IJMS, Vol. 21, Pages 5420: DNA Methyltransferase 1 (DNMT1) Acts on Neurodegeneration by Modulating Proteostasis-Relevant Intracellular Processes International Journal of Molecular Sciences doi: 10.3390/ijms21155420 Authors: Cathrin Bayer Georg Pitschelatow Nina Hannemann Jenice Linde Julia Reichard Daniel Pensold Geraldine Zimmer-Bensch The limited regenerative capacity of neurons requires a tightly orchestrated cell death and survival regulation in the context of longevity,...
Thu Jul 30, 2020 03:00
IJMS, Vol. 21, Pages 5424: Long Non-Coding RNAs in Atrial Fibrillation: Pluripotent Stem Cell-Derived Cardiomyocytes as a Model System International Journal of Molecular Sciences doi: 10.3390/ijms21155424 Authors: Emre Bektik Douglas B. Cowan Da-Zhi Wang Atrial fibrillation (AF) is a type of sustained arrhythmia in humans often characterized by devastating alterations to the cardiac conduction system as well as the structure of the atria. AF can lead to decreased cardiac function,...
Thu Jul 30, 2020 03:00
IJMS, Vol. 21, Pages 5423: Resveratrol Favors Adhesion and Biofilm Formation of Lacticaseibacillus paracasei subsp. paracasei Strain ATCC334 International Journal of Molecular Sciences doi: 10.3390/ijms21155423 Authors: Jana Al Azzaz Alissar Al Tarraf Arnaud Heumann David Da Silva Barreira Julie Laurent Ali Assifaoui Aurélie Rieu Jean Guzzo Pierre Lapaquette Bacterial strains of the Lactobacillaceae family are widely used as probiotics for their multifaceted potential...
Thu Jul 30, 2020 03:00
IJMS, Vol. 21, Pages 5422: Network Neuromodulation of Opioid and GABAergic Receptors Following a Combination of “Juvenile” and “Adult Stress” in Rats International Journal of Molecular Sciences doi: 10.3390/ijms21155422 Authors: Omer Horovitz Ziv Ardi Shiri Karni Ashkenazi Gilad Ritov Rachel Anunu Gal Richter-Levin Early life stress is suggested to alter behavioral responses during stressful challenges in adulthood and to exacerbate pathological symptoms that reminisce...
Thu Jul 30, 2020 03:00
IJMS, Vol. 21, Pages 5427: Polyamine Oxidase Is Involved in Spermidine Reduction of Transglutaminase Type 2-Catalyzed βH-Crystallins Polymerization in Calcium-Induced Experimental Cataract International Journal of Molecular Sciences doi: 10.3390/ijms21155427 Authors: Carlo Mischiati Giordana Feriotto Claudio Tabolacci Fabio Domenici Sonia Melino Ilaria Borromeo Cinzia Forni Angelo De Martino Simone Beninati In an in vitro Ca2+-induced cataract model, the progression...
Thu Jul 30, 2020 03:00
IJMS, Vol. 21, Pages 5419: Genome-Wide Identification and Expression Profile of TPS Gene Family in Dendrobium officinale and the Role of DoTPS10 in Linalool Biosynthesis International Journal of Molecular Sciences doi: 10.3390/ijms21155419 Authors: Zhenming Yu Conghui Zhao Guihua Zhang Jaime A. Teixeira da Silva Jun Duan Terpene synthase (TPS) is a critical enzyme responsible for the biosynthesis of terpenes, which possess diverse roles in plant growth and development. Although...
Thu Jul 30, 2020 03:00
IJMS, Vol. 21, Pages 5417: Application of Antibodies to Neuronally Expressed Nogo-A Increases Neuronal Survival and Neurite Outgrowth International Journal of Molecular Sciences doi: 10.3390/ijms21155417 Authors: Vini Nagaraj Thomas Theis Anmol Singh Johal Arihant Seth Jada Gore Neha Arsha Mukti Patel Helen Baixia Hao Nikki Kurian Melitta Schachner Nogo-A, a glycoprotein expressed in oligodendrocytes and central nervous system myelin, inhibits regeneration...
Thu Jul 30, 2020 03:00
IJMS, Vol. 21, Pages 5421: D-amino Acids in Plants: Sources, Metabolism, and Functions International Journal of Molecular Sciences doi: 10.3390/ijms21155421 Authors: Üner Kolukisaoglu Although plants are permanently exposed to D-amino acids (D-AAs) in the rhizosphere, these compounds were for a long time regarded as generally detrimental, due to their inhibitory effects on plant growth. Recent studies showed that this statement needs a critical revision. There were several reports of...
