IJMS, Vol. 21, Pages 2181: Dimension Reduction and Clustering Models for Single-Cell RNA Sequencing Data: A Comparative Study International Journal of Molecular Sciences doi: 10.3390/ijms21062181 Authors: Chao Feng Shufen Liu Hao Zhang Renchu Guan Dan Li Fengfeng Zhou Yanchun Liang Xiaoyue Feng With recent advances in single-cell RNA sequencing, enormous transcriptome datasets have been generated. These datasets have furthered our understanding of cellular heterogeneity...
Sun Mar 22, 2020 02:00
IJMS, Vol. 21, Pages 2182: XPA: DNA Repair Protein of Significant Clinical Importance International Journal of Molecular Sciences doi: 10.3390/ijms21062182 Authors: Lucia Borszéková Pulzová Thomas A. Ward Miroslav Chovanec The nucleotide excision repair (NER) pathway is activated in response to a broad spectrum of DNA lesions, including bulky lesions induced by platinum-based chemotherapeutic agents. Expression levels of NER factors and resistance to chemotherapy has been examined...
Sun Mar 22, 2020 02:00
IJMS, Vol. 21, Pages 2180: Fucoxanthin Ameliorates Atopic Dermatitis Symptoms by Regulating Keratinocytes and Regulatory Innate Lymphoid Cells International Journal of Molecular Sciences doi: 10.3390/ijms21062180 Authors: Chika Natsume Nao Aoki Tomoko Aoyama Keisuke Senda Mio Matsui Airi Ikegami Kosuke Tanaka Yasu-Taka Azuma Takashi Fujita Fucoxanthin (FX) is a xanthophyll that is contained abundantly in marine plants. The biological action of FX includes its...
Sun Mar 22, 2020 02:00
IJMS, Vol. 21, Pages 2179: Ablation of Endothelial TRPV4 Channels Alters the Dynamic Ca2+ Signaling Profile in Mouse Carotid Arteries International Journal of Molecular Sciences doi: 10.3390/ijms21062179 Authors: Stuart J. McFarland David S. Weber Chung-sik Choi Mike T. Lin Mark S. Taylor Transient receptor potential vanilloid 4 channels (TRPV4) are pivotal regulators of vascular homeostasis. Altered TRPV4 signaling has recently been implicated in various cardiovascular diseases,...
Sun Mar 22, 2020 02:00
IJMS, Vol. 21, Pages 2178: Paraneoplastic Dermatoses: A Brief General Review and an Extensive Analysis of Paraneoplastic Pemphigus and Paraneoplastic Dermatomyositis International Journal of Molecular Sciences doi: 10.3390/ijms21062178 Authors: Didona Fania Didona Eming Hertl Di Zenzo : Skin manifestations of systemic disease and malignancy are extremely polymorphous. Clinicians should be familiarized with paraneoplastic dermatoses in order to perform an early diagnosis...
Sat Mar 21, 2020 02:00
IJMS, Vol. 21, Pages 2177: Expression Analyses of Soybean VOZ Transcription Factors and the Role of GmVOZ1G in Drought and Salt Stress Tolerance International Journal of Molecular Sciences doi: 10.3390/ijms21062177 Authors: Bo Li Jia-Cheng Zheng Ting-Ting Wang Dong-Hong Min Wen-Liang Wei Jun Chen Yong-Bin Zhou Ming Chen Zhao-Shi Xu You-Zhi Ma Vascular plant one-zinc-finger (VOZ) transcription factor, a plant specific one-zinc-finger-type transcriptional activator,...
Sat Mar 21, 2020 02:00
IJMS, Vol. 21, Pages 2175: Biofabrication of SDF-1 Functionalized 3D-Printed Cell-Free Scaffolds for Bone Tissue Regeneration International Journal of Molecular Sciences doi: 10.3390/ijms21062175 Authors: Lauer Wolf Mehler Götz Rüzgar Baranowski Henrich Rommens Ritz Large segmental bone defects occurring after trauma, bone tumors, infections or revision surgeries are a challenge for surgeons. The aim of our study was to develop a new biomaterial utilizing...
Sat Mar 21, 2020 02:00
IJMS, Vol. 21, Pages 2172: Regulation of Adipogenesis and Lipid Deposits by Collapsin Response Mediator Protein 2 International Journal of Molecular Sciences doi: 10.3390/ijms21062172 Authors: Yih-Hsin Chang Jen-Ning Tsai Shu-Wen Chang Wei-Ting Hsu Ching-Ping Yang Chiao-Wan Hsiao Ming-Yuh Shiau As emerging evidence suggesting neurodegenerative diseases and metabolic diseases have common pathogenesis, we hypothesized that the neurite outgrowth-controlling collapsin response...
