Increasing evidences indicate that high-risk HPV variants are heterogeneous in carcinogenicity and ethnic dispersion. In this work, we identified genetic signatures for convenient determination of lineage/sublineage of HPV16, 18, 52 and 58 variants. Using publicly available genomes, we found that E2 of HPV16, L2 of HPV18, L1 and LCR of HPV52, and L2, LCR and E1 of HPV58 contain the proper genetic signature for lineage/sublineage classification. Sets of hierarchical signature nucleotide positions...
Thu Jul 30, 2020 03:00
Monocytes, macrophages, and myeloid dendritic cells are central to the host response to cancer, and generally not in a good way. Tumor-associated macrophages, often the most abundant cells in tumor microenvironments, are recruited and "corrupted" by malignant cells to aid the growth and spread of…
Thu Jul 30, 2020 03:00
Abstract Introduction New Heights is a voluntary school-based program that provides a well-defined system of supports for expectant and parenting students in Washington, DC, and was found to be effective at improving educational outcomes. This study explores the program elements and practices that, when used together, improved academic outcomes for New Heights participants and define a possible roadmap for service providers interested...
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Abstract Evaluate the cytocompatibility of Calen®/ZO, Calcicur®, Vitapex®, Endoflas®, and zinc oxide/eugenol-based (ZOE) root canal pastes (RCP) to human primary osteoblasts (HPO) through a simplified model for primary teeth. The model employed pipette tips filled with 0.037 g of paste, exposed to 185 µL of culture medium for 24 h (n = 6). Release of components was analysed by Proton Nuclear Magnetic Resonance Spectroscopy (1H-NMR). HPO were exposed to conditioned media for 24 h....
Thu Jul 30, 2020 03:00
Publication date: Available online 30 July 2020Source: Sleep MedicineAuthor(s): Teresa Arora, Mohammed Al-Houqani
Thu Jul 30, 2020 20:59
Researchers have investigated evolutionary and ecological changes in ants in the South Pacific archipelago of Fiji to examine a controversial theory for how evolution occurs on islands.
Thu Jul 30, 2020 18:01
The Collegium Ramazzini is an independent, international society composed of 180 physicians and scientists from 35 countries. Its mission is to increase scientific knowledge of the environmental and occupational causes of disease and to transmit this knowledge to decision-makers, the media and the global public to prevent disease, promote health and save lives.Collegium Ramazzini calls urgently for preventive measures internationally and in every country to reduce risk of COVID-19 infection in workersThe...
Thu Jul 30, 2020 19:00
Publication date: Available online 29 July 2020Source: Revue des Maladies RespiratoiresAuthor(s): J. Ruuth-Praz, M. Faure, E. Gomez, I. Petit, N. Petitpain, A. Chaouat, F. Chabot
Thu Jul 30, 2020 18:30
Abstract In heterogeneous habitats, individuals sharing a larger part of their home-range are also likely to live in a very similar environment. This ‘common environment’ effect can generate phenotypic similarities between neighbours and lead to the structuring of phenotypes through the habitat. In this study, we used an intensely monitored population of hihi (or stitchbird, Notiomystis cincta) from New Zealand, to assess whether home-range overlap and genetic relatedness between...
Thu Jul 30, 2020 03:00
Publication date: Available online 29 July 2020Source: CortexAuthor(s): Monica Consonni, Eleonora Dalla Bella, Valeria Elisa Contarino, Enrica Bersano, Giuseppe Lauria
Thu Jul 30, 2020 17:49
Summary Hermansky‐Pudlak syndrome (HPS) is a rare recessive disorder characterized by oculocutaneous albinism or ocular albinism, bleeding diathesis, and other symptoms such as colitis and pulmonary fibrosis. Eleven causative genes have been identified for HPS‐1~HPS‐11 subtypes in humans. We have identified 16 newly reported patients including the first HPS‐2 case in the Chinese population. In a total of 40 HPS patients, hypopigmentation was milder in HPS‐3, HPS‐5 and HPS‐6 patients than in HPS‐1...
