Medicine by Alexandros G. Sfakianakis

Population dynamics of decision making in temperate bacteriophages [NEW RESULTS]

Due to their ability to choose between lysis and lysogeny, temperate bacteriophages represent a classic model system to study the molecular basis of decision making. The coinfection of individual bacteria by multiple, genetically identical phages is known to alter the infection outcome and favor lysogeny over lytic development. However, it is not clear what role the ability of individual phages to sense and respond to coinfections plays in the phage-host infection dynamics at the population level....

Phylogenomics of the leaf-footed bug subfamily Coreinae (Hemiptera: Coreidae): applicability of ultraconserved elements at shallower depths [NEW RESULTS]

Fri Mar 20, 2020 02:00

Baits targeting invertebrate ultraconserved elements (UCEs) are becoming more common for phylogenetic studies. Recent studies have shown that invertebrate UCEs typically encode proteins - and thus, are functionally different from more conserved vertebrate UCEs - can resolve deep divergences (e.g., superorder to family ranks). However, the ability of the invertebrate UCE baits to robustly resolve relationships at shallower phylogenetic scales (i.e., tribes and congeners) has been generally limited...

The genetic basis for PRC1 complex diversity emerged early in animal evolution [NEW RESULTS]

Fri Mar 20, 2020 02:00

Polycomb group proteins are essential regulators of developmental processes across animals. Despite their importance, studies on Polycomb are often restricted to classical model systems and, as such, little is known about the evolution of these important chromatin regulators. Here we focus on Polycomb Repressive Complex 1 (PRC1) and trace the evolution of core components of canonical and non-canonical PRC1 complexes in animals. Previous work suggested that a major expansion in the number of PRC1...

End-to-end delivery quality assurance of computed tomography–based high-dose-rate brachytherapy using a gel dosimeter

Fri Mar 20, 2020 02:00

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Brachytherapy

Publication date: Available online 21 March 2020Source: BrachytherapyAuthor(s): Hidenobu Tachibana, Yusuke Watanabe, Shinya Mizukami, Takuya Maeyama, Tsuyoshi Terazaki, Ryuzo Uehara, Tetsuo Akimoto

Brachytherapy

Sun Mar 22, 2020 19:50

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Synthesis of Near-Infrared Emitting Gold Nanoclusters for Biological Applications

A reliable and easily reproducible method for preparation of functionalizable, near-infrared emitting photoluminescent gold nanoclusters and their direct detection inside HeLa cells by flow cytometry and confocal laser scanning microscopy is described.

Human Peripheral Blood Neutrophil Isolation for Interrogating the Parkinson's Associated LRRK2 Kinase Pathway by Assessing Rab10 Phosphorylation

Sun Mar 22, 2020 19:40

Mutations in the leucine rich repeat kinase 2 gene (LRRK2) cause hereditary Parkinson’s disease. We have developed an easy and robust method for assessing LRRK2-controlled phosphorylation of Rab10 in human peripheral blood neutrophils. This may help identify individuals with increased LRRK2 kinase pathway activity.

Slicing and Culturing Pig Hearts under Physiological Conditions

Sat Mar 21, 2020 19:49

This protocol describes how to slice and culture heart tissue under physiological conditions for 6 days. This culture system could be used as a platform for testing the efficacy of novel heart failure therapeutics as well as reliable testing of acute cardiotoxicity in a 3D heart model.

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

Fri Mar 20, 2020 20:44

This work presets an advanced protocol to accurately assess tumor loading by detection of green fluorescent protein and bioluminescence signals as well as the integration of quantitative molecular detection technique.

ScienceDirect Publication: Brain Research Bulletin

Fri Mar 20, 2020 19:44

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Evolutionary Psychiatry

Next Steps

The pandemic is here. What is in store for us, and how do we move forward as soon as possible?

