Publication date: Available online 29 July 2020Source: Auris Nasus LarynxAuthor(s): Tomonori Joko, Hiroyuki Yamada, Takuya Kimura, Masato Teraoka, Naohito Hato
Thu Jul 30, 2020 16:55
Abstract Objectives In patients with N3 head and neck squamous cell carcinoma (HNSCC), N3‐disease is associated with high regional relapse and metastatic risks. Patients with resectable N3‐disease have better prognosis although their metastatic risk may be similar as in patients with unresectable disease. Neoadjuvant chemotherapy has been associated with lower metastatic rates but N3 patients may die of rapid locoregional progression. We assessed outcomes with the three modalities in patients...
Wed Jul 29, 2020 20:30
Abstract Percutaneous drains are frequently used in head and neck surgery cases. However, although effective at preventing postoperative haematoma formation their use can also be associated with significant complications, including infection, fistulae, pain, psychosocial implications, and most notably prolongation of hospital stay. As such, some authors have advocated approaches to minimise or avoid the use of percutaneous drains altogether, mainly through the use of surgical adjuncts such as fibrin...
Wed Jul 29, 2020 12:13
Conditions: Advanced Bile Duct Carcinoma; Advanced Breast Carcinoma; Advanced Cervical Carcinoma; Advanced Endometrial Carcinoma; Advanced Esophageal Carcinoma; Advanced Gastric Carcinoma; Advanced Head and Neck Carcinoma; Advanced Lung Non-Small Cell Carcinoma; Advanced Lung Small Cell Carcinoma; Advanced Malignant Solid Neoplasm; Advanced Ovarian Carcinoma; Advanced Penile Carcinoma; Advanced Pleural Malignant Mesothelioma; Advanced Urothelial Carcinoma; Anatomic Stage III Breast Cancer AJCC v8;...
Thu Jul 30, 2020 15:02
Related Articles Multiple spontaneous skull base cerebrospinal fluid leaks: some insights from an international retrospective collaborative study. Eur Arch Otorhinolaryngol. 2020 Jul 28;: Authors: Dallan I, Cambi C, Emanuelli E, Cazzador D, Canevari FR, Borsetto D, Tysome JR, Donnelly NP, Rigante M, Georgalas C, Alobid I, Molteni G, Marchioni D, Shahzada AK, Scarano M, Seccia V, Pasquini E Abstract PURPOSE: Spontaneous skull base cerebrospinal...
Thu Jul 30, 2020 15:11
Related Articles Nasal versus oronasal mask in patients under auto-adjusting continuous positive airway pressure titration: a real-life study. Eur Arch Otorhinolaryngol. 2020 Jul 28;: Authors: Duarte RLM, Mendes BA, Oliveira-E-Sá TS, Magalhães-da-Silveira FJ, Gozal D Abstract PURPOSE: Mask type (nasal versus oronasal) can affect the optimal pressure required to correct the apnea/hypopnea index (AHI) in obstructive sleep apnea (OSA) subjects...
Thu Jul 30, 2020 15:11
Related Articles Olfactory and taste disorders in healthcare workers with COVID-19 infection. Eur Arch Otorhinolaryngol. 2020 Jul 28;: Authors: Villarreal IM, Morato M, Martínez-RuizCoello M, Navarro A, Garcia-Chillerón R, Ruiz Á, de Almeida IV, Mazón L, Plaza G Abstract PURPOSE: Severe acute respiratory syndrome caused by COVID-19 has spread globally for the last few months. Healthcare workers (HCW) are overexposed and infection rates are higher...
Thu Jul 30, 2020 15:11
This cross-sectional study evaluates whether diversity of practice, clinical productivity, and Medicare payment differ between male and female otolaryngologists and whether any identified variation is influenced by practice setting.
Thu Jul 30, 2020 03:00
A 71-year-old man previously treated for p16-positive (human papillomavirus-related) oropharyngeal squamous cell carcinoma presented with concern for regional recurrence. Fine needle aspiration of the thyroid gland was performed with immunohistochemical staining positive for p16, CK5, and p40 and negative for thyroid transcription factor 1. What is your diagnosis?
Thu Jul 30, 2020 03:00
This narrative review discusses how we should interpret negative and positive results from commercial molecular tests of thyroid nodules and whether available data support the routine use of these assays for all cytologically indeterminate thyroid nodules.
Thu Jul 30, 2020 03:00
This cohort study analyzes data from the Public Health Information System database to evaluate the prevalence of cholesteatoma in children with Down syndrome.
Thu Jul 30, 2020 03:00
An 85-year-old woman presents with a history of frontal pain and pressure and progressive nontender facial edema; endoscopy findings reveal a mucosal soft tissue mass, and biopsy results show epithelioid shaped cells in whorled lobulated pattern. What is your diagnosis?
Thu Jul 30, 2020 03:00
This systematic review examines evidence on the risks of aerosolization and transmission of severe acute respiratory syndrome coronavirus 2 from patients to health care personnel during endoscopy of the upper aerodigestive tract.
