Κυριακή 22 Μαρτίου 2020


Combination of statin/vitamin D and metastatic castration-resistant prostate cancer (CRPC): a post hoc analysis of two randomized clinical trials
Abstract In castration-resistant prostate cancer (CRPC) patients, observational studies have reported that statins may boost the antitumor activity of abiraterone (AA) and data suggest an improvement in efficacy; conclusions with vitamin D are less clear but an eventual benefit has been pointed. We conducted a post hoc analysis of individual patient data of CRPC patients treated with prednisone and/or AA with or without statins/vitamin D on randomized clinical trials. In the COU-AA-301...
Clinical and translational oncology
Fri Mar 20, 2020 02:00
Telomere attrition in childhood cancer survivors
Childhood cancer survivors experience substantial treatment-related morbidity and biomarkers of long-term survivor health are needed. Leukocyte telomere length is shortened in childhood cancer survivors and associates with the occurrence of numerous chronic health conditions. Healthy lifestyle factors can attenuate telomere attrition in young-adult survivors, implicating critical windows for intervention.
Clinical Cancer Research Online First Articles
Fri Mar 20, 2020 17:41
Assessment of the Efficacy of Therapies Following Venetoclax Discontinuation in CLL Reveals BTK inhibition as an Effective Strategy
Purpose: Venetoclax-based therapy is a standard of care option in front-line and relapsed/refractory CLL. Patient management following venetoclax discontinuation remains non-standard and poorly understood. Experimental Design: To address this, we conducted a large international study to identify a cohort of 326 patients who discontinued venetoclax and have been subsequently treated. Co-primary endpoints were overall response rate (ORR) and progression free survival (PFS) for the post-venetoclax treatments...
Clinical Cancer Research Online First Articles
Fri Mar 20, 2020 17:41
Identification of Non-Small Cell Lung Cancer Sensitive to Systemic Cancer Therapies Using Radiomics
Purpose:Using standard-of-care CT images obtained from patients with a diagnosis of non–small cell lung cancer (NSCLC), we defined radiomics signatures predicting the sensitivity of tumors to nivolumab, docetaxel, and gefitinib.Experimental Design:Data were collected prospectively and analyzed retrospectively across multicenter clinical trials [nivolumab, n = 92, CheckMate017 (NCT01642004), CheckMate063 (NCT01721759); docetaxel, n = 50, CheckMate017; gefitinib, n = 46, (NCT00588445)]. Patients were...
Clinical Cancer Research Online First Articles
Fri Mar 20, 2020 09:05
Comparative efficacy of 20 graft-versus-host disease prophylaxis therapies for patients after hematopoietic stem-cell transplantation: a multiple-treatments network meta-analysis
Publication date: Available online 20 March 2020Source: Critical Reviews in Oncology/HematologyAuthor(s): Xin Lv, Jiaqian Qi, Meng Zhou, Bingyu Shi, Chengsen Cai, Yaqiong Tang, Tingting Pan, Yue Han
Critical Reviews in Oncology/Hematology (open access)
Sat Mar 21, 2020 22:50
Adjuvant chemotherapy in biliary tract cancer patients: a systematic review and meta-analysis of randomized controlled trials
Publication date: Available online 19 March 2020Source: Critical Reviews in Oncology/HematologyAuthor(s): Rafael Caparica, Marco Bruzzone, Georges El Hachem, Marcello Ceppi, Matteo Lambertini, João Glasberg, Evandro de Azambuja, Jean-Luc Van Laethem, Alain Hendlisz
Critical Reviews in Oncology/Hematology (open access)
Fri Mar 20, 2020 13:57
Older versus younger adults with gastric cancer receiving perioperative treatment: Results from the CRITICS trial
