IJMS, Vol. 21, Pages 5436: Growth Inhibitory Signaling of the Raf/MEK/ERK Pathway International Journal of Molecular Sciences doi: 10.3390/ijms21155436 Authors: Pui-Kei Wu Andrew Becker Jong-In Park In response to extracellular stimuli, the Raf/MEK/extracellular signal-regulated kinase (ERK) pathway regulates diverse cellular processes. While mainly known as a mitogenic signaling pathway, the Raf/MEK/ERK pathway can mediate not only cell proliferation and survival but also cell...
Thu Jul 30, 2020 03:00
IJMS, Vol. 21, Pages 5467: Induced Pluripotent Stem Cells: Hope in the Treatment of Diseases, including Muscular Dystrophies International Journal of Molecular Sciences doi: 10.3390/ijms21155467 Authors: Daniela Gois Beghini Samuel Iwao Horita Cynthia Machado Cascabulho Luiz Anastácio Alves Andrea Henriques-Pons Induced pluripotent stem (iPS) cells are laboratory-produced cells that combine the biological advantages of somatic adult and stem cells for cell-based therapy....
Thu Jul 30, 2020 03:00
IJMS, Vol. 21, Pages 5449: High-Throughput Liquid Chromatography–Tandem Mass Spectrometry Quantification of Glycosaminoglycans as Biomarkers of Mucopolysaccharidosis II International Journal of Molecular Sciences doi: 10.3390/ijms21155449 Authors: Junhua Wang Akhil Bhalla Julie C. Ullman Meng Fang Ritesh Ravi Annie Arguello Elliot Thomsen Buyankhishig Tsogtbaatar Jing L. Guo Lukas L. Skuja Jason C. Dugas Sonnet S. Davis Suresh B. Poda Kannan Gunasekaran...
Thu Jul 30, 2020 03:00
IJMS, Vol. 21, Pages 5466: Key Process and Factors Controlling the Direct Translocation of Cell-Penetrating Peptide through Bio-Membrane International Journal of Molecular Sciences doi: 10.3390/ijms21155466 Authors: Kazutami Sakamoto Taku Morishita Kenichi Aburai Kenichi Sakai Masahiko Abe Ikuhiko Nakase Shiroh Futaki Hideki Sakai Cell-penetrating peptide (CPP) can directly penetrate the cytosol (cytolysis) and is expected to be a potent vector for a drug delivery...
Thu Jul 30, 2020 03:00
IJMS, Vol. 21, Pages 5464: FcεRI Signaling in the Modulation of Allergic Response: Role of Mast Cell-Derived Exosomes International Journal of Molecular Sciences doi: 10.3390/ijms21155464 Authors: Mario Lecce Rosa Molfetta Nadia Domenica Milito Angela Santoni Rossella Paolini Mast cells (MCs) are immune cells that act as environment resident sentinels playing a crucial role in Th2-mediated immune responses, including allergic reactions. Distinguishing features of MCs are...
Thu Jul 30, 2020 03:00
IJMS, Vol. 21, Pages 5461: A Modified Protocol of Diethylnitrosamine Administration in Mice to Model Hepatocellular Carcinoma International Journal of Molecular Sciences doi: 10.3390/ijms21155461 Authors: Azra Memon Yuliya Pyao Yerin Jung Jung Il Lee Woon Kyu Lee We aimed to create an animal model for hepatocellular carcinoma (HCC) with a short time, a high survival rate, as well as a high incidence of HCC in both males and females than previously reported. The Diethylnitrosamine...
Thu Jul 30, 2020 03:00
IJMS, Vol. 21, Pages 5462: Insights into the Effect of Curcumin and (–)-Epigallocatechin-3-Gallate on the Aggregation of Aβ(1–40) Monomers by Means of Molecular Dynamics International Journal of Molecular Sciences doi: 10.3390/ijms21155462 Authors: Francesco Tavanti Alfonso Pedone Maria Cristina Menziani In this study, we compared the effects of two well-known natural compounds on the early step of the fibrillation process of amyloid-β (1–40), responsible for...
Thu Jul 30, 2020 03:00
IJMS, Vol. 21, Pages 5465: Aquilariae Lignum Methylene Chloride Fraction Attenuates IL-1β-Driven Neuroinflammation in BV2 Microglial Cells International Journal of Molecular Sciences doi: 10.3390/ijms21155465 Authors: Jin-Seok Lee Yoo-Jin Jeon Ji-Yun Kang Sam-Keun Lee Hwa-Dong Lee Chang-Gue Son Microglial hyperactivation and neuroinflammation are known to induce neuronal death, which is one of the main causes of neurodegenerative disorders. We previously found that Aquilariae...
