Related ArticlesDefining Expertise in Cancer Nursing Practice. Cancer Nurs. 2020 Mar 17;: Authors: Krishnasamy M, Webb UMM, Babos SLC, Duong JTT, Rohde JEN, Ting NYH, Milne D, Koproski T, Mathieson J Abstract BACKGROUND: Thirty-five years ago, Benner defined an expert nurse as one who applies deep knowledge and experience across different contexts and clinical situations. Since that time, there has been little exploration of expertise in cancer nursing....
Sat Mar 21, 2020 12:48
Related ArticlesImmune escape mechanisms in head and neck squamous cell carcinoma and implication for new immunotherapy approach. Curr Opin Oncol. 2020 Mar 19;: Authors: Merlano MC, Denaro N, Garrone O Abstract PURPOSE OF REVIEW: The aim of this review is to describe the major steps leading to the immunosuppressive tumor microenvironment and to summarize some of the new immunotherapies that interfere with these mechanisms. RECENT FINDINGS: Immunotherapy...
Sat Mar 21, 2020 12:48
Related ArticlesExtracellular vesicle tetraspanin-8 level predicts distant metastasis in non-small cell lung cancer after concurrent chemoradiation. Sci Adv. 2020 Mar;6(11):eaaz6162 Authors: Liu Y, Fan J, Xu T, Ahmadinejad N, Hess K, Lin SH, Zhang J, Liu X, Liu L, Ning B, Liao Z, Hu TY Abstract Non-small cell lung cancer (NSCLC) is the most commonly diagnosed cancer and the leading cause of cancer death worldwide. More than half of patients with NSCLC...
Sat Mar 21, 2020 12:48
Related ArticlesClinical development of immunotherapies for HER2+ breast cancer: a review of HER2-directed monoclonal antibodies and beyond. NPJ Breast Cancer. 2020;6:10 Authors: Costa RLB, Czerniecki BJ Abstract Human epidermal growth factor receptor 2-positive (HER2+) breast cancer accounts for ~25% of breast cancer cases. Monoclonal antibodies (mAbs) against HER2 have led to unparalleled clinical benefit for a subset of patients with HER2+ breast...
Sat Mar 21, 2020 12:48
Related ArticlesMetronomic paclitaxel improves the efficacy of PD-1 monoclonal antibodies in breast cancer by transforming the tumor immune microenvironment. Am J Transl Res. 2020;12(2):519-530 Authors: Chen Q, Xia R, Zheng W, Zhang L, Li P, Sun X, Shi J Abstract The clinical efficacy of PD-1/PD-L1 monoclonal antibodies (mAbs) in triple-negative breast cancer (TNBC) is unsatisfactory. Immunotherapy combined with chemotherapy shows good therapeutic potential....
Sat Mar 21, 2020 12:48
Related ArticlesDistinct expression and prognostic values of the replication protein A family in gastric cancer. Oncol Lett. 2020 Mar;19(3):1831-1841 Authors: Zhang Y, Yu C Abstract The replication protein A (RPA)1-4 family are single-stranded DNA-binding proteins that are essential components of DNA replication, repair and recombination, and cell cycle regulation. The present study aimed to evaluate the prognostic value of the RPA family members in...
Sat Mar 21, 2020 12:48
Related ArticlesMapping of Current Obstacles for Rationalizing Use of Medicines (CORUM) in Europe: Current Situation and Potential Solutions. Front Pharmacol. 2020;11:144 Authors: Gad M, Salem A, Oortwijn W, Hill R, Godman B Abstract Introduction: There are increasing concerns regarding the inappropriate use of medicines with expenditure continuing to grow driven by increasing sales in oncology and orphan diseases, enhanced by their emotive nature. As...
Sat Mar 21, 2020 12:48
Lipoadenoma of the Parathyroid Gland: Characterization of an Institutional Series Spanning 28 Years.
Related ArticlesLipoadenoma of the Parathyroid Gland: Characterization of an Institutional Series Spanning 28 Years. Endocr Pathol. 2020 Mar 19;: Authors: Juhlin CC, Falhammar H, Zedenius J, Nilsson IL, Höög A Abstract Parathyroid lipoadenomas (PLAs) are rare tumors, and case descriptions are limited, < 80 to date. As a consequence, scarce information regarding the etiology of these enigmatic lesions is available. We searched our departmental pathology...
Sat Mar 21, 2020 12:48
Related ArticlesSelective targeting of BD1 and BD2 of the BET proteins in cancer and immuno-inflammation. Science. 2020 Mar 19;: Authors: Gilan O, Rioja I, Knezevic K, Bell MJ, Yeung MM, Harker NR, Lam EYN, Chung CW, Bamborough P, Petretich M, Urh M, Atkinson SJ, Bassil AK, Roberts EJ, Vassiliadis D, Burr ML, Preston AGS, Wellaway C, Werner T, Gray JR, Michon AM, Gobbetti T, Kumar V, Soden PE, Haynes A, Vappiani J, Tough DF, Taylor S, Dawson SJ, Bantscheff M, Lindon M,...
