Biomolecules, Vol. 10, Pages 476: Actionable Potentials of Less Frequently Mutated Genes in Colorectal Cancer and Their Roles in Precision Medicine Biomolecules doi: 10.3390/biom10030476 Authors: Mohd Yunos Ab Mutalib Tieng Abu Jamal Global statistics have placed colorectal cancer (CRC) as the third most frequently diagnosed cancer and the fourth principal cause of cancer-related deaths worldwide. Improving survival for CRC is as important as early detection. Personalized...
Fri Mar 20, 2020 02:00
Biomolecules, Vol. 10, Pages 475: Consistency of the Tools That Predict the Impact of Single Nucleotide Variants (SNVs) on Gene Functionality: The BRCA1 Gene Biomolecules doi: 10.3390/biom10030475 Authors: Javier Murillo Flavio Spetale Serge Guillaume Pilar Bulacio Ignacio Garcia Labari Olivier Cailloux Sebastien Destercke Elizabeth Tapia Single nucleotide variants (SNVs) occurring in a protein coding gene may disrupt its function in multiple ways. Predicting this...
Fri Mar 20, 2020 02:00
Biomolecules, Vol. 10, Pages 474: Glycerol as Alternative Co-Solvent for Water Extraction of Polyphenols from Carménère Pomace: Hot Pressurized Liquid Extraction and Computational Chemistry Calculations Biomolecules doi: 10.3390/biom10030474 Authors: Nils Leander Huamán-Castilla María Salomé Mariotti-Celis Maximiliano Martínez-Cifuentes José Ricardo Pérez-Correa Glycerol is a co-solvent for water extraction that has been shown to be highly effective for obtaining polyphenol...
Fri Mar 20, 2020 02:00
Biomolecules, Vol. 10, Pages 473: An Alternatively Translated Connexin 43 Isoform, GJA1-11k, Localizes to the Nucleus and Can Inhibit Cell Cycle Progression Biomolecules doi: 10.3390/biom10030473 Authors: Irina Epifantseva Shaohua Xiao Rachel E. Baum André G. Kléber TingTing Hong Robin M. Shaw Connexin 43 (Cx43) is a gap junction protein that assembles at the cell border to form intercellular gap junction (GJ) channels which allow for cell–cell communication...
Fri Mar 20, 2020 02:00
Biosensors, Vol. 10, Pages 28: AC and DC Differential Bridge Structure Suitable for Electrochemical Interfacial Capacitance Biosensing Applications Biosensors doi: 10.3390/bios10030028 Authors: Sara Neshani Charles K. A. Nyamekye Scott Melvin Emily A. Smith Degang J. Chen Nathan M. Neihart This paper presents a capacitive differential bridge structure with both AC and DC excitation and balancing capability for low cost electrode-solution interfacial capacitance biosensing...
Sun Mar 22, 2020 02:00
Brain Sciences, Vol. 10, Pages 182: Keeping in Touch with Mental Health: The Orienting Reflex and Behavioral Outcomes from Calatonia Brain Sciences doi: 10.3390/brainsci10030182 Authors: Anita Ribeiro Blanchard William Edgar Comfort Physical and psychological therapy based on touch has been gradually integrated into broader mental health settings in the past two decades, evolving from a variety of psychodynamic, neurobiological and trauma-based approaches, as well as Eastern and spiritual...
Sun Mar 22, 2020 02:00
Brain Sciences, Vol. 10, Pages 181: Multi-View Based Multi-Model Learning for MCI Diagnosis Brain Sciences doi: 10.3390/brainsci10030181 Authors: Ping Cao Jie Gao Zuping Zhang Mild cognitive impairment (MCI) is the early stage of Alzheimer’s disease (AD). Automatic diagnosis of MCI by magnetic resonance imaging (MRI) images has been the focus of research in recent years. Furthermore, deep learning models based on 2D view and 3D view have been widely used in the diagnosis...
Fri Mar 20, 2020 02:00
Cancers, Vol. 12, Pages 753: Molecular Profiling for Predictors of Radiosensitivity in Patients with Breast or Head-and-Neck Cancer Cancers doi: 10.3390/cancers12030753 Authors: Kimi Drobin Michal Marczyk Martin Halle Daniel Danielsson Anna Papiez Traimate Sangsuwan Annika Bendes Mun-Gwan Hong Ulrika Qundos Mats Harms-Ringdahl Peter Wersäll Joanna Polanska Jochen M. Schwenk Siamak Haghdoost Nearly half of all cancers are treated with radiotherapy...
