Abstract In castration-resistant prostate cancer (CRPC) patients, observational studies have reported that statins may boost the antitumor activity of abiraterone (AA) and data suggest an improvement in efficacy; conclusions with vitamin D are less clear but an eventual benefit has been pointed. We conducted a post hoc analysis of individual patient data of CRPC patients treated with prednisone and/or AA with or without statins/vitamin D on randomized clinical trials. In the COU-AA-301...
Fri Mar 20, 2020 02:00
Childhood cancer survivors experience substantial treatment-related morbidity and biomarkers of long-term survivor health are needed. Leukocyte telomere length is shortened in childhood cancer survivors and associates with the occurrence of numerous chronic health conditions. Healthy lifestyle factors can attenuate telomere attrition in young-adult survivors, implicating critical windows for intervention.
Fri Mar 20, 2020 17:41
Purpose: Venetoclax-based therapy is a standard of care option in front-line and relapsed/refractory CLL. Patient management following venetoclax discontinuation remains non-standard and poorly understood. Experimental Design: To address this, we conducted a large international study to identify a cohort of 326 patients who discontinued venetoclax and have been subsequently treated. Co-primary endpoints were overall response rate (ORR) and progression free survival (PFS) for the post-venetoclax treatments...
Fri Mar 20, 2020 17:41
Purpose:Using standard-of-care CT images obtained from patients with a diagnosis of non–small cell lung cancer (NSCLC), we defined radiomics signatures predicting the sensitivity of tumors to nivolumab, docetaxel, and gefitinib.Experimental Design:Data were collected prospectively and analyzed retrospectively across multicenter clinical trials [nivolumab, n = 92, CheckMate017 (NCT01642004), CheckMate063 (NCT01721759); docetaxel, n = 50, CheckMate017; gefitinib, n = 46, (NCT00588445)]. Patients were...
Fri Mar 20, 2020 09:05
Publication date: Available online 20 March 2020Source: Critical Reviews in Oncology/HematologyAuthor(s): Xin Lv, Jiaqian Qi, Meng Zhou, Bingyu Shi, Chengsen Cai, Yaqiong Tang, Tingting Pan, Yue Han
Sat Mar 21, 2020 22:50
Publication date: Available online 19 March 2020Source: Critical Reviews in Oncology/HematologyAuthor(s): Rafael Caparica, Marco Bruzzone, Georges El Hachem, Marcello Ceppi, Matteo Lambertini, João Glasberg, Evandro de Azambuja, Jean-Luc Van Laethem, Alain Hendlisz
Fri Mar 20, 2020 13:57
Publication date: May 2020Source: European Journal of Cancer, Volume 130Author(s): Astrid E. Slagter, Benjamin Tudela, Romy M. van Amelsfoort, Karolina Sikorska, Johanna W. van Sandick, Cornelis J.H. van de Velde, Nicole C.T. van Grieken, Pehr Lind, Marianne Nordsmark, Hein Putter, Maarten C.C.M. Hulshof, Hanneke W.M. van Laarhoven, Cecile Grootscholten, Jeffrey P.B.M. Braak, Elma Meershoek-Klein Kranenbarg, Edwin P.M. Jansen, Annemieke Cats, Marcel Verheij
Sat Mar 21, 2020 14:55
Publication date: Available online 20 March 2020Source: European Journal of CancerAuthor(s): Po-Hsin Lee, Teng-Yu Lee, Gee-Chen Chang
Fri Mar 20, 2020 23:12
Publication date: Available online 19 March 2020Source: European Journal of Surgical OncologyAuthor(s): Peter Schullian, Gregor Laimer, Daniel Putzer, Elliot Levy, Eva Braunwarth, Stefan Stättner, Reto Bale
Fri Mar 20, 2020 16:56
ABSTRACT Infant leukemias are a rare group of neoplasms that are clinically and biologically distinct from their pediatric and adult counterparts. Unlike leukemia in older children where survival rates are generally favorable, infants with leukemia have a 5‐year event‐free survival rate of <50%. The majority of infant leukemias are characterized by KMT2A (MLL) rearrangements (~70‐80% in acute lymphoblastic leukemia), which appear to be drivers of early leukemogenesis. In this report we describe...
Fri Mar 20, 2020 21:43
Epidemiological evidence for the association between postdiagnostic metformin use and survival in patients with colorectal cancer (CRC) remains limited. Using the Taiwan Cancer Registry database, a cohort of 16,676 diabetic patients newly diagnosed with CRC from January 1, 2004 through December 31, 2014, followed until December 31, 2016, was identified. Postdiagnostic use of metformin (two or more prescriptions after CRC diagnosis) was defined as a time‐dependent covariate with 6‐month lag. Multivariate...
Sat Mar 21, 2020 09:40
Abstract Metabolic phenotypes of cancer cells are heterogeneous and flexible as a tumour mass is a hurriedly evolving system capable of constant adaptation to oxygen and nutrient availability. The exact type of cancer metabolism arises from the combined effects of factors intrinsic to the cancer cells and factors proposed by the tumour microenvironment. As a result, a condition termed oncogenic metabolic symbiosis in which components of the tumour microenvironment (TME) promote tumour growth often...
Sat Mar 21, 2020 09:40
Abstract Purpose Several scoring systems have been proposed to predict the outcome of transarterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC). However, the application of these scores to a bridging to transplant setting is poorly validated. Evaluation of the applicability of prognostic scores for patients undergoing TACE in palliative intention vs. bridging therapy to liver transplantation (LT) is...
Sat Mar 21, 2020 17:43
In the original article, the title of the article is “Restoration of MARCK enhances chemosensitivity in cancer”. The authors would like to change the article title to “Restoration of MARCKS enhances chemosensitivity in cancer” by adding a letter “S” to the word MARCK.
