During the period from 1922 to 1942, several carcinogens were identified in coal tar, industrial oils, and petroleum, and radium was added to x‐ray as a potential carcinogen. It was proven that some viruses are capable of causing cancer, and the dependency of prostatic and mammary hyperplasia and carcinoma on naturally occurring hormones was established. Colon cancer was linked to hereditary and nonhereditary polyposis. A permanent place for diagnostic radiology was defined and radiation therapy...
Sat Mar 21, 2020 09:47
Background Although medical financial hardship (MFH) resulting from sequelae of cancer and treatment has been reported in other racial/ethnic populations, little is known about MFH among Native Hawaiian and Pacific Islander (NHPI) cancer survivors. Methods One hundred fifty adult NHPI cancer survivors were identified from the 2014 NHPI National Health Interview Survey (NHIS). Cancer survivors were those with a history of cancer (excluding nonmelanoma/unknown type of skin cancer). MFH...
Sat Mar 21, 2020 09:47
Fri Mar 20, 2020 06:53
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Fri Mar 20, 2020 09:00
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Fri Mar 20, 2020 09:00
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Fri Mar 20, 2020 09:00
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Fri Mar 20, 2020 09:00
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Fri Mar 20, 2020 09:00
Background Uveal melanoma is highly aggressive, and overall prognosis depends on mutation status. Fine‐needle aspiration biopsies (FNABs) play an important role in obtaining fresh tissue for cytologic diagnosis and molecular studies. It has been suggested that, although FNAB usually provides high diagnostic accuracy, there may be limited cellularity, which may compromise diagnostic potential for molecular studies. FNABs of uveal melanocytic lesions were evaluated to assess sample adequacy for both...
Sat Mar 21, 2020 13:55
Sat Mar 21, 2020 13:55
Abstract Immune checkpoint blocking antibodies are currently being tested in ovarian cancer (OC) patients and have shown some responses in early clinical trials. However, it remains unclear how human OC cancer cells regulate lymphocyte activation in response to therapy. In this study, we have established and optimised an in vitro tumour-immune co-culture system (TICS), which is specifically designed to quantify the activation of multiple primary human lymphocyte subsets and human...
Sat Mar 21, 2020 02:00
Abstract With dichotomous etiology and pathogenesis, intestinal type and diffuse type gastric cancers vary in their clinical and molecular features to the point of representing distinct entities. However, the differences of tumor-infiltrating immune cells within the two types of gastric cancer have not been well researched. This study was aimed to evaluate the functional impact of Lauren classification on immune contexture in gastric cancer patients. Tumor tissues of gastric cancer...
Sat Mar 21, 2020 02:00
Abstract In view of the relatively limited efficacy of immunotherapies targeting the PD-1–PD-L1 axis in triple-negative breast cancer (TNBC) and of published reports on tumor-promoting roles of TNFR2+ tumor-infiltrating lymphocytes (TNFR2+ TILs), we determined the incidence of TNFR2+ TILs in TNBC patient tumors, their association with disease outcome and relations with PD-1+ TILs. Using a cohort of treatment-naïve TNBC patients with long follow-up (n = 70), we determined the presence...
Fri Mar 20, 2020 02:00
Abstract Chronic infection with Helicobacter pylori cagA‐positive strains is causally associated with the development of gastric diseases, most notably gastric cancer. The cagA‐encoded CagA protein, which is injected into gastric epithelial cells via bacterial type IV secretion, undergoes tyrosine phosphorylation at the EPIYA segments (EPIYA‐A, EPIYA‐B, EPIYA‐C, and EPIYA‐D), which are present in various numbers and combinations in its C‐terminal polymorphic region, thereby enabling CagA to promiscuously...
Sat Mar 21, 2020 09:48
Publication date: Available online 19 March 2020Source: Cancer/RadiothérapieAuthor(s): M. Chasseray, G. Dissaux, F. Lucia, N. Boussion, G. Goasduff, O. Pradier, V. Bourbonne, U. Schick
Fri Mar 20, 2020 13:27
Cancers, Vol. 12, Pages 753: Molecular Profiling for Predictors of Radiosensitivity in Patients with Breast or Head-and-Neck Cancer Cancers doi: 10.3390/cancers12030753 Authors: Kimi Drobin Michal Marczyk Martin Halle Daniel Danielsson Anna Papiez Traimate Sangsuwan Annika Bendes Mun-Gwan Hong Ulrika Qundos Mats Harms-Ringdahl Peter Wersäll Joanna Polanska Jochen M. Schwenk Siamak Haghdoost Nearly half of all cancers are treated...