Sat Mar 21, 2020 02:00
IJMS, Vol. 21, Pages 2176: Role of HMGB1 in an Animal Model of Vascular Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion International Journal of Molecular Sciences doi: 10.3390/ijms21062176 Authors: Amelia Nur Vidyanti Jia-Yu Hsieh Kun-Ju Lin Yao-Ching Fang Ismail Setyopranoto Chaur-Jong Hu The pathophysiology of vascular cognitive impairment (VCI) is associated with chronic cerebral hypoperfusion (CCH). Increased high-mobility group box protein 1 (HMGB1),...
Sat Mar 21, 2020 02:00
IJMS, Vol. 21, Pages 2174: The Roles of NO and H2S in Sperm Biology: Recent Advances and New Perspectives International Journal of Molecular Sciences doi: 10.3390/ijms21062174 Authors: Kadlec Ros-Santaella Pintus After being historically considered as noxious agents, nitric oxide (NO) and hydrogen sulfide (H2S) are now listed as gasotransmitters, gaseous molecules that play a key role in a variety of cellular functions. Both NO and H2S are endogenously produced, enzymatically...
Sat Mar 21, 2020 02:00
IJMS, Vol. 21, Pages 2173: The Role of Reactive Oxygen Species in the Life Cycle of the Mitochondrion International Journal of Molecular Sciences doi: 10.3390/ijms21062173 Authors: Paola Venditti Sergio Di Meo Currently, it is known that, in living systems, free radicals and other reactive oxygen and nitrogen species play a double role, because they can cause oxidative damage and tissue dysfunction and serve as molecular signals activating stress responses that are beneficial to the...
Sat Mar 21, 2020 02:00
IJMS, Vol. 21, Pages 2169: Knockdown of Musashi RNA Binding Proteins Decreases Radioresistance but Enhances Cell Motility and Invasion in Triple-Negative Breast Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21062169 Authors: Fabian M. Troschel Annemarie Minte Yahia Mahmoud Ismail Amr Kamal Mahmoud Salah Abdullah Sarah Hamdy Ahmed Marie Deffner Björn Kemper Ludwig Kiesel Hans Theodor Eich Sherif Abdelaziz Ibrahim Martin Götte Burkhard...
Sat Mar 21, 2020 02:00
IJMS, Vol. 21, Pages 2171: Integrated Transcriptional and Proteomic Profiling Reveals Potential Amino Acid Transporters Targeted by Nitrogen Limitation Adaptation International Journal of Molecular Sciences doi: 10.3390/ijms21062171 Authors: Liao Tang Zhou Song Hua Zhang Nitrogen (N) is essential for plant growth and crop productivity. Organic N is a major form of remobilized N in plants’ response to N limitation. It is necessary to understand the regulatory...
Sat Mar 21, 2020 02:00
IJMS, Vol. 21, Pages 2170: eIF4E and Interactors from Unicellular Eukaryotes International Journal of Molecular Sciences doi: 10.3390/ijms21062170 Authors: Ross-Kaschitza Altmann eIF4E, the mRNA cap-binding protein, is well known as a general initiation factor allowing for mRNA-ribosome interaction and cap-dependent translation in eukaryotic cells. In this review we focus on eIF4E and its interactors in unicellular organisms such as yeasts and protozoan eukaryotes. In a first part,...
Sat Mar 21, 2020 02:00
IJMS, Vol. 21, Pages 2167: Computational Study on the Effect of Inactivating/Activating Mutations on the Inhibition of MEK1 by Trametinib International Journal of Molecular Sciences doi: 10.3390/ijms21062167 Authors: Jingxuan Zhu Congcong Li Hengzheng Yang Xiaoqing Guo Tianci Huang Weiwei Han Activation of the mitogen-activated protein kinase (MAPK) signaling pathway regulated by human MAP kinase 1 (MEK1) is associated with the carcinogenesis and progression of numerous...
Sat Mar 21, 2020 02:00
IJMS, Vol. 21, Pages 2168: Structural Requirements of Benzofuran Derivatives Dehydro-δ- and Dehydro-ε-Viniferin for Antimicrobial Activity Against the Foodborne Pathogen Listeria monocytogenes International Journal of Molecular Sciences doi: 10.3390/ijms21062168 Authors: Giorgia Catinella Luce M. Mattio Loana Musso Stefania Arioli Diego Mora Giovanni Luca Beretta Nadia Zaffaroni Andrea Pinto Sabrina Dallavalle In a recent study, we investigated the antimicrobial...
