Related Articlesc-di-AMP hydrolysis by the phosphodiesterase AtaC promotes differentiation of multicellular bacteria. Proc Natl Acad Sci U S A. 2020 Mar 18;: Authors: Latoscha A, Drexler DJ, Al-Bassam MM, Bandera AM, Kaever V, Findlay KC, Witte G, Tschowri N Abstract Antibiotic-producing Streptomyces use the diadenylate cyclase DisA to synthesize the nucleotide second messenger c-di-AMP, but the mechanism for terminating c-di-AMP signaling and the proteins...
Fri Mar 20, 2020 13:08
Related ArticlesIron sequestration by transferrin 1 mediates nutritional immunity in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2020 Mar 18;: Authors: Iatsenko I, Marra A, Boquete JP, Peña J, Lemaitre B Abstract Iron sequestration is a recognized innate immune mechanism against invading pathogens mediated by iron-binding proteins called transferrins. Despite many studies on antimicrobial activity of transferrins in vitro, their specific in vivo...
Fri Mar 20, 2020 13:08
Related ArticlesSynthesis of phosphoramidate-linked DNA by a modified DNA polymerase. Proc Natl Acad Sci U S A. 2020 Mar 18;: Authors: Lelyveld VS, Zhang W, Szostak JW Abstract All known polymerases copy genetic material by catalyzing phosphodiester bond formation. This highly conserved activity proceeds by a common mechanism, such that incorporated nucleoside analogs terminate chain elongation if the resulting primer strand lacks a terminal hydroxyl...
Fri Mar 20, 2020 13:08
Related ArticlesSmall protein folds at the root of an ancient metabolic network. Proc Natl Acad Sci U S A. 2020 Mar 18;: Authors: Raanan H, Poudel S, Pike DH, Nanda V, Falkowski PG Abstract Life on Earth is driven by electron transfer reactions catalyzed by a suite of enzymes that comprise the superfamily of oxidoreductases (Enzyme Classification EC1). Most modern oxidoreductases are complex in their structure and chemistry and must have evolved from...
Fri Mar 20, 2020 13:08
Related ArticlesComputational design of closely related proteins that adopt two well-defined but structurally divergent folds. Proc Natl Acad Sci U S A. 2020 Mar 18;: Authors: Wei KY, Moschidi D, Bick MJ, Nerli S, McShan AC, Carter LP, Huang PS, Fletcher DA, Sgourakis NG, Boyken SE, Baker D Abstract The plasticity of naturally occurring protein structures, which can change shape considerably in response to changes in environmental conditions, is critical...
Fri Mar 20, 2020 13:08
Related ArticlesAn autoinhibitory intramolecular interaction proof-reads RNA recognition by the essential splicing factor U2AF2. Proc Natl Acad Sci U S A. 2020 Mar 18;: Authors: Kang HS, Sánchez-Rico C, Ebersberger S, Sutandy FXR, Busch A, Welte T, Stehle R, Hipp C, Schulz L, Buchbender A, Zarnack K, König J, Sattler M Abstract The recognition of cis-regulatory RNA motifs in human transcripts by RNA binding proteins (RBPs) is essential for gene regulation....
Fri Mar 20, 2020 13:08
Related ArticlesProbing allosteric coupling in a constitutively open mutant of the ion channel KcsA using solid-state NMR. Proc Natl Acad Sci U S A. 2020 Mar 18;: Authors: Sun Z, Xu Y, Zhang D, McDermott AE Abstract Transmembrane allosteric coupling is a feature of many critical biological signaling events. Here we test whether transmembrane allosteric coupling controls the potassium binding affinity of the prototypical potassium channel KcsA in the...
Fri Mar 20, 2020 13:08
Related ArticlesAll-nanofiber-based, ultrasensitive, gas-permeable mechanoacoustic sensors for continuous long-term heart monitoring. Proc Natl Acad Sci U S A. 2020 Mar 18;: Authors: Nayeem MOG, Lee S, Jin H, Matsuhisa N, Jinno H, Miyamoto A, Yokota T, Someya T Abstract The prolonged and continuous monitoring of mechanoacoustic heart signals is essential for the early diagnosis of cardiovascular diseases. These bodily acoustics have low intensity and...