Thu Jul 30, 2020 03:00
IJMS, Vol. 21, Pages 5418: Extracellular Vesicle Membrane-Associated Proteins: Emerging Roles in Tumor Angiogenesis and Anti-Angiogenesis Therapy Resistance International Journal of Molecular Sciences doi: 10.3390/ijms21155418 Authors: Song Yi Ko Honami Naora The tumor vasculature is essential for tumor growth and metastasis, and is a prime target of several anti-cancer agents. Increasing evidence indicates that tumor angiogenesis is stimulated by extracellular vesicles (EVs) that...
Thu Jul 30, 2020 03:00
IJMS, Vol. 21, Pages 5416: Peroxidan Plays a Tumor-Promoting Role in Oral Squamous Cell Carcinoma International Journal of Molecular Sciences doi: 10.3390/ijms21155416 Authors: Miyako Kurihara-Shimomura Tomonori Sasahira Hiroyuki Shimomura Tadaaki Kirita Despite dramatic progress in cancer diagnosis and treatment, the five-year survival rate of oral squamous cell carcinoma (OSCC) is still only about 50%. Thus, the need for elucidating the molecular mechanisms underlying OSCC...
Thu Jul 30, 2020 03:00
IJMS, Vol. 21, Pages 5415: Apocynin Treatment Prevents Cardiac Connexin 43 Hemichannels Hyperactivity by Reducing Nitroso-Redox Stress in Mdx Mice International Journal of Molecular Sciences doi: 10.3390/ijms21155415 Authors: Alejandra Z. Vielma Mauricio P. Boric Daniel R. Gonzalez Duchenne muscular dystrophy (DMD) is a fatal disease that causes cardiomyopathy and is associated with oxidative stress. In the heart, oxidative stress interferes with the location of connexin 43 (Cx43)...
Thu Jul 30, 2020 03:00
IJNS, Vol. 6, Pages 60: Long-Term Outcomes of Adult Patients with Homocystinuria before and after Newborn Screening International Journal of Neonatal Screening doi: 10.3390/ijns6030060 Authors: Kenji Yamada Kazunori Yokoyama Kikumaro Aoki Takeshi Taketani Seiji Yamaguchi Background: Homocystinuria (HCU) is a rare inherited metabolic disease. In Japan, newborn screening (NBS) for HCU (cystathionine β-synthase deficiency) was initiated in 1977. We compared the outcomes...
Thu Jul 30, 2020 03:00
JCM, Vol. 9, Pages 2443: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Efficacy of Repeat Immunoadsorption Journal of Clinical Medicine doi: 10.3390/jcm9082443 Authors: Markus Tölle Helma Freitag Michaela Antelmann Jelka Hartwig Mirjam Schuchardt Markus van der Giet Kai-Uwe Eckardt Patricia Grabowski Carmen Scheibenbogen (1) Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex neuroimmunological disease. There is evidence for an autoimmune...
Thu Jul 30, 2020 03:00
JCM, Vol. 9, Pages 2444: Effect of an Enhanced Self-Care Protocol on Lymphedema Status among People Affected by Moderate to Severe Lower-Limb Lymphedema in Bangladesh, a Cluster Randomized Controlled Trial Journal of Clinical Medicine doi: 10.3390/jcm9082444 Authors: Janet Douglass Hayley Mableson Sarah Martindale Sanya Tahmina Jhara Mohammad Jahirul Karim Muhammad Mujibur Rahman Abdullah Al Kawsar Abul Khair ASM Sultan Mahmood AKM Fazlur Rahman Salim Mahmud Chowdhury...
Thu Jul 30, 2020 03:00
JCM, Vol. 9, Pages 2441: A Panel of Broad-Spectrum Antivirals in Topical Ophthalmic Medications from the Drug Repurposing Approach during and after the Coronavirus Disease 2019 Era Journal of Clinical Medicine doi: 10.3390/jcm9082441 Authors: Napoli Mangoni Gentile Braghiroli Fossarello The coronavirus disease 2019 (COVID-19) represents a global concern of public health caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Its clinical manifestations...
Thu Jul 30, 2020 03:00
JCM, Vol. 9, Pages 2442: Racial Disparities-Associated COVID-19 Mortality among Minority Populations in the US Journal of Clinical Medicine doi: 10.3390/jcm9082442 Authors: Donald J. Alcendor Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a betacoronavirus that causes the novel coronavirus disease 2019 (COVID-19), is highly transmissible and pathogenic for humans and may cause life-threatening disease and mortality, especially in individuals with underlying comorbidities....