Thu Jul 30, 2020 03:00
IJMS, Vol. 21, Pages 5459: A Curcumin Analog Exhibits Multiple Biologic Effects on the Pathogenesis of Alzheimer’s Disease and Improves Behavior, Inflammation, and β-Amyloid Accumulation in a Mouse Model International Journal of Molecular Sciences doi: 10.3390/ijms21155459 Authors: Ih-Jen Su Hong-Yi Chang Hui-Chen Wang Kuen-Jer Tsai Drugs for the treatment of Alzheimer’s disease (AD) are in urgent demand due to the unmet need and the social burden associated with the...
Thu Jul 30, 2020 03:00
IJMS, Vol. 21, Pages 5453: Clinical Significance of Expression Changes and Promoter Methylation of PLA2R1 in Tissues of Breast Cancer Patients International Journal of Molecular Sciences doi: 10.3390/ijms21155453 Authors: Noha Mitwally Einas Yousef Ahmad Abd Al Aziz Mohamed Taha Phospholipase A2 receptor 1 (PLA2R1) expression and its role in the initiation and progression of breast cancer are an unresolved issue. PLA2R1 was found to endorse several tumor suppressive responses,...
Thu Jul 30, 2020 03:00
IJMS, Vol. 21, Pages 5458: MicroRNA-Dependent Targeting of RSU1 and the IPP Adhesion Complex Regulates the PTEN/PI3K/AKT Signaling Pathway in Breast Cancer Cell Lines International Journal of Molecular Sciences doi: 10.3390/ijms21155458 Authors: Yong-Chul Kim Mary L. Cutler (1) Background: The microRNA (miR)-directed control of gene expression is correlated with numerous physiological processes as well as the pathological features of tumors. The focus of this study is on the role...
Thu Jul 30, 2020 03:00
IJMS, Vol. 21, Pages 5457: Inhaled Argon Impedes Hepatic Regeneration after Ischemia/Reperfusion Injury in Rats International Journal of Molecular Sciences doi: 10.3390/ijms21155457 Authors: Sophia M. Schmitz Henriette Dohmeier Christian Stoppe Patrick H. Alizai Sandra Schipper Ulf P. Neumann Mark Coburn Tom F. Ulmer Organoprotective effects of noble gases are subject of current research. One important field of interest is the effect of noble gases on hepatic regenerative...
Thu Jul 30, 2020 03:00
IJMS, Vol. 21, Pages 5456: Immune-Checkpoint Blockade Therapy in Lymphoma International Journal of Molecular Sciences doi: 10.3390/ijms21155456 Authors: Ayumi Kuzume SungGi Chi Nobuhiko Yamauchi Yosuke Minami Tumor cells use immune-checkpoint pathways to evade the host immune system and suppress immune cell function. These cells express programmed cell-death protein 1 ligand 1 (PD-L1)/PD-L2, which bind to the programmed cell-death protein 1 (PD-1) present on cytotoxic T cells,...
Thu Jul 30, 2020 03:00
IJMS, Vol. 21, Pages 5463: Bioinformatics and Molecular Insights to Anti-Metastasis Activity of Triethylene Glycol Derivatives International Journal of Molecular Sciences doi: 10.3390/ijms21155463 Authors: Vidhi Malik Sukant Garg Sajal Afzal Jaspreet Kaur Dhanjal Chae-Ok Yun Sunil C. Kaul Durai Sundar Renu Wadhwa The anti-metastatic and anti-angiogenic activities of triethylene glycol derivatives have been reported. In this study, we investigated their molecular...
Thu Jul 30, 2020 03:00
IJMS, Vol. 21, Pages 5452: Molecular Basis of Mitochondrial and Peroxisomal Division Machineries International Journal of Molecular Sciences doi: 10.3390/ijms21155452 Authors: Yuuta Imoto Kie Itoh Yukio Fujiki Mitochondria and peroxisomes are ubiquitous subcellular organelles that are highly dynamic and possess a high degree of plasticity. These organelles proliferate through division of pre-existing organelles. Studies on yeast, mammalian cells, and unicellular algae have led...
Thu Jul 30, 2020 03:00
IJMS, Vol. 21, Pages 5454: Intra-Articular Injection of Stromal Cell-Derived Factor 1α Promotes Meniscal Healing via Macrophage and Mesenchymal Stem Cell Accumulation in a Rat Meniscal Defect Model International Journal of Molecular Sciences doi: 10.3390/ijms21155454 Authors: Yohei Nishida Yusuke Hashimoto Kumi Orita Kazuya Nishino Takuya Kinoshita Hiroaki Nakamura The stromal-cell-derived factor-1α (SDF-1) is well-known for playing important roles in the regeneration...
