Related ArticlesMachine Learning and Feature Selection Applied to SEER Data to Reliably Assess Thyroid Cancer Prognosis. Sci Rep. 2020 Mar 20;10(1):5176 Authors: Mourad M, Moubayed S, Dezube A, Mourad Y, Park K, Torreblanca-Zanca A, Torrecilla JS, Cancilla JC, Wang J Abstract Utilizing historical clinical datasets to guide future treatment choices is beneficial for patients and physicians. Machine learning and feature selection algorithms (namely,...
Sun Mar 22, 2020 14:02
Related ArticlesThe optimal imaging window for dysplastic colorectal polyp detection using c-Met targeted fluorescence molecular endoscopy. J Nucl Med. 2020 Mar 20;: Authors: de Jongh SJ, Vrouwe JPM, Voskuil FJ, Schmidt I, Westerhof J, Koornstra JJ, de Kam ML, Karrenbeld A, Hardwick JCH, Robinson DJ, Burggraaf J, Kamerling IMC, Nagengast WB Abstract Rationale: Fluorescence molecular endoscopy (FME) is an emerging technique that has the potential...
Sun Mar 22, 2020 14:02
Related ArticlesRare case of dual gastrointestinal perforations. BMJ Case Rep. 2020 Mar 19;13(3): Authors: Hudson D, Foo J, Robertson J Abstract A 49-year-old man presented to the nearest emergency department profoundly septic with significantly raised inflammatory markers. He had a background of floor of mouth invasive squamous cell carcinoma for which he underwent complex head and neck surgery followed by adjuvant radiotherapy and insertion of...
Sun Mar 22, 2020 14:02
Related ArticlesMotor skills in children with strabismus. J AAPOS. 2020 Mar 17;: Authors: Hemptinne C, Aerts F, Pellissier T, Ruiz CR, Cardoso VA, Vanderveken C, Yüksel D Abstract PURPOSE: To assess the extent to which strabismus in children was associated with motor difficulties and to examine which parameters of strabismus were most closely associated with motor development. METHODS: The motor skills of children who were suffering from...
Sun Mar 22, 2020 14:02
Related ArticlesAnesthetic tracheal wound before total thyroidectomy and lymphadenectomy surgical procedure. Eur Ann Otorhinolaryngol Head Neck Dis. 2020 Mar 17;: Authors: Rougier G, Seguin-Givelet A, D'Honneur G, Choussy O PMID: 32197938 [PubMed - as supplied by publisher]
Sun Mar 22, 2020 14:02
Related Articles2,3,4',5-Tetrahydroxystilbene-2-O-β-D-Glucoside (THSG) Activates the Nrf2 Antioxidant Pathway and Attenuates Oxidative Stress-Induced Cell Death in Mouse Cochlear UB/OC-2 Cells. Biomolecules. 2020 Mar 18;10(3): Authors: Wu TY, Lin JN, Luo ZY, Hsu CJ, Wang JS, Wu HP Abstract Oxidative stress plays a critical role in the pathogenesis of hearing loss, and 2,3,4',5-tetrahydroxystilbene-2-O-β-D-glucoside (THSG) exerts antioxidant effects...
Sun Mar 22, 2020 12:03
Related ArticlesmiRNA expression can classify pediatric thyroid lesions and increases the diagnostic yield of mutation testing. Pediatr Blood Cancer. 2020 Mar 20;:e28276 Authors: Franco AT, Labourier E, Ablordeppey KK, Surrey LF, Mostoufi-Moab S, Isaza A, Adzick NS, Kazahaya K, Kumar G, Bauer AJ Abstract BACKGROUND: Genetic alterations in multiple cell signaling pathways are involved in the molecular pathogenesis of thyroid cancer. Oncogene mutation...
Sat Mar 21, 2020 12:02
Related ArticlesLack of miR-1246 in small extracellular vesicle blunts tumorigenesis of laryngeal carcinoma cells by regulating Cyclin G2. IUBMB Life. 2020 Mar 20;: Authors: Huang Q, Hsueh CY, Guo Y, Wu XF, Li JY, Zhou L Abstract Small extracellular vesicle (sEV) has precise impacts on tumor microenvironment and play vital functions in intercellular interaction. However, the functional role of sEV miRNA on laryngeal squamous cell carcinoma (LSCC)...