Evolutionary Psychiatry

Sun Mar 22, 2020 18:15

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Attenuation of noisy environment-induced neuroinflammation and dysfunction of learning and memory by minocycline during perioperative period in mice

Publication date: June 2020Source: Brain Research Bulletin, Volume 159Author(s): Fei Lin, Yuxin Zheng, Linghui Pan, Zhiyi Zuo

ScienceDirect Publication: Brain Research Bulletin

Sun Mar 22, 2020 19:31

Hypothermia protects neurons against ischemia/reperfusion-induced pyroptosis via m6A-mediated activation of PTEN and the PI3K/Akt/GSK-3β signaling pathway

Publication date: Available online 19 March 2020Source: Brain Research BulletinAuthor(s): Meng-Yuan Diao, Ying Zhu, Jing Yang, Shao-Song Xi, Xin Wen, Qiao Gu, Wei Hu

ScienceDirect Publication: Brain Research Bulletin

Fri Mar 20, 2020 16:27

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Challenges of pesticide exposure assessment in occupational studies of chronic diseases

In this issue of Occupational and Environmental Medicine, Ohlander and colleagues review methods used to assess pesticide exposure in occupational epidemiology studies over the last 25 years .1 Their findings are striking for two reasons. The first is the very large number of studies published during this time period. Pesticides have been linked to almost every category of chronic disease, including cancer, respiratory, neurological and autoimmune diseases, as well as reproductive outcomes. The authors...

Chronic renal disease among lead-exposed workers

Sun Mar 22, 2020 18:00

BackgroundVery high exposure to inorganic lead causes serious kidney damage. We have studied workers with occupational exposure and data on blood lead.MethodsWe extended follow-up for 7 more years, for a previously studied cohort of 58 307 male workers who were part of a surveillance programme in 11 different states. Mortality was assessed using the National Death Index, and end-stage renal disease (ESRD) incidence was assessed using the US Renal Data System. We conducted internal analyses via Cox...

Who maintains good health functioning? The contribution of social, work-related and behavioural factors to mental and physical health functioning trajectories in ageing employees

Sun Mar 22, 2020 18:00

ObjectivesThe determinants of poor functioning and subsequent early exit from work are well established but very little is known about the positive determinants of maintaining good functioning among the ageing workforce. We investigated modifiable determinants of maintaining good mental and physical health functioning.MethodsWe used prospective survey data collected across four waves among the midlife employees of the City of Helsinki, Finland, 2000–2017 (n=3342). Health functioning was repeatedly...

Sun Mar 22, 2020 18:00

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New aspect of allergic contact dermatitis, an inflammatory skin disorder mediated by mast cells: can il-38 help?

Publication date: Available online 21 March 2020Source: Medical HypothesesAuthor(s): Dorita Lauritano, Gianpaolo Ronconi, Alessandro Caraffa, Carla Enrica Gallenga, Spyros K. Kritas, Paolo Di Emidio, Stefano Martinotti, Giulia Tetè, Rhiannon Ross, Pio Conti

Renin-angiotensin system: the unexpected flaw inside the human immune system revealed by SARS-CoV-2

Sun Mar 22, 2020 18:10

Publication date: Available online 21 March 2020Source: Medical HypothesesAuthor(s): Luca Roncati, Graziana Gallo, Antonio Manenti, Beniamino Palmieri

Theoretical basis for optimal surgical incision planning to reduce hypertrophic scar formation

Sun Mar 22, 2020 18:10

Publication date: July 2020Source: Medical Hypotheses, Volume 140Author(s): H.O. Rennekampff, M. Tenenhaus

Fri Mar 20, 2020 17:31

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Editorial Board

Publication date: 15 April 2020Source: Journal of Proteomics, Volume 217Author(s):

Use of the serum glycan state to predict ovarian cancer patients' clinical response to chemotherapy treatment

Sun Mar 22, 2020 17:47

Publication date: Available online 21 March 2020Source: Journal of ProteomicsAuthor(s): Ran Zhao, Guiling Lin, Yisheng Wang, Wenjun Qin, Tong Gao, Jing Han, Ruihuan Qin, Yiqing Pan, Jie Sun, Changhao Ren, Shingfang Ren, Congjian Xu

Proteomic dissection of the similar and different responses of wheat to drought, salinity and submergence during seed germination

Sat Mar 21, 2020 23:38

Publication date: Available online 20 March 2020Source: Journal of ProteomicsAuthor(s): Mingke Yan, Caiwen Xue, Yi Xiong, Xiangxiang Meng, Bingjuan Li, Renfang Shen, Ping Lan

Proteomics analysis reveals the role of ubiquitin specific protease (USP47) in Epithelial to Mesenchymal Transition (EMT) induced by TGFβ2 in breast cells