Wed Jul 29, 2020 18:43
Abstract Introduction To assess pain response rate (RR) and quality of life (QoL), in patients with moderate/severe neuropathic pain (NP) due to bone metastasis (BM) undergoing palliative 3D radiotherapy plus tapentadol. Methods We conducted a prospective multicentre pilot study. Patients were assessed before radiotherapy using the validated questionnaire (Douleur Neuropathique en 4 questions). Response to radiotherapy (8 Gy–30 Gy/1–10fr) at one and two months was assessed according the...
Wed Jul 29, 2020 16:59
Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): William Gustavo Lima, Júlio César Moreira Brito, Waleska Stephanie da Cruz Nizer
Thu Jul 30, 2020 15:15
Related Articles Development of an accurate bedside swallowing evaluation decision tree algorithm for detecting aspiration in acute respiratory failure survivors. Chest. 2020 Jul 25;: Authors: Moss M, White SD, Warner H, Dvorkin D, Fink D, Gomez-Taborda S, Higgins C, Krisciunas GP, Levitt JE, McKeehan J, McNally E, Rubio A, Scheel R, Siner JM, Vojnik R, Langmore SE Abstract BACKGROUND: The bedside swallowing evaluation (BSE) is an assessment...
Thu Jul 30, 2020 14:06
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. Background:The efficacy of next-generation epidermal growth factor receptor-tyrosine kinase inhibitors in patients with advanced non-small cell lung cancer who have failed first-generation epidermal growth factor receptor-tyrosine kinase inhibitors still remains under investigation.Objective:The aim of this meta-analysis was to systematically assess the efficacy and safety profiles of next-generation epidermal...
Wed Jul 29, 2020 12:48
Acute pancreatitis is a common inflammatory pancreatic disorder, often caused by gallstone disease and frequently requiring hospitalization.
Wed Jul 29, 2020 03:00
Abstract Image fusion (IF) attracts the researchers in the areas of the medical industry as valuable information could be afforded through the fusion of images that enable the clinical decisions to remain effective. With the aim to render an effective image fusion, this paper concentrates on the Bayesian fusion approach, which is tuned optimally using the proposed Fractional Bird Swarm Optimization (Fractional-BSA). The medical image fusion is progressed using the MRI brain image...
Thu Jul 30, 2020 03:00
Abstract Mate choice in plants is poorly understood, in particular its indirect genetic benefits, but also the direct benefits of avoiding harmful matings. In the herb Collinsia heterophylla , delayed stigma receptivity has been suggested to enhance pollen competition, potentially functioning as a female mate choice trait. Previous studies show that this trait can mitigate the cost of early fertilization caused by pollen, thus providing a direct benefit. We performed two‐donor pollinations during...
Wed Jul 29, 2020 22:49
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. Little is known about the effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on pregnant women, fetuses, and neonates, especially when the virus is contracted early in pregnancy. The literature is especially lacking on the effects of SARS-CoV-2 on extremely preterm (<28 weeks gestation) infants who have underdeveloped immune systems. We report the case of an extremely preterm,...
Wed Jul 29, 2020 14:38
Cancer Informatics, Volume 19, Issue , January-December 2020. Background:Cancer is the second leading cause of death globally. Despite developing countries including Ethiopia continuing to shoulder the greatest burden, insufficient research has been conducted to determine geographical and other characteristic effects. The main objective of this study was to assess the distribution and risk of cancer and determine the effects of some common clinical patient characteristics on current patient status...
Thu Jul 30, 2020 08:19
Abstract Prescribing the frequency, duration, or volume of training is simple as these factors can be altered by manipulating the number of exercise sessions per week, the duration of each session, or the total work performed in a given time frame (e.g., per week). However, prescribing exercise intensity is complex and controversy exists regarding the reliability and validity of the methods used to determine and prescribe intensity. This controversy arises from the absence of...
Thu Jul 30, 2020 03:00
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