Local glucocorticosteroid (“steroid”) therapy is widely used to treat the inner ears of patients with Menière's disease, idiopathic sudden sensorineural hearing loss and in combination with cochlear implants. Applied steroids have included dexamethasone, methylprednisolone, and triamcinolone. In reality, however, this is often not true and the steroid forms commonly applied are dexamethasone-phosphate, methylprednisolone-hemisuccinate, or triamcinolone-acetonide. In each case, the additional component...
Wed Mar 18, 2020 02:00
What anthropologists glean from policy makers’ statements about globalization and development can be very different from what most voters hear. As she steered the United Kingdom through Brexit, former Prime Minister Theresa May said “talk of greater globalization…means their [British] jobs being outsourced and wages undercut.” Analysts of antiglobalization follow these sorts of pronouncements by focusing on their economic nationalism and supposed rejection of the post-World War II order. Anthropologists...
Fri Mar 20, 2020 16:00
Abstract Coix lachrymal-jobi L. var. ma-yuen Stapf of Gramineae are annual or perennial herbs and an important food-medicine homologous plants of high value in nutrition, health protection, and comprehensive utilization. In recent years, the revival of researches on its roles in food and medicinal applications of this underutilized grass for food security and economic empowerment of rural communities has been seen . In this research, Coix kernel endophytic fungi were isolated and...
Fri Mar 20, 2020 02:00
Therapeutic Hypothermia and Temperature Management, Ahead of Print.
Fri Mar 20, 2020 09:00
Publication date: May 2020Source: Journal of Human Evolution, Volume 142Author(s): Patrick Schmidt, Peter Hiscock
Fri Mar 20, 2020 16:18
Publication date: May 2020Source: Journal of Human Evolution, Volume 142Author(s): Kevin D. Hunt
Fri Mar 20, 2020 16:18
Publication date: May 2020Source: Journal of Human Evolution, Volume 142Author(s): Annabelle L. Lockey, Zeresenay Alemseged, Jean-Jacques Hublin, Matthew M. Skinner
Fri Mar 20, 2020 16:18
Publication date: Available online 19 March 2020Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Julia L.M. Dunn, Tetsuo Shoda, Julie M. Caldwell, Ting Wen, Seema S. Aceves, Margaret H. Collins, Evan S. Dellon, Gary W. Falk, John Leung, Lisa J. Martin, Paul Menard-Katcher, Amanda Rudman-Spergel, Jonathan M. Spergel, Joshua B. Wechsler, Guang-Yu Yang, Glenn T. Furuta, Marc E. Rothenberg, CEGIR
Fri Mar 20, 2020 16:18
Publication date: Available online 19 March 2020Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Kathleen M. Buchheit, Daniel F. Dwyer, Jose Ordovas-Montanes, Howard R. Katz, Erin Lewis, Marko Vukovic, Juying Lai, Lora Bankova, Neil Bhattacharyya, Alex K. Shalek, Nora A. Barrett, Joshua A. Boyce, Tanya M. Laidlaw
Fri Mar 20, 2020 16:18
Conditions: Lung Cancer; Head and Neck Cancer; Bladder Cancer; Esophageal Cancer; MesotheliomaInterventions: Biological: S-488210; Biological: S-488211Sponsor: ShionogiRecruiting
Fri Mar 20, 2020 16:08
Fri Mar 20, 2020 02:00
Publication date: Available online 19 March 2020Source: Pathology - Research and PracticeAuthor(s): Gitte Hedegaard Jensen, Michael Bau Mortensen, Günter Klöppel, Michael Friberg Bruun Nielsen, Ole Nielsen, Sönke Detlefsen
Fri Mar 20, 2020 16:04
Publication date: Available online 19 March 2020Source: Pathology - Research and PracticeAuthor(s): Borislav A. Alexiev, Amir Behdad, Xinyan Lu, Esther Cheng, Sandeep Samant
Fri Mar 20, 2020 16:04
Publication date: Available online 20 March 2020Source: Annals of Anatomy - Anatomischer AnzeigerAuthor(s): Monika Puzio, Jakub Hadzik, Artur Błaszczyszyn, Tomasz Gedrange, Marzena Dominiak
Fri Mar 20, 2020 15:41
Abstract Purpose To investigate whether heat shock protein 90 (HSP90) is involved in complement regulation in ischemic postconditioning (IPC). Methods The left coronary artery of rats underwent 30 min of occlusion, followed by 120 min of reperfusion and treatment with IPC via 3 cycles of 30s reperfusion and 30s occlusion. The rats were injected intraperitoneally with 1 mg/kg HSP90 inhibitor geldanamycin (GA) after anesthesia. Eighty rats were randomly divided into four groups: sham, ischemia-reperfusion...
