IJMS, Vol. 21, Pages 2143: Role of uL3 in the Crosstalk between Nucleolar Stress and Autophagy in Colon Cancer Cells International Journal of Molecular Sciences doi: 10.3390/ijms21062143 Authors: Annalisa Pecoraro Pietro Carotenuto Brunella Franco Rossella De Cegli Giulia Russo Annapina Russo The nucleolus is the site of ribosome biogenesis and has been recently described as important sensor for a variety of cellular stressors. In the last two decades, it has been largely...
Fri Mar 20, 2020 02:00
IJMS, Vol. 21, Pages 2140: Hydrophobin-Protein A Fusion Protein Produced in Plants Efficiently Purified an Anti-West Nile Virus Monoclonal Antibody from Plant Extracts via Aqueous Two-Phase Separation International Journal of Molecular Sciences doi: 10.3390/ijms21062140 Authors: Collin Jugler Jussi Joensuu Qiang Chen The development of monoclonal antibodies (mAbs) has provided vast opportunities to treat a wide range of diseases from cancer to viral infections. While plant-based...
Fri Mar 20, 2020 02:00
IJMS, Vol. 21, Pages 2142: Sexually Dimorphic Behavioral Profile in a Transgenic Model Enabling Targeted Recombination in Active Neurons in Response to Ketamine and (2R,6R)-Hydroxynorketamine Administration International Journal of Molecular Sciences doi: 10.3390/ijms21062142 Authors: David P. Herzog Ratnadevi M. Mellema Floortje Remmers Beat Lutz Marianne B. Müller Giulia Treccani Background: Rapid-acting antidepressants ketamine and (2R,6R)-hydroxynorketamine ((2R,6R)-HNK)...
Fri Mar 20, 2020 02:00
IJMS, Vol. 21, Pages 2139: Pioglitazone and Deoxyribonucleoside Combination Treatment Increases Mitochondrial Respiratory Capacity in m.3243A>G MELAS Cybrid Cells International Journal of Molecular Sciences doi: 10.3390/ijms21062139 Authors: Harrison J. Burgin M. Isabel G. Lopez Sanchez Craig M. Smith Ian A. Trounce Matthew McKenzie The lack of effective treatments for mitochondrial disease has seen the development of new approaches, including those that aim to stimulate...
Fri Mar 20, 2020 02:00
IJMS, Vol. 21, Pages 2141: Center of Biomedical Research Excellence in Matrix Biology: Building Research Infrastructure, Supporting Young Researchers, and Fostering Collaboration International Journal of Molecular Sciences doi: 10.3390/ijms21062141 Authors: Julia Thom Oxford Ken A. Cornell Jared J. Romero Diane B. Smith Tracy L. Yarnell Rhiannon M. Wood Cheryl L. Jorcyk Trevor J. Lujan Allan R. Albig Kristen A. Mitchell Owen M. McDougal Daniel Fologea David...
Fri Mar 20, 2020 02:00
IJMS, Vol. 21, Pages 2136: A Compensatory U1snRNA Partially Rescues FAH Splicing and Protein Expression in a Splicing-Defective Mouse Model of Tyrosinemia Type I International Journal of Molecular Sciences doi: 10.3390/ijms21062136 Authors: Dario Balestra Daniela Scalet Mattia Ferrarese Silvia Lombardi Nicole Ziliotto Chrystal C. Croes Naomi Petersen Piter Bosma Federico Riccardi Franco Pagani Mirko Pinotti Stan F. J. van de Graaf The elucidation of aberrant...
Fri Mar 20, 2020 02:00
IJMS, Vol. 21, Pages 2137: Insights into the Therapeutic Potential of Glucocorticoid Receptor Modulators for Neurodegenerative Diseases International Journal of Molecular Sciences doi: 10.3390/ijms21062137 Authors: De Nicola Meyer Guennoun Schumacher Hunt Belanoff de Kloet Gonzalez Deniselle Glucocorticoids are crucial for stress-coping, resilience, and adaptation. However, if the stress hormones become dysregulated, the vulnerability to stress-related diseases...
Fri Mar 20, 2020 02:00
IJMS, Vol. 21, Pages 2135: Intervertebral Disc Diseases PART 2: A Review of the Current Diagnostic and Treatment Strategies for Intervertebral Disc Disease International Journal of Molecular Sciences doi: 10.3390/ijms21062135 Authors: Pang Hung Wu Hyeun Sung Kim Il-Tae Jang With an aging population, there is a proportional increase in the prevalence of intervertebral disc diseases. Intervertebral disc diseases are the leading cause of lower back pain and disability. With a high...
