Chronic hepatitis C virus (HCV) infection is a major global health problem affecting 1% of the world population. The Sustainable Development Goals that were adopted by the United Nations General Assembly in 2015 included combating viral hepatitis. In May 2016, the World Health Assembly set targets…
Thu Mar 19, 2020 02:00
Related ArticlesComparative In Vitro Cytotoxicity Studies of 177Lu-CHX-A″-DTPA-Trastuzumab and 177Lu-CHX-A″-DTPA-F(ab')2-Trastuzumab in HER2-Positive Cancer Cell Lines. Cancer Biother Radiopharm. 2020 Mar 20;: Authors: Sharma R, Kameswaran M, Dash A Abstract Background: Human epidermal growth factor receptor 2 (HER2) is found to be amplified in ∼15%-20% of breast cancers. In this study, the authors report the synthesis and comparative in vitro therapeutic...
Sat Mar 21, 2020 12:24
Related ArticlesExtra-Small Gold Nanospheres Decorated With a Thiol Functionalized Biodegradable and Biocompatible Linear Polyamidoamine as Nanovectors of Anticancer Molecules. Front Bioeng Biotechnol. 2020;8:132 Authors: Bloise N, Massironi A, Della Pina C, Alongi J, Siciliani S, Manfredi A, Biggiogera M, Rossi M, Ferruti P, Ranucci E, Visai L Abstract Gold nanoparticles are elective candidate for cancer therapy. Current efforts are devoted to developing...
Sat Mar 21, 2020 12:24
Related ArticlesReal-World Data of Triplet Combination of Trastuzumab, Lapatinib, and Chemotherapy in HER2-Positive Metastatic Breast Cancer: A Multicenter Retrospective Study. Front Oncol. 2020;10:271 Authors: Li Y, Gong C, Lu Q, Zhou Z, Luo T, Li W, Li G, Ge R, Xu F, Wang B Abstract Introduction: Combination of trastuzumab (T) and lapatinib (L) has been showed to significantly improve the prognosis of HER2+ heavily pretreated metastatic breast cancer...
Sat Mar 21, 2020 12:24
Related ArticlesOvercome trastuzumab resistance of breast cancer using anti-HER2 chimeric antigen receptor T cells and PD1 blockade. Am J Cancer Res. 2020;10(2):688-703 Authors: Li H, Yuan W, Bin S, Wu G, Li P, Liu M, Yang J, Li X, Yang K, Gu H Abstract Trastuzumab-resistance is still a major challenge in treating patients with HER2 positive breast cancer. In this study, we tried to overcome transtuzumab-resistance by examining the therapeutic efficacy...
Sat Mar 21, 2020 12:24
Management of the axilla following neoadjuvant chemotherapy for breast cancer- A change in practice.
Related ArticlesManagement of the axilla following neoadjuvant chemotherapy for breast cancer- A change in practice. Surgeon. 2020 Mar 16;: Authors: Riogi B, Sripadam R, Barker D, Harris O, Innes H, Chagla L Abstract OBJECTIVES: Chemotherapy in the neo adjuvant setting has allowed downsizing of breast tumours thus allowing patients to benefit from breast conservation surgery. The effect of neoadjuvant chemotherapy (NAC) has also been observed in the...
Sat Mar 21, 2020 12:24
Related ArticlesRoles of neutrophil/lymphocyte ratio in prognosis and in differentiation of potential beneficiaries in HER2-positive breast cancer with trastuzumab therapy. BMC Cancer. 2020 Mar 19;20(1):235 Authors: Ding N, Huang J, Li N, Yuan J, Wang S, Xiao Z Abstract BACKGROUND: The relationship of neutrophil/lymphocyte ratio (NLR) to prognosis of HER2-positive breast cancer (BC) is not well studied. We aimed to assess the prognostic role of NLR in...