Sat Mar 21, 2020 12:02
Related ArticlesAltered fractionation diminishes importance of tumor volume in oropharyngeal cancer: Subgroup analysis of ARTSCAN-trial. Head Neck. 2020 Mar 20;: Authors: Adrian G, Gebre-Medhin M, Kjellén E, Wieslander E, Zackrisson B, Nilsson P Abstract BACKGROUND: A large tumor volume negatively impacts the outcome of radiation therapy (RT). Altered fractionation (AF) can improve local control (LC) compared with conventional fractionation (CF)....
Sat Mar 21, 2020 12:02
Related ArticlesUtilization of microvascular couplers in salvage arterial anastomosis in head and neck free flap surgery: Case series and literature review. Head Neck. 2020 Mar 20;: Authors: Li MM, Tamaki A, Seim NB, Kang SY, Ozer E, Agrawal A, Old MO Abstract BACKGROUND: In microvascular reconstruction of ablative oncologic defects, coupler devices have traditionally been used for venous anastomosis, whereas the arterial anastomosis is hand-sewn....
Sat Mar 21, 2020 12:02
Related ArticlesAutomated proton treatment planning with robust optimization using constrained hierarchical optimization. Med Phys. 2020 Mar 20;: Authors: Taasti VT, Hong L, Deasy JO, Zarepisheh M Abstract PURPOSE: We present a method for fully automated generation of high quality robust proton treatment plans using hierarchical optimization. To fill the gap between the two common extreme robust optimization approaches, i.e., stochastic and worst-case,...
Sat Mar 21, 2020 12:02
Related ArticlesLINC00114 promoted nasopharyngeal carcinoma progression and radioresistance in vitro and in vivo through regulating ERK/JNK signaling pathway via targeting miR-203. Eur Rev Med Pharmacol Sci. 2020 Mar;24(5):2491-2504 Authors: Han YY, Liu K, Xie J, Li F, Wang Y, Yan B Abstract OBJECTIVE: Nasopharyngeal carcinoma (NPC) is a malignancy and is prone to distant metastasis and radioresistance. Long non-coding RNAs (lncRNAs) play vital roles...
Sat Mar 21, 2020 12:02
Related ArticlesSimultaneous application of ultrasound and sialendoscopy: experience in the management of stenosis and other non-sialolithiasis-related salivary gland disorders. Eur Rev Med Pharmacol Sci. 2020 Mar;24(5):2196-2204 Authors: Koch M, Schapher M, Goncalves M, Iro H, Mantsopoulos K Abstract OBJECTIVE: To assess the value of the simultaneous application of ultrasound and sialendoscopy (US+SE) in several salivary gland diseases not caused...
Sat Mar 21, 2020 12:02
Related ArticlesMortality Risk in Necrotizing Fasciitis: National Prevalence, Trend, and Burden. Surg Infect (Larchmt). 2020 Mar 20;: Authors: Al-Qurayshi Z, Nichols RL, Killackey MT, Kandil E Abstract Background: Necrotizing fasciitis (NF) is a fulminant, life-threating infection of fascia and subcutaneous tissue. Because of the low incidence, previous studies were statistically underpowered to assess factors associated with the risk of mortality....
Sat Mar 21, 2020 12:02
Related ArticlesPractical Aspects of Otolaryngologic Clinical Services During the 2019 Novel Coronavirus Epidemic: An Experience in Hong Kong. JAMA Otolaryngol Head Neck Surg. 2020 Mar 20;: Authors: Chan JYK, Wong EWY, Lam W PMID: 32196070 [PubMed - as supplied by publisher]
Sat Mar 21, 2020 12:02
Related ArticlesDiagnostic accuracy of different clinical screening criteria for blunt cerebrovascular injuries compared to liberal state of the art computed tomography angiography in major trauma. J Trauma Acute Care Surg. 2020 Mar 18;: Authors: Müther M, Sporns PB, Hanning U, Düsing H, Hartensuer R, Raschke M, Schwake M, Stummer W, Glasgow S Abstract BACKGROUND: Blunt cerebrovascular injuries (BCVI) can significantly impact morbidity and mortality...