Fri Mar 20, 2020 02:00
IJMS, Vol. 21, Pages 2134: Distal Unfolding of Ferricytochrome c Induced by the F82K Mutation International Journal of Molecular Sciences doi: 10.3390/ijms21062134 Authors: Daniela Lalli Camilla Rosa Marco Allegrozzi Paola Turano It is well known that axial coordination of heme iron in mitochondrial cytochrome c has redox-dependent stability. The Met80 heme iron axial ligand in the ferric form of the protein is relatively labile and can be easily replaced by alternative amino...
Fri Mar 20, 2020 02:00
IJMS, Vol. 21, Pages 2132: Tyrosine–Chlorambucil Conjugates Facilitate Cellular Uptake through L-Type Amino Acid Transporter 1 (LAT1) in Human Breast Cancer Cell Line MCF-7 International Journal of Molecular Sciences doi: 10.3390/ijms21062132 Authors: Piman Pocasap Natthida Weerapreeyakul Juri Timonen Juulia Järvinen Jukka Leppänen Jussi Kärkkäinen Jarkko Rautio l-type amino acid transporter 1 (LAT1) is an amino acid transporter that is overexpressed in several types...
Fri Mar 20, 2020 02:00
IJMS, Vol. 21, Pages 2131: Influence of Salt Stress on Growth of Spermosphere Bacterial Communities in Different Peanut (Arachis hypogaea L.) Cultivars International Journal of Molecular Sciences doi: 10.3390/ijms21062131 Authors: Yang Xu Dai Zhang Liangxiang Dai Hong Ding Dunwei Ci Feifei Qin Guanchu Zhang Zhimeng Zhang Background: Exposure of seeds to high salinity can cause reduced germination and poor seedling establishment. Improving the salt tolerance of peanut...
Fri Mar 20, 2020 02:00
IJMS, Vol. 21, Pages 2133: Modification of the Mammalian Endomembrane System in Healthy and Diseased Cells International Journal of Molecular Sciences doi: 10.3390/ijms21062133 Authors: Jeremy C. Simpson One remarkable characteristic of eukaryotic cells is the complexity of their membrane systems [...]
Fri Mar 20, 2020 02:00
IJMS, Vol. 21, Pages 2138: Hericium Erinaceus Prevents DEHP-Induced Mitochondrial Dysfunction and Apoptosis in PC12 Cells International Journal of Molecular Sciences doi: 10.3390/ijms21062138 Authors: Ines Amara Maria Scuto Agata Zappalà Maria Laura Ontario Antonio Petralia Salwa Abid-Essefi Luigi Maiolino Anna Signorile Angela Trovato Salinaro Vittorio Calabrese Hericium Erinaceus (HE) is a medicinal plant known to possess anticarcinogenic, antibiotic, and...
Fri Mar 20, 2020 02:00
IJMS, Vol. 21, Pages 2130: Use of STAT6 Phosphorylation Inhibitor and Trimethylglycine as New Adjuvant Therapies for 5-Fluorouracil in Colitis-Associated Tumorigenesis International Journal of Molecular Sciences doi: 10.3390/ijms21062130 Authors: Mónica G. Mendoza-Rodríguez C. Ángel Sánchez-Barrera Blanca E. Callejas Verónica García-Castillo Diana L. Beristain-Terrazas Norma L. Delgado-Buenrostro Yolanda I. Chirino Sonia A. León-Cabrera Miriam Rodríguez-Sosa Emma...
Fri Mar 20, 2020 02:00
IJMS, Vol. 21, Pages 2129: Dissecting the Genetic Architecture of Aphanomyces Root Rot Resistance in Lentil by QTL Mapping and Genome-Wide Association Study International Journal of Molecular Sciences doi: 10.3390/ijms21062129 Authors: Yu Ma Afef Marzougui Clarice J. Coyne Sindhuja Sankaran Dorrie Main Lyndon D. Porter Deus Mugabe Jamin A. Smitchger Chongyuan Zhang Md. Nurul Amin Naser Rasheed Stephen P. Ficklin Rebecca J. McGee Lentil (Lens culinaris...
Fri Mar 20, 2020 02:00
IJMS, Vol. 21, Pages 2128: Cardiac miRNA Expression and their mRNA Targets in a Rat Model of Prediabetes International Journal of Molecular Sciences doi: 10.3390/ijms21062128 Authors: Éva Sághy Imre Vörös Bence Ágg Bernadett Kiss Gábor Koncsos Zoltán V. Varga Anikó Görbe Zoltán Giricz Rainer Schulz Péter Ferdinandy Little is known about the mechanism of prediabetes-induced cardiac dysfunction. Therefore, we aimed to explore key molecular changes with transcriptomic...