Sat Mar 21, 2020 12:48
Related ArticlesEfficient identification of multiple pathways: RNA-Seq analysis of livers from 56Fe ion irradiated mice. BMC Bioinformatics. 2020 Mar 20;21(1):118 Authors: Nia AM, Chen T, Barnette BL, Khanipov K, Ullrich RL, Bhavnani SK, Emmett MR Abstract BACKGROUND: mRNA interaction with other mRNAs and other signaling molecules determine different biological pathways and functions. Gene co-expression network analysis methods have been widely used...
Sat Mar 21, 2020 12:48
Related ArticlesAdvances in Antibody-Drug Conjugate Design: Current Clinical Landscape and Future Innovations. SLAS Discov. 2020 Mar 20;:2472555220912955 Authors: Gauzy-Lazo L, Sassoon I, Brun MP Abstract The targeted delivery of potent cytotoxic molecules into cancer cells is considered a promising anticancer strategy. The design of clinically effective antibody-drug conjugates (ADCs), in which biologically active drugs are coupled through chemical...
Sat Mar 21, 2020 12:48
Related ArticlesBiomarkers of neoadjuvant/adjuvant chemotherapy for breast cancer. Chin Clin Oncol. 2020 Mar 13;: Authors: Iwamoto T, Kajiwara Y, Zhu Y, Iha S Abstract The improvement of tumor biomarkers prepared for clinical use is a long process. A good biomarker should predict not only prognosis but also the response to therapies. In this review, we describe the biomarkers of neoadjuvant/adjuvant chemotherapy for breast cancer, considering different...
Sat Mar 21, 2020 12:48
Related ArticlesAldehyde biphenyl chalcones induce immunogenic apoptotic-like cell death and are promising new safe compounds against a wide range of hematologic cancers. Future Med Chem. 2020 Mar 19;: Authors: Maioral MF, Stefanes NM, Neuenfeldt PD, Chiaradia-Delatorre LD, Nunes RJ, Santos-Silva MC Abstract Aim: Investigate the apoptotic mechanisms of two new aldehyde biphenyl chalcones on leukemia cells. Materials & methods: From a series of 71...
Fri Mar 20, 2020 14:03
Related ArticlesA new selective pharmacological enhancer of the Orai1 Ca2+ channel reveals roles for Orai1 in smooth and skeletal muscle functions. ACS Pharmacol Transl Sci. 2020 Feb 14;3(1):135-147 Authors: Azimi I, Stevenson RJ, Zhang X, Meizoso-Huesca A, Xin P, Johnson M, Flanagan JU, Chalmers SB, Yoast RE, Kapure JS, Ross BP, Vetter I, Ashton MR, Launikonis BS, Denny WA, Trebak M, Monteith GR Abstract Store operated calcium (Ca2+) entry is an important...
Fri Mar 20, 2020 14:03
Related ArticlesBack to the Future-Moving Forward for Testicular Cancer Survivors. JNCI Cancer Spectr. 2020 Apr;4(2):pkz082 Authors: Nichols CR, Nappi L, Kollmannsberger C, Hamilton R, Daneshmand S PMID: 32190816 [PubMed]
Fri Mar 20, 2020 14:03
Related ArticlesEsophageal, gastric cancer and immunotherapy: small steps in the right direction? Transl Gastroenterol Hepatol. 2020;5:9 Authors: Zayac A, Almhanna K Abstract The treatment of advanced, solid-tumor oncology has been reshaped over the last eight years with the development and FDA approval of several immune checkpoint inhibitors (ICIs) comprised of monoclonal antibodies targeting either PD-1, PD-L1, or CTLA-4 across numerous disease states...
Fri Mar 20, 2020 14:03
Related ArticlesHepatobiliary cancers and immunotherapy: where are we now and where are we heading? Transl Gastroenterol Hepatol. 2020;5:8 Authors: Zayac A, Almhanna K Abstract Primary liver cancers are a heterogenous collection of diseases with variable natural histories and treatments. This review article will focus on hepatocellular carcinoma (HCC), intrahepatic and extrahepatic cholangiocarcinoma, and gallbladder cancer, and the use of immune checkpoint...
Fri Mar 20, 2020 14:03
Related ArticlesNab-paclitaxel and atezolizumab for the treatment of PD-L1-positive, metastatic triple-negative breast cancer: review and future directions. Expert Rev Precis Med Drug Dev. 2020;5(2):59-65 Authors: Kagihara JA, Andress M, Diamond JR Abstract Introduction: Breast cancer is the most common malignancy in women in the United States and triple-negative breast cancer (TNBC) accounts for 15-20%. The standard of care for metastatic TNBC has been...