Sun Mar 22, 2020 02:00
Cancers, Vol. 12, Pages 752: Upregulation of Protein Synthesis and Proteasome Degradation Confers Sensitivity to Proteasome Inhibitor Bortezomib in Myc-Atypical Teratoid/Rhabdoid Tumors Cancers doi: 10.3390/cancers12030752 Authors: Huy Minh Tran Kuo-Sheng Wu Shian-Ying Sung Chun Austin Changou Tsung-Han Hsieh Yun-Ru Liu Yen-Lin Liu Min-Lan Tsai Hsin-Lun Lee Kevin Li-Chun Hsieh Wen-Chang Huang Muh-Lii Liang Hsin-Hung Chen Yi-Yen Lee Shih-Chieh Lin Donald...
Sun Mar 22, 2020 02:00
Cancers, Vol. 12, Pages 751: Immunotherapy in Glioblastoma: Current Shortcomings and Future Perspectives Cancers doi: 10.3390/cancers12030751 Authors: Bas Weenink Pim J. French Peter A.E. Sillevis Smitt Reno Debets Marjolein Geurts Glioblastomas are aggressive, fast-growing primary brain tumors. After standard-of-care treatment with radiation in combination with temozolomide, the overall prognosis of newly diagnosed patients remains poor, with a 2-year survival rate of less...
Sun Mar 22, 2020 02:00
Cancers, Vol. 12, Pages 750: Calcium Release-Activated Calcium (CRAC) Channel Inhibition Suppresses Pancreatic Ductal Adenocarcinoma Cell Proliferation and Patient-Derived Tumor Growth Cancers doi: 10.3390/cancers12030750 Authors: Husain Yar Khan Gabriel B. Mpilla Rachel Sexton Srikant Viswanadha Kumar V. Penmetsa Amro Aboukameel Maria Diab Mandana Kamgar Mohammed Najeeb Al-Hallak Mark Szlaczky Anteneh Tesfaye Steve Kim Philip A. Philip Ramzi M. Mohammad...
Sun Mar 22, 2020 02:00
Cancers, Vol. 12, Pages 749: Non-Coding microRNAs as Novel Potential Tumor Markers in Testicular Cancer Cancers doi: 10.3390/cancers12030749 Authors: Manuel Regouc Gazanfer Belge Anja Lorch Klaus-Peter Dieckmann Martin Pichler Testicular cancer is an important disease with increasing incidence and a high burden of morbidity and mortality in young men worldwide. Histological examination of the testicular tissue after orchiectomy plays an important role alongside patient history,...
Sun Mar 22, 2020 02:00
Cancers, Vol. 12, Pages 747: Association between Angiotensin-Converting Enzyme Inhibitors and Lung Cancer—A Nationwide, Population-Based, Propensity Score-Matched Cohort Study Cancers doi: 10.3390/cancers12030747 Authors: Shih-Yi Lin Cheng-Li Lin Cheng-Chieh Lin Wu-Huei Hsu Chia-Der Lin I.-Kuan Wang Chung-Y. Hsu Chia-Hung Kao Background: Direct evidence of lung cancer risk in Asian users of angiotensin-converting enzyme inhibitors (ACEIs) is lacking. Methods: The...
Sat Mar 21, 2020 02:00
Cancers, Vol. 12, Pages 748: KLF5 Is Crucial for Androgen-AR Signaling to Transactivate Genes and Promote Cell Proliferation in Prostate Cancer Cells Cancers doi: 10.3390/cancers12030748 Authors: Juan Li Baotong Zhang Mingcheng Liu Xing Fu Xinpei Ci Jun A Changying Fu Ge Dong Rui Wu Zhiqian Zhang Liya Fu Jin-Tang Dong Androgen/androgen receptor (AR) signaling drives both the normal prostate development and prostatic carcinogenesis, and patients with advanced...
Sat Mar 21, 2020 02:00
Cancers, Vol. 12, Pages 746: Immune-Complexome Analysis Identifies Immunoglobulin-Bound Biomarkers That Predict the Response to Chemotherapy of Pancreatic Cancer Patients Cancers doi: 10.3390/cancers12030746 Authors: Giorgia Mandili Laura Follia Giulio Ferrero Hiroyuki Katayama Wang Hong Amin A. Momin Michela Capello Daniele Giordano Rosella Spadi Maria Antonietta Satolli Andrea Evangelista Samir M. Hanash Francesca Cordero Francesco Novelli Pancreatic...