Fri Mar 20, 2020 15:27
Abstract Purpose To evaluate the local effect of simvastatin (SVT) combined with deproteinized bovine bone (DBB) with hydroxyapatite/β-tricalcium phosphate biphasic ceramics (HA/TCP) and with collagen sponge (CS) on bone repair in critical size defects (CSDs) in rat calvaria. Methods Forty-two 5-mm diameter CSDs were made bilaterally in the calvaria of 18 rats. The animals were allocated according to the type of biomaterial and associations used to fill the CSD. After 8 weeks, the animals were...
Fri Mar 20, 2020 15:27
Abstract Purpose To investigate the protective effect of Ganoderma lucidum on testicular torsion/detorsion (T/D)-induced ischemia-reperfusion (I/R) injury. Methods Thirty male Wistar albino rats were randomly categorized into 3 groups: Group 1: sham, Group 2 ( T/D): 2,5 hours of ischemia and 7 days of reperfusion, Group 3 (T/D+ G. lucidum ): 2,5 hours of ischemia and 7 days of reperfusion and 7 days of 20 mg/kg via gastric gavage G. lucidum polysaccharides per day. Biochemical assays of Malondialdehyde...
Fri Mar 20, 2020 15:27
Fri Mar 20, 2020 12:51
Abstract The aortic pathologies are well recognized on imaging. However, conventionally cardiac and proximal aortic abnormalities were only seen on dedicated cardiac or aortic studies due to need for ECG gating. Advances in CT technology have allowed motionless imaging of the chest and abdomen, leading to an increased visualization of cardiac and aortic root diseases on non-ECG-gated imaging. The advances are mostly driven by high pitch due to faster gantry rotation and table...
Fri Mar 20, 2020 02:00
Abstract Objectives This in vitro study aimed to investigate the color changes of the bracket-bonded tooth surfaces after the use of 4 different mouthwashes. Materials and methods A total of 100 human premolar teeth were randomly divided into 10 equal groups. Color values (L*a*b*) of the buccal surfaces of each tooth were assessed using a digital spectrophotometer....
Fri Mar 20, 2020 02:00
Abstract Objectives Evidence about modifications of dental luting materials to minimize biological failure at the “marginal gap” between teeth and fixed prosthodontics is scarce. We compared a copper-modified (Co-ZOP) and a conventional zinc oxide phosphate cement (ZOP) in terms of antimicrobial and cytotoxic potentials in vitro and in vivo. Materials and methods ...
Fri Mar 20, 2020 02:00
Abstract Objectives We evaluated the effects of low-level laser therapy (LLLT) using an infrared laser (IRL) and a red laser (RL) on the pulp of molar teeth in rats after dental bleaching to assess inflammation, collagen fiber maturation, and tertiary dentin formation. Materials and methods Eighty Wistar rats (Rattus norvegicus, albinus) were randomly divided...
Fri Mar 20, 2020 02:00
Publication date: Available online 19 March 2020Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Amanda M. Malacrida, Victor H.C. Dias, Alex F. Silva, Adriele R. dos Santos, Gabriel B. Cesar, Evandro Bona, Paula A.Z. Campanerut-Sá, Wilker Caetano, Jane Martha Graton Mikcha
Fri Mar 20, 2020 14:48
Publication date: Available online 20 March 2020Source: Anesthesiology ClinicsAuthor(s): Susan M. Walters, Ellen W. Richter, Tatiana Lutzker, Suraj Patel, Anita N. Vincent, Amanda M. Kleiman
Fri Mar 20, 2020 14:47
Publication date: Available online 19 March 2020Source: Gene Expression PatternsAuthor(s): Anna Ghilardi, Alberto Diana, Laura Prosperi, Luca Del Giacco
Fri Mar 20, 2020 14:39
Abstract The conclusions of EFSA following the peer review of the initial risk assessments carried out by the competent authorities of the rapporteur Member State Austria and co‐rapporteur Member State Greece for the pesticide active substance kieselgur (diatomaceous earth) and the considerations as regards the inclusion of the substance in Annex IV of Regulation (EC) No 396/2005 are reported. The context of the peer review was that required by Commission Implementing Regulation (EU) No 844/2012,...
Fri Mar 20, 2020 14:36
Introduction: The aim of this study was to investigate and compare the auditory findings in migraine, vestibular migraine (VM), and healthy controls. Methods: Twenty-eight migraine patients (56 ears), 18 VM (36 ears), and 25 healthy controls (50 ears) were included. Audiometry, speech discrimination scores, distortion product optoacoustic emission (DPOAE), and auditory brainstem response were tested. Results: The pure tone in the VM group showed higher thresholds at lower frequencies (250, 500, 1,000,...