Thu Jul 30, 2020 03:00
JCM, Vol. 9, Pages 2440: Identification and Validation of Circulating Micrornas as Prognostic Biomarkers in Pancreatic Ductal Adenocarcinoma Patients Undergoing Surgical Resection Journal of Clinical Medicine doi: 10.3390/jcm9082440 Authors: Natalia Gablo Karolina Trachtova Vladimir Prochazka Jan Hlavsa Tomas Grolich Igor Kiss Josef Srovnal Alona Rehulkova Martin Lovecek Pavel Skalicky Ioana Berindan-Neagoe Zdenek Kala Ondrej Slaby Pancreatic ductal...
Thu Jul 30, 2020 03:00
JCM, Vol. 9, Pages 2439: Core Outcome Measurement Instruments for Clinical Trials of Total Knee Arthroplasty: A Systematic Review Journal of Clinical Medicine doi: 10.3390/jcm9082439 Authors: Vivien Reynaud Anargyros Verdilos Bruno Pereira Stéphane Boisgard Frédéric Costes Emmanuel Coudeyre (1) Background: We have updated knowledge of the psychometric qualities of patient-reported outcome measures and, for the first time, systematically reviewed and compared the psychometric...
Thu Jul 30, 2020 03:00
JCM, Vol. 9, Pages 2438: Predicting the Role of DNA Polymerase β Alone or with KRAS Mutations in Advanced NSCLC Patients Receiving Platinum-Based Chemotherapy Journal of Clinical Medicine doi: 10.3390/jcm9082438 Authors: Maria Francesca Alvisi Monica Ganzinelli Helena Linardou Elisa Caiola Giuseppe Lo Russo Fabiana Letizia Cecere Anna Cecilia Bettini Amanda Psyrri Michele Milella Eliana Rulli Alessandra Fabbri Marcella De Maglie Pierpaolo Romanelli Samuel...
Thu Jul 30, 2020 03:00
JCM, Vol. 9, Pages 2436: Effects of 24-Week Exergame Intervention on the Gray Matter Volume of Different Brain Structures in Women with Fibromyalgia: A Single-Blind, Randomized Controlled Trial Journal of Clinical Medicine doi: 10.3390/jcm9082436 Authors: Juan Luis Leon-Llamas Santos Villafaina Alvaro Murillo-Garcia Francisco Javier Dominguez-Muñoz Narcis Gusi Background: Exergame-induced changes in the volume of brain gray matter have not been studied in fibromyalgia (FM)....
Thu Jul 30, 2020 03:00
JCM, Vol. 9, Pages 2437: The Use of Bispectral Index Monitoring Does Not Change Intraoperative Exposure to Volatile Anesthetics in Children Journal of Clinical Medicine doi: 10.3390/jcm9082437 Authors: Cornelius A. Sullivan Chinyere Egbuta Raymond S. Park Karina Lukovits David Cavanaugh Keira P. Mason The exposure of infants and children to volatile anesthetics, such as sevoflurane, has been a topic of concern with respect to the potential risk for long term neurocognitive...
Thu Jul 30, 2020 03:00
JCM, Vol. 9, Pages 2434: Menopausal Transition, Body Mass Index, and Prevalence of Mammographic Dense Breasts in Middle-Aged Women Journal of Clinical Medicine doi: 10.3390/jcm9082434 Authors: Eun Young Kim Yoosoo Chang Jiin Ahn Ji-Sup Yun Yong Lai Park Chan Heun Park Hocheol Shin Seungho Ryu The interrelationship between menopausal stage, excessive adiposity and dense breasts remains unclear. We aimed to investigate the relationship between menopausal stage and...
Thu Jul 30, 2020 03:00
JCM, Vol. 9, Pages 2435: Cardiovascular Manifestations and Complications of Pheochromocytomas and Paragangliomas Journal of Clinical Medicine doi: 10.3390/jcm9082435 Authors: Shams Y-Hassan Henrik Falhammar Pheochromocytomas and paragangliomas (PPGLs) are rare neuro-endocrine tumors. The catecholamine surge causes paroxysmal or chronic secondary hypertension. PPGLs may present as hypertensive- or PPGL-crisis with severe life-threatening cardiac and cerebrovascular complications. PPGLs-induced...
