Δευτέρα 23 Μαρτίου 2020


12/15-Lipoxygenase Deficiency Impairs Neutrophil Granulopoiesis and Lung Proinflammatory Responses to Aspergillus fumigatus [INFECTIOUS DISEASE AND HOST RESPONSE]
Key Points12/15-Lipoxygenase is required for inflammatory responses during fungal infection. 12/15-Lipoxygenase is required for neutrophil granulopoiesis.
The Journal of Immunology current issue
Mon Mar 23, 2020 22:00
TCRs with Distinct Specificity Profiles Use Different Binding Modes to Engage an Identical Peptide-HLA Complex [MOLECULAR AND STRUCTURAL IMMUNOLOGY]
Key PointsA single-chain pHLA phage library was used to profile TCR specificities for pHLA. TCRs that bind to a common peptide can target different features of the peptide. Engaging different peptide features results in distinct peptide repertoires.
The Journal of Immunology current issue
Mon Mar 23, 2020 22:00
Cutting Edge: The Use of Topical Aminoglycosides as an Effective Pull in "Prime and Pull" Vaccine Strategy [CUTTING EDGE]
Key PointsIntravaginal neomycin can pull CD8 T cells to the vaginal mucosa. Neomycin-recruited CD8 T cells become tissue resident and protect mice from HSV-2. Neomycin can replace recombinant chemokine CXCL10 in prime and pull vaccine.
The Journal of Immunology current issue
Mon Mar 23, 2020 22:00
4-1BBL Regulates the Polarization of Macrophages, and Inhibition of 4-1BBL Signaling Alleviates Imiquimod-Induced Psoriasis [INNATE IMMUNITY AND INFLAMMATION]
Key Points4-1BBL signaling regulates metabolism and polarization in macrophages. Blocking 4-1BBL signaling alleviates the severity of psoriasis in mice. Targeting 4-1BBL signaling can be an option for treating psoriasis in patients.
The Journal of Immunology current issue
Mon Mar 23, 2020 22:00
Cutting Edge: Activation-Induced Iron Flux Controls CD4 T Cell Proliferation by Promoting Proper IL-2R Signaling and Mitochondrial Function [CUTTING EDGE]
Key PointsTCR stimulation induces intracellular iron flux that correlates with proliferation. Iron fuels proliferation by contributing to IL-2R signaling in activated T cells. Iron is required for proper mitochondrial function after T cell activation.
The Journal of Immunology current issue
Mon Mar 23, 2020 22:00
Activation of the Intracellular Pattern Recognition Receptor NOD2 Promotes Acute Myeloid Leukemia (AML) Cell Apoptosis and Provides a Survival Advantage in an Animal Model of AML [TUMOR IMMUNOLOGY]
Key PointsIFN- primes the NOD2 pathway in AML, increasing susceptibility to MTP-PE. MTP-PE plus IFN- induces AML blast apoptosis via caspase-1. MTP-PE plus IFN- matures and activates disease-suppressed NK cells.
The Journal of Immunology current issue
Mon Mar 23, 2020 22:00
Natural T Cell Epitope Containing Methyl Lysines on Mycobacterial Heparin-Binding Hemagglutinin [ANTIGEN RECOGNITION AND RESPONSES]
Key PointsPosttranslationally methylated peptides can be recognized by human T cells. Methyl lysines are part of the T cell epitope on heparin-binding hemagglutinin. Methylated peptides induce IFN- secretion upon M. tuberculosis infection.
The Journal of Immunology current issue
Mon Mar 23, 2020 22:00
Antileishmanial Drugs Modulate IL-12 Expression and Inflammasome Activation in Primary Human Cells [INNATE IMMUNITY AND INFLAMMATION]
Key PointsAntileishmanial drugs inhibit CD4 and CD8 T cell proliferation. Antileishmanial drugs inhibit IL-12 expression in monocytes. Amphotericin B induces NLRP3 inflammasome activation.
The Journal of Immunology current issue
Mon Mar 23, 2020 22:00
Slit2 May Underlie Divergent Induction by Thyrotropin of IL-23 and IL-12 in Human Fibrocytes [AUTOIMMUNITY]
Key PointsSlit2, a neuron repellant, can determine fibrocyte cytokine expression repertoires. Slit2 attenuates IL-23 while enhancing IL-12. Divergent IL-23 and IL-12 expression is mediated through JNK.