Sat Mar 21, 2020 12:02
Related ArticlesPediatric Difficult Airway Response Team Utilization in the Emergency Department: A Case Series. Pediatr Emerg Care. 2020 Mar 13;: Authors: Kelly GS, Deanehan JK, Dalesio NM Abstract OBJECTIVES: A multidisciplinary pediatric difficult airway team was created at our institution to respond to hospital-wide airway emergencies. We report the characteristics, indications, and outcomes of these activations that occur in the pediatric emergency...
Sat Mar 21, 2020 12:02
Related ArticlesThe association between Bell's palsy and rheumatoid arthritis: A longitudinal study. Medicine (Baltimore). 2020 Mar;99(12):e19568 Authors: Lee SY, Lim JS, Oh DJ, Park B, Park IS, Choi HG Abstract This study aimed to evaluate the relationship between Bell's palsy and rheumatoid arthritis in a national sample cohort from Korea.Data were collected for individuals ≥20 years old from 2002 to 2013 in the Korean National Health Insurance...
Sat Mar 21, 2020 12:02
Related ArticlesComparison of preoxygenation with a high-flow nasal cannula and a simple mask before intubation during induction of general anesthesia in patients undergoing head and neck surgery: Study protocol clinical trial (SPIRIT Compliant). Medicine (Baltimore). 2020 Mar;99(12):e19525 Authors: Jo JY, Kim WJ, Ku S, Choi SS Abstract BACKGROUND: To assess the arterial oxygen partial pressure (PaO2) at defined time points during preoxygenation...
Sat Mar 21, 2020 12:02
Related ArticlesSteroid Nomenclature in Inner Ear Therapy. Otol Neurotol. 2020 Mar 18;: Authors: Salt AN, Plontke SK Abstract : Local glucocorticosteroid ("steroid") therapy is widely used to treat the inner ears of patients with Menière's disease, idiopathic sudden sensorineural hearing loss and in combination with cochlear implants. Applied steroids have included dexamethasone, methylprednisolone, and triamcinolone. In reality, however, this is...
Sat Mar 21, 2020 12:02
Related ArticlesIncidence of Fistula Formation and Velopharyngeal Insufficiency in Early Versus Standard Cleft Palate Repair. J Craniofac Surg. 2020 Mar 17;: Authors: Eliason MJ, Hadford S, Green L, Reeves T Abstract The goals of cleft palate repair are well-established; however, there does exist difference in practice patterns regarding the most appropriate patient age for palatoplasty. The optimal timing is debated and influenced by cleft type,...
Sat Mar 21, 2020 12:02
Related ArticlesEndoscopic Transoral Resection of Tongue Base Ancient Schwannoma. J Craniofac Surg. 2020 Mar 17;: Authors: Yaslikaya S, Kizilay A, Şamdanci E Abstract Schwannoma is a benign slow growing nerve sheath tumor that is typically encapsulated and composed of well-differentiated schwann cells. Schwannomas may take origin from different nerves such as cranial, spinal nerves, and the sympathetic chain. Approximately 25% to 45% of all occur...
Sat Mar 21, 2020 12:02
Related ArticlesTransoral Robotic Surgery in the Management of a Tongue Base Schwannoma. J Craniofac Surg. 2020 Mar 17;: Authors: Petruzzi G, Costantino A, Arosio AD, De Virgilio A, Pichi B, Zocchi J, Mercante G, Spriano G, Pellini R Abstract Schwannomas are the most common benign tumors arising from the peripheral nerve sheath, and the intraoral location is very atypical, representing less than 1% of all cases. Surgical excision is the treatment...
Sat Mar 21, 2020 12:02
Related ArticlesImmune escape mechanisms in head and neck squamous cell carcinoma and implication for new immunotherapy approach. Curr Opin Oncol. 2020 Mar 19;: Authors: Merlano MC, Denaro N, Garrone O Abstract PURPOSE OF REVIEW: The aim of this review is to describe the major steps leading to the immunosuppressive tumor microenvironment and to summarize some of the new immunotherapies that interfere with these mechanisms. RECENT FINDINGS:...