Sat Mar 21, 2020 02:00
IJMS, Vol. 21, Pages 2166: Thymosin β4-Enhancing Therapeutic Efficacy of Human Adipose-Derived Stem Cells in Mouse Ischemic Hindlimb Model International Journal of Molecular Sciences doi: 10.3390/ijms21062166 Authors: Jong-Ho Kim I-Rang Lim Chi-Yeon Park Hyung Joon Joo Ji-Min Noh Seung-Cheol Choi Soon Jun Hong Do-Sun Lim Thymosin β4 (Tβ4) is a G-actin sequestering protein that contributes to diverse cellular activities, such as migration and angiogenesis....
Sat Mar 21, 2020 02:00
IJMS, Vol. 21, Pages 2164: Combined Treatment with Sodium-Glucose Cotransporter-2 Inhibitor (Canagliflozin) and Dipeptidyl Peptidase-4 Inhibitor (Teneligliptin) Alleviates NASH Progression in A Non-Diabetic Rat Model of Steatohepatitis International Journal of Molecular Sciences doi: 10.3390/ijms21062164 Authors: Takahiro Ozutsumi Tadashi Namisaki Naotaka Shimozato Kosuke Kaji Yuki Tsuji Daisuke Kaya Yukihisa Fujinaga Masanori Furukawa Keisuke Nakanishi Shinya Sato...
Sat Mar 21, 2020 02:00
IJMS, Vol. 21, Pages 2165: Degeneration of Lumbar Intervertebral Discs: Characterization of Anulus Fibrosus Tissue and Cells of Different Degeneration Grades International Journal of Molecular Sciences doi: 10.3390/ijms21062165 Authors: Stefan Stich Michal Jagielski Anja Fleischmann Carola Meier Patricia Bussmann Benjamin Kohl Julia Schmidt Jan-Philipp Krüger Michaela Endres Mario Cabraja Kolja Reimann Dominik Laue Wolfgang Ertel Michael Sittinger ...
Sat Mar 21, 2020 02:00
IJMS, Vol. 21, Pages 2163: Connexin/Innexin Channels in Cytoplasmic Organelles. Are There Intracellular Gap Junctions? A Hypothesis! International Journal of Molecular Sciences doi: 10.3390/ijms21062163 Authors: Camillo Peracchia This paper proposes the hypothesis that cytoplasmic organelles directly interact with each other and with gap junctions forming intracellular junctions. This hypothesis originated over four decades ago based on the observation that vesicles lining gap junctions...
Sat Mar 21, 2020 02:00
IJMS, Vol. 21, Pages 2162: Bulked Segregant Analysis Coupled with Whole-Genome Sequencing (BSA-Seq) Mapping Identifies a Novel pi21 Haplotype Conferring Basal Resistance to Rice Blast Disease International Journal of Molecular Sciences doi: 10.3390/ijms21062162 Authors: Tingmin Liang Wenchao Chi Likun Huang Mengyu Qu Shubiao Zhang Zi-Qiang Chen Zai-Jie Chen Dagang Tian Yijie Gui Xiaofeng Chen Zonghua Wang Weiqi Tang Songbiao Chen Basal or partial resistance...
Sat Mar 21, 2020 02:00
IJMS, Vol. 21, Pages 2160: The Role of Dorsal Raphe Serotonin Neurons in the Balance between Reward and Aversion International Journal of Molecular Sciences doi: 10.3390/ijms21062160 Authors: Yuma Nagai Kaito Takayama Naoya Nishitani Chihiro Andoh Masashi Koda Hisashi Shirakawa Takayuki Nakagawa Kazuki Nagayasu Akihiro Yamanaka Shuji Kaneko Background: Reward processing is fundamental for animals to survive and reproduce. Many studies have shown the importance...
Sat Mar 21, 2020 02:00
IJMS, Vol. 21, Pages 2161: The Lack of Evidence for an Association between Cancer Biomarker Conversion Patterns and CTC-Status in Patients with Metastatic Breast Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21062161 Authors: Stefan Stefanovic Thomas M. Deutsch Sabine Riethdorf Chiara Fischer Andreas Hartkopf Peter Sinn Manuel Feisst Klaus Pantel Michael Golatta Sara Y. Brucker Marc Sütterlin Andreas Schneeweiss Markus Wallwiener ...