Sun Mar 22, 2020 02:00
Cancers, Vol. 12, Pages 752: Upregulation of Protein Synthesis and Proteasome Degradation Confers Sensitivity to Proteasome Inhibitor Bortezomib in Myc-Atypical Teratoid/Rhabdoid Tumors Cancers doi: 10.3390/cancers12030752 Authors: Huy Minh Tran Kuo-Sheng Wu Shian-Ying Sung Chun Austin Changou Tsung-Han Hsieh Yun-Ru Liu Yen-Lin Liu Min-Lan Tsai Hsin-Lun Lee Kevin Li-Chun Hsieh Wen-Chang Huang Muh-Lii Liang Hsin-Hung Chen Yi-Yen Lee Shih-Chieh...
Sun Mar 22, 2020 02:00
Cancers, Vol. 12, Pages 751: Immunotherapy in Glioblastoma: Current Shortcomings and Future Perspectives Cancers doi: 10.3390/cancers12030751 Authors: Bas Weenink Pim J. French Peter A.E. Sillevis Smitt Reno Debets Marjolein Geurts Glioblastomas are aggressive, fast-growing primary brain tumors. After standard-of-care treatment with radiation in combination with temozolomide, the overall prognosis of newly diagnosed patients remains poor, with a 2-year survival rate...
Sun Mar 22, 2020 02:00
Cancers, Vol. 12, Pages 750: Calcium Release-Activated Calcium (CRAC) Channel Inhibition Suppresses Pancreatic Ductal Adenocarcinoma Cell Proliferation and Patient-Derived Tumor Growth Cancers doi: 10.3390/cancers12030750 Authors: Husain Yar Khan Gabriel B. Mpilla Rachel Sexton Srikant Viswanadha Kumar V. Penmetsa Amro Aboukameel Maria Diab Mandana Kamgar Mohammed Najeeb Al-Hallak Mark Szlaczky Anteneh Tesfaye Steve Kim Philip A. Philip Ramzi...
Sun Mar 22, 2020 02:00
Cancers, Vol. 12, Pages 749: Non-Coding microRNAs as Novel Potential Tumor Markers in Testicular Cancer Cancers doi: 10.3390/cancers12030749 Authors: Manuel Regouc Gazanfer Belge Anja Lorch Klaus-Peter Dieckmann Martin Pichler Testicular cancer is an important disease with increasing incidence and a high burden of morbidity and mortality in young men worldwide. Histological examination of the testicular tissue after orchiectomy plays an important role alongside patient...
Sun Mar 22, 2020 02:00
Cancers, Vol. 12, Pages 748: KLF5 Is Crucial for Androgen-AR Signaling to Transactivate Genes and Promote Cell Proliferation in Prostate Cancer Cells Cancers doi: 10.3390/cancers12030748 Authors: Juan Li Baotong Zhang Mingcheng Liu Xing Fu Xinpei Ci Jun A Changying Fu Ge Dong Rui Wu Zhiqian Zhang Liya Fu Jin-Tang Dong Androgen/androgen receptor (AR) signaling drives both the normal prostate development and prostatic carcinogenesis, and...
Sat Mar 21, 2020 02:00
Cancers, Vol. 12, Pages 747: Association between Angiotensin-Converting Enzyme Inhibitors and Lung Cancer—A Nationwide, Population-Based, Propensity Score-Matched Cohort Study Cancers doi: 10.3390/cancers12030747 Authors: Shih-Yi Lin Cheng-Li Lin Cheng-Chieh Lin Wu-Huei Hsu Chia-Der Lin I.-Kuan Wang Chung-Y. Hsu Chia-Hung Kao Background: Direct evidence of lung cancer risk in Asian users of angiotensin-converting enzyme inhibitors (ACEIs) is lacking....
Sat Mar 21, 2020 02:00
Cancers, Vol. 12, Pages 746: Immune-Complexome Analysis Identifies Immunoglobulin-Bound Biomarkers That Predict the Response to Chemotherapy of Pancreatic Cancer Patients Cancers doi: 10.3390/cancers12030746 Authors: Giorgia Mandili Laura Follia Giulio Ferrero Hiroyuki Katayama Wang Hong Amin A. Momin Michela Capello Daniele Giordano Rosella Spadi Maria Antonietta Satolli Andrea Evangelista Samir M. Hanash Francesca Cordero Francesco Novelli...