Thu Jul 30, 2020 03:00
Laryngorhinootologie 2020; 99: 504-505DOI: 10.1055/a-1123-3835© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Thu Jul 30, 2020 02:00
Laryngorhinootologie 2020; 99: 528-530DOI: 10.1055/a-1123-3956© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Thu Jul 30, 2020 02:00
Laryngorhinootologie 2020; 99: 507-508DOI: 10.1055/a-1192-2433© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Thu Jul 30, 2020 02:00
Laryngorhinootologie 2020; 99: 586-587DOI: 10.1055/a-1123-4011© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Thu Jul 30, 2020 02:00
Laryngorhinootologie 2020; 99: 508-509DOI: 10.1055/a-1177-2151© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Thu Jul 30, 2020 02:00
Laryngorhinootologie 2020; 99: 566-567DOI: 10.1055/a-1123-3978© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Thu Jul 30, 2020 02:00
Laryngorhinootologie 2020; 99: 509-510DOI: 10.1055/a-1180-2473© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Thu Jul 30, 2020 02:00
Laryngorhinootologie 2020; 99: 583-585DOI: 10.1055/a-1123-4000© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Thu Jul 30, 2020 02:00
Laryngorhinootologie 2020; 99: 568-582DOI: 10.1055/a-1148-2494What is right? Tonsillotomy or tonsillectomy? Moreover, when and what has to be preferred? Is the discussion never ending? No, and this is good. Tonsil surgery is and will remain a frequent surgical procedure for the otolaryngologist. Especially, because many children are operated, and because – also rare – significant complications can occur, a quality-controlled benefit-risk-analysis is important. Part of this is systematic analysis...
Thu Jul 30, 2020 02:00
Subungual melanomas (SUM) arise beneath the nails of the hands and feet, and account for 0.7–3.5% of all malignant melanomas. Most studies include SUM in the category of acral melanoma, but understanding the specific features of SUM is critical for improving patient care. In this study, we performed a site-specific comparison of the clinical and molecular features between 54 cases of SUM and 78 cases of nonsubungual acral melanoma. Compared to patients with acral melanoma, patients with SUM were...
Fri Jul 24, 2020 03:00
We report a case of anti-protein death 1-induced sarcoid-like reaction in a 63-year-old Caucasian male who was diagnosed with stage IV-M1a melanoma. He was initially treated with pembrolizumab monotherapy (Q3W) and had a complete response after 14 cycles. However, relapse was suspected 3 months later with appearance of hilar, mediastinal and hepatic hilar lymph nodes as well as a skin lesion. Biopsy of both the hilar lymph nodes and the skin lesion demonstrated sarcomatoid granulomatosis. Pembrolizumab...
Fri Jul 24, 2020 03:00
Background This study aimed to assess whether dabrafenib/trametinib and vemurafenib/cobimetinib treatments are associated with a change in skeletal muscle area (SMA) and total fat-free mass (FFM) assessed by computed tomography (CT), and to compare the efficacy and safety profile of these treatments in patients with metastatic melanoma. Methods Thirty-one patients treated with B-Raf proto-oncogene, serine/threonine kinase/MAPK extracellular receptor kinase inhibitors were included between...
Fri Jul 24, 2020 03:00
Immune checkpoint inhibitors (ICI) have altered the prognosis of patients with melanoma over the past few years, with immune-related adverse effects (irAEs) being the only factor limiting their use. Neurologic and cardiac irAEs are rare, but usually severe. We reviewed the files of patients with melanoma treated with ICIs in one center to retrieve data from patients with neurologic irAEs. Patients with a combination of neurologic and cardiac manifestations were further analyzed. We also reviewed...
Fri Jul 24, 2020 03:00
Herein, we wanted to explore the molecular landscape of mucosal melanoma from different sites and identify potential molecular targets for future therapy. Mucosal melanomas (N = 40) from different sites (conjunctiva, sinonasal cavity, rectum, and vagina) were investigated. Targeted next-generation sequencing along with Nanostring gene expression profiling was performed. Genetically, conjunctival melanoma was characterized by BRAF-V600E (30%) and NF1 mutations (17%). Mucosal melanomas at nonsun-exposed...
Fri Jul 24, 2020 03:00
Variants in the Melanocortin 1 Receptor (MC1R) gene have been associated with an increased risk of melanoma, but the role in nevus count is unclear. We investigated if specific MC1R gene variants or the number of MC1R gene variants and phenotypical features were associated with nevus count. A total of 494 participants of the ‘Leiden skin cancer study’ were included and the MC1R gene coding sequence was analysed by single-strand conformation polymorphism analysis followed by sequencing of unknown...
Fri Jul 24, 2020 03:00
Publication date: Available online 29 July 2020Source: European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): M. Puechmaille, C. Lambert, K. Aubry, P. Bordure, A. Bozorg-Grayeli, O. Deguine, C. Eyermann, V. Franco-Vidal, B. Godey, N. Guevara, A. Karkas, N. Klopp, M. Labrousse, J.-P. Lebreton, Y. Lerosey, E. Lescanne, N. Loundon, R. Marianowski, F. Merklen, K. Mezouaghi
Thu Jul 30, 2020 18:14
Publication date: Available online 29 July 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Natasha D. Dombrowski, Youjin Li, Cher X. Zhao, Pankaj B. Agrawal, Reza Rahbar
Thu Jul 30, 2020 17:48
Publication date: Available online 29 July 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Saad Elzayat, Haitham Elfarargy, Ibrahim A. Kabbash, Ihab Nada, Ahmed M. Mehanna, Hossam S. Elsherief
Thu Jul 30, 2020 17:48
Abstract BackgroundMedical robotic has enabled a significant advancement in the field of modern spine surgery, especially in pedicle screw fixation. A plethora of studies focused on the accuracy of pedicle fixation in robotic‐assisted (RA) technology. However, it is not clear whether RA techniques can improve patients' clinical outcomes.MethodsWe retrieved relevant studies that compare the differences between RA and freehand (FH) techniques in spine surgeries from the following databases: PubMed,...
Wed Jul 29, 2020 18:19
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