Nature Communications, Published online: 30 July 2020; doi:10.1038/s41467-020-17644-0Current preclinical models to investigate human HR + breast cancer progression and response to immunotherapy in vivo are limited. Here, the authors demonstrate that mammary tumours driven by a synthetic progestin combined with an oral carcinogen recapitulate several immunobiological features of human HR + breast cancers.
Thu Jul 30, 2020 03:00
Nature Communications, Published online: 30 July 2020; doi:10.1038/s41467-020-17526-5The transcripts generated by frameshifts and indels in cancer are frequently degraded by nonsense mediated decay. Here, the authors show that some of these transcripts can escape this degradation mechanism and their prevalence correlates with tumour response to immunotherapy.
Thu Jul 30, 2020 03:00
Nature Communications, Published online: 30 July 2020; doi:10.1038/s41467-020-17561-2The ATPase SecA drives Sec-dependent protein translocation across the bacterial plasma membrane. Here, the authors combine kinetic translocation measurements with single-molecule force spectroscopy and demonstrate that the SecA motor generates mechanical force to unfold and translocate preproteins.
Thu Jul 30, 2020 03:00
Nature Communications, Published online: 30 July 2020; doi:10.1038/s41467-020-17641-3Clinical proteomics critically depends on the ability to acquire highly reproducible data over an extended period of time. Here, the authors assess reproducibility over four months across different mass spectrometers and develop a computational approach to mitigate variation among instruments over time.
Thu Jul 30, 2020 03:00
Nature Communications, Published online: 30 July 2020; doi:10.1038/s41467-020-17264-8Linearly chirped microwave waveforms with high time-bandwidth products would have important applications but are difficult to achieve. Here the authors generate such a waveform in a photonic setting by implementing a micro-disk resonator as a tunable optical bandpass filter in a Fourier-domain mode-locked laser.
Thu Jul 30, 2020 03:00
Nature Communications, Published online: 30 July 2020; doi:10.1038/s41467-020-17653-zFormation of peptide bonds in cold gas-phase environments might represent a prebiotic synthesis route of polypeptides. Here, the authors show the formation of up to tetra-peptide species in the collision of He2+ ions, with kinetic energies typical for solar wind ions, with cold β-alanine clusters.
Thu Jul 30, 2020 03:00
Nature Communications, Published online: 30 July 2020; doi:10.1038/s41467-020-17606-6Protein, MatP, binds to and delays segregation of the ter region of the bacterial chromosome before cell division. Here, the authors show that MatP displays multiple activities to promote optimal pairing of sister ter regions until cell division.
Thu Jul 30, 2020 03:00
Nature Communications, Published online: 30 July 2020; doi:10.1038/s41467-020-17578-7Defective rhythmic metabolism is associated with high-fat diet feeding and obesity. The authors show that the clock gene BMAL1 drives paraventricular hypothalamic neuron activity via rhythmic GABAergic neurotransmission, and that this mediates diurnal metabolism and diet-induced obesity.
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