Sat Mar 21, 2020 12:24
Related ArticlesBiomarkers of neoadjuvant/adjuvant chemotherapy for breast cancer. Chin Clin Oncol. 2020 Mar 13;: Authors: Iwamoto T, Kajiwara Y, Zhu Y, Iha S Abstract The improvement of tumor biomarkers prepared for clinical use is a long process. A good biomarker should predict not only prognosis but also the response to therapies. In this review, we describe the biomarkers of neoadjuvant/adjuvant chemotherapy for breast cancer, considering different...
Sat Mar 21, 2020 12:24
Related ArticlesThe LSD1 inhibitor iadademstat (ORY-1001) targets SOX2-driven breast cancer stem cells: a potential epigenetic therapy in luminal-B and HER2-positive breast cancer subtypes. Aging (Albany NY). 2020 Mar 18;12: Authors: Cuyàs E, Gumuzio J, Verdura S, Brunet J, Bosch-Barrera J, Martin-Castillo B, Alarcón T, Encinar JA, Martin ÁG, Menendez JA Abstract SOX2 is a core pluripotency-associated transcription factor causally related to cancer initiation,...
Fri Mar 20, 2020 14:43
Related ArticlesIdentification of Long Noncoding RNAs as Predictors of Survival in Triple-Negative Breast Cancer Based on Network Analysis. Biomed Res Int. 2020;2020:8970340 Authors: Li XX, Wang LJ, Hou J, Liu HY, Wang R, Wang C, Xie WH Abstract Breast cancer is the most common cancer observed in adult females, worldwide. Due to the heterogeneity and varied molecular subtypes of breast cancer, the molecular mechanisms underlying carcinogenesis in different...
Fri Mar 20, 2020 14:43
Related ArticlesAutomated MRI volumetry as a diagnostic tool for Alzheimer's disease: Validation of icobrain dm. Neuroimage Clin. 2020 Mar 12;26:102243 Authors: Struyfs H, Sima DM, Wittens M, Ribbens A, Pedrosa de Barros N, Phan TV, Ferraz Meyer MI, Claes L, Niemantsverdriet E, Engelborghs S, Van Hecke W, Smeets D Abstract Brain volumes computed from magnetic resonance images have potential for assisting with the diagnosis of individual dementia patients,...
Sat Mar 21, 2020 12:19
Abstract A genetic basis of congenital isolated hypogonadotropic hypogonadism (CHH) can be defined in almost 50% of cases, albeit not necessarily the complete genetic basis. Next-generation sequencing (NGS) techniques have led to the discovery of a great number of loci, each of which has illuminated our understanding of human gonadotropin-releasing hormone (GnRH) neurons, either in respect of their embryonic development or their neuroendocrine regulation as the “pilot light” of...
Sat Mar 21, 2020 02:00
Publication date: Available online 20 March 2020Source: American Journal of Infection ControlAuthor(s): Sadru-Dean Walji, Marc G. Aucoin
Sat Mar 21, 2020 12:07
Publication date: Available online 20 March 2020Source: American Journal of Infection ControlAuthor(s): Amos Nyamadzawo, Junko Nishio, Shinobu Okada, Rudo Nyamakura
Sat Mar 21, 2020 12:07
Related ArticlesCONSTRUCTION AND VALIDATION OF IN VITRO DOSE-RESPONSE CALIBRATION CURVE USING DICENTRIC CHROMOSOME ABERRATION. Radiat Prot Dosimetry. 2020 Mar 20;: Authors: Mirrezaei E, Setayeshi S, Zakeri F, Baradaran S Abstract Cytogenetic biodosimetry is a well-known method for quantifying the absorbed dose based on measuring biological radiation effects. To correlate the induced chromosomal abberrations with the absorbed dose of the individuals,...