Fri Mar 20, 2020 20:44

Publication date: Available online 19 March 2020Source: Journal of ProteomicsAuthor(s): Virgínia Campos Silvestrini, Carolina Hassibe Thomé, Daniele Albuquerque, Camila de Souza Palma, Germano Aguiar Ferreira, Guilherme Pauperio Lanfredi, Ana Paula Masson, Lara Elis Alberici Delsin, Fernanda Ursoli Ferreira, Felipe Canto de Souza, Lyris Martins Franco de Godoy, Adriano Aquino, Emanuel Carrilho, Rodrigo Alexandre Panepucci, Dimas Tadeu Covas, Vitor Marcel Faça

Phosphoproteomic analysis of mammalian infective Trypanosoma brucei subjected to heat shock suggests atypical mechanisms for thermotolerance

Fri Mar 20, 2020 20:44

Publication date: Available online 19 March 2020Source: Journal of ProteomicsAuthor(s): Cher P. Ooi, Corinna Benz, Michael D. Urbaniak

Does the protein corona take over the selectivity of molecularly imprinted nanoparticles? The biological challenges to recognition

Fri Mar 20, 2020 20:44

Publication date: Available online 19 March 2020Source: Journal of ProteomicsAuthor(s): Annalaura Capriotti, Susy Piovesana, Riccardo Zenezini Chiozzi, Carmela Maria Montone, Alessandra Maria Bossi, Aldo Laganà

Elevated CO2 and temperature influence key proteins and metabolites associated with photosynthesis, antioxidant and carbon metabolism in Picrorhiza kurroa

Fri Mar 20, 2020 20:44

Publication date: Available online 19 March 2020Source: Journal of ProteomicsAuthor(s): Rajiv Kumar, Robin Joshi, Manglesh Kumari, Reema Thakur, Dinesh Kumar, Sanjay Kumar

An experimentally generated peptide database increases the sensitivity of XL-MS with complex samples

Fri Mar 20, 2020 20:44

Publication date: Available online 19 March 2020Source: Journal of ProteomicsAuthor(s): Iwan Parfentev, Sandra Schilbach, Patrick Cramer, Henning Urlaub

Fri Mar 20, 2020 20:44

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Can the Coronary Artery Calcium Score Scan Reduce the Radiation Dose in Coronary Computed Tomography Angiography?

Publication date: Available online 21 March 2020Source: Academic RadiologyAuthor(s): Liang Jin, Yiyi Gao, An'qi Jiang, Zhenlin Li, Peijun Wang, Ming Li

Characterizing Static and Dynamic Fractional Amplitude of Low-Frequency Fluctuation and its Prediction of Clinical Dysfunction in Patients with Diffuse Axonal Injury

Sun Mar 22, 2020 17:02

Publication date: Available online 21 March 2020Source: Academic RadiologyAuthor(s): Fuqing Zhou, Jie Zhan, Tao Gong, Wenhua Xu, Hongmei Kuang, Jian Li, Yinhua Wang, Honghan Gong

Coronavirus Disease (COVID-19): Spectrum of CT Findings and Temporal Progression of the Disease

Sat Mar 21, 2020 16:34

Publication date: Available online 20 March 2020Source: Academic RadiologyAuthor(s): Mingzhi Li, Pinggui Lei, Bingliang Zeng, Zongliang Li, Peng Yu, Bing Fan, Chuanhong Wang, Zicong Li, Jian Zhou, Shaobo Hu, Hao Liu

Collaborative Opportunities for Radiology Quality Improvement Projects

Sat Mar 21, 2020 16:34

Publication date: Available online 20 March 2020Source: Academic RadiologyAuthor(s): Kesav Raghavan, Robert M. Hicks, Marc D. Kohli, K. Pallav Kolli, Jason N. Itri, David J. Seidenwurm, Karen G. Ordovas

Imaging Features of Coronavirus disease 2019 (COVID-19): Evaluation on Thin-Section CT

Sat Mar 21, 2020 16:34

Publication date: Available online 20 March 2020Source: Academic RadiologyAuthor(s): Chun Shuang Guan, Zhi Bin Lv, Shuo Yan, Yan Ni Du, Hui Chen, Lian Gui Wei, Ru Ming Xie, Bu Dong Chen

Postneoadjuvant Chemotherapy Response in Advanced Ovarian Cancer: Radiological and Clinical Implications

Sat Mar 21, 2020 16:34

Publication date: Available online 20 March 2020Source: Academic RadiologyAuthor(s): Kimberly L. Shampain, Ashish P. Wasnik