Sat Mar 21, 2020 12:02
Related ArticlesDe-intensification for HPV positive oropharyngeal cancer: and yet it moves!: 2019 in review. Clin Transl Radiat Oncol. 2020 May;22:40-43 Authors: Bonomo P, Livi L Abstract In the last decade, the recognition of the strongly positive prognostic impact of human papilloma virus (HPV) infection on the natural history of squamous cell carcinoma of the oropharynx has reshaped the historical monolithic view of a "one-size-fits-all approach"...
Sat Mar 21, 2020 12:02
Related ArticlesComparison of autophagy inducibility in various tyrosine kinase inhibitors and their enhanced cytotoxicity via inhibition of autophagy in cancer cells in combined treatment with azithromycin. Biochem Biophys Rep. 2020 Jul;22:100750 Authors: Tanaka H, Hino H, Moriya S, Kazama H, Miyazaki M, Takano N, Hiramoto M, Tsukahara K, Miyazawa K Abstract Tyrosine kinase inhibitors (TKIs) induce autophagy in many types of cancer cells. We previously...
Sat Mar 21, 2020 12:02
Related ArticlesExtracellular vesicle tetraspanin-8 level predicts distant metastasis in non-small cell lung cancer after concurrent chemoradiation. Sci Adv. 2020 Mar;6(11):eaaz6162 Authors: Liu Y, Fan J, Xu T, Ahmadinejad N, Hess K, Lin SH, Zhang J, Liu X, Liu L, Ning B, Liao Z, Hu TY Abstract Non-small cell lung cancer (NSCLC) is the most commonly diagnosed cancer and the leading cause of cancer death worldwide. More than half of patients with...
Sat Mar 21, 2020 12:02
Related ArticlesDirect measurement of vertical forces shows correlation between mechanical activity and proteolytic ability of invadopodia. Sci Adv. 2020 Mar;6(11):eaax6912 Authors: Dalaka E, Kronenberg NM, Liehm P, Segall JE, Prystowsky MB, Gather MC Abstract Mechanobiology plays a prominent role in cancer invasion and metastasis. The ability of a cancer to degrade extracellular matrix (ECM) is likely connected to its invasiveness. Many cancer cells...
Sat Mar 21, 2020 12:02
Related ArticlesIdentification and Analysis of Glioblastoma Biomarkers Based on Single Cell Sequencing. Front Bioeng Biotechnol. 2020;8:167 Authors: Cheng Q, Li J, Fan F, Cao H, Dai ZY, Wang ZY, Feng SS Abstract Glioblastoma (GBM) is one of the most common and aggressive primary adult brain tumors. Tumor heterogeneity poses a great challenge to the treatment of GBM, which is determined by both heterogeneous GBM cells and a complex tumor microenvironment....
Sat Mar 21, 2020 12:02
Related ArticlesRegulatory Role of Hexokinase 2 in Modulating Head and Neck Tumorigenesis. Front Oncol. 2020;10:176 Authors: Li WC, Huang CH, Hsieh YT, Chen TY, Cheng LH, Chen CY, Liu CJ, Chen HM, Huang CL, Lo JF, Chang KW Abstract To support great demand of cell growth, cancer cells preferentially obtain energy and biomacromolecules by glycolysis over mitochondrial oxidative phosphorylation (OxPhos). Among all glycolytic enzymes, hexokinase (HK),...
Sat Mar 21, 2020 12:02
Related ArticlesRenal hemangiopericytoma in 15 year old female-treated laparoscopically. Urol Case Rep. 2020 Jul;31:101132 Authors: Anakievski D, Kalchev K Abstract Hemangiopericytoma (HPC) is rare in the urogenital system, most frequently occurs in the pelvis, head and neck, and meninges, it is extremely rare in the kidney. US, CT, or MRI do not show any specific sign of renal HPC that might aid in the differential diagnosis with other renal tumors,...
