L ARP7 Is a BRCA1 Ubiquitinase Substrate and Regulates Genome Stability and Tumorigenesis. Cell Rep. 2020 Jul 28;32(4):107974 Authors: Zhang F, Yan P, Yu H, Le H, Li Z, Chen J, Liang X, Wang S, Wei W, Liu L, Zhang Y, Ji X, Xie A, Chen W, Han Z, Pu WT, Chen S, Chen Y, Sun K, Ge B, Zhang B Abstract Attenuated DNA repair leads to genomic instability and tumorigenesis. BRCA1/BARD1 are the best-known tumor suppressors that promote homology recombination...
Thu Jul 30, 2020 14:47
Related Articles Topical treatment for facial burns. Cochrane Database Syst Rev. 2020 Jul 29;7:CD008058 Authors: Hoogewerf CJ, Hop MJ, Nieuwenhuis MK, Oen IM, Middelkoop E, Van Baar ME Abstract BACKGROUND: Burn injuries are an important health problem. They occur frequently in the head and neck region. The face is the area central to a person's identity that provides our most expressive means of communication. Topical interventions are currently...
Thu Jul 30, 2020 14:47
Related Articles A metal-organic framework based inner ear delivery system for the treatment of noise-induced hearing loss. Nanoscale. 2020 Jul 29;: Authors: Xu X, Lin K, Wang Y, Xu K, Sun Y, Yang X, Yang M, He Z, Zhang Y, Zheng H, Chen X Abstract Noise-induced hearing loss (NIHL) is associated with both acute and chronic noise exposure. The application of steroid hormones is the first-line treatment for NIHL. However, a high dose of steroid...
Thu Jul 30, 2020 14:47
Related Articles Proteome and microbiota analysis highlight Lactobacillus plantarum TWK10 supplementation improves energy metabolism and exercise performance in mice. Food Sci Nutr. 2020 Jul;8(7):3525-3534 Authors: Chen YM, Liao CC, Huang YC, Chen MY, Huang CC, Chen WC, Chiu YS Abstract Lactobacillus plantarum TWK10 (LP10) is a probiotic known to improve endurance exercise performance. Here, we analyze the proteomics and metagenomic changes...
Thu Jul 30, 2020 14:47
Related Articles Pterostilbene protects cochlea from ototoxicity in streptozotocin-induced diabetic rats by inhibiting apoptosis. PLoS One. 2020;15(7):e0228429 Authors: Özdaş S, Taştekin B, Gürgen SG, Özdaş T, Pelit A, Erkan SO, Tuhanioğlu B, Gülnar B, Görgülü O Abstract Diabetes mellitus (DM) causes ototoxicity by inducing oxidative stress, microangiopathy, and apoptosis in the cochlear sensory hair cells. The natural anti-oxidant pterostilbene...
Thu Jul 30, 2020 14:47
Related Articles Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation. Nat Commun. 2020 04 29;11(1):2086 Authors: Kong LR, Ong RW, Tan TZ, Mohamed Salleh NAB, Thangavelu M, Chan JV, Koh LYJ, Periyasamy G, Lau JA, Le TBU, Wang L, Lee M, Kannan S, Verma CS, Lim CM, Chng WJ, Lane DP, Venkitaraman A, Hung HT, Cheok CF, Goh BC Abstract Gain of function (GOF) DNA binding domain (DBD) mutations of TP53 upregulate chromatin...
Thu Jul 30, 2020 14:47
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