Sat Mar 21, 2020 02:00
Cancers, Vol. 12, Pages 745: A Disintegrin and Metalloproteinase 9 (ADAM9) in Advanced Hepatocellular Carcinoma and Their Role as a Biomarker During Hepatocellular Carcinoma Immunotherapy Cancers doi: 10.3390/cancers12030745 Authors: Sooyeon Oh YoungJoon Park Hyun-Jung Lee Jooho Lee Soo-Hyeon Lee Young-Seok Baek Su-Kyung Chun Seung-Min Lee Mina Kim Young-Eun Chon Yeonjung Ha Yuri Cho Gi Jin Kim Seong-Gyu Hwang KyuBum Kwack The chemotherapeutics...
Sat Mar 21, 2020 02:00
Cancers, Vol. 12, Pages 743: Gauging the Impact of Cancer Treatment Modalities on Circulating Tumor Cells (CTCs) Cancers doi: 10.3390/cancers12030743 Authors: Trevor J. Mathias Katarina T. Chang Stuart S. Martin Michele I. Vitolo The metastatic cascade consists of multiple complex steps, but the belief that it is a linear process is diminishing. In order to metastasize, cells must enter the blood vessels or body cavities (depending on the cancer type) via active or passive mechanisms....
Sat Mar 21, 2020 02:00
Cancers, Vol. 12, Pages 744: Antibody-Drug Conjugate Using Ionized Cys-Linker-MMAE as the Potent Payload Shows Optimal Therapeutic Safety Cancers doi: 10.3390/cancers12030744 Authors: Yanming Wang Lianqi Liu Shiyong Fan Dian Xiao Fei Xie Wei Li Wu Zhong Xinbo Zhou Monomethyl auristatin E (MMAE) is the most popular and widely used cytotoxin in the development of antibody-drug conjugates (ADCs). However, current MMAE-based ADCs are all constructed using cleavable linkers,...
Sat Mar 21, 2020 02:00
Cancers, Vol. 12, Pages 742: The Role of PTEN Loss in Immune Escape, Melanoma Prognosis and Therapy Response Cancers doi: 10.3390/cancers12030742 Authors: Rita Cabrita Shamik Mitra Adriana Sanna Henrik Ekedahl Kristina Lövgren Håkan Olsson Christian Ingvar Karolin Isaksson Martin Lauss Ana Carneiro Göran Jönsson Checkpoint blockade therapies have changed the clinical management of metastatic melanoma patients considerably, showing survival benefits. Despite...
Sat Mar 21, 2020 02:00
Cancers, Vol. 12, Pages 741: Molecular Engineering Strategies Tailoring the Apoptotic Response to a MET Therapeutic Antibody Cancers doi: 10.3390/cancers12030741 Authors: Chiara Modica Simona Gallo Cristina Chiriaco Martina Spilinga Paolo Maria Comoglio Tiziana Crepaldi Cristina Basilico Elisa Vigna The MET oncogene encodes a tyrosine kinase receptor involved in the control of a complex network of biological responses that include protection from apoptosis and stimulation...
Sat Mar 21, 2020 02:00
Cancers, Vol. 12, Pages 740: Mitotane Concentrations Influence Outcome in Patients with Advanced Adrenocortical Carcinoma Cancers doi: 10.3390/cancers12030740 Authors: Puglisi Calabrese Basile Ceccato Scaroni Altieri Della Casa Loli Pivonello De Martino Canu Russo Badalamenti Torlontano Stigliano Ferraù Arnaldi Saba Quirino Perotti Berchialla Terzolo Mitotane is the main option of treatment for advanced...
Fri Mar 20, 2020 02:00
Cancers, Vol. 12, Pages 739: The Multifactorial Role of PARP-1 in Tumor Microenvironment Cancers doi: 10.3390/cancers12030739 Authors: Juan Manuel Martí Mónica Fernández-Cortés Santiago Serrano-Sáenz Esteban Zamudio-Martinez Daniel Delgado-Bellido Angel Garcia-Diaz Francisco Javier Oliver Poly(ADP-ribose) polymerases (PARPs), represent a family of 17 proteins implicated in a variety of cell functions; some of them possess the enzymatic ability to synthesize and attach...
Fri Mar 20, 2020 02:00
Cancers, Vol. 12, Pages 737: Recognition Dynamics of Cancer Mutations on the ERp57-Tapasin Interface
Cancers, Vol. 12, Pages 737: Recognition Dynamics of Cancer Mutations on the ERp57-Tapasin Interface Cancers doi: 10.3390/cancers12030737 Authors: Monikaben Padariya Umesh Kalathiya Douglas R. Houston Javier Antonio Alfaro Down regulation of the major histocompatibility class (MHC) I pathway plays an important role in tumour development, and can be achieved by suppression of HLA expression or mutations in the MHC peptide-binding pocket. The peptide-loading complex (PLC) loads...