Sat Mar 21, 2020 12:02
Related ArticlesFBP1 binds to the bromodomain of BRD4 to inhibit pancreatic cancer progression. Am J Cancer Res. 2020;10(2):523-535 Authors: Yang C, Zhu S, Yang H, Fan P, Meng Z, Zhao J, Zhang K, Jin X Abstract Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive tumour that is characteristically unresponsive to most chemotherapeutic regimens. Bromodomain and extra terminal domain (BET) inhibitors that specifically repress the function...
Sat Mar 21, 2020 12:02
Related ArticlesTLR4 activation leads to anti-EGFR therapy resistance in head and neck squamous cell carcinoma. Am J Cancer Res. 2020;10(2):454-472 Authors: Ju H, Hu Z, Lu Y, Wu Y, Zhang L, Wei D, Guo W, Xia W, Liu S, Ren G, Hu J Abstract Epidermal growth factor receptor (EGFR) is highly expressed in head and neck squamous cell carcinoma (HNSCC) and related to cancer progression. The resistance to anti-EGFR therapy remains a major clinical problem...
Sat Mar 21, 2020 12:02
Related ArticlesThe neoadjuvant paradigm reinvigorated: a review of pre-surgical immunotherapy in HNSCC. Cancers Head Neck. 2020;5:4 Authors: Stafford M, Kaczmar J Abstract Background: There remains up to a 50% recurrence rate in advanced p16- head and neck squamous cell carcinoma with current standard of care treatment. In an attempt to improve survival, multiple trials administering induction or neoadjuvant chemotherapy have been conducted but...
Sat Mar 21, 2020 12:02
Related ArticlesOptimizing COPD treatment in patients with lung- or head and neck cancer does not improve quality of life - a randomized, pilot, clinical trial. Eur Clin Respir J. 2020;7(1):1731277 Authors: Gottlieb M, Mellemgaard A, Marsaa K, Godtfredsen N Abstract Background: Chronic obstructive pulmonary disease (COPD) is a common comorbidity in patients with lung and head- and neck cancer. Patients with lung cancer who also suffer from COPD have...
Sat Mar 21, 2020 12:02
Related ArticlesLong noncoding RNA, LINC00460, as a prognostic biomarker in head and neck squamous cell carcinoma (HNSCC). Am J Transl Res. 2020;12(2):684-696 Authors: Chaudhary R, Wang X, Cao B, De La Iglesia J, Masannat J, Song F, Hernandez-Prera JC, Gimbrone NT, Slebos RJ, Chung CH Abstract Head and neck squamous cell carcinoma (HNSCC) is an aggressive epithelial malignancy characterized by frequent mutations and metastasis. Long noncoding RNAs...
Sat Mar 21, 2020 12:02
Related ArticlesTunicamycin induces ER stress and inhibits tumorigenesis of head and neck cancer cells by inhibiting N-glycosylation. Am J Transl Res. 2020;12(2):541-550 Authors: Wang Y, Zhang L, He Z, Deng J, Zhang Z, Liu L, Ye W, Liu S Abstract Glycosylation plays an important role in the genesis of various cancers. The inhibition of glycosylation disturbs the protein folding machinery, causing the accumulation of unfolded proteins in the cell...
Sat Mar 21, 2020 12:02
Related ArticlesOverexpression of HURP mRNA in head and neck carcinoma and association with in vitro response to vinorelbine. Oncol Lett. 2020 Mar;19(3):2502-2507 Authors: Al-Khafaji ASK, Pantazi P, Acha-Sagredo A, Schache A, Risk JM, Shaw RJ, Liloglou T Abstract HURP gene encodes the hepatoma upregulated protein (HURP), a microtubule associated protein regulating mitotic spindle dynamics, which promotes chromosomal congression and alignment during...
Sat Mar 21, 2020 12:02
Related ArticlesBiglycan as a potential diagnostic and prognostic biomarker in multiple human cancers. Oncol Lett. 2020 Mar;19(3):1673-1682 Authors: Zhao SF, Yin XJ, Zhao WJ, Liu LC, Wang ZP Abstract Biglycan (BGN), a key member of the small leucine-rich proteoglycan family, is an important component of the extracellular matrix. Clinical studies have demonstrated that upregulation of BGN is associated with poor prognosis in patients with various...
Sat Mar 21, 2020 12:02
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