Thu Jul 30, 2020 03:00
JCM, Vol. 9, Pages 2433: Small Cell Lung Cancer from Traditional to Innovative Therapeutics: Building a Comprehensive Network to Optimize Clinical and Translational Research Journal of Clinical Medicine doi: 10.3390/jcm9082433 Authors: Shanmuga Subbiah Arin Nam Natasha Garg Amita Behal Prakash Kulkarni Ravi Salgia Small cell lung cancer (SCLC) is an aggressive, complex disease with a distinct biology that contributes to its poor prognosis. Management of SCLC is still widely...
Thu Jul 30, 2020 03:00
JCM, Vol. 9, Pages 2431: Implementation of a Multidisciplinary Allied Health Optimisation Clinic for Cancer Patients with Complex Needs Journal of Clinical Medicine doi: 10.3390/jcm9082431 Authors: Hannah Ray Anna Beaumont Jenelle Loeliger Alicia Martin Celia Marston Karla Gough Shilpa Bordia Maria Ftanou Nicole Kiss This study examined the feasibility of implementing a multidisciplinary allied health model of care (MOC) for cancer patients with complex needs....
Thu Jul 30, 2020 03:00
JCM, Vol. 9, Pages 2432: Lifestyle-Related Exposure to Cadmium and Lead is Associated with Diabetic Kidney Disease Journal of Clinical Medicine doi: 10.3390/jcm9082432 Authors: Ilse J. M. Hagedoorn Christina M. Gant Sanne v. Huizen Ronald G. H. J. Maatman Gerjan Navis Stephan J. L. Bakker Gozewijn D. Laverman Background: Environmental factors contributing to diabetic kidney disease are incompletely understood. We investigated whether blood cadmium and lead concentrations...
Thu Jul 30, 2020 03:00
JCM, Vol. 9, Pages 2430: Comparison of BRAF Mutation Screening Strategies in a Large Real-Life Series of Advanced Melanoma Patients Journal of Clinical Medicine doi: 10.3390/jcm9082430 Authors: Maria Colombino Carla Rozzo Panagiotis Paliogiannis Milena Casula Antonella Manca Valentina Doneddu Maria Antonietta Fedeli Maria Cristina Sini Grazia Palomba Marina Pisano Paolo A. Ascierto Corrado Caracò Amelia Lissia Antonio Cossu Giuseppe Palmieri Malignant...
Thu Jul 30, 2020 03:00
JoF, Vol. 6, Pages 122: Review of the Novel Investigational Antifungal Olorofim Journal of Fungi doi: 10.3390/jof6030122 Authors: Wiederhold The incidence of invasive fungal infections caused by molds and endemic fungi is increasing. There is also concern regarding increased rates of reduced susceptibility or frank resistance among Aspergillus and Coccidioides species, while Scedosporium species, Lomentospora prolificans, and Fusarium species are inherently less susceptible or intrinsically...
Thu Jul 30, 2020 03:00
JoF, Vol. 6, Pages 121: Chromatin Structure and Drug Resistance in Candida spp. Journal of Fungi doi: 10.3390/jof6030121 Authors: O’Kane Weild M. Hyland Anti-microbial resistance (AMR) is currently one of the most serious threats to global human health and, appropriately, research to tackle AMR garnishes significant investment and extensive attention from the scientific community. However, most of this effort focuses on antibiotics, and research into anti-fungal resistance (AFR)...
Thu Jul 30, 2020 03:00
J. Imaging, Vol. 6, Pages 75: No-Reference Image Quality Assessment Based on the Fusion of Statistical and Perceptual Features Journal of Imaging doi: 10.3390/jimaging6080075 Authors: Domonkos Varga The goal of no-reference image quality assessment (NR-IQA) is to predict the quality of an image as perceived by human observers without using any pristine, reference images. In this study, an NR-IQA algorithm is proposed which is driven by a novel feature vector containing statistical and...
Thu Jul 30, 2020 03:00
J. Imaging, Vol. 6, Pages 74: No-Reference Quality Assessment of In-Capture Distorted Videos Journal of Imaging doi: 10.3390/jimaging6080074 Authors: Mirko Agarla Luigi Celona Raimondo Schettini We introduce a no-reference method for the assessment of the quality of videos affected by in-capture distortions due to camera hardware and processing software. The proposed method encodes both quality attributes and semantic content of each video frame by using two Convolutional Neural...