Fri Mar 20, 2020 02:00
IJNS, Vol. 6, Pages 23: The Role of Extended CFTR Gene Sequencing in Newborn Screening for Cystic Fibrosis International Journal of Neonatal Screening doi: 10.3390/ijns6010023 Authors: Anne Bergougnoux Maureen Lopez Emmanuelle Girodon There has been considerable progress in the implementation of newborn screening (NBS) programs for cystic fibrosis (CF), with DNA analysis being part of an increasing number of strategies. Thanks to advances in genomic sequencing technologies, CFTR-extended...
Sat Mar 21, 2020 02:00
JCM, Vol. 9, Pages 870: Emergent Properties of the HNF4α-PPARγ Network May Drive Consequent Phenotypic Plasticity in NAFLD Journal of Clinical Medicine doi: 10.3390/jcm9030870 Authors: Sahoo Singh Chakraborty Jolly Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease in adults and children. It is characterized by excessive accumulation of lipids in the hepatocytes of patients without any excess alcohol intake. With a global presence...
Sun Mar 22, 2020 02:00
JCM, Vol. 9, Pages 869: Knowledge of Rare Respiratory Diseases among Paediatricians and Medical School Students Journal of Clinical Medicine doi: 10.3390/jcm9030869 Authors: María Ángeles Requena-Fernández Francisco Dasí Silvia Castillo Rafael Barajas-Cenobi María Mercedes Navarro-García Amparo Escribano Alpha-1-antitrypsin deficiency (AATD) and primary ciliary dyskinesia (PCD) are underdiagnosed rare diseases showing a median diagnostic delay of five to ten years, which...
Sun Mar 22, 2020 02:00
JCM, Vol. 9, Pages 867: Evaluation of Proinflammatory, NF-kappaB Dependent Cytokines: IL-1α, IL-6, IL-8, and TNF-α in Tissue Specimens and Saliva of Patients with Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders Journal of Clinical Medicine doi: 10.3390/jcm9030867 Authors: Karolina Babiuch Beata Kuśnierz-Cabala Barbara Kęsek Krzysztof Okoń Dagmara Darczuk Maria Chomyszyn-Gajewska Background: Oral squamous cell carcinoma (OSCC) is a life-threatening...
Sat Mar 21, 2020 02:00
JCM, Vol. 9, Pages 868: Effect of Botulinum Toxin A on Scar Healing after Thyroidectomy: A Prospective Double-blind Randomized Controlled Trial Journal of Clinical Medicine doi: 10.3390/jcm9030868 Authors: Dong Sik Bae Do Hoon Koo Ji Eun Kim Jae-mahn Cho Jun-Ook Park The persistence of neck scarring is a common concern among patients undergoing thyroidectomy. Botulinum toxin A (BTA (Botox)) has been shown to suppress scar enlargement at the incision site. The objective of...
Sat Mar 21, 2020 02:00
JCM, Vol. 9, Pages 866: Endoscopic Ultrasound-Guided Treatments for Non-Variceal Upper GI Bleeding: A Review of the Literature Journal of Clinical Medicine doi: 10.3390/jcm9030866 Authors: Claudio Giovanni De Angelis Pablo Cortegoso Valdivia Stefano Rizza Ludovica Venezia Felice Rizzi Marcantonio Gesualdo Giorgio Maria Saracco Rinaldo Pellicano Endoscopic injection of glues, clotting factors, or sclerosing agents is a well-known therapy for the treatment of non-variceal...
Sat Mar 21, 2020 02:00
JCM, Vol. 9, Pages 864: Clinical Characteristics and Outcome of Patients with Infective Endocarditis Diagnosed in a Department of Internal Medicine Journal of Clinical Medicine doi: 10.3390/jcm9030864 Authors: Louis Kreitmann David Montaigne David Launay Sandrine Morell-Dubois Hélène Maillard Marc Lambert Eric Hachulla Vincent Sobanski Clinical manifestations of infective endocarditis (IE) can be highly non-specific. Our objective was to describe the clinical characteristics...
Sat Mar 21, 2020 02:00
JCM, Vol. 9, Pages 865: Make Sure You Have a Safety Net: Updates in the Prevention and Management of Infectious Complications in Stem Cell Transplant Recipients Journal of Clinical Medicine doi: 10.3390/jcm9030865 Authors: Carlos A. Q. Santos Yoona Rhee Michael T. Czapka Aamir S. Kazi Laurie A. Proia Hematopoietic stem cell transplant recipients are at increased risk of infection and immune dysregulation due to reception of cytotoxic chemotherapy; development of graft versus...