The Journal of Immunology current issue
Mon Mar 23, 2020 22:00
Circulating Ficolin-2 and Ficolin-3 Form Heterocomplexes [INNATE IMMUNITY AND INFLAMMATION]
Key PointsStable ficolin-2/-3 heterocomplexes exist in normal human serum and plasma. Concentrations of ficolin-2/-3 complexes correlate with ficolin-2 and -3 in plasma.
The Journal of Immunology current issue
Mon Mar 23, 2020 22:00
IL-37 Represses the Autoimmunity in Myasthenia Gravis via Directly Targeting Follicular Th and B Cells [AUTOIMMUNITY]
Key PointsReduced IL-37 was associated with the pathogenesis of MG. Tfh and B cells highly express IL-37 receptor SIGIRR. IL-37 represses the activation of Tfh and B cells via STAT3 signaling.
The Journal of Immunology current issue
Mon Mar 23, 2020 22:00
Osteopontin and iCD8{alpha} Cells Promote Intestinal Intraepithelial Lymphocyte Homeostasis [MUCOSAL IMMUNOLOGY]
Key PointsOsteopontin promotes homeostasis of mouse and human IEL, mediated by its ligand CD44. iCD8α cells produce osteopontin, which impacts the survival of other IEL. Lack of osteopontin renders mice susceptible to intestinal inflammation.
The Journal of Immunology current issue
Mon Mar 23, 2020 22:00
Fumarate Upregulates Surface Expression of ULBP2/ULBP5 by Scavenging Glutathione Antioxidant Capacity [IMMUNE REGULATION]
Key PointsThe citric acid cycle metabolite fumarate upregulates ULBP2/5 surface expression. A high fumarate level induces redox changes, resulting in ROS production. ROS production by fumarate associates with ULBP2/5 surface expression.
The Journal of Immunology current issue
Mon Mar 23, 2020 22:00
Top Reads [TOP READS]
The Journal of Immunology current issue
Mon Mar 23, 2020 22:00
Ezh2 Represses Transcription of Innate Lymphoid Genes in B Lymphocyte Progenitors and Maintains the B-2 Cell Fate [IMMUNE SYSTEM DEVELOPMENT]
Key PointsEzh2 is required for repression of ILC2 transcription factors in pro-B lymphocytes. Lin28b is expressed in Ezh2-deficient pro-B lymphocytes. Ezh2 limits conversion of adult pro-B lymphocytes into fetal-like B-1 cells.
The Journal of Immunology current issue
Mon Mar 23, 2020 22:00
Dendritic Cells of Mesenteric and Regional Lymph Nodes Contribute to Yersinia enterocolitica O:3-Induced Reactive Arthritis in TNFRp55-/- Mice [INFECTIOUS DISEASE AND HOST RESPONSE]
Key PointsIntestinal DCs migrate to RLN on ReA onset. TNFRp55 deficiency promotes CCR7 expression. FTY720 reduces DC migration and suppresses ReA.
The Journal of Immunology current issue
Mon Mar 23, 2020 22:00
Unparalleled Rapid Evolution of KIR Genes in Rhesus and Cynomolgus Macaque Populations [IMMUNOGENETICS]
Key PointsKIR genes evolved rapidly in closely related macaque species and their populations. Hybrid KIR genes in macaques are generated frequently by recombination.
The Journal of Immunology current issue
Mon Mar 23, 2020 22:00
Zebrafish NIK Mediates IFN Induction by Regulating Activation of IRF3 and NF-{kappa}B [INNATE IMMUNITY AND INFLAMMATION]
Key PointsZebrafish NIK positively regulates antiviral response through the induction of IFN. IKKα phosphorylates the NIK at the residue Thr432. The IKKα–NIK complex mediates the activation of IRF3 and NF-B.
The Journal of Immunology current issue
Mon Mar 23, 2020 22:00
Regulatory T Cells Induced by Single-Peptide Liposome Immunotherapy Suppress Islet-Specific T Cell Responses to Multiple Antigens and Protect from Autoimmune Diabetes [IMMUNOTHERAPY AND VACCINES]
Key PointsTolerizing liposomes encapsulate a high-affinity islet CD4+ mimotope with calcitriol. Liposome administration s.c. at onset of hyperglycemia suppresses diabetes progression. Mimotope-specific T cells cross-regulate IGRP-specific CD8+ T cells in PLN.
The Journal of Immunology current issue
Mon Mar 23, 2020 22:00
OTUD1 Negatively Regulates Type I IFN Induction by Disrupting Noncanonical Ubiquitination of IRF3 [INNATE IMMUNITY AND INFLAMMATION]
Key PointsOTUD1 restricts IRF3 activity in a nonproteolytic manner. OTUD1 deubiquitinates and inhibits DNA binding capacity of IRF3. Virus-induced K6-linked ubiquitination of IRF3 is indispensable for its DNA binding capacity.