Thu Jul 30, 2020 03:00
IJMS, Vol. 21, Pages 5441: Magnetic Stimulation Drives Macrophage Polarization in Cell to–Cell Communication with IL-1β Primed Tendon Cells International Journal of Molecular Sciences doi: 10.3390/ijms21155441 Authors: Adriana Vinhas Ana F. Almeida Ana I. Gonçalves Márcia T. Rodrigues Manuela E. Gomes Inflammation is part of the natural healing response, but it has been simultaneously associated with tendon disorders, as persistent inflammatory events contribute to physiological...
Thu Jul 30, 2020 03:00
IJMS, Vol. 21, Pages 5435: The Ubiquitin Gene Expression Pattern and Sensitivity to UBB and UBC Knockdown Differentiate Primary 23132/87 and Metastatic MKN45 Gastric Cancer Cells International Journal of Molecular Sciences doi: 10.3390/ijms21155435 Authors: Emanuele Salvatore Scarpa Filippo Tasini Rita Crinelli Chiara Ceccarini Mauro Magnani Marzia Bianchi Gastric cancer (GC) is one of the most common and lethal cancers. Alterations in the ubiquitin (Ub) system play key...
Thu Jul 30, 2020 03:00
IJMS, Vol. 21, Pages 5451: Osteosarcoma-Derived Extracellular Vesicles Induce Lung Fibroblast Reprogramming International Journal of Molecular Sciences doi: 10.3390/ijms21155451 Authors: Alekhya Mazumdar Joaquin Urdinez Aleksandar Boro Jessica Migliavacca Matthias J.E. Arlt Roman Muff Bruno Fuchs Jess Gerrit Snedeker Ana Gvozdenovic Tumor-secreted extracellular vesicles (EVs) have been identified as mediators of cancer–host intercellular communication...
Thu Jul 30, 2020 03:00
IJMS, Vol. 21, Pages 5446: Bioluminescent Properties of Semi-Synthetic Obelin and Aequorin Activated by Coelenterazine Analogues with Modifications of C-2, C-6, and C-8 Substituents International Journal of Molecular Sciences doi: 10.3390/ijms21155446 Authors: Elena V. Eremeeva Tianyu Jiang Natalia P. Malikova Minyong Li Eugene S. Vysotski Ca2+-regulated photoproteins responsible for bioluminescence of a variety of marine organisms are single-chain globular proteins within...
Thu Jul 30, 2020 03:00
IJMS, Vol. 21, Pages 5443: Application of Coordination Compounds with Transition Metal Ions in the Chemical Industry—A Review International Journal of Molecular Sciences doi: 10.3390/ijms21155443 Authors: Jacek Malinowski Dominika Zych Dagmara Jacewicz Barbara Gawdzik Joanna Drzeżdżon This publication presents the new trends and opportunities for further development of coordination compounds used in the chemical industry. The review describes the influence of various physicochemical...
Thu Jul 30, 2020 03:00
IJMS, Vol. 21, Pages 5434: Expanding Role of Dopaminergic Inhibition in Hypercapnic Responses of Cultured Rat Carotid Body Cells: Involvement of Type II Glial Cells International Journal of Molecular Sciences doi: 10.3390/ijms21155434 Authors: Erin M. Leonard Colin A. Nurse Dopamine (DA) is a well-studied neurochemical in the mammalian carotid body (CB), a chemosensory organ involved in O2 and CO2/H+ homeostasis. DA released from receptor (type I) cells during chemostimulation is...
Thu Jul 30, 2020 03:00
IJMS, Vol. 21, Pages 5448: Proteinaceous Transformers: Structural and Functional Variability of Human sHsps International Journal of Molecular Sciences doi: 10.3390/ijms21155448 Authors: Mareike Riedl Annika Strauch Dragana A.M. Catici Martin Haslbeck The proteostasis network allows organisms to support and regulate the life cycle of proteins. Especially regarding stress, molecular chaperones represent the main players within this network. Small heat shock proteins (sHsps) are...
Thu Jul 30, 2020 03:00
IJMS, Vol. 21, Pages 5433: Parthenolide Has Negative Effects on In Vitro Enhanced Osteogenic Phenotypes by Inflammatory Cytokine TNF-α via Inhibiting JNK Signaling International Journal of Molecular Sciences doi: 10.3390/ijms21155433 Authors: Jin-Ho Park Young-Hoon Kang Sun-Chul Hwang Se Heang Oh June-Ho Byun Nuclear factor kappa B (NF-κB) regulates inflammatory gene expression and represents a likely target for novel disease treatment approaches, including skeletal...