Sat Mar 21, 2020 02:00
Cancers, Vol. 12, Pages 745: A Disintegrin and Metalloproteinase 9 (ADAM9) in Advanced Hepatocellular Carcinoma and Their Role as a Biomarker During Hepatocellular Carcinoma Immunotherapy Cancers doi: 10.3390/cancers12030745 Authors: Sooyeon Oh YoungJoon Park Hyun-Jung Lee Jooho Lee Soo-Hyeon Lee Young-Seok Baek Su-Kyung Chun Seung-Min Lee Mina Kim Young-Eun Chon Yeonjung Ha Yuri Cho Gi Jin Kim Seong-Gyu Hwang KyuBum Kwack The...
Sat Mar 21, 2020 02:00
Cancers, Vol. 12, Pages 744: Antibody-Drug Conjugate Using Ionized Cys-Linker-MMAE as the Potent Payload Shows Optimal Therapeutic Safety Cancers doi: 10.3390/cancers12030744 Authors: Yanming Wang Lianqi Liu Shiyong Fan Dian Xiao Fei Xie Wei Li Wu Zhong Xinbo Zhou Monomethyl auristatin E (MMAE) is the most popular and widely used cytotoxin in the development of antibody-drug conjugates (ADCs). However, current MMAE-based ADCs are all constructed using...
Sat Mar 21, 2020 02:00
Cancers, Vol. 12, Pages 743: Gauging the Impact of Cancer Treatment Modalities on Circulating Tumor Cells (CTCs) Cancers doi: 10.3390/cancers12030743 Authors: Trevor J. Mathias Katarina T. Chang Stuart S. Martin Michele I. Vitolo The metastatic cascade consists of multiple complex steps, but the belief that it is a linear process is diminishing. In order to metastasize, cells must enter the blood vessels or body cavities (depending on the cancer type) via active or passive...
Sat Mar 21, 2020 02:00
Cancers, Vol. 12, Pages 742: The Role of PTEN Loss in Immune Escape, Melanoma Prognosis and Therapy Response Cancers doi: 10.3390/cancers12030742 Authors: Rita Cabrita Shamik Mitra Adriana Sanna Henrik Ekedahl Kristina Lövgren Håkan Olsson Christian Ingvar Karolin Isaksson Martin Lauss Ana Carneiro Göran Jönsson Checkpoint blockade therapies have changed the clinical management of metastatic melanoma patients considerably, showing survival...
Sat Mar 21, 2020 02:00
Cancers, Vol. 12, Pages 741: Molecular Engineering Strategies Tailoring the Apoptotic Response to a MET Therapeutic Antibody Cancers doi: 10.3390/cancers12030741 Authors: Chiara Modica Simona Gallo Cristina Chiriaco Martina Spilinga Paolo Maria Comoglio Tiziana Crepaldi Cristina Basilico Elisa Vigna The MET oncogene encodes a tyrosine kinase receptor involved in the control of a complex network of biological responses that include protection from apoptosis...
Sat Mar 21, 2020 02:00
Cancers, Vol. 12, Pages 740: Mitotane Concentrations Influence Outcome in Patients with Advanced Adrenocortical Carcinoma Cancers doi: 10.3390/cancers12030740 Authors: Puglisi Calabrese Basile Ceccato Scaroni Altieri Della Casa Loli Pivonello De Martino Canu Russo Badalamenti Torlontano Stigliano Ferraù Arnaldi Saba Quirino Perotti Berchialla Terzolo Mitotane is the main option...
Fri Mar 20, 2020 02:00
Cancers, Vol. 12, Pages 739: The Multifactorial Role of PARP-1 in Tumor Microenvironment Cancers doi: 10.3390/cancers12030739 Authors: Juan Manuel Martí Mónica Fernández-Cortés Santiago Serrano-Sáenz Esteban Zamudio-Martinez Daniel Delgado-Bellido Angel Garcia-Diaz Francisco Javier Oliver Poly(ADP-ribose) polymerases (PARPs), represent a family of 17 proteins implicated in a variety of cell functions; some of them possess the enzymatic ability to synthesize...
Fri Mar 20, 2020 02:00
Cancers, Vol. 12, Pages 738: Review of Indications of FDA-Approved Immune Checkpoint Inhibitors per NCCN Guidelines with the Level of Evidence Cancers doi: 10.3390/cancers12030738 Authors: Raju K. Vaddepally Prakash Kharel Ramesh Pandey Rohan Garje Abhinav B. Chandra Cancer is associated with higher morbidity and mortality and is the second leading cause of death in the US. Further, in some nations, cancer has overtaken heart disease as the leading cause of mortality....