The Journal of Immunology current issue
Mon Mar 23, 2020 22:00
{gamma}{delta} T Cells Kill Plasmodium falciparum in a Granzyme- and Granulysin-Dependent Mechanism during the Late Blood Stage [INFECTIOUS DISEASE AND HOST RESPONSE]
Key Points T cells expand and develop cytolytic potential in response to malaria cultures. T cells inhibit parasite growth in a contact- and granzyme-dependent manner. Granulysin delivers granzyme B into RBCs to kill late-stage parasites.
The Journal of Immunology current issue
Mon Mar 23, 2020 22:00
Zebrafish GSDMEb Cleavage-Gated Pyroptosis Drives Septic Acute Kidney Injury In Vivo [INNATE IMMUNITY AND INFLAMMATION]
Key PointsGSDMEb is an evolutionary pyroptosis executor downstream of caspy2 in zebrafish. Caspy2–GSDMEb signaling activation drives proximal renal tubular damage. GSDMEb cleavage-mediated pyroptosis enhances septic AKI in vivo.
The Journal of Immunology current issue
Mon Mar 23, 2020 22:00
AMP-Activated Protein Kinase Restricts Zika Virus Replication in Endothelial Cells by Potentiating Innate Antiviral Responses and Inhibiting Glycolysis [INFECTIOUS DISEASE AND HOST RESPONSE]
Key PointsZIKV inhibits AMPK signaling and increases glycolysis to promote viral replication. AMPK potentiates antiviral immune response and inhibits ZIKV-induced glycolysis. AMPK ablation increases ZIKV replication and reduces innate antiviral responses.
The Journal of Immunology current issue
Mon Mar 23, 2020 22:00
Macrophage Migration and Phagocytosis Are Controlled by Kindlin-3's Link to the Cytoskeleton [MOLECULAR AND STRUCTURAL IMMUNOLOGY]
Key PointsKindlin-3–PXN/LPXN interact by the F0 domain of Kindlin-3 and the LIM4 domain of PXN/LPXN. The Kindlin-3–PXN/LPXN link limits membrane blebbing and macrophage migration. Kindlin-3–PXN/LPXN interactions inhibit macrophage phagocytosis.
The Journal of Immunology current issue
Mon Mar 23, 2020 22:00
A TGF-{beta}- and p63-Responsive Enhancer Regulates IFN-{kappa} Expression in Human Keratinocytes [INFECTIOUS DISEASE AND HOST RESPONSE]
Key PointsIFNK expression is regulated by AP2α/, SMAD4, jun-B, and p63 in keratinocytes. The TGF-β pathway activates IFNK expression via jun-B and SMAD4. ERK1/2 inhibit IFNK expression.
The Journal of Immunology current issue
Mon Mar 23, 2020 22:00
Mapping the Chromosomal Insertion Site of the GFP Transgene of UBC-GFP Mice to the MHC Locus [TRANSPLANTATION]
Key PointsThe UBC-GFP transgene is inserted next to the MHC locus on mouse chromosome 17. UBC-GFP BALB/cBy congenic mice retain their founder UBC-GFP C57BL/6 MHC haplotype.
The Journal of Immunology current issue
Mon Mar 23, 2020 22:00
A Novel Neutralizing Antibody Targeting a Unique Cross-Reactive Epitope on the hi Loop of Domain II of the Envelope Protein Protects Mice against Duck Tembusu Virus [INFECTIOUS DISEASE AND HOST RESPONSE]
Key PointsNeutralizing mAb 1G2 recognized only monomer E protein under nonreducing conditions. Broadly cross-reactive epitope 227GSSAGTWQN235 was identified. 1G2 could completely protect mice against lethal DTMUV challenge.
The Journal of Immunology current issue
Mon Mar 23, 2020 22:00
A New Humanized Mouse Model Mimics Humans in Lacking {alpha}-Gal Epitopes and Secreting Anti-Gal Antibodies [NOVEL IMMUNOLOGICAL METHODS]
Key PointsThe NSG/α-Galnull mouse model mimics the human tissues in lacking α-Gal epitopes. Humanized NSG/α-Galnull mice support the development of functional human B cells. Humanized NSG/α-Galnull mice secrete human Abs to α-Gal epitopes.
The Journal of Immunology current issue
Mon Mar 23, 2020 22:00

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