Thu Jul 30, 2020 03:00
IJMS, Vol. 21, Pages 5444: Genomic Characterization and Expression of Juvenile Hormone Esterase-Like Carboxylesterase Genes in Pacific White Shrimp, Litopenaeus vannamei International Journal of Molecular Sciences doi: 10.3390/ijms21155444 Authors: Xiaoxi Zhang Jianbo Yuan Xiaojun Zhang Jianhai Xiang Fuhua Li The sesquiterpenoid methyl farnesoate (MF), a juvenile hormone (JH) analog, plays important roles in many physiological processes of crustaceans, such as morphogenesis,...
Thu Jul 30, 2020 03:00
IJMS, Vol. 21, Pages 5445: Proteomic Analysis of Peri-Wounding Tissue Expressions in Extracorporeal Shock Wave Enhanced Diabetic Wound Healing in a Streptozotocin-Induced Diabetes Model International Journal of Molecular Sciences doi: 10.3390/ijms21155445 Authors: Rong-Fu Chen Ming-Yu Yang Ching-Jen Wang Chun-Ting Wang Yur-Ren Kuo Our former studies have demonstrated that extracorporeal shock wave therapy (ESWT) could enhance diabetic wound healing but the bio-mechanisms...
Thu Jul 30, 2020 03:00
IJMS, Vol. 21, Pages 5447: Tissue-Specific Decellularization Methods: Rationale and Strategies to Achieve Regenerative Compounds International Journal of Molecular Sciences doi: 10.3390/ijms21155447 Authors: Unai Mendibil Raquel Ruiz-Hernandez Sugoi Retegi-Carrion Nerea Garcia-Urquia Beatriz Olalde-Graells Ander Abarrategi The extracellular matrix (ECM) is a complex network with multiple functions, including specific functions during tissue regeneration. Precisely, the...
Thu Jul 30, 2020 03:00
IJMS, Vol. 21, Pages 5440: Heterologous Expression of Poplar WRKY18/35 Paralogs in Arabidopsis Reveals Their Antagonistic Regulation on Pathogen Resistance and Abiotic Stress Tolerance via Variable Hormonal Pathways International Journal of Molecular Sciences doi: 10.3390/ijms21155440 Authors: Li Guo Chaofeng Li Yuanzhong Jiang Keming Luo Changzheng Xu WRKY transcription factors (WRKY TFs) are one of the largest protein families in plants, and most of them play vital roles...
Thu Jul 30, 2020 03:00
IJMS, Vol. 21, Pages 5439: Proteomics and Metabolomics for Cystic Fibrosis Research International Journal of Molecular Sciences doi: 10.3390/ijms21155439 Authors: Nara Liessi Nicoletta Pedemonte Andrea Armirotti Clarissa Braccia The aim of this review article is to introduce the reader to the state-of-the-art of the contribution that proteomics and metabolomics sciences are currently providing for cystic fibrosis (CF) research: from the understanding of cystic fibrosis transmembrane...
Thu Jul 30, 2020 03:00
IJMS, Vol. 21, Pages 5438: Mesenchymal Stem Cells in Aplastic Anemia and Myelodysplastic Syndromes: The “Seed and Soil” Crosstalk International Journal of Molecular Sciences doi: 10.3390/ijms21155438 Authors: Bruno Fattizzo Juri A. Giannotta Wilma Barcellini There is growing interest in the contribution of the marrow niche to the pathogenesis of bone marrow failure syndromes, i.e., aplastic anemia (AA) and myelodysplastic syndromes (MDSs). In particular, mesenchymal stem cells...
Thu Jul 30, 2020 03:00
IJMS, Vol. 21, Pages 5437: Innate Immune Response to Tick-Borne Pathogens: Cellular and Molecular Mechanisms Induced in the Hosts International Journal of Molecular Sciences doi: 10.3390/ijms21155437 Authors: Alessandra Torina Sara Villari Valeria Blanda Stefano Vullo Marco Pio La Manna Mojtaba Shekarkar Shekarkar Azgomi Diana Di Di Liberto José de la Fuente Guido Sireci Many pathogens are transmitted by tick bites, including Anaplasma spp., Ehrlichia spp.,...