Publication date: May 2020Source: European Journal of Cancer, Volume 130Author(s): Astrid E. Slagter, Benjamin Tudela, Romy M. van Amelsfoort, Karolina Sikorska, Johanna W. van Sandick, Cornelis J.H. van de Velde, Nicole C.T. van Grieken, Pehr Lind, Marianne Nordsmark, Hein Putter, Maarten C.C.M. Hulshof, Hanneke W.M. van Laarhoven, Cecile Grootscholten, Jeffrey P.B.M. Braak, Elma Meershoek-Klein Kranenbarg, Edwin P.M. Jansen, Annemieke Cats, Marcel Verheij
European Journal of Cancer
Sat Mar 21, 2020 14:55
Hepatitis B flare during osimertinib targeted therapy in a lung cancer patient with a resolved hepatitis B virus infection
Publication date: Available online 20 March 2020Source: European Journal of CancerAuthor(s): Po-Hsin Lee, Teng-Yu Lee, Gee-Chen Chang
European Journal of Cancer
Fri Mar 20, 2020 23:12
Stereotactic radiofrequency ablation as first-line treatment of recurrent HCC following hepatic resection
Publication date: Available online 19 March 2020Source: European Journal of Surgical OncologyAuthor(s): Peter Schullian, Gregor Laimer, Daniel Putzer, Elliot Levy, Eva Braunwarth, Stefan Stättner, Reto Bale
European Journal of Surgical Oncology (EJSO)
Fri Mar 20, 2020 16:56
Cryptic and atypical KMT2A‐USP2 and KMT2A‐USP8 rearrangements identified by mate pair sequencing in infant and childhood leukemia
ABSTRACT Infant leukemias are a rare group of neoplasms that are clinically and biologically distinct from their pediatric and adult counterparts. Unlike leukemia in older children where survival rates are generally favorable, infants with leukemia have a 5‐year event‐free survival rate of <50%. The majority of infant leukemias are characterized by KMT2A (MLL) rearrangements (~70‐80% in acute lymphoblastic leukemia), which appear to be drivers of early leukemogenesis. In this report we describe...
Genes, Chromosomes and Cancer
Fri Mar 20, 2020 21:43
Postdiagnostic Metformin Use and Survival of Patients With Colorectal Cancer: A Nationwide Cohort study
Epidemiological evidence for the association between postdiagnostic metformin use and survival in patients with colorectal cancer (CRC) remains limited. Using the Taiwan Cancer Registry database, a cohort of 16,676 diabetic patients newly diagnosed with CRC from January 1, 2004 through December 31, 2014, followed until December 31, 2016, was identified. Postdiagnostic use of metformin (two or more prescriptions after CRC diagnosis) was defined as a time‐dependent covariate with 6‐month lag. Multivariate...
International Journal of Cancer
Sat Mar 21, 2020 09:40
Caveolin‐1 in oncogenic metabolic symbiosis
Abstract Metabolic phenotypes of cancer cells are heterogeneous and flexible as a tumour mass is a hurriedly evolving system capable of constant adaptation to oxygen and nutrient availability. The exact type of cancer metabolism arises from the combined effects of factors intrinsic to the cancer cells and factors proposed by the tumour microenvironment. As a result, a condition termed oncogenic metabolic symbiosis in which components of the tumour microenvironment (TME) promote tumour growth often...
International Journal of Cancer
Sat Mar 21, 2020 09:40
Applicability of scoring systems predicting outcome of transarterial chemoembolization for hepatocellular carcinoma
Abstract Purpose Several scoring systems have been proposed to predict the outcome of transarterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC). However, the application of these scores to a bridging to transplant setting is poorly validated. Evaluation of the applicability of prognostic scores for patients undergoing TACE in palliative intention vs. bridging therapy to liver transplantation (LT) is...
Journal of Cancer Research and Clinical Oncology
Sat Mar 21, 2020 17:43
Correction to: Restoration of MARCKS enhances chemosensitivity in cancer
In the original article, the title of the article is “Restoration of MARCK enhances chemosensitivity in cancer”. The authors would like to change the article title to “Restoration of MARCKS enhances chemosensitivity in cancer” by adding a letter “S” to the word MARCK.