Sat Mar 21, 2020 12:07
Related ArticlesCHARACTERIZATION OF SAND SAMPLES FROM KARACHI BEACHES USING GAMMA SPECTROMETRY AND XRD. Radiat Prot Dosimetry. 2020 Mar 20;: Authors: Zeb J, Wasim M, Shah SA, Khanam S, Tahir H, Qadri M Abstract Chemical phase and distribution of natural radionuclides (226Ra, 232Th and 40K) were determined for sand samples collected from ten different beaches of Karachi. All samples, except one, were identified with major and minor phases as SiO2...
Sat Mar 21, 2020 12:07
Related ArticlesINDOOR RADON AND THORON IN THE VICINITY OF PROPOSED URANIUM MINING SITE: A CASE STUDY AT DASARLAPALLY VILLAGE, TELANGANA STATE, INDIA. Radiat Prot Dosimetry. 2020 Mar 20;: Authors: Suman G, Reddy KVK, Reddy MS, Reddy CG, Reddy PY Abstract Studies are being conducted for the past few decades in and around the uranium mining sites across the globe to identify environmental nuclear radiation risk to the common public. The area near Dasarlapally...
Sat Mar 21, 2020 12:07
Related ArticlesORGAN EQUIVALENT DOSE AND LIFETIME ATTRIBUTABLE RISK OF CANCER INCIDENCE AND MORTALITY ASSOCIATED WITH CARDIAC CT ANGIOGRAPHY. Radiat Prot Dosimetry. 2020 Mar 20;: Authors: Hosseini Nasab SMB, Deevband MR, Shabestani-Monfared A, Hoseini Amoli SA, Fatehi Feyzabad SH Abstract The aim of this study is the calculation of equivalent organ dose and estimation of lifetime attributable risk (LAR) of cancer incidence and mortality related...
Sat Mar 21, 2020 12:07
Related ArticlesOcular vestibular evoked myogenic potential (VEMP) reveals mesencephalic HTLV-1-associated neurological disease. PLoS One. 2019;14(12):e0217327 Authors: Silva TR, Labanca L, Caporali JFM, Santos MAR, Resende LM, Scoralick Dias RT, Utsch Gonçalves D Abstract PURPOSE: Vestibular Myogenic Evoked Potential (VEMP) evaluates vestibulo-ocular and vestibulo-collic reflexes involved in the function of the otolithic organs and their afferent...
Sat Mar 21, 2020 12:02
Intestinal/enteric heterotopia of the vulva is an extremely rare disease with only 3 cases described in the literature. We report here an unusual case of this disease occurring in a 26-year-old patient in a context of Crohn’s disease. To the best of our knowledge, such type of association has not been previously described. The potential origins of these lesions including metaplastic transformation, dysontogenetic changes, or epithelial colonic displacement/implantation are discussed.
Sat Mar 21, 2020 09:20
Sat Mar 21, 2020 11:54
ABSTRACT INTRODUCTION The deep fibular sensory nerve can be recorded to evaluate for peripheral nerve injury, however it can be challenging in some individuals. Anatomic variation could account for some of this difficulty. Cadaver dissection and electrophysiologic testing was used to characterize deep and superficial fibular sensory nerve supply to the foot. MATERIALS AND METHODS Nineteen feet from 15 (8 males and 7 females) cadavers were dissected to identify the deep fibular [and...
Fri Mar 20, 2020 20:47
Fri Mar 20, 2020 20:47
ABSTRACT Introduction The shape of the talus determines the positional and kinematic features of the subtalar, talonavicular, and talocrural joints during walking. Thus, detailed knowledge of the pattern of sexual dimorphism of the human talus may be useful for revealing the pathogenetic mechanism of foot and knee disorders, which are more prevalent in females. The aim of this study was to characterize and visualize the three‐dimensional shape variations of the talus in relation to sex and...
Fri Mar 20, 2020 20:47
ABSTRACT Blood vessel tortuosity results from increased diameter and length in response to higher hemodynamic loads. Tortuosity metrics have not been determined for abnormal superior cerebral veins (SCVs) draining cerebral arteriovenous malformations (AVM). Draining vein (DV) tortuosity may influence safety and efficacy of retrograde microcatheter navigation during transvenous treatment of pial AVMs. Here we quantify SCV tortuosity in normal subjects and AVM patients using two image segmentation...