Thu Jul 30, 2020 03:00
IJMS, Vol. 21, Pages 5442: Hsp22 with an N-Terminal Domain Truncation Mediates a Reduction in Tau Protein Levels International Journal of Molecular Sciences doi: 10.3390/ijms21155442 Authors: Jack M. Webster April L. Darling Taylor A. Sanders Danielle M. Blazier Yamile Vidal-Aguiar David Beaulieu-Abdelahad Drew G. Plemmons Shannon E. Hill Vladimir N. Uversky Paula C. Bickford Chad A. Dickey Laura J. Blair Misfolding, aggregation and accumulation of proteins...
Thu Jul 30, 2020 03:00
IJMS, Vol. 21, Pages 5432: Extracellular Vesicles-Based Drug Delivery Systems: A New Challenge and the Exemplum of Malignant Pleural Mesothelioma International Journal of Molecular Sciences doi: 10.3390/ijms21155432 Authors: Stefano Burgio Leila Noori Antonella Marino Gammazza Claudia Campanella Mariantonia Logozzi Stefano Fais Fabio Bucchieri Francesco Cappello Celeste Caruso Bavisotto Research for the most selective drug delivery to tumors represents a fascinating...
Thu Jul 30, 2020 03:00
IJMS, Vol. 21, Pages 5431: Functional Alterations in the Olfactory Neuronal Circuit Occur before Hippocampal Plasticity Deficits in the P301S Mouse Model of Tauopathy: Implications for Early Diagnosis and Translational Research in Alzheimer’s Disease International Journal of Molecular Sciences doi: 10.3390/ijms21155431 Authors: Abdallah Ahnaou Daniela Rodriguez-Manrique Ria Biermans Sofie Embrechts Nikolay V. Manyakov Wilhelmus H. Drinkenburg Alzheimer’s disease...
Thu Jul 30, 2020 03:00
IJMS, Vol. 21, Pages 5430: Genetics in Cartilage Lesions: Basic Science and Therapy Approaches International Journal of Molecular Sciences doi: 10.3390/ijms21155430 Authors: Dawid Szwedowski Joanna Szczepanek Łukasz Paczesny Przemysław Pękała Jan Zabrzyński Jacek Kruczyński Cartilage lesions have a multifactorial nature, and genetic factors are their strongest determinants. As biochemical and genetic studies have dramatically progressed over the past decade, the molecular...
Thu Jul 30, 2020 03:00
IJMS, Vol. 21, Pages 5429: More Bone with Less Minerals? The Effects of Dietary Phosphorus on the Post-Cranial Skeleton in Zebrafish International Journal of Molecular Sciences doi: 10.3390/ijms21155429 Authors: Silvia Cotti Ann Huysseune Wolfgang Koppe Martin Rücklin Federica Marone Eva M. Wölfel Imke A. K. Fiedler Björn Busse Antonella Forlino P. Eckhard Witten Dietary phosphorus (P) is essential for bone mineralisation in vertebrates. P deficiency can cause...
Thu Jul 30, 2020 03:00
IJMS, Vol. 21, Pages 5425: Epigenetic Silencing of LMX1A Contributes to Cancer Progression in Lung Cancer Cells International Journal of Molecular Sciences doi: 10.3390/ijms21155425 Authors: Ti-Hui Wu Shan-Yueh Chang Yu-Lueng Shih Chih-Feng Chian Hung Chang Ya-Wen Lin Epigenetic modification is considered a major mechanism of the inactivation of tumor suppressor genes that finally contributes to carcinogenesis. LIM homeobox transcription factor 1α (LMX1A) is...
Thu Jul 30, 2020 03:00
IJMS, Vol. 21, Pages 5426: Corneal UV Protective Effects of a Topical Antioxidant Formulation: A Pilot Study on In Vivo Rabbits International Journal of Molecular Sciences doi: 10.3390/ijms21155426 Authors: Marisa Palazzo Francesco Vizzarri Lubomir Ondruška Michele Rinaldi Luigi Pacente Germano Guerra Francesco Merolla Ciro Caruso Ciro Costagliola This study aimed to evaluate the protective effect of a topical antioxidant and ultraviolet (UV) shielding action...
Thu Jul 30, 2020 03:00
IJMS, Vol. 21, Pages 5428: Moderate High Caloric Maternal Diet Impacts Dam Breast Milk Metabotype and Offspring Lipidome in a Sex-Specific Manner International Journal of Molecular Sciences doi: 10.3390/ijms21155428 Authors: Marie-Cécile Alexandre-Gouabau Agnès David-Sochard Anne-Lise Royer Patricia Parnet Vincent Paillé Lactation is a critical period during which maternal sub- or over-nutrition affect milk composition and offspring development that can have lasting health...
Thu Jul 30, 2020 03:00
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