Fri Mar 20, 2020 02:00
Cancers, Vol. 12, Pages 735: Treatment Strategies and Survival Outcomes in Breast Cancer Cancers doi: 10.3390/cancers12030735 Authors: Cheung Treatment strategies for breast cancer are wide-ranging and often based on a multi-modality approach, depending on the stage and biology of the tumour and the acceptance and tolerance of the patient [...]
Fri Mar 20, 2020 02:00
Cancers, Vol. 12, Pages 734: Extracellular Vesicle lincRNA-p21 Expression in Tumor-Draining Pulmonary Vein Defines Prognosis in NSCLC and Modulates Endothelial Cell Behavior Cancers doi: 10.3390/cancers12030734 Authors: Joan J. Castellano Ramon M. Marrades Laureano Molins Nuria Viñolas Jorge Moises Jordi Canals Bing Han Yan Li Daniel Martinez Mariano Monzó Alfons Navarro Hypoxia-induced upregulation of lincRNA-p21 in tumor tissue was previously shown by...
Fri Mar 20, 2020 02:00
Cancers, Vol. 12, Pages 736: The Emerging Roles of RNA Modifications in Glioblastoma Cancers doi: 10.3390/cancers12030736 Authors: Zhen Dong Hongjuan Cui Glioblastoma (GBM) is a grade IV glioma that is the most malignant brain tumor type. Currently, there are no effective and sufficient therapeutic strategies for its treatment because its pathological mechanism is not fully characterized. With the fast development of the Next Generation Sequencing (NGS) technology, more than 170 kinds...
Fri Mar 20, 2020 02:00
Cancers, Vol. 12, Pages 738: Review of Indications of FDA-Approved Immune Checkpoint Inhibitors per NCCN Guidelines with the Level of Evidence Cancers doi: 10.3390/cancers12030738 Authors: Raju K. Vaddepally Prakash Kharel Ramesh Pandey Rohan Garje Abhinav B. Chandra Cancer is associated with higher morbidity and mortality and is the second leading cause of death in the US. Further, in some nations, cancer has overtaken heart disease as the leading cause of mortality. Identification...
Fri Mar 20, 2020 02:00
Cancers, Vol. 12, Pages 732: Comparison of Current Surgical and Non-Surgical Treatment Strategies for Early and Locally Advanced Stage Glottic Laryngeal Cancer and Their Outcome Cancers doi: 10.3390/cancers12030732 Authors: Olgun Elicin Roland Giger For the treatment of early and locally advanced glottic laryngeal cancer, multiple strategies are available. These are pursued and supported by different levels of evidence, but also by national and institutional traditions. The purpose...
Fri Mar 20, 2020 02:00
Cancers, Vol. 12, Pages 733: Primary Neuroendocrine Neoplasms of the Breast: Case Series and Literature Review Cancers doi: 10.3390/cancers12030733 Authors: Burcin Özdirik Antonin Kayser Andrea Ullrich Lynn J. Savic Markus Reiss Frank Tacke Bertram Wiedenmann Henning Jann Christoph Roderburg Primary neuroendocrine carcinoma of the breast (NECB) as defined by the World Health Organization (WHO) in 2012 is a rare, but possibly under-diagnosed entity. It is heterogeneous...
Fri Mar 20, 2020 02:00
Cancers, Vol. 12, Pages 731: Tyrosine Kinase Inhibitors in Cancer: Breakthrough and Challenges of Targeted Therapy Cancers doi: 10.3390/cancers12030731 Authors: Charles Pottier Margaux Fresnais Marie Gilon Guy Jérusalem Rémi Longuespée Nor Eddine Sounni Receptor tyrosine kinases (RTKs) are key regulatory signaling proteins governing cancer cell growth and metastasis. During the last two decades, several molecules targeting RTKs were used in oncology as a first or second...
Fri Mar 20, 2020 02:00
Cancers, Vol. 12, Pages 730: Gastrointestinal Stromal Tumours (GIST) in Young Adult (18–40 Years) Patients: A Report from the Dutch GIST Registry Cancers doi: 10.3390/cancers12030730 Authors: Nikki S. IJzerman Cas Drabbe Dide den Hollander Mahmoud Mohammadi Hester van Boven Ingrid M.E. Desar Hans Gelderblom Dirk J. Grünhagen An K.L. Reyners Max M. van Noesel Ron H.J. Mathijssen Neeltje Steeghs Winette T.A. van der Graaf Gastrointestinal stromal tumour...