Fri Mar 20, 2020 14:03
Related ArticlesPersonalized selective internal radiation therapy in liver metastasis of thyroid cancer with impaired liver function: A case report. Radiol Case Rep. 2020 May;15(5):548-551 Authors: Herchuelz M, Marin G, Derijckere ID, Vouche M, Delatte P, Donckier V, Liberale G, Hendlisz A, Artigas C, Bourgeois P, Flamen P Abstract Follicular thyroid cancer (FTC) is a less common form of differentiated thyroid cancer. Liver metastasis of differentiated...
Fri Mar 20, 2020 14:03
Related ArticlesOptimal Timing of Radiotherapy Following Gross Total or Subtotal Resection of Glioblastoma: A Real-World Assessment using the National Cancer Database. Sci Rep. 2020 Mar 18;10(1):4926 Authors: Buszek SM, Al Feghali KA, Elhalawani H, Chevli N, Allen PK, Chung C Abstract Treatment for glioblastoma (GBM) includes surgical resection and adjuvant radiotherapy (RT) and chemotherapy. The optimal time interval between surgery and RT remains unclear....
Fri Mar 20, 2020 12:08
Related ArticlesHelical tomotherapy: Comparison of Hi-ART and Radixact clinical patient treatments at the Technical University of Munich. Sci Rep. 2020 Mar 18;10(1):4928 Authors: Kraus KM, Kampfer S, Wilkens JJ, Schüttrumpf L, Combs SE Abstract The helical tomotherapy (HT) Hi-ART system was installed at our department in April 2007. In July 2018 the first Radixact system in Germany has been launched for clinical use. We present differences, advantages...
Fri Mar 20, 2020 12:08
Related ArticlesHigh hepatocyte growth factor expression in primary tumor predicts better overall survival in male breast cancer. Breast Cancer Res. 2020 Mar 18;22(1):30 Authors: Qiu SQ, van Rooijen J, Nienhuis HH, van der Vegt B, Timmer-Bosscha H, van Leeuwen-Stok E, Walenkamp AME, van Deurzen CHM, de Bock GH, de Vries EGE, Schröder CP Abstract BACKGROUND: Breast cancer is rare in men, but management is focused on tumor characteristics commonly found...
Fri Mar 20, 2020 12:08
Related ArticlesLandscape of Tumor Suppressor Mutations in Acute Myeloid Leukemia. J Clin Med. 2020 Mar 16;9(3): Authors: Panuzzo C, Signorino E, Calabrese C, Ali MS, Petiti J, Bracco E, Cilloni D Abstract Acute myeloid leukemia is mainly characterized by a complex and dynamic genomic instability. Next-generation sequencing has significantly improved the ability of diagnostic research to molecularly characterize and stratify patients. This detailed outcome...
Fri Mar 20, 2020 12:08
Related ArticlesThe current state of molecular testing in the treatment of patients with solid tumors, 2019. CA Cancer J Clin. 2019 07;69(4):305-343 Authors: El-Deiry WS, Goldberg RM, Lenz HJ, Shields AF, Gibney GT, Tan AR, Brown J, Eisenberg B, Heath EI, Phuphanich S, Kim E, Brenner AJ, Marshall JL Abstract The world of molecular profiling has undergone revolutionary changes over the last few years as knowledge, technology, and even standard clinical...
Fri Mar 20, 2020 12:08
Related ArticlesMachine Learning in Nuclear Medicine: Part 1-Introduction. J Nucl Med. 2019 04;60(4):451-458 Authors: Uribe CF, Mathotaarachchi S, Gaudet V, Smith KC, Rosa-Neto P, Bénard F, Black SE, Zukotynski K Abstract This article, the first in a 2-part series, provides an introduction to machine learning (ML) in a nuclear medicine context. This part addresses the history of ML and describes common algorithms, with illustrations of when they can...
Fri Mar 20, 2020 12:08
Related ArticlesManeuvering the Management of a Rare Case of Primary Undifferentiated Cardiac Sarcoma. Am J Case Rep. 2020 Mar 21;21:e918878 Authors: Abbas HA, Amini B, Wang WL, Ravi V Abstract BACKGROUND Primary cardiac tumors are rare and mostly benign. Cardiac sarcomas are the most common malignant neoplasms of the heart and harbor a dismal prognosis of 6 to 12 months. The diagnosis of cardiac sarcomas may be challenging. Treatment entails surgical...
Sun Mar 22, 2020 14:27
Related ArticlesSpontaneous Pneumothorax After Rupture of the Cavity as the Initial Presentation of Tuberculosis in the Emergency Department. Am J Case Rep. 2020 Mar 20;21:e920393 Authors: Briones-Claudett KH, Briones-Claudett MH, Posligua Moreno A, Estupiñan Vargas D, Martinez Alvarez ME, Grunauer Andrade M Abstract BACKGROUND Spontaneous pneumothorax can be secondary to a wide variety of lung diseases. Spontaneous pneumothorax secondary to pulmonary...