Fri Mar 20, 2020 20:47
Front cover: Cover image: see M. Butt et al., ‘The anatomical basis for transcutaneous auricular vagus nerve stimulation’, this issue.
Sat Mar 21, 2020 11:47
Sonoelastography image of the gastrocnemius medius muscle showing its degree of elasticity (red indicates soft tissues, green indicates intermediate elasticity, and blue indicates hard tissues). Abstract Musculoskeletal conditions can change tissue elasticity. Knowledge of musculoskeletal elasticity could therefore aid clinical diagnosis and management. Sonoelastography is an ultrasound‐based system that examines the material properties of tissues, and it may be useful in musculoskeletal practice....
Sat Mar 21, 2020 11:47
Abstract Objective Assess occurrence of the dendritic spine scaffolding protein Drebrin as pathophysiologically relevant autoantibody target in patients with recurrent seizures and suspected encephalitis as leading symptoms. Methods Sera of four patients with adult onset epilepsy and suspected encephalitis of unresolved etiology and equivalent results in autoantibody screening were subjected to epitope identification. We combined a wide array of approaches ranging from immunoblotting,...
Sat Mar 21, 2020 11:41
Abstract Observational studies showed alcohol drinking behaviors may be associated with the risk of ALS, whereas contradictory findings emerged and whether such association is causal is unclear. We here investigate the causal relationship between alcohol consumption and ALS. By leveraging instruments from large‐scale genome‐wide association studies, we performed a comprehensive Mendelian randomization analysis and found alcohol consumption was causally associated with ALS, leading to ~1.5 fold...
Sat Mar 21, 2020 11:41
Publication date: Available online 20 March 2020Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): P. Glen, D. Farrugia, J. Farrier
Sat Mar 21, 2020 11:36
Publication date: Available online 20 March 2020Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): K. Zaoui, A. Jung, W. Wimmer, M. Engel, M.A. Möhlenbruch, P.A. Federspil
Sat Mar 21, 2020 11:36
Abstract Recently, novel experimental approaches and molecular techniques have demonstrated that a male's experiences can be transmitted through his germline via epigenetic processes. These findings suggest that paternal exposures influence phenotypic variation in unexposed progeny–a proposal that runs counter to canonical ideas about inheritance developed during the 20th century. Nevertheless, support for paternal germline epigenetic inheritance (GEI) in nonhuman mammals continues to grow and the...
Sat Mar 21, 2020 11:36
New Findings What is the central question of this study? Does progesterone reduce the effect of chronic intermittent hypoxia (CIH) on arterial blood pressure, respiratory control, and oxidative stress in the central nervous system in ovariectomized rats? What is the main finding and its importance? Progesterone does not prevent the elevation of arterial blood pressure in rats exposed to CIH, but normalizes respiratory control, and reduces cerebral oxidative stress. This study draws...
Sat Mar 21, 2020 11:34
New Findings What is the central question of this study? Hypoxia reportedly does not impair thermoregulation during exercise in compensable heat stress conditions, but whether it has an impact on maximal heat dissipation and therefore the critical environmental limit for the physiological compensability of core temperature is unknown. What is the main finding and its importance? Although skin blood flow was higher in hypoxia, no differences in sweat rates or the critical environmental...
Fri Mar 20, 2020 10:36
New Findings What is the topic for this review? This review summarizes recent discoveries in mitochondrial development and morphology studied with electron microscopy. What advances does it highlight? Although mitochondria are generally considered to be isolated from each other, this review highlights recently discovered evidence for the presence of intermitochondrial communication structures in cardiac and skeletal muscle, in animal models and humans. Within striated muscles, the means...
Fri Mar 20, 2020 10:36
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