Journal of Cancer Research and Clinical Oncology
Sat Mar 21, 2020 17:43
Elevated TOP2A and UBE2C expressions correlate with poor prognosis in patients with surgically resected lung adenocarcinoma: a study based on immunohistochemical analysis and bioinformatics
Abstract Purpose Lung cancer has the highest morbidity and mortality among all cancer types. Reliable prognostic biomarkers are needed to identify high-risk patients apart from TNM system for precision medicine. The present study is designed to identify robust prognostic biomarkers in lung adenocarcinoma (LUAD) based on integration of multiple GEO datasets, The Cancer Genome Atlas (TCGA) database and Clinical Proteomic Tumor Analysis...
Journal of Cancer Research and Clinical Oncology
Sat Mar 21, 2020 17:43
Precise therapeutic effect of self-assembling gold nanocluster–PTEN complexes on an orthotropic model of liver cancer
Abstract Purpose Presently, liver cancer is still one of the malignant tumors with high mortality. As far as the treatment of liver cancer is concerned, the most effective method is still liver transplantation. But every year, many liver cancer patients die from the lack of a proper liver transplant, or from waiting for a liver transplant. Therefore, it is very important to find new and effective treatment for patients with liver...
Journal of Cancer Research and Clinical Oncology
Sat Mar 21, 2020 17:43
Proton therapy re-irradiation preserves health-related quality of life in large recurrent glioblastoma
Abstract Purpose Proton therapy could minimize the risk of side effects and, therefore, reduce the possible detrimental effect on health-related quality of life (HRQOL) of re-irradiation. The aim of this study was to determine the effect of re-irradiation with active scanning proton therapy on recurrent glioblastoma (GBM) in terms of HRQOL scored by the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire...
Journal of Cancer Research and Clinical Oncology
Sat Mar 21, 2020 02:00
Significance of unphosphorylated and phosphorylated heat shock protein 27 as a prognostic biomarker in pancreatic ductal adenocarcinoma
Abstract Purpose Few studies reported about the potential of unphosphorylated heat shock protein 27 (HSP27) and phosphorylated heat shock protein 27 (pHSP27) as a predictor for survival and gemcitabine resistance in pancreatic ductal adenocarcinoma (PDAC). In this study, we analysed the expression patterns of pHSP27 and HSP27 in a patient population after surgery and correlated the immunohistochemical results with clinicopathological...
Journal of Cancer Research and Clinical Oncology
Sat Mar 21, 2020 02:00
Runt-related transcription factor 1 promotes apoptosis and inhibits neuroblastoma progression in vitro and in vivo
Runt-related transcription factor 1 (RUNX1) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters and can accelerate apoptosis in various tumors. However, the r...
Journal of Experimental & Clinical Cancer Research - Latest Articles
Fri Mar 20, 2020 02:00
Identification of pancreatic cancer type related factors by Weighted Gene Co-Expression Network Analysis
Abstract This study aims to identify the core modules associated with pancreatic cancer (PC) types and the ncRNAs and transcription factors (TFs) that regulate core module genes by weighted gene co-expression network analysis (WGCNA). WGCNA was used to analyze the union of genes related to PC in NCBI and OMIM databases and the differentially expressed genes screened by TCGA-PAAD database. Samples were clustered according to gene expression in gene modules and Fisher exact method...
Medical Oncology
Sat Mar 21, 2020 02:00
Contaminated and misidentified cell lines commonly use in cancer research
Abstract Cell line authentication is important for credibility concern and scientific reproducibility. Authenticated cancer cell lines retain the properties of the cancers of origin and serve valuable resources for medical research. Experimental results commonly will be validated in more than one cell line to avoid specific cell line effect not generalizable to the disease on the whole. The use of appropriate and verified cell lines would therefore be very important in preclinical studies of translational...