Sat Mar 21, 2020 02:00
IJMS, Vol. 21, Pages 2159: Molecular Mechanisms of PARP-1 Inhibitor 7-Methylguanine International Journal of Molecular Sciences doi: 10.3390/ijms21062159 Authors: Dmitry Nilov Natalya Maluchenko Tatyana Kurgina Sergey Pushkarev Alexandra Lys Mikhail Kutuzov Nadezhda Gerasimova Alexey Feofanov Vytas Švedas Olga Lavrik Vasily M. Studitsky 7-Methylguanine (7-MG), a natural compound that inhibits DNA repair enzyme poly(ADP-ribose) polymerase 1 (PARP-1), can...
Fri Mar 20, 2020 02:00
IJMS, Vol. 21, Pages 2157: Neurochemical Plasticity of nNOS-, VIP- and CART-Immunoreactive Neurons Following Prolonged Acetylsalicylic Acid Supplementation in the Porcine Jejunum International Journal of Molecular Sciences doi: 10.3390/ijms21062157 Authors: Rząp Czajkowska Całka Aspirin, also known as acetylsalicylic acid (ASA), is a commonly used anti-inflammatory drug that has analgesic and antipyretic properties. The side effects are well known, however, knowledge concerning...
Fri Mar 20, 2020 02:00
IJMS, Vol. 21, Pages 2158: Alpha-Smooth Muscle Actin-Positive Perivascular Cells in Diabetic Retina and Choroid International Journal of Molecular Sciences doi: 10.3390/ijms21062158 Authors: Soo Jin Kim Sang A. Kim Yeong A. Choi Do Young Park Junyeop Lee Structural alterations of pericytes in microvessels are important features of diabetic retinopathy. Although capillary pericytes had been known not to have α-smooth muscle actin (αSMA), a recent study...
Fri Mar 20, 2020 02:00
IJMS, Vol. 21, Pages 2155: Development of a Cartilage Oligomeric Matrix Protein Neo-Epitope Assay for the Detection of Intra-Thecal Tendon Disease International Journal of Molecular Sciences doi: 10.3390/ijms21062155 Authors: Roger Smith Patrik Önnerfjord Kristin Holmgren Shacko di Grado Jayesh Dudhia The diagnosis of tendon injury relies on clinical signs and diagnostic imaging but imaging is subjective and does not always correlate with clinical signs. A molecular marker...
Fri Mar 20, 2020 02:00
IJMS, Vol. 21, Pages 2153: Gomisin N from Schisandra chinensis Ameliorates Lipid Accumulation and Induces a Brown Fat-Like Phenotype through AMP-Activated Protein Kinase in 3T3-L1 Adipocytes International Journal of Molecular Sciences doi: 10.3390/ijms21062153 Authors: Lee Lee Kim Chei Jin Oh Lee Obesity results from an imbalance between energy intake and energy expenditure, in which excess fat is stored as triglycerides (TGs) in white adipocytes. Recent studies...
Fri Mar 20, 2020 02:00
IJMS, Vol. 21, Pages 2154: Radon Biomonitoring and microRNA in Lung Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21062154 Authors: Rakhmet Bersimbaev Alessandra Pulliero Olga Bulgakova Kussainova Asia Akmara Aripova Alberto Izzotti Radon is the number one cause of lung cancer in non-smokers. microRNA expression in human bronchial epithelium cells is altered by radon, with particular reference to upregulation of miR-16, miR-15, miR-23, miR-19, miR-125,...
Fri Mar 20, 2020 02:00
IJMS, Vol. 21, Pages 2152: Biosurfactants: Eco-Friendly and Innovative Biocides against Biocorrosion
IJMS, Vol. 21, Pages 2152: Biosurfactants: Eco-Friendly and Innovative Biocides against Biocorrosion International Journal of Molecular Sciences doi: 10.3390/ijms21062152 Authors: Płaza Achal Corrosion influenced by microbes, commonly known as microbiologically induced corrosion (MIC), is associated with biofilm, which has been one of the problems in the industry. The damages of industrial equipment or infrastructures due to corrosion lead to large economic and environmental problems....
Fri Mar 20, 2020 02:00
IJMS, Vol. 21, Pages 2151: H3K4me3 Is a Potential Mediator for Antiproliferative Effects of Calcitriol (1α,25(OH)2D3) in Ovarian Cancer Biology International Journal of Molecular Sciences doi: 10.3390/ijms21062151 Authors: Han Jeschke Kuhn Hester Czogalla Mahner Rottmann Mayr Schmoeckel Trillsch Posttranslational histone modification plays an important role in tumorigenesis. Histone modification is a dynamic response of chromatin to various signals,...