Fri Mar 20, 2020 13:08
Related ArticlesInfluenza hemagglutinin drives viral entry via two sequential intramembrane mechanisms. Proc Natl Acad Sci U S A. 2020 Mar 18;: Authors: Pabis A, Rawle RJ, Kasson PM Abstract Enveloped viruses enter cells via a process of membrane fusion between the viral envelope and a cellular membrane. For influenza virus, mutational data have shown that the membrane-inserted portions of the hemagglutinin protein play a critical role in achieving fusion....
Fri Mar 20, 2020 13:08
Related ArticlesMetabolic control analysis of hepatic glycogen synthesis in vivo. Proc Natl Acad Sci U S A. 2020 Mar 18;: Authors: Nozaki Y, Petersen MC, Zhang D, Vatner DF, Perry RJ, Abulizi A, Haedersdal S, Zhang XM, Butrico GM, Samuel VT, Mason GF, Cline GW, Petersen KF, Rothman DL, Shulman GI Abstract Multiple insulin-regulated enzymes participate in hepatic glycogen synthesis, and the rate-controlling step responsible for insulin stimulation of...
Fri Mar 20, 2020 13:08
Related ArticlesEvolution of dispersal in a spatially heterogeneous population with finite patch sizes. Proc Natl Acad Sci U S A. 2020 Mar 18;: Authors: Parvinen K, Ohtsuki H, Wakano JY Abstract Dispersal is one of the fundamental life-history strategies of organisms, so understanding the selective forces shaping the dispersal traits is important. In the Wright's island model, dispersal evolves due to kin competition even when dispersal is costly, and...
Fri Mar 20, 2020 13:08
Related Articlesβ-Arrestin2 arrests the clearance of tau in FTLD. Proc Natl Acad Sci U S A. 2020 Mar 18;: Authors: Thathiah A PMID: 32188777 [PubMed - as supplied by publisher]
Fri Mar 20, 2020 13:08
Related ArticlesImplicit expression of uncertainty - suggestion of an empirically derived framework. BMC Med Educ. 2020 Mar 20;20(1):83 Authors: Gärtner J, Berberat PO, Kadmon M, Harendza S Abstract BACKGROUND: Uncertainty occurs in physicians' daily work in almost every clinical context and is also present in the clinical reasoning process. The way physicians communicate uncertainty in their thinking process during handoffs is crucial for patient safety...
Sun Mar 22, 2020 15:18
Related ArticlesPerceptions and attitudes towards dementia among university students in Malaysia. BMC Med Educ. 2020 Mar 20;20(1):82 Authors: Griffiths AW, Cheong WL, Saw PS, Parveen S Abstract BACKGROUND: One of the major challenges worldwide is the stigma associated with dementia. There is limited dementia awareness within Malaysian communities, including levels of confusion regarding the differences between dementia and the usual ageing progress,...
Sat Mar 21, 2020 13:55
Related ArticlesWhat makes an online problem-based group successful? A learning analytics study using social network analysis. BMC Med Educ. 2020 Mar 18;20(1):80 Authors: Saqr M, Nouri J, Vartiainen H, Malmberg J Abstract BACKGROUND: Although there is a wealth of research focusing on PBL, most studies employ self-reports, surveys, and interviews as data collection methods and have an exclusive focus on students. There is little research that has studied...
Fri Mar 20, 2020 12:27
Related ArticlesBurnout syndrome, extracurricular activities and social support among Brazilian internship medical students: a cross-sectional analysis. BMC Med Educ. 2020 Mar 18;20(1):81 Authors: Fontana MCP, Generoso IP, Sizilio A, Bivanco-Lima D Abstract BACKGROUND: Burnout syndrome (BS) is highly prevalent among medical students and is associated with lower empathy and worsening of medical students ́ mental health. The aim of our study was to identify...