Molecular Carcinogenesis
Sat Mar 21, 2020 10:53
Feasibility of Breast-Conservation Therapy and Hypofractionated Radiation in the Setting of Prior Breast Augmentation
Publication date: Available online 20 March 2020Source: Practical Radiation OncologyAuthor(s): Audree B. Tadros, Tracy-Ann Moo, Emily C. Zabor, Erin F. Gillespie, Atif Khan, Beryl McCormick, Oren Cahlon, Simon N. Powell, Robert Allen, Monica Morrow, Lior Z. Braunstein
Practical Radiation Oncology
Sat Mar 21, 2020 17:37
Electromagnetic transponders localization and real-time tracking for prostate cancer radiotherapy: clinical impact of metallic hip prostheses
Publication date: Available online 19 March 2020Source: Practical Radiation OncologyAuthor(s): Marta Bottero, Giovanna Dipasquale, Andrea Lancia, Raymond Miralbell, Maud Jaccard, Thomas Zilli
Practical Radiation Oncology
Fri Mar 20, 2020 17:28
Exploring the Relationship of Radiation Dose Exposed to the Length of Esophagus and Weight Loss in Patients with Lung Cancer
Publication date: Available online 19 March 2020Source: Practical Radiation OncologyAuthor(s): Peijin Han, Russell Hales, Pranav Lakshminarayanan, Zhi Cheng, Christen Elledge, Alex Negron, Sarah Hazell, Chen Hu, Cole Friedes, Lori Anderson, Jeffrey Hoff, Kristen Marrone, Harry Quon, Todd McNutt, K. Ranh Voong
Practical Radiation Oncology
Fri Mar 20, 2020 17:28
The Fusion of Incident Learning and Failure Mode and Effects Analysis for Data-Driven Patient Safety Improvements
Publication date: Available online 19 March 2020Source: Practical Radiation OncologyAuthor(s): Kelly C. Paradis, Katherine Woch Naheedy, Martha Matuszak, Rojano Kashani, Pamela Burger, Jean M. Moran
Practical Radiation Oncology
Fri Mar 20, 2020 17:28
High Quality Clinical Stereotactic Radiosurgery Planning and Delivery with Standard Resolution (5mm) Multileaf Collimation and Multiple Isocentres
Publication date: Available online 19 March 2020Source: Practical Radiation OncologyAuthor(s): Maxwell Robinson, Clare Tunstall, Frank Van den Heuvel, Claire Hobbs, Sriram Padmanaban
Practical Radiation Oncology
Fri Mar 20, 2020 17:28
A Comparison of a Moderately Hypofractionated IMRT Planning Technique Used in a Randomised UK External Beam Radiotherapy Trial with an in-house technique for Localised Prostate Cancer
Publication date: Available online 19 March 2020Source: Reports of Practical Oncology & RadiotherapyAuthor(s): Gleeson Ian
Reports of Practical Oncology & Radiotherapy
Fri Mar 20, 2020 15:23
Predicting toxicity for Head and Neck cancer patients undergoing radiation therapy: an independent and external validation of MDASI-HN based nomogram
Publication date: Available online 19 March 2020Source: Reports of Practical Oncology & RadiotherapyAuthor(s): Nishant Vidyasagar, Janaki Manur Gururajachar
Reports of Practical Oncology & Radiotherapy
Fri Mar 20, 2020 15:23
Prostatic irradiation-induced sexual dysfunction: A review and multidisciplinary guide to management in the radical radiotherapy era (Part I Defining the Organ at Risk for sexual toxicities)
Publication date: Available online 19 March 2020Source: Reports of Practical Oncology & RadiotherapyAuthor(s): Marigdalia K. Ramirez-Fort, Marc J. Rogers, Roberto Santiago, Sean S. Mahase, M. Junaid Niaz, Melissa Mendez, Yi Zheng, Xiang Kong, Shearwood McClelland, James A. Kashanian, Xiaodong Wu, Neil H. Bander, Peter Schlegel, John P. Mulhall, Christopher S. Lange
Reports of Practical Oncology & Radiotherapy
Fri Mar 20, 2020 15:23
Association between Bacillus Calmette-Guerin (BCG) vaccination and lymphoma risk: A systematic review and meta-analysis
Publication date: April 2020Source: Cancer Epidemiology, Volume 65Author(s): Charlotte Salmon, Florence Conus, Marie-Élise Parent, Andrea Benedetti, Marie-Claude Rousseau
ScienceDirect Publication: Cancer Epidemiology (open access)
Sat Mar 21, 2020 18:05

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