Fri Mar 20, 2020 12:50
Abstract Purpose The aim was to examine changes in the bone-derived hormone lipocalin 2 (LCN2) levels in patients with active acromegaly and to investigate the potential roles of LCN2 and osteocalcin in glucose metabolism. Methods We recruited 50 consecutive acromegalic patients. Of those, 39 patients with complete postoperative follow-up data were...
Fri Mar 20, 2020 02:00
Related ArticlesShould patients stop their biologic treatment during the COVID-19 pandemic. J Dermatolog Treat. 2020 Mar 19;:1-2 Authors: Bashyam AM, Feldman SR PMID: 32191143 [PubMed - as supplied by publisher]
Fri Mar 20, 2020 13:56
Related ArticlesValue of reflectance confocal microscopy for the monitoring of rosacea during treatment with topical ivermectin. J Dermatolog Treat. 2020 Mar 19;:1-9 Authors: Logger JGM, Peppelman M, van Erp PEJ, de Jong EMGJ, Nguyen KP, Driessen RJB Abstract Background: Reflectance confocal microscopy (RCM) enables noninvasive Demodex mite detection in rosacea. Objective scoring of rosacea severity is currently lacking.Objectives: To determine the value...
Fri Mar 20, 2020 13:56
Nature Communications, Published online: 20 March 2020; doi:10.1038/s41467-020-15284-yHeparan sulfates (HS) contain functionally relevant structural motifs, but determining their monosaccharide sequence remains challenging. Here, the authors develop an ion mobility mass spectrometry-based method that allows unambiguous characterization of HS sequences and structure-activity relationships.
Fri Mar 20, 2020 02:00
Nature Communications, Published online: 20 March 2020; doi:10.1038/s41467-020-15305-wEvidence for sperm small noncoding RNA-mediated intergenerational transmission implies communication from responsive somatic cells to sperm. Here, authors show that epididymal cells alter extracellular vesicle cargo after stress exposure, to impact offspring neurodevelopment and stress reactivity.
Fri Mar 20, 2020 02:00
Nature Communications, Published online: 20 March 2020; doi:10.1038/s41467-020-15279-9Aneuploidy caused by chromosomal instability is frequently observed in cancer, but little is known about its contribution to tumor development. Here, the authors show that in the mouse intestine, the consequences of aneuploidy are exquisitely dependent on both its extent and anatomical location.
Fri Mar 20, 2020 02:00
Nature Communications, Published online: 20 March 2020; doi:10.1038/s41467-020-15293-xThe characterization of clusters in single-molecule microscopy data is vital to reconstruct emerging spatial patterns. Here, the authors present a fast and accurate machine-learning approach to clustering, to address the issues related to the size of the data and to sample heterogeneity.
Fri Mar 20, 2020 02:00
Nature Communications, Published online: 20 March 2020; doi:10.1038/s41467-020-15201-3Pushing the low temperature limit of refrigerators beyond milli-kelvin regime holds the promise for new discoveries in the nano-electronic devices. Here, Sarsby et al. achieve 500 micro-kelvin electron temperature using combined on-chip and off-chip nuclear refrigeration techniques.
Fri Mar 20, 2020 02:00
Nature Communications, Published online: 20 March 2020; doi:10.1038/s41467-020-15237-5The re-wiring of the metabolic machinery is a common feature in cancer. Here, the authors show, using paired normal and prostate cancer samples that the cancer samples exhibit a shift to succinate respiration, which is associated with elevated levels of mitochondrial DNA mutations.
Fri Mar 20, 2020 02:00
Nature Communications, Published online: 20 March 2020; doi:10.1038/s41467-020-15314-9Root nodules are of key importance in nitrogen fixation. Here, the authors report on an electrically powered artificial root nodule for nitrogen fixation made from silicon-based microwires which can accommodate nitrogen fixing symbiotic bacteria for fixing nitrogen into biomass and free ammonia.
Fri Mar 20, 2020 02:00
Nature Communications, Published online: 20 March 2020; doi:10.1038/s41467-020-15211-1Robo3 is a divergent, multifunctional member of the Robo receptor family that mediates axon guidance by its ligand NELL2 instead of the canonical Slit ligands. Here, the authors present the crystal structures of human Robo3 in complex with NELL1 and NELL2, and they show through biophysical and functional assays how NELL-Robo3 affinity and ligand-induced receptor multimerization control axon guidance activity.
Fri Mar 20, 2020 02:00
Fri Mar 20, 2020 02:00
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