Fri Mar 20, 2020 12:27
Related ArticlesCD19+ B-cells in autoantibody-negative limbic encephalitis. Epilepsy Behav. 2020 Mar 18;106:107016 Authors: Hansen N, Önder D, Schwing K, Widman G, Leelaarporn P, Prusseit I, Surges R, Becker AJ, Witt JA, Helmstaedter C, Elger CE Abstract PURPOSE: Flow cytometry helps to elucidate the cellular immune repertoire's mechanisms in patients with temporal lobe epilepsy (TLE) due to limbic encephalitis (LE) subcategories and carries potential...
Sun Mar 22, 2020 14:36
Related ArticlesThe ketogenic diet all grown up-Ketogenic diet therapies for adults. Epilepsy Res. 2020 Mar 10;162:106319 Authors: Husari KS, Cervenka MC Abstract The use of ketogenic diet therapies (KDT) in adults has expanded in the last two decades and has been accompanied by a surge of new retrospective as well as prospective studies evaluating its efficacy in adults with epilepsy. In this review article, we will highlight the recent clinical trials...
Sun Mar 22, 2020 14:36
Related ArticlesSafety of adjunctive treatment with cenobamate in patients with uncontrolled focal seizures. Lancet Neurol. 2020 Apr;19(4):288 Authors: Mudigoudar B, Wheless J PMID: 32199091 [PubMed - as supplied by publisher]
Sun Mar 22, 2020 14:36
Related ArticlesSafety of adjunctive treatment with cenobamate in patients with uncontrolled focal seizures - Authors' reply. Lancet Neurol. 2020 Apr;19(4):288-289 Authors: Krauss GL, Klein P, Brandt C, Lee SK, Milanov I, Milovanovic M, Steinhoff BJ, Kamin M PMID: 32199090 [PubMed - as supplied by publisher]
Sun Mar 22, 2020 14:36
Related ArticlesRefractory and Super-refractory Status Epilepticus. Indian Pediatr. 2020 Mar 15;57(3):239-253 Authors: Samanta D, Garrity L, Arya R Abstract CONTEXT: Refractory status epilepticus (RSE) and super-refractory status epilepticus (SRSE) are neurological emergencies with considerable mortality and morbidity. In this paper, we provide an overview of causes, evaluation, treatment, and consequences of RSE and SRSE, reflecting the lack of high-quality...
Sun Mar 22, 2020 14:36
Related ArticlesClinical Profile and Short-term Outcome of Pediatric Status Epilepticus at a Tertiary-care Center in Northern India. Indian Pediatr. 2020 Mar 15;57(3):213-217 Authors: Chetan C, Sharma S, Mathur SB, Jain P, Aneja S Abstract OBJECTIVE: To assess clinical profile and short term treatment outcomes of pediatric status epilepticus (SE) at a tertiary-care center in northern India. METHODS: Prospective cohort study enrolled children...
Sun Mar 22, 2020 14:36
Related ArticlesENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries. Transl Psychiatry. 2020 Mar 20;10(1):100 Authors: Thompson PM, Jahanshad N, Ching CRK, Salminen LE, Thomopoulos SI, Bright J, Baune BT, Bertolín S, Bralten J, Bruin WB, Bülow R, Chen J, Chye Y, Dannlowski U, de Kovel CGF, Donohoe G, Eyler LT, Faraone SV, Favre P, Filippi CA, Frodl T, Garijo D, Gil Y, Grabe HJ, Grasby KL, Hajek...
Sun Mar 22, 2020 14:36
Related ArticlesIonotropic Glutamate Receptors in Epilepsy: A Review Focusing on AMPA and NMDA Receptors. Biomolecules. 2020 Mar 18;10(3): Authors: Hanada T Abstract It is widely accepted that glutamate-mediated neuronal hyperexcitation plays a causative role in eliciting seizures. Among glutamate receptors, the roles of N-methyl-D-aspartate (NMDA) and α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors in physiological and pathological...