Sat Mar 21, 2020 17:43
Abstract Purpose Lung cancer has the highest morbidity and mortality among all cancer types. Reliable prognostic biomarkers are needed to identify high-risk patients apart from TNM system for precision medicine. The present study is designed to identify robust prognostic biomarkers in lung adenocarcinoma (LUAD) based on integration of multiple GEO datasets, The Cancer Genome Atlas (TCGA) database and Clinical Proteomic Tumor Analysis...
Sat Mar 21, 2020 17:43
Abstract Purpose Presently, liver cancer is still one of the malignant tumors with high mortality. As far as the treatment of liver cancer is concerned, the most effective method is still liver transplantation. But every year, many liver cancer patients die from the lack of a proper liver transplant, or from waiting for a liver transplant. Therefore, it is very important to find new and effective treatment for patients with liver...
Sat Mar 21, 2020 17:43
Abstract Purpose Proton therapy could minimize the risk of side effects and, therefore, reduce the possible detrimental effect on health-related quality of life (HRQOL) of re-irradiation. The aim of this study was to determine the effect of re-irradiation with active scanning proton therapy on recurrent glioblastoma (GBM) in terms of HRQOL scored by the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire...
Sat Mar 21, 2020 02:00
Abstract Purpose Few studies reported about the potential of unphosphorylated heat shock protein 27 (HSP27) and phosphorylated heat shock protein 27 (pHSP27) as a predictor for survival and gemcitabine resistance in pancreatic ductal adenocarcinoma (PDAC). In this study, we analysed the expression patterns of pHSP27 and HSP27 in a patient population after surgery and correlated the immunohistochemical results with clinicopathological...
Sat Mar 21, 2020 02:00
Runt-related transcription factor 1 (RUNX1) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters and can accelerate apoptosis in various tumors. However, the r...
Fri Mar 20, 2020 02:00
Abstract This study aims to identify the core modules associated with pancreatic cancer (PC) types and the ncRNAs and transcription factors (TFs) that regulate core module genes by weighted gene co-expression network analysis (WGCNA). WGCNA was used to analyze the union of genes related to PC in NCBI and OMIM databases and the differentially expressed genes screened by TCGA-PAAD database. Samples were clustered according to gene expression in gene modules and Fisher exact method...
Sat Mar 21, 2020 02:00
Abstract Cell line authentication is important for credibility concern and scientific reproducibility. Authenticated cancer cell lines retain the properties of the cancers of origin and serve valuable resources for medical research. Experimental results commonly will be validated in more than one cell line to avoid specific cell line effect not generalizable to the disease on the whole. The use of appropriate and verified cell lines would therefore be very important in preclinical studies of translational...
Sat Mar 21, 2020 10:53
Publication date: Available online 20 March 2020Source: Practical Radiation OncologyAuthor(s): Audree B. Tadros, Tracy-Ann Moo, Emily C. Zabor, Erin F. Gillespie, Atif Khan, Beryl McCormick, Oren Cahlon, Simon N. Powell, Robert Allen, Monica Morrow, Lior Z. Braunstein
Sat Mar 21, 2020 17:37
Publication date: Available online 19 March 2020Source: Practical Radiation OncologyAuthor(s): Marta Bottero, Giovanna Dipasquale, Andrea Lancia, Raymond Miralbell, Maud Jaccard, Thomas Zilli
Fri Mar 20, 2020 17:28
Publication date: Available online 19 March 2020Source: Practical Radiation OncologyAuthor(s): Peijin Han, Russell Hales, Pranav Lakshminarayanan, Zhi Cheng, Christen Elledge, Alex Negron, Sarah Hazell, Chen Hu, Cole Friedes, Lori Anderson, Jeffrey Hoff, Kristen Marrone, Harry Quon, Todd McNutt, K. Ranh Voong
Fri Mar 20, 2020 17:28
Publication date: Available online 19 March 2020Source: Practical Radiation OncologyAuthor(s): Kelly C. Paradis, Katherine Woch Naheedy, Martha Matuszak, Rojano Kashani, Pamela Burger, Jean M. Moran
Fri Mar 20, 2020 17:28
Publication date: Available online 19 March 2020Source: Practical Radiation OncologyAuthor(s): Maxwell Robinson, Clare Tunstall, Frank Van den Heuvel, Claire Hobbs, Sriram Padmanaban
Fri Mar 20, 2020 17:28
Publication date: Available online 19 March 2020Source: Reports of Practical Oncology & RadiotherapyAuthor(s): Gleeson Ian
Fri Mar 20, 2020 15:23
Publication date: Available online 19 March 2020Source: Reports of Practical Oncology & RadiotherapyAuthor(s): Nishant Vidyasagar, Janaki Manur Gururajachar
Fri Mar 20, 2020 15:23
Publication date: Available online 19 March 2020Source: Reports of Practical Oncology & RadiotherapyAuthor(s): Marigdalia K. Ramirez-Fort, Marc J. Rogers, Roberto Santiago, Sean S. Mahase, M. Junaid Niaz, Melissa Mendez, Yi Zheng, Xiang Kong, Shearwood McClelland, James A. Kashanian, Xiaodong Wu, Neil H. Bander, Peter Schlegel, John P. Mulhall, Christopher S. Lange
Fri Mar 20, 2020 15:23
Publication date: April 2020Source: Cancer Epidemiology, Volume 65Author(s): Charlotte Salmon, Florence Conus, Marie-Élise Parent, Andrea Benedetti, Marie-Claude Rousseau
Sat Mar 21, 2020 18:05
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου