Related ArticlesImpact of a short version of the CONSORT checklist for peer reviewers to improve the reporting of randomised controlled trials published in biomedical journals: study protocol for a randomised controlled trial. BMJ Open. 2020 Mar 19;10(3):e035114 Authors: Speich B, Schroter S, Briel M, Moher D, Puebla I, Clark A, Maia Schlüssel M, Ravaud P, Boutron I, Hopewell S Abstract INTRODUCTION: Transparent and accurate reporting is essential for...
Sun Mar 22, 2020 14:12
Related ArticlesMinocycline for the treatment of mental health and neurological conditions: study protocol of a systematic review and meta-analysis. BMJ Open. 2020 Mar 19;10(3):e035080 Authors: Bortolasci CC, Marx W, Walker AJ, Hasebe K, Kavanagh BE, Morris MJ, Mohebbi M, Turner A, Gray L, Berk L, Walder K, Berk M, Dean OM Abstract INTRODUCTION: Due to the anti-inflammatory, antioxidant and anti-apoptotic properties of minocycline, clinical trials have...
Sun Mar 22, 2020 14:12
Related ArticlesMindfulness-based programme for residents: study protocol of a randomised controlled trial. BMJ Open. 2020 Mar 19;10(3):e035025 Authors: Aeschbach VM, Fendel JC, Göritz AS, Schmidt S Abstract INTRODUCTION: Residency is a stressful phase associated with high prevalence of mental distress. Besides impaired personal health, mental distress in residents has an impact on the quality of patient care and produces economic costs. Therefore, there...
Sun Mar 22, 2020 14:12
Related ArticlesUsing trigger tools to identify triage errors by ambulance dispatch nurses in Sweden: an observational study. BMJ Open. 2020 Mar 19;10(3):e035004 Authors: Spangler D, Edmark L, Winblad U, Colldén-Benneck J, Borg H, Blomberg H Abstract OBJECTIVES: This study aimed to assess whether trigger tools were useful identifying triage errors among patients referred to non-emergency care by emergency medical dispatch nurses, and to describe the...
Sun Mar 22, 2020 14:12
Related ArticlesPhysical activity and risk of behavioural and mental health disorders in kindergarten children: analysis of a series of cross-sectional complete enumeration (census) surveys. BMJ Open. 2020 Mar 19;10(3):e034847 Authors: O'Brien K, Agostino J, Ciszek K, Douglas KA Abstract OBJECTIVES: There is mixed evidence on the relationship between physical activity and behavioural and mental health. We aimed to estimate the association between physical...
Sun Mar 22, 2020 14:12
Related ArticlesWhat are potential barriers and enablers to patient and physician participation in Canadian cell therapy trials for stroke? A stakeholder interview study. BMJ Open. 2020 Mar 19;10(3):e034354 Authors: Lalu MM, Foster M, Presseau J, Dowlatshahi D, Castillo G, Cardenas A, Tam W, Zlepnig J, Timpson D, Dong YY, Juneau P, Fergusson DA Abstract OBJECTIVES: Early phase cell therapy trials face many barriers to successful, timely completion. To...
Sun Mar 22, 2020 14:12
Related ArticlesShort-term associations between ambient air pollution and stroke hospitalisations: time-series study in Shenzhen, China. BMJ Open. 2020 Mar 19;10(3):e032974 Authors: Guo Y, Xie X, Lei L, Zhou H, Deng S, Xu Y, Liu Z, Bao J, Peng J, Huang C Abstract OBJECTIVE: To investigate the association between ambient air pollution and stroke morbidity in different subgroups and seasons. METHODS: We performed a time-series analysis based on...
Sun Mar 22, 2020 14:12
Related ArticlesCardiac arrest after pulmonary aspiration in hospitalised patients: a national observational study. BMJ Open. 2020 Mar 19;10(3):e032264 Authors: Albert M, Herlitz J, Rawshani A, Ringh M, Claesson A, Djärv T, Nordberg P Abstract OBJECTIVE: To study characteristics and outcomes among patients with in-hospital cardiac arrest (IHCA) due to pulmonary aspiration. DESIGN: A retrospective observational study based on data from the Swedish...
Sun Mar 22, 2020 14:12
Related ArticlesAssociation of magnesium intake with type 2 diabetes and total stroke: an updated systematic review and meta-analysis. BMJ Open. 2020 Mar 19;10(3):e032240 Authors: Zhao B, Zeng L, Zhao J, Wu Q, Dong Y, Zou F, Gan L, Wei Y, Zhang W Abstract OBJECTIVE: The detailed associations between type 2 diabetes (T2D) and total stroke and magnesium intake as well as the dose-response trend should be updated in a timely manner. DESIGN: Systematic...
Sun Mar 22, 2020 14:12
Related ArticlesAntiretroviral drug class and anaemia risk in the current treatment era among people living with HIV in the USA: a clinical cohort study. BMJ Open. 2020 Mar 19;10(3):e031487 Authors: Harding BN, Whitney BM, Nance RM, Crane HM, Burkholder G, Moore RD, Mathews WC, Eron JJ, Hunt PW, Volberding P, Rodriguez B, Mayer K, Saag MS, Kitahata MM, Heckbert SR, Delaney JAC Abstract OBJECTIVE: Anaemia is common among people living with HIV (PLWH)...
Sun Mar 22, 2020 14:12
Related ArticlesValidation of an algorithm to evaluate the appropriateness of outpatient antibiotic prescribing using big data of Chinese diagnosis text. BMJ Open. 2020 Mar 19;10(3):e031191 Authors: Zhao H, Bian J, Wei L, Li L, Ying Y, Zhang Z, Yao X, Zhuo L, Cao B, Zhang M, Zhan S Abstract OBJECTIVE: We aimed to evaluate the validity of an algorithm to classify diagnoses according to the appropriateness of outpatient antibiotic use in the context of...
Sun Mar 22, 2020 14:12
Related ArticlesPrevalence of and factors associated with violations of a campus smoke-free policy: a cross-sectional survey of undergraduate students on a university campus in the USA. BMJ Open. 2020 Mar 19;10(3):e030504 Authors: Ramachandran S, Bentley S, Casey E, Bentley JP Abstract OBJECTIVE: The aim of this study is to estimate the prevalence of smoking behaviour on campus and to identify the key factors that influence adherence to a campus smoke-free...
Sun Mar 22, 2020 14:12
24 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "BMJ Open"[jour] These pubmed results were generated on 2020/03/21PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Sat Mar 21, 2020 14:23
24 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "BMJ Open"[jour] These pubmed results were generated on 2020/03/21PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Sat Mar 21, 2020 12:24
Related ArticlesSynthesis, anticancer evaluation and molecular docking studies of new heterocycles linked to sulfonamide moiety as novel human topoisomerase types I and II poisons. Bioorg Chem. 2020 Mar 06;98:103725 Authors: Halawa AH, Elgammal WE, Hassan SM, Hassan AH, Nassar HS, Ebrahim HY, Mehany ABM, El-Agrody AM Abstract A series of heterocyclic compounds with a sulfonamide moiety were synthesized from reaction of enaminone 4 with active methylene...
Sun Mar 22, 2020 14:12
Related ArticlesCustomized hybrid and NIR-light triggered thermoresponsive drug delivery microparticles synthetized by photopolymerization in a one-step flow focusing continuous microreactor. Colloids Surf B Biointerfaces. 2020 Feb 25;190:110904 Authors: Ortiz de Solorzano I, Mendoza G, Arruebo M, Sebastian V Abstract Photopolymerization is a selective technique that takes advantage of light-sensitive molecules to initiate and propagate monomeric...
Sun Mar 22, 2020 14:12
Related ArticlesMultifaceted Function of MicroRNA-299-3p Fosters an Antitumor Environment Through Modulation of Androgen Receptor and VEGFA Signaling Pathways in Prostate Cancer. Sci Rep. 2020 Mar 20;10(1):5167 Authors: Ganapathy K, Staklinski S, Hasan MF, Ottman R, Andl T, Berglund AE, Park JY, Chakrabarti R Abstract Prostate cancer (PCa) is one of the most common cancers to affect men worldwide. Androgen receptor (AR) signaling is central to PCa...
Sun Mar 22, 2020 14:12
Related ArticlesAnticancer properties of the fatty acid synthase inhibitor TVB-3166 on oral squamous cell carcinoma cell lines. Arch Oral Biol. 2020 Mar 10;113:104707 Authors: Aquino IG, Bastos DC, Cuadra-Zelaya FJM, Teixeira IF, Salo T, Coletta RD, Graner E Abstract OBJECTIVE: Fatty acid synthase (FASN) is overexpressed in several human cancers, including oral squamous cell carcinoma (OSCC). TVB-3166 is a recently described FASN inhibitor with antitumor...
Sat Mar 21, 2020 12:21
Related ArticlesThe JAK1/2 inhibitor ruxolitinib delays premature aging phenotypes. Aging Cell. 2020 Mar 20;:e13122 Authors: Griveau A, Wiel C, Ziegler DV, Bergo MO, Bernard D Abstract Hutchinson-Gilford progeria syndrome (HGPS) is caused by an LMNA mutation that results in the production of the abnormal progerin protein. Children with HGPS display phenotypes of premature aging and have an average lifespan of 13 years. We found earlier that the targeting...
Sat Mar 21, 2020 12:21
Related ArticlesEpidermal Keratinocyte Depletion during Five Weeks of Radiotherapy is Associated with DNA Double-Strand Break Foci, Cell Growth Arrest and Apoptosis: Evidence of Increasing Radioresponsiveness and Lack of Repopulation; the Number of Melanocytes Remains Unchanged. Radiat Res. 2020 Mar 20;: Authors: Turesson I, Simonsson M, Hermansson I, Book M, Sigurdadottir S, Thunberg U, Qvarnström F, Johansson KA, Fessé P, Nyman J Abstract During...
Sat Mar 21, 2020 12:21
Related ArticlesCell-Cycle Arrest Biomarkers: Usefulness for Cardiac Surgery-Related Acute Kidney Injury in Neonates and Infants. Pediatr Crit Care Med. 2020 Mar 13;: Authors: Bojan M, Pieroni L, Semeraro M, Froissart M Abstract OBJECTIVES: Cell cycle arrest urine biomarkers have recently been shown to be early indicators of acute kidney injury in various clinical settings in critically ill adults and children. The product of tissue inhibitor metalloproteinase...
Sat Mar 21, 2020 12:21
Related ArticlesThe oncogenic role of REG γ is exerted by activating the Wnt/β-catenin signaling pathway in osteosarcoma. Am J Transl Res. 2020;12(2):563-573 Authors: Yin Z, Peng Z, Wang Z, Meng Q Abstract BACKGROUND: Proteasome activator γ (REG γ) expression was found to be upregulated and to play critical roles in several cancers. However, the effect of REG γ on osteosarcoma (OS) remains unclear. The objective of the present study was to explore...
Sat Mar 21, 2020 12:21
Related ArticlesHistone deacetylase inhibitor MGCD0103 causes cell cycle arrest, apoptosis, and autophagy in liver cancer cells. J Cancer. 2020;11(7):1915-1926 Authors: Liao B, Sun Q, Yuan Y, Yin Y, Qiao J, Jiang P Abstract Background: Liver cancer is a common cause of cancer-related death all over the world. MGCD0103, a histone deacetylase inhibitor, exerts antitumor effect on various cancers. However, its role in liver cancer remains unclear. Methods:...
Sat Mar 21, 2020 12:21
Related ArticlesRepositioning of Hypoglycemic Drug Linagliptin for Cancer Treatment. Front Pharmacol. 2020;11:187 Authors: Li Y, Li Y, Li D, Li K, Quan Z, Wang Z, Sun Z Abstract Background: Drug repositioning, development of new uses for marketed drugs, is an effective way to discover new antitumor compounds. In this study, we used a new method, filtering compounds via molecular docking to find key targets combination. Methods: The data...
Sat Mar 21, 2020 12:21
Related Articles4,4'-Diisothiocyanatostilbene-2,2'-disulfonate Modulates Voltage Gated K+ Current and Influences Cell Cycle Arrest in Androgen Sensitive and Insensitive Human Prostate Cancer Cell Lines. Toxicol Mech Methods. 2020 Mar 20;:1-28 Authors: George K, Thomas NS, Malathi R Abstract The stilbene derivative, 4,4'-diisothiocyanatostilbene-2,2'-disulphonic acid (DIDS), an anion channel blocker is used in the present study to evaluate its modulatory...
Sat Mar 21, 2020 12:21
Related ArticlesRelationship between the antiproliferative properties of Cu(II) complexes with the Schiff base derived from pyridine-2-carboxaldehyde and 5,6-diamino-1,3-dimethyluracil and the redox status mediated by antioxidant defense systems on glioma tumoral cells. J Inorg Biochem. 2020 Mar 06;207:111053 Authors: Illán-Cabeza NA, Jiménez-Pulido SB, Hueso-Ureña F, Ramírez-Expósito MJ, Martínez-Martos JM, Moreno-Carretero MN Abstract A set of...
Sat Mar 21, 2020 12:21
Related ArticlesIn Vitro Anti-Prostate Cancer Activity of Two Ebselen Analogues. Pharmaceuticals (Basel). 2020 Mar 17;13(3): Authors: Kaczor-Keller KB, Pawlik A, Scianowski J, Pacuła A, Obieziurska M, Marcheggiani F, Cirilli I, Tiano L, Antosiewicz J Abstract Scientific research has been underway for decades in order to develop an effective anticancer drug, and it has become crucial to find a novel and effective chemotherapeutics in the case of prostate...
Sat Mar 21, 2020 12:21
Related ArticlesKnockdown of Kinesin Family 15 Inhibits Osteosarcoma through Suppressing Cell Proliferation and Promoting Cell Apoptosis. Chemotherapy. 2019;64(4):187-196 Authors: Wu Z, Zhang H, Sun Z, Wang C, Chen Y, Luo P, Yan W Abstract Kinesin family (KIF) members have vital roles in mitosis, meiosis, and transport of macromolecules in eukaryotic cells. In this study, we aimed to investigate the role of KIF15 in osteosarcoma. Immunohistochemical...
Sat Mar 21, 2020 12:21
Related ArticlesInhibition of PI3K pathway using BKM120 intensified the chemo-sensitivity of breast cancer cells to arsenic trioxide (ATO). Int J Biochem Cell Biol. 2019 11;116:105615 Authors: Alipour F, Riyahi N, Safaroghli-Azar A, Sari S, Zandi Z, Bashash D Abstract Although conventional therapeutic approaches have brought remarkable advantages for the treatment of breast cancer (BC), drug-resistance still remains as a leading cause of tumor recurrence...
Sat Mar 21, 2020 12:21
Related ArticlesSynergistic Cytotoxic Effect of Busulfan and the PARP Inhibitor Veliparib in Myeloproliferative Neoplasms. Biol Blood Marrow Transplant. 2019 05;25(5):855-860 Authors: Patel PR, Senyuk V, Rodriguez NS, Oh AL, Bonetti E, Mahmud D, Barosi G, Mahmud N, Rondelli D Abstract Patients with high-risk myeloproliferative neoplasms (MPNs), and in particular myelofibrosis (MF), can be cured only with allogeneic hematopoietic stem cell transplantation...
Sat Mar 21, 2020 12:21
Related ArticlesIsoliquiritigenin Suppressed Esophageal Squamous Carcinoma Growth by Blocking EGFR Activation and Inducing Cell Cycle Arrest. Biomed Res Int. 2020;2020:9259852 Authors: Ye L, Zhang J, Zhang Y, Gu B, Zhu H, Mao X Abstract Isoliquiritigenin (ILQ) is a natural product isolated from licorice root which has served as traditional Chinese medicine for a long time. Recently, the antitumor effects of ILQ have been widely studied in various...
Fri Mar 20, 2020 13:27
Related ArticlesExtracellular vesicles from senescent hepatic stellate cells promote cell viability of hepatoma cells through increasing EGF secretion from differentiated THP-1 cells. Biomed Rep. 2020 Apr;12(4):163-170 Authors: Miyazoe Y, Miuma S, Miyaaki H, Kanda Y, Nakashiki S, Sasaki R, Haraguchi M, Shibata H, Honda T, Taura N, Nakao K Abstract Since the discovery of the senescence-associated secretory phenotype, the role of senescent hepatic...
Fri Mar 20, 2020 13:27
Related ArticlesInhibition of Uncoupling Protein 2 Enhances the Radiosensitivity of Cervical Cancer Cells by Promoting the Production of Reactive Oxygen Species. Oxid Med Cell Longev. 2020;2020:5135893 Authors: Liu CH, Huang ZH, Dong XY, Zhang XQ, Li YH, Zhao G, Sun BS, Shen YN Abstract Objective: The mechanism of enhanced radiosensitivity induced by mitochondrial uncoupling protein UCP2 was investigated in HeLa cells to provide a theoretical basis...
Fri Mar 20, 2020 13:27
Related ArticlesEriodictyol exerts potent anticancer activity against A549 human lung cancer cell line by inducing mitochondrial-mediated apoptosis, G2/M cell cycle arrest and inhibition of m-TOR/PI3K/Akt signalling pathway. Arch Med Sci. 2020;16(2):446-452 Authors: Zhang Y, Zhang R, Ni H Abstract Introduction: Eriodictyol is an important flavonoid and is commonly present across the plant kingdom. Flavonoids have been reported to show incredible...
Fri Mar 20, 2020 13:27
Related ArticlesNovel Chemo-Photothermal Therapy in Breast Cancer Using Methotrexate-Loaded Folic Acid Conjugated Au@SiO2 Nanoparticles. Nanoscale Res Lett. 2020 Mar 19;15(1):62 Authors: Agabeigi R, Rasta SH, Rahmati-Yamchi M, Salehi R, Alizadeh E Abstract Low level laser therapy (LLLT) is known as a safe type of phototherapy to target tumor tissue/cells. Besides, using targeted nanoparticles increases the successfulness of cancer therapy. This study...
Fri Mar 20, 2020 12:27
Related ArticlesA metabolic switch regulates the transition between growth and diapause in C. elegans. BMC Biol. 2020 Mar 18;18(1):31 Authors: Penkov S, Raghuraman BK, Erkut C, Oertel J, Galli R, Ackerman EJM, Vorkel D, Verbavatz JM, Koch E, Fahmy K, Shevchenko A, Kurzchalia TV Abstract BACKGROUND: Metabolic activity alternates between high and low states during different stages of an organism's life cycle. During the transition from growth to quiescence,...
Fri Mar 20, 2020 12:27
Related ArticlesActivation of Intrinsic Apoptosis and G1 Cell Cycle Arrest by a Triazole Precursor, N-(4-chlorophenyl)-2-(4-(3,4,5-trimethoxybenzyloxy)benzoyl)-hydrazinecarbothioamide in Breast Cancer Cell Line. Anticancer Agents Med Chem. 2020 Mar 17;: Authors: Bernardine S, Leong KH, Ariffin A, Kareem HS, Cheah KKH Abstract BACKGROUND: Oxadiazoles, triazoles, and their respective precursors have been shown to exhibit various pharmacological properties,...
Fri Mar 20, 2020 12:27
Related ArticlesIdentification of Deregulated Pathways, Key Regulators, and Novel miRNA-mRNA Interactions in HPV-Mediated Transformation. Cancers (Basel). 2020 Mar 16;12(3): Authors: Babion I, Miok V, Jaspers A, Huseinovic A, Steenbergen RDM, van Wieringen WN, Wilting SM Abstract Next to a persistent infection with high-risk human papillomavirus (HPV), molecular changes are required for the development of cervical cancer. To identify which molecular...
Fri Mar 20, 2020 12:27
Related ArticlesEvaluation of a metal artifact reduction algorithm and an optimization filter in the estimation of peri-implant dehiscence defects by using cone beam computed tomography: an in-vitro study. Oral Surg Oral Med Oral Pathol Oral Radiol. 2020 Mar 17;: Authors: Bayrak S, Orhan K, Kursun Çakmak ES, Görürgöz C, Odabaşı O, Yilmaz D, Atakan C Abstract OBJECTIVES: The aim of this study was to assess the effect of a metal artifact reduction...
Sun Mar 22, 2020 14:12
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