Sun Mar 22, 2020 13:15
Related ArticlesResting-state functional MRI connectivity impact on epilepsy surgery plan and surgical candidacy: prospective clinical work. J Neurosurg Pediatr. 2020 Mar 20;:1-8 Authors: Boerwinkle VL, Mirea L, Gaillard WD, Sussman BL, Larocque D, Bonnell A, Ronecker JS, Troester MM, Kerrigan JF, Foldes ST, Appavu B, Jarrar R, Williams K, Wilfong AA, Adelson PD Abstract OBJECTIVE: The authors' goal was to prospectively quantify the impact of resting-state...
Sat Mar 21, 2020 12:17
Related ArticlesThe epidemiology of comorbidities among multiple sclerosis patients in northeastern Poland. Mult Scler Relat Disord. 2020 Mar 14;41:102051 Authors: Kapica-Topczewska K, Tarasiuk J, Chorąży M, Czarnowska A, Brola W, Szczepański M, Kochanowicz J, Kułakowska A Abstract BACKGROUND: To determine and compare comorbidity levels in the multiple sclerosis (MS) population in Poland using a matched cohort from the general population. METHODS:...
Sat Mar 21, 2020 12:17
Related ArticlesRepurposed molecules for antiepileptogenesis: Missing an opportunity to prevent epilepsy? Epilepsia. 2020 Mar;61(3):359-386 Authors: Klein P, Friedman A, Hameed MQ, Kaminski RM, Bar-Klein G, Klitgaard H, Koepp M, Jozwiak S, Prince DA, Rotenberg A, Twyman R, Vezzani A, Wong M, Löscher W Abstract Prevention of epilepsy is a great unmet need. Acute central nervous system (CNS) insults such as traumatic brain injury (TBI), cerebrovascular...
Sat Mar 21, 2020 12:17
Related ArticlesLamotrigine add-on therapy for drug-resistant focal epilepsy. Cochrane Database Syst Rev. 2020 Mar 20;3:CD001909 Authors: Panebianco M, Bresnahan R, Ramaratnam S, Marson AG Abstract BACKGROUND: This is an updated version of the Cochrane Review previously published in 2016. Epilepsy is a common neurological disorder, affecting 0.5% to 1% of the population. For nearly 30% of these people, their epilepsy is resistant to currently available...
Sat Mar 21, 2020 12:17
Related ArticlesMAGNOLIA OFFICINALIS REDUCES INFLAMMATION AND DAMAGE INDUCED BY RECURRENT STATUS EPILEPTICUS IN IMMATURE RATS. Curr Pharm Des. 2020 Mar 20;: Authors: Orozco-Suarez S, Vega-García A, Rocha L, Guevara-Guzmán R, Guerra-Araiza C, Feria-Romero I, Gallardo JM, Neri-Gomez T, Suárez-Santiago JE Abstract BACKGROUND: Neuroinflammation induced in response to damage caused by status epilepticus (SE) activates the interleukin (IL)1-β pathway and proinflammatory...
Sat Mar 21, 2020 12:17
Related ArticlesEffects of carbamazepine, eslicarbazepine, valproic acid and levetiracetam on bone microarchitecture in rats. Pharmacol Rep. 2020 Mar 19;: Authors: Diemar SS, Sejling AS, Eiken P, Ellegaard M, Ding M, Andersen NB, Jørgensen NR Abstract BACKGROUND: Metabolic bone disease and fractures are a great problem for patients with epilepsy. The use of antiepileptic drugs (AEDs) is known to play an essential role in the progression of bone loss...
Sat Mar 21, 2020 12:17
Related ArticlesA comparison of resting state functional magnetic resonance imaging to invasive electrocortical stimulation for sensorimotor mapping in pediatric patients. Neuroimage Clin. 2019;23:101850 Authors: Roland JL, Hacker CD, Snyder AZ, Shimony JS, Zempel JM, Limbrick DD, Smyth MD, Leuthardt EC Abstract Localizing neurologic function within the brain remains a significant challenge in clinical neurosurgery. Invasive mapping with direct electrocortical...
