated with disruption of left–right (L–R) asymmetry is broad and heterogenous, with variants in over 25 genes implicated thus far. Of these, deleterious variants in the Growth/Differentiation Factor 1 (GDF1) gene have been shown to cause heterotaxy with varied complex heart malformations of left–right patterning, in 23 individuals reported to date, either in monoallelic or biallelic state. We report three unrelated individuals exhibiting...
American Journal of Medical Genetics Part A
Sat Mar 07, 2020 13:03
Paternal mosaicism for a novel PBX1 mutation associated with recurrent perinatal death: Phenotypic expansion of the PBX1‐related syndrome
Abstract Autosomal dominant (de novo) mutations in PBX1 are known to cause congenital abnormalities of the kidney and urinary tract (CAKUT), with or without extra‐renal abnormalities. Using trio exome sequencing, we identified a PBX1 p.(Arg107Trp) mutation in a deceased one‐day‐old neonate presenting with CAKUT, asplenia, and severe bilateral diaphragmatic thinning and eventration. Further investigation by droplet digital PCR revealed that the mutation had occurred post‐zygotically in the father,...
American Journal of Medical Genetics Part A
Sat Mar 07, 2020 01:11
Expansion of the phenotype of lateral meningocele syndrome
Abstract Lateral meningocele syndrome (LMS) is due to specific pathogenic variants in the last exon of NOTCH3 gene. Besides the lateral meningoceles, this condition presents with dysmorphic features, short stature, congenital heart defects, and feeding difficulties. Here, we report a girl with neurosensorial hearing loss, severe gastroesophageal reflux disease, congenital heart defects, multiple renal cysts, kyphosis and left‐convex scoliosis, dysmorphic features, and mild developmental delay....
American Journal of Medical Genetics Part A
Sat Mar 07, 2020 01:11
The novel R211Q POP1 homozygous mutation causes different pathogenesis and skeletal changes from those of previously reported POP1‐associated anauxetic dysplasia
Abstract Processing of Precursor RNA 1 (POP1) is a core protein component shared by two essential closely related eukaryotic ribonucleoprotein complexes: RNase MRP (the mitochondrial RNA processing ribonuclease) and RNase P. Recently, five patients harboring mutations in POP1 have been reported with severe spondylo‐epi‐metaphyseal dysplasia and extremely short stature. We report a unique clinical phenotype resulting from the novel homozygous R211Q POP1 mutation in three patients from one family,...
American Journal of Medical Genetics Part A
Sat Mar 07, 2020 01:11
Haploinsufficiency of the basic helix–loop–helix transcription factor HAND2 causes congenital heart defects
Abstract Congenital heart defects (CHDs) are caused by a disruption in heart morphogenesis, which is dependent, in part, on a network of transcription factors (TFs) that regulate myocardial development. Heterozygous sequence variants in the basic helix–loop–helix TF gene heart and neural crest derivatives expressed 2 (HAND2) have been reported among some patients with CHDs; however, HAND2 has not yet been established as a Mendelian disease gene. We report a 31‐month‐old male with unicommissural...
American Journal of Medical Genetics Part A
Sat Mar 07, 2020 01:11
Comments to the Editorial “Vascunet, VQI, and the International Consortium of Vascular Registries- Unique Collaborations for Quality Improvement in Vascular Surgery
Publication date: Available online 6 March 2020Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Maria F. Giannoni, Fabrizio D'Abate, Arnaldo Ippoliti
ScienceDirect Publication: European Journal of Vascular and Endovascular Surgery
Sat Mar 07, 2020 11:56
An Unusual Case of Scalp Metastasis from Breast Cancer
Publication date: May 2020Source: World Neurosurgery, Volume 137Author(s): Yu-fei Liu, Ling-yu Liu, Shi-lin Xia, Tao Li, Jun Li
World Neurosurgery
Sat Mar 07, 2020 11:51
Isolated Intracranial Rosai-Dorfman Disease: Case Report and Review of the Literature
Publication date: May 2020Source: World Neurosurgery, Volume 137Author(s): Matthew A. Boissaud-Cooke, Kush Bhatt, David A. Hilton, Samiul Muquit
World Neurosurgery
Sat Mar 07, 2020 11:51
Sporadic Meningioangiomatosis Presenting as a Middle Cranial Fossa Arachnoid Cyst
Publication date: May 2020Source: World Neurosurgery, Volume 137Author(s): Brian Y.L. Chan, Khurshid Z. Merchant, Jennifer G.C. Teo, Kenneth T.E. Chang, David C.Y. Low, Sharon Y.Y. Low
World Neurosurgery
Sat Mar 07, 2020 11:51
Novel Technique for Detection of Actual Position of Clot During Endovascular Clot Retrieval: Assessment of Microcatheter Withdrawing Angiography
Publication date: May 2020Source: World Neurosurgery, Volume 137Author(s): Tomotaka Ohshima, Aichi Niwa, Reo Kawaguchi, Naoki Matsuo, Shigeru Miyachi
World Neurosurgery
Sat Mar 07, 2020 11:51
The Role of Long Noncoding RNAs in the Biology of Pituitary Adenomas
Publication date: May 2020Source: World Neurosurgery, Volume 137Author(s): Ozal Beylerli, Ilgiz Gareev, Valentin Pavlov, Xin Chen, Shiguang Zhao
World Neurosurgery
Sat Mar 07, 2020 11:51
Trochlear Schwannoma Arising from Transition Zone of Nerve Sheath in the Pineal Region: Case Report and Review of the Literature
Publication date: May 2020Source: World Neurosurgery, Volume 137Author(s): Yu-Hsiang Lan, Ying-Ching Li, Cheng-Nen Chang, Bo Zhang, Yu-Jen Lu
World Neurosurgery
Fri Mar 06, 2020 16:43
PACs: Keys to the Kingdom, or Should We Send Them PAC-ing?
Publication date: May 2020Source: World Neurosurgery, Volume 137Author(s): Russell J. Andrews
World Neurosurgery
Fri Mar 06, 2020 16:43
Spontaneous Spinal Epidural Hematoma After Normal Spontaneous Delivery with Epidural Analgesia: Case Report and Literature Review
Publication date: May 2020Source: World Neurosurgery, Volume 137Author(s): Hong-Xiang Zheng, Tee-Tau Eric Nyam, Che-An Liu, Yao-Lin Lee, Jinn-Rung Kuo, Kuan-Chin Sung
World Neurosurgery
Fri Mar 06, 2020 16:43
Selenium enhances TRPA1 channel-mediated activity of temozolomide in SH-SY5Y neuroblastoma cells
Abstract Purpose Neuroblastoma is a malignant solid tumor that originates from the sympathetic nervous system in early childhood. Temozolomide is used for treatment in high-risk groups with low treatment response of neuroblastomas. TRPA1 channels in neuroblastoma cells are calcium permeable channels that can be activated by reactive oxygen species (ROT). In this study, we aimed to evaluate the level of activity of temozolomide and selenium...
Latest Results for Child's Nervous System
Sat Mar 07, 2020 02:00

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