Sat Mar 21, 2020 02:00
JCM, Vol. 9, Pages 863: Multi-Platform Characterization of Cerebrospinal Fluid and Serum Metabolome of Patients Affected by Relapsing–Remitting and Primary Progressive Multiple Sclerosis Journal of Clinical Medicine doi: 10.3390/jcm9030863 Authors: Federica Murgia Lorena Lorefice Simone Poddighe Giuseppe Fenu Maria Antonietta Secci Maria Giovanna Marrosu Eleonora Cocco Luigi Atzori Background: Multiple sclerosis (MS) is a chronic immunemediated disease of the central...
Sat Mar 21, 2020 02:00
JCM, Vol. 9, Pages 862: Effects of a Multicomponent Exercise Program in Older Adults with Non-Small-Cell Lung Cancer during Adjuvant/Palliative Treatment: An Intervention Study Journal of Clinical Medicine doi: 10.3390/jcm9030862 Authors: Ilem D. Rosero Robinson Ramírez-Vélez Nicolas Martínez-Velilla Bernardo Abel Cedeño-Veloz Idoia Morilla Mikel Izquierdo Clinical intervention studies support the efficacy and safety of exercise programs as a treatment modality for non-small-cell...
Sat Mar 21, 2020 02:00
JCM, Vol. 9, Pages 861: Transcatheter Aortic Valve Replacement with Self-Expandable ACURATE neo as compared to Balloon-Expandable SAPIEN 3 in Patients with Severe Aortic Stenosis: Meta-analysis of Randomized and Propensity-Matched Studies. J. Clin. Med. 2020, 9, 397 Journal of Clinical Medicine doi: 10.3390/jcm9030861 Authors: Mirosław Gozdek Kamil Zieliński Michał Pasierski Matteo Matteucci Dario Fina Federica Jiritano Paolo Meani Giuseppe Maria Raffa Pietro Giorgio...
Fri Mar 20, 2020 02:00
JCM, Vol. 9, Pages 860: Outcomes Associated with Respiratory Failure for Patients with Cardiogenic Shock and Acute Myocardial Infarction: A Substudy of the CULPRIT-SHOCK Trial Journal of Clinical Medicine doi: 10.3390/jcm9030860 Authors: Giménez Miller Alviar Diepen Granger Montalescot Windecker Maier Serpytis Serpytis Oldroyd Noc Fuernau Huber Sandri Waha-Thiele Schneider Ouarrak Zeymer Desch Thiele Background:...
Fri Mar 20, 2020 02:00
JCM, Vol. 9, Pages 858: Analysis of Predisposing Factors for Rapid Dental Calculus Formation Journal of Clinical Medicine doi: 10.3390/jcm9030858 Authors: Carla Fons-Badal Antonio Fons-Font Carlos Labaig-Rueda M. Fernanda Solá-Ruiz Eduardo Selva-Otaolaurruchi Rubén Agustín-Panadero Background: Calculus accumulation varies widely between individuals. Dental calculus has been associated with the principal periodontal diseases. The aim of this study was to analyze individual...
Fri Mar 20, 2020 02:00
JCM, Vol. 9, Pages 859: The Prognostic Value of High Platelet Reactivity in Ischemic Stroke Depends on the Etiology: A Pilot Study Journal of Clinical Medicine doi: 10.3390/jcm9030859 Authors: Adam Wiśniewski Karolina Filipska Joanna Sikora Robert Ślusarz Grzegorz Kozera Background: Reduced aspirin response may result in a worse prognosis and a poor clinical outcome in ischemic stroke. The aim of this prospective pilot study was to assess the relationship between platelet...
Fri Mar 20, 2020 02:00
JCM, Vol. 9, Pages 856: The Role of Bone Marrow Mesenchymal Stem Cell Derived Extracellular Vesicles (MSC-EVs) in Normal and Abnormal Hematopoiesis and Their Therapeutic Potential Journal of Clinical Medicine doi: 10.3390/jcm9030856 Authors: Batsali Georgopoulou Mavroudi Matheakakis Pontikoglou Papadaki Mesenchymal stem cells (MSCs) represent a heterogeneous cellular population responsible for the support, maintenance, and regulation of normal hematopoietic stem...