Thu Jul 30, 2020 03:00
Life, Vol. 10, Pages 128: Nanoscopic Approach to Study the Early Stages of Epithelial to Mesenchymal Transition (EMT) of Human Retinal Pigment Epithelial (RPE) Cells in Vitro Life doi: 10.3390/life10080128 Authors: Lilia A. Chtcheglova Andreas Ohlmann Danila Boytsov Peter Hinterdorfer Siegfried G. Priglinger Claudia S. Priglinger The maintenance of visual function is supported by the proper functioning of the retinal pigment epithelium (RPE), representing a mosaic of polarized...
Thu Jul 30, 2020 03:00
Medicina, Vol. 56, Pages 383: Parkinson’s Disease, Periodontitis and Patient-Related Outcomes: A Cross-Sectional Study Medicina doi: 10.3390/medicina56080383 Authors: Patrícia Lyra Vanessa Machado Luís Proença Josefa Domingos Catarina Godinho José João Mendes João Botelho Background and objectives: People with Parkinson’s disease (PD) may be at risk of having bad periodontal status. A consistent periodontal examination is critical to investigate how it impacts...
Thu Jul 30, 2020 03:00
Medicina, Vol. 56, Pages 382: Association between Corrected QT Interval and C-Reactive Protein in Patients with Inflammatory Bowel Diseases Medicina doi: 10.3390/medicina56080382 Authors: Angelo Viscido Annalisa Capannolo Renata Petroni Gianpiero Stefanelli Giulia Zerboni Massimo De Martinis Stefano Necozione Maria Penco Giuseppe Frieri Giovanni Latella Silvio Romano Background and objectives: Electrocardiograph abnormalities (i.e., QT interval prolongation)...
Thu Jul 30, 2020 03:00
Medicines, Vol. 7, Pages 46: Modulation of Th1/Th2 Cytokine Balance by Quercetin In Vitro Medicines doi: 10.3390/medicines7080046 Authors: Yoshihito Tanaka Atsuko Furuta Kazuhito Asano Hitome Kobayashi Background: Allergic rhinitis (AR) is well known to be an IgE-mediated chronic inflammatory disease in the nasal wall, which is primarily mediated by Th2-type cytokines such as IL-4, IL-5, and IL-13. Although quercetin is also accepted to attenuate the development of allergic...
Thu Jul 30, 2020 03:00
Medicines, Vol. 7, Pages 45: Trying to Solve the Puzzle of the Interaction of Ascorbic Acid and Iron: Redox, Chelation and Therapeutic Implications Medicines doi: 10.3390/medicines7080045 Authors: George J. Kontoghiorghes Annita Kolnagou Christina N. Kontoghiorghe Loukia Mourouzidis Viktor A. Timoshnikov Nikolay E. Polyakov Iron and ascorbic acid (vitamin C) are essential nutrients for the normal growth and development of humans, and their deficiency can result in serious...
Thu Jul 30, 2020 03:00
MPs, Vol. 3, Pages 55: Quantitative Microdialysis: Experimental Protocol and Software for Small Molecule Protein Affinity Determination and for Exclusion of Compounds with Poor Physicochemical Properties Methods and Protocols doi: 10.3390/mps3030055 Authors: Steven Shave Nhan T. Pham Connor B. Śmieja Manfred Auer Quantitative microdialysis is a traditional biophysical affinity determination technique. In the development of the detailed experimental protocol presented, we used...
Thu Jul 30, 2020 03:00
MPs, Vol. 3, Pages 54: IsoSearch: An Untargeted and Unbiased Metabolite and Lipid Isotopomer Tracing Strategy from HR-LC-MS/MS Datasets Methods and Protocols doi: 10.3390/mps3030054 Authors: He Huang Min Yuan Phillip Seitzer Susan Ludwigsen John M. Asara Stable isotopic tracer analysis is a technique used to determine carbon or nitrogen atom incorporation into biological systems. A number of mass spectrometry based approaches have been developed for this purpose, including...
Thu Jul 30, 2020 03:00
Microorganisms, Vol. 8, Pages 1162: A Cross-Sectional Study of the Gut Microbiota Composition in Moscow Long-Livers Microorganisms doi: 10.3390/microorganisms8081162 Authors: Daria A. Kashtanova Nataliya S. Klimenko Irina D. Strazhesko Elizaveta V. Starikova Oksana E. Glushchenko Denis A. Gudkov Olga N. Tkacheva The aim was to assess the gut microbiota of long-livers from Moscow. This study included two groups of patients who signed their consent to participate. The...
Thu Jul 30, 2020 03:00
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