Fri Mar 20, 2020 02:00
Cancers, Vol. 12, Pages 735: Treatment Strategies and Survival Outcomes in Breast Cancer Cancers doi: 10.3390/cancers12030735 Authors: Cheung Treatment strategies for breast cancer are wide-ranging and often based on a multi-modality approach, depending on the stage and biology of the tumour and the acceptance and tolerance of the patient [...]
Fri Mar 20, 2020 02:00
Cancers, Vol. 12, Pages 734: Extracellular Vesicle lincRNA-p21 Expression in Tumor-Draining Pulmonary Vein Defines Prognosis in NSCLC and Modulates Endothelial Cell Behavior Cancers doi: 10.3390/cancers12030734 Authors: Joan J. Castellano Ramon M. Marrades Laureano Molins Nuria Viñolas Jorge Moises Jordi Canals Bing Han Yan Li Daniel Martinez Mariano Monzó Alfons Navarro Hypoxia-induced upregulation of lincRNA-p21 in tumor tissue was previously...
Fri Mar 20, 2020 02:00
Cancers, Vol. 12, Pages 736: The Emerging Roles of RNA Modifications in Glioblastoma Cancers doi: 10.3390/cancers12030736 Authors: Zhen Dong Hongjuan Cui Glioblastoma (GBM) is a grade IV glioma that is the most malignant brain tumor type. Currently, there are no effective and sufficient therapeutic strategies for its treatment because its pathological mechanism is not fully characterized. With the fast development of the Next Generation Sequencing (NGS) technology, more than...
Fri Mar 20, 2020 02:00
Cancers, Vol. 12, Pages 737: Recognition Dynamics of Cancer Mutations on the ERp57-Tapasin Interface
Cancers, Vol. 12, Pages 737: Recognition Dynamics of Cancer Mutations on the ERp57-Tapasin Interface Cancers doi: 10.3390/cancers12030737 Authors: Monikaben Padariya Umesh Kalathiya Douglas R. Houston Javier Antonio Alfaro Down regulation of the major histocompatibility class (MHC) I pathway plays an important role in tumour development, and can be achieved by suppression of HLA expression or mutations in the MHC peptide-binding pocket. The peptide-loading complex (PLC)...
Fri Mar 20, 2020 02:00
Cancers, Vol. 12, Pages 733: Primary Neuroendocrine Neoplasms of the Breast: Case Series and Literature Review Cancers doi: 10.3390/cancers12030733 Authors: Burcin Özdirik Antonin Kayser Andrea Ullrich Lynn J. Savic Markus Reiss Frank Tacke Bertram Wiedenmann Henning Jann Christoph Roderburg Primary neuroendocrine carcinoma of the breast (NECB) as defined by the World Health Organization (WHO) in 2012 is a rare, but possibly under-diagnosed entity....
Fri Mar 20, 2020 02:00
Cancers, Vol. 12, Pages 732: Comparison of Current Surgical and Non-Surgical Treatment Strategies for Early and Locally Advanced Stage Glottic Laryngeal Cancer and Their Outcome Cancers doi: 10.3390/cancers12030732 Authors: Olgun Elicin Roland Giger For the treatment of early and locally advanced glottic laryngeal cancer, multiple strategies are available. These are pursued and supported by different levels of evidence, but also by national and institutional traditions. The...
Fri Mar 20, 2020 02:00
Cancers, Vol. 12, Pages 731: Tyrosine Kinase Inhibitors in Cancer: Breakthrough and Challenges of Targeted Therapy Cancers doi: 10.3390/cancers12030731 Authors: Charles Pottier Margaux Fresnais Marie Gilon Guy Jérusalem Rémi Longuespée Nor Eddine Sounni Receptor tyrosine kinases (RTKs) are key regulatory signaling proteins governing cancer cell growth and metastasis. During the last two decades, several molecules targeting RTKs were used in oncology as a first...
Fri Mar 20, 2020 02:00
Cancers, Vol. 12, Pages 730: Gastrointestinal Stromal Tumours (GIST) in Young Adult (18–40 Years) Patients: A Report from the Dutch GIST Registry Cancers doi: 10.3390/cancers12030730 Authors: Nikki S. IJzerman Cas Drabbe Dide den Hollander Mahmoud Mohammadi Hester van Boven Ingrid M.E. Desar Hans Gelderblom Dirk J. Grünhagen An K.L. Reyners Max M. van Noesel Ron H.J. Mathijssen Neeltje Steeghs Winette T.A. van der Graaf Gastrointestinal...
Fri Mar 20, 2020 02:00
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