Fri Mar 20, 2020 02:00
JCM, Vol. 9, Pages 855: Multifunctional Properties of Quercitrin-Coated Porous Ti-6Al-4V Implants for Orthopaedic Applications Assessed In Vitro Journal of Clinical Medicine doi: 10.3390/jcm9030855 Authors: Maria Antonia Llopis-Grimalt Aina Arbós Maria Gil-Mir Aleksandra Mosur Prathamesh Kulkarni Armando Salito Joana M. Ramis Marta Monjo (1) One strategy to improve the outcome of orthopedic implants is to use porous implants with the addition of a coating with an...
Fri Mar 20, 2020 02:00
JCM, Vol. 9, Pages 854: Effects of Contemporary Irrigant Activation Schemes and Subsequent Placement of an Interim Dressing on Bacterial Presence and Activity in Root Canals Associated with Asymptomatic Apical Periodontitis Journal of Clinical Medicine doi: 10.3390/jcm9030854 Authors: Carvalho Nardello Fernandes Bruno Paz Iglecias Honório Mayer Gavini Pinheiro New tools for activating endodontic irrigants have evolved, yet their impact on root canal...
Fri Mar 20, 2020 02:00
JCM, Vol. 9, Pages 853: Biphasic Temporal Relationship between Cancers and Systemic Sclerosis: A Clinical Series from Montpellier University Hospital and Review of the Literature Journal of Clinical Medicine doi: 10.3390/jcm9030853 Authors: Léo Partouche Radjiv Goulabchand Alexandre Thibault Jacques Maria Sophie Rivière Christian Jorgensen Valérie Rigau Céline Bourgier Didier Bessis Alain Le Quellec Isabelle Quere Jacques Morel Philippe Guilpain Cancer...
Fri Mar 20, 2020 02:00
JCM, Vol. 9, Pages 857: Body Mass Index and Calprotectin Blood Level Correlation in Healthy Children: An Individual Patient Data Meta-Analysis Journal of Clinical Medicine doi: 10.3390/jcm9030857 Authors: Grand Rochette Dutheil Gozal Calcaterra Berni Canani Cobanoglu Derikx Terrin Pereira Merlin Background: Calprotectin (CP) is a protein complex involved in many inflammatory diseases. Obesity is characterized by low-grade inflammation and elevated...
Fri Mar 20, 2020 02:00
JCM, Vol. 9, Pages 846: Ischemia-Reperfusion Injury in Marginal Liver Grafts and the Role of Hypothermic Machine Perfusion: Molecular Mechanisms and Clinical Implications Journal of Clinical Medicine doi: 10.3390/jcm9030846 Authors: Czigany Lurje Schmelzle Schöning Öllinger Raschzok Sauer Tacke Strnad Trautwein Neumann Fronek Mehrabi Pratschke Schlegel Lurje Ischemia-reperfusion injury (IRI) constitutes a significant source...
Fri Mar 20, 2020 02:00
JCM, Vol. 9, Pages 848: High Risk of Sustained Ventricular Arrhythmia Recurrence After Acute Myocarditis Journal of Clinical Medicine doi: 10.3390/jcm9030848 Authors: Rosier Zouaghi Barré Martins Probst Marijon Sadoul Chauveau Costa Badoz Peyrol Barraud Massoullie Eschalier Espinosa Lesaffre Garcia Degand Noël Mansourati Extramiana Algalarrondo Devilliers Cottin Gandjbakhch Guenancia Acute...
Fri Mar 20, 2020 02:00
JCM, Vol. 9, Pages 851: Increased Amygdala Activations during the Emotional Experience of Death-Related Pictures in Complicated Grief: An fMRI Study Journal of Clinical Medicine doi: 10.3390/jcm9030851 Authors: Manuel Fernández-Alcántara Juan Verdejo-Román Francisco Cruz-Quintana Miguel Pérez-García Andrés Catena-Martínez María Inmaculada Fernández-Ávalos María Nieves Pérez-Marfil Complicated grief (CG) is associated with alterations in various components of emotional...
Fri Mar 20, 2020 02:00
JCM, Vol. 9, Pages 845: The Treatment of Ingrown Nail: Chemical Matricectomy With Phenol Versus Aesthetic Reconstruction. A Single Blinded Randomized Clinical Trial Journal of Clinical Medicine doi: 10.3390/jcm9030845 Authors: Muriel-Sánchez Becerro-de-Bengoa-Vallejo Montaño-Jiménez Coheña-Jiménez Background: In onychocryptosis surgery, incisional and non-incisional matricectomy is indicated according to the stage. The chemical matricectomy with 88% phenol solution is the...
Fri Mar 20, 2020 02:00
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