Fri Mar 20, 2020 02:00
Cells, Vol. 9, Pages 775: Pirfenidone Inhibits Cell Proliferation and Collagen I Production of Primary Human Intestinal Fibroblasts Cells doi: 10.3390/cells9030775 Authors: Yingying Cui Mengfan Zhang Changsen Leng Tjasso Blokzijl Bernadien H. Jansen Gerard Dijkstra Klaas Nico Faber Intestinal fibrosis is a common complication of inflammatory bowel disease. So far, there is no safe and effective drug for intestinal fibrosis. Pirfenidone is an anti-fibrotic compound available...
Sun Mar 22, 2020 02:00
Cells, Vol. 9, Pages 774: Lamin A and Prelamin a Counteract Migration of Osteosarcoma Cells Cells doi: 10.3390/cells9030774 Authors: Camilla Evangelisti Francesca Paganelli Gaia Giuntini Elisabetta Mattioli Alessandra Cappellini Giulia Ramazzotti Irene Faenza Maria Cristina Maltarello Alberto M. Martelli Katia Scotlandi Francesca Chiarini Giovanna Lattanzi A type lamins are fundamental components of the nuclear lamina. Changes in lamin A expression correlate...
Sun Mar 22, 2020 02:00
Cells, Vol. 9, Pages 773: Heme, A Metabolic Sensor, Directly Regulates the Activity of the KDM4 Histone Demethylase Family and Their Interactions with Partner Proteins Cells doi: 10.3390/cells9030773 Authors: Purna Chaitanya Konduri Tianyuan Wang Narges Salamat Li Zhang The KDM4 histone demethylase subfamily is constituted of yeast JmjC domain-containing proteins, such as Gis1, and human Gis1 orthologues, such as KDM4A/B/C. KDM4 proteins have important functions in regulating...
Sun Mar 22, 2020 02:00
Cells, Vol. 9, Pages 772: Functional Phenotypes of Human Vγ9Vδ2 T Cells in Lymphoid Stress Surveillance Cells doi: 10.3390/cells9030772 Authors: Oliver Nussbaumer Martin Thurnher Butyrophilin and butyrophilin-like proteins select γδ T cells and direct the migration of γδ T cell subsets to distinct anatomical sites. γδ T cells expressing Vδ2 paired with Vγ9 (Vγ9Vδ2 T cells) are the predominant...
Sun Mar 22, 2020 02:00
Cells, Vol. 9, Pages 771: Selective Ablation of Dehydrodolichyl Diphosphate Synthase in Murine Retinal Pigment Epithelium (RPE) Causes RPE Atrophy and Retinal Degeneration Cells doi: 10.3390/cells9030771 Authors: Marci L. DeRamus Stephanie J. Davis Sriganesh Ramachandra Rao Cyril Nyankerh Delores Stacks Timothy W. Kraft Steven J. Fliesler Steven J. Pittler Patients with certain defects in the dehydrodolichyl diphosphate synthase (DHDDS) gene (RP59; OMIM #613861)...
Sat Mar 21, 2020 02:00
Cells, Vol. 9, Pages 770: Validation of Reference Genes for Gene Expression Studies by RT-qPCR in HepaRG Cells during Toxicity Testing and Disease Modelling Cells doi: 10.3390/cells9030770 Authors: Brzeszczyńska Brzeszczyński Samuel Morgan Morley Plevris Hayes Gene expression analysis by quantitative real-time polymerase chain reaction (RT-qPCR) is routinely used in biomedical studies. The reproducibility and reliability of the data fundamentally depends on experimental...
Sat Mar 21, 2020 02:00
Cells, Vol. 9, Pages 769: Evolution of Epileptiform Activity in Zebrafish by Statistical-Based Integration of Electrophysiology and 2-Photon Ca2+ Imaging Cells doi: 10.3390/cells9030769 Authors: Olga Cozzolino Federico Sicca Emanuele Paoli Francesco Trovato Filippo M. Santorelli Gian Michele Ratto Maria Marchese The study of sources and spatiotemporal evolution of ictal bursts is critical for the mechanistic understanding of epilepsy and for the validation of anti-epileptic...
Sat Mar 21, 2020 02:00
Cells, Vol. 9, Pages 768: NK cells and CD38: Implication for (Immuno)Therapy in Plasma Cell Dyscrasias Cells doi: 10.3390/cells9030768 Authors: Renato Zambello Gregorio Barilà Sabrina Manni Francesco Piazza Gianpietro Semenzato Immunotherapy represents a promising new avenue for the treatment of multiple myeloma (MM) patients, particularly with the availability of Monoclonal Antibodies (mAbs) as anti-CD38 Daratumumab and Isatuximab and anti-SLAM-F7 Elotuzumab. Although a...
Sat Mar 21, 2020 02:00
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