Fri Mar 20, 2020 02:00
IJMS, Vol. 21, Pages 2156: Interactions of Whey Proteins with Metal Ions International Journal of Molecular Sciences doi: 10.3390/ijms21062156 Authors: Agnieszka Rodzik Paweł Pomastowski Gulyaim N. Sagandykova Bogusław Buszewski Whey proteins tend to interact with metal ions, which have implications in different fields related to human life quality. There are two impacts of such interactions: they can provide opportunities for applications in food and nutraceuticals, but may...
Fri Mar 20, 2020 02:00
IJMS, Vol. 21, Pages 2149: Astaxanthin n-Octanoic Acid Diester Ameliorates Insulin Resistance and Modulates Gut Microbiota in High-Fat and High-Sucrose Diet-Fed Mice International Journal of Molecular Sciences doi: 10.3390/ijms21062149 Authors: Yuan Gao Lu Yang Yaoxian Chin Fang Liu Robert W. Li Shihan Yuan Changhu Xue Jie Xu Qingjuan Tang Astaxanthin n-octanoic acid diester (AOD) is a type of astaxanthin connecting medium-chain fatty acids with a more stable...
Fri Mar 20, 2020 02:00
IJMS, Vol. 21, Pages 2148: Neuroimaging Biomarkers for Predicting Treatment Response and Recurrence of Major Depressive Disorder International Journal of Molecular Sciences doi: 10.3390/ijms21062148 Authors: Kang Cho The acute treatment duration for major depressive disorder (MDD) is 8 weeks or more. Treatment of patients with MDD without predictors of treatment response and future recurrence presents challenges and clinical problems to patients and physicians. Recently, many neuroimaging...
Fri Mar 20, 2020 02:00
IJMS, Vol. 21, Pages 2147: High-Protein Diet Induces Hyperuricemia in a New Animal Model for Studying Human Gout International Journal of Molecular Sciences doi: 10.3390/ijms21062147 Authors: Fan Hong Aijuan Zheng Pengfei Xu Jialin Wang Tingting Xue Shu Dai Shijia Pan Yuan Guo Xinlu Xie Letong Li Xiaoxiao Qiao Guohua Liu Yonggong Zhai Hyperuricemia is a central risk factor for gout and increases the risk for other chronic diseases, including cardiometabolic...
Fri Mar 20, 2020 02:00
IJMS, Vol. 21, Pages 2150: Detection of Age-Related Changes in Tendon Molecular Composition by Raman Spectroscopy—Potential for Rapid, Non-Invasive Assessment of Susceptibility to Injury International Journal of Molecular Sciences doi: 10.3390/ijms21062150 Authors: Nai-Hao Yin Anthony W. Parker Pavel Matousek Helen L. Birch The lack of clinical detection tools at the molecular level hinders our progression in preventing age-related tendon pathologies. Raman spectroscopy can...
Fri Mar 20, 2020 02:00
IJMS, Vol. 21, Pages 2146: Huntingtin Lowering Strategies International Journal of Molecular Sciences doi: 10.3390/ijms21062146 Authors: Franz Marxreiter Judith Stemick Zacharias Kohl Trials using antisense oligonucleotide technology to lower Huntingtin levels in Huntington’s disease (HD) are currently ongoing. This progress, taking place only 27 years after the identification of the Huntingtin gene (HTT) in 1993 reflects the enormous development in genetic engineering...
Fri Mar 20, 2020 02:00
IJMS, Vol. 21, Pages 2144: Modulation of NLRP3 Inflammasome through Formyl Peptide Receptor 1 (Fpr-1) Pathway as a New Therapeutic Target in Bronchiolitis Obliterans Syndrome International Journal of Molecular Sciences doi: 10.3390/ijms21062144 Authors: D’Amico Fusco Cordaro Siracusa Peritore Gugliandolo Crupi Scuto Cuzzocrea Di Paola Impellizzeri Chronic rejection is the major leading cause of morbidity and mortality after lung transplantation....
Fri Mar 20, 2020 02:00
IJMS, Vol. 21, Pages 2145: Iron Metabolism at the Interface between Host and Pathogen: From Nutritional Immunity to Antibacterial Development International Journal of Molecular Sciences doi: 10.3390/ijms21062145 Authors: Marialaura Marchetti Omar De Bei Stefano Bettati Barbara Campanini Sandra Kovachka Eleonora Gianquinto Francesca Spyrakis Luca Ronda Nutritional immunity is a form of innate immunity widespread in both vertebrates and invertebrates. The term refers...
Fri Mar 20, 2020 02:00
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