Sat Mar 21, 2020 12:17
Related ArticlesA case report of sudden epileptic death linked to thermal water after mud therapy. Med Leg J. 2020 Mar;88(1):44-47 Authors: Matteo S, Marina S, Donata F, Rossella S PMID: 32191572 [PubMed - as supplied by publisher]
Fri Mar 20, 2020 14:15
Related ArticlesAnesthetic Management of a Patient With a Vagal Nerve Stimulator. Anesth Prog. 2020;67(1):16-22 Authors: Yamagata K, Hirose Y, Tanaka K, Yoshida M, Ohnuki T, Sendo R, Niwa H, Sugimura M Abstract Vagal nerve stimulation (VNS) is an established adjunctive treatment for patients with refractory epilepsy. VNS is effective in many cases, but few patients achieve complete elimination of seizures. Furthermore, VNS can cause respiratory complications,...
Fri Mar 20, 2020 14:15
Related ArticlesOxcarbazepine for trigeminal neuralgia may induce lower extremity weakness: A case report. World J Clin Cases. 2020 Mar 06;8(5):922-927 Authors: Song HG, Nahm FS Abstract BACKGROUND: Although few studies have reported hyponatremia due to carbamazepine or oxcarbazepine in patients with epilepsy, no study has investigated cases of carbamazepine- or oxcarbazepine-induced hyponatremia or unsteady gait in patients with neuropathic pain. Herein,...
Fri Mar 20, 2020 14:15
Related ArticlesIntrathecal Infusion of Autologous Adipose-Derived Regenerative Cells in Autoimmune Refractory Epilepsy: Evaluation of Safety and Efficacy. Stem Cells Int. 2020;2020:7104243 Authors: Szczepanik E, Mierzewska H, Antczak-Marach D, Figiel-Dabrowska A, Terczynska I, Tryfon J, Krzesniak N, Noszczyk BH, Sawicka E, Domanska-Janik K, Sarnowska A Abstract Objective/Purpose. Evaluation of efficacy and safety of autologous adipose-derived regenerative...
Fri Mar 20, 2020 14:15
Related ArticlesPregabalin adjunctive therapy for focal onset seizures in children 1 month to <4 years of age: A double-blind, placebo-controlled, video-electroencephalographic trial. Epilepsia. 2020 Mar 18;: Authors: Mann D, Antinew J, Knapp L, Almas M, Liu J, Scavone J, Yang R, Modequillo M, Makedonska I, Ortiz M, Kyrychenko A, Nordli D, Farkas V, Farkas MK, A0081042 study group Abstract OBJECTIVE: To evaluate the efficacy and safety of pregabalin...
Fri Mar 20, 2020 12:47
Related ArticlesStiripentol alleviates neuropathic pain in L5 spinal nerve-transected mice. J Anesth. 2020 Mar 18;: Authors: Fujiwara A, Nakao K, Ueno T, Matsumura S, Ito S, Minami T Abstract PURPOSE: Antiepileptic drugs are used not only for the treatment of epilepsy but also for that of neuropathic pain. However, their action mechanisms have not always been well explained. Stiripentol, an effective antiepileptic drug indicated as a therapeutic for...
Fri Mar 20, 2020 12:47
Related ArticlesEarly-onset dementia: diagnostic challenges. BMJ Case Rep. 2020 Mar 17;13(3): Authors: Elhusein B, Mahgoub OB, Khairi A Abstract A 56-year-old man was brought to our hospital by his family, seeking medical treatment for the patient's long-standing progressive word-finding difficulties, forgetfulness, agitation and social withdrawal. After multiple previous physician consultations, the patient was mistakenly diagnosed with epilepsy and...
Fri Mar 20, 2020 12:47
Related ArticlesIs there a role for microRNAs in epilepsy diagnostics? Expert Rev Mol Diagn. 2020 Mar 19;: Authors: Bauer S, Schütz V, Strzelczyk A, Rosenow F Abstract INTRODUCTION: Epilepsy is a disease group that encompasses numerous brain pathologies, all leading to spontaneous seizures. Several diagnostic needs in the area of epilepsy diagnostics remain unmet. MicroRNAs (miRNAs) have emerged as potential biomarkers of disease.Areas covered: We review...
Fri Mar 20, 2020 12:47
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