Sat Mar 21, 2020 13:47
Related ArticlesEmergent Phenol Injection of Bilateral Stellate Ganglion for Management of Refractory Malignant Ventricular Arrhythmias. Am J Case Rep. 2020 Mar 19;21:e921465 Authors: Luke WR, Daoud EG, Latif OS Abstract BACKGROUND Management of incessant electrical storm is poorly defined. These 2 case studies demonstrate a simplified percutaneous approach to achieve stellate ganglion ablation (SGA) and to promptly control malignant ventricular arrhythmias....
Fri Mar 20, 2020 12:45
Related ArticlesComprehensive Phenotyping of Human PB NK Cells by Flow Cytometry. Cytometry A. 2020 Mar 21;: Authors: Del Zotto G, Antonini F, Pesce S, Moretta F, Moretta L, Marcenaro E Abstract The NK cell compartment provides powerful innate defenses against virus-infected and tumor cells. Specific NK cell receptors control this process and maintain the immune system homeostasis and prevent autoimmunity. A wide variety of NK cell subsets with different...
Sun Mar 22, 2020 14:25
Related ArticlesStructural analysis of TIFA: Insight into TIFA-dependent signal transduction in innate immunity. Sci Rep. 2020 Mar 20;10(1):5152 Authors: Nakamura T, Hashikawa C, Okabe K, Yokote Y, Chirifu M, Toma-Fukai S, Nakamura N, Matsuo M, Kamikariya M, Okamoto Y, Gohda J, Akiyama T, Semba K, Ikemizu S, Otsuka M, Inoue JI, Yamagata Y Abstract TRAF-interacting protein with a forkhead-associated (FHA) domain (TIFA), originally identified as an adaptor...
Sun Mar 22, 2020 14:25
Related ArticlesGlobal proteomic analysis deciphers the mechanism of action of plant derived oleic acid against Candida albicans virulence and biofilm formation. Sci Rep. 2020 Mar 20;10(1):5113 Authors: Muthamil S, Prasath KG, Priya A, Precilla P, Pandian SK Abstract Candida albicans is a commensal fungus in humans, mostly found on the mucosal surfaces of the mouth, gut, vagina and skin. Incidence of ever increasing invasive candidiasis in immunocompromised...
Sun Mar 22, 2020 14:25
Related ArticlesProinflammatory S100A8 Induces PD-L1 Expression in Macrophages, Mediating Tumor Immune Escape. J Immunol. 2020 Mar 20;: Authors: Li Z, Wang J, Zhang X, Liu P, Zhang X, Wang J, Zheng X, Wei L, Peng Q, Liu C, Yan Q, Shen S, Li X, Ma J Abstract S100A8 is a damage-associated molecular pattern protein released by monocytes, playing a decisive role in the development of inflammation. Nonresolving inflammation is viewed as a driving force in...
Sun Mar 22, 2020 14:25
Related ArticlesThe uricosuric benzbromarone disturbs the mitochondrial redox homeostasis and activates the NRF2 signaling pathway in HepG2 cells. Free Radic Biol Med. 2020 Mar 17;: Authors: Roos NJ, Duthaler U, Bouitbir J, Krähenbühl S Abstract The uricosuric benzbromarone is a mitochondrial toxicant associated with severe liver injury in patients treated with this drug. Since dysfunctional mitochondria can increase mitochondrial superoxide (O2•-) production,...
Sun Mar 22, 2020 14:25
Related ArticlesECM Characterization Reveals a Massive Activation of Acute Phase Response during FSGS. Int J Mol Sci. 2020 Mar 18;21(6): Authors: Bukosza EN, Kornauth C, Hummel K, Schachner H, Huttary N, Krieger S, Nöbauer K, Oszwald A, Razzazi Fazeli E, Kratochwill K, Aufricht C, Szénási G, Hamar P, Gebeshuber CA Abstract The glomerular basement membrane (GBM) and extra-cellular matrix (ECM) are essential to maintain a functional interaction between...
Sun Mar 22, 2020 12:26
Related ArticlesPERK-Mediated Unfolded Protein Response Signaling Restricts Replication of the Tick-Borne Flavivirus Langat Virus. Viruses. 2020 Mar 18;12(3): Authors: Lewy TG, Offerdahl DK, Grabowski JM, Kellman E, Mlera L, Chiramel A, Bloom ME Abstract The unfolded protein response (UPR) maintains protein-folding homeostasis in the endoplasmic reticulum (ER) and has been implicated as both beneficial and detrimental to flavivirus infection. Protein...
Sun Mar 22, 2020 12:26
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