Abstract Bladder cancer (BCa) is one of the most common urinary malignancies in the world. Growing evidence suggests that epithelial-to-mesenchymal transition (EMT) is a major contributor for BCa metastasis. lncRNA small nucleolar RNA host gene 16 (SNHG16) has been reported as a tumor promoter in many cancers. This study aims to investigate the function and mechanism of SNHG16 on EMT in BCa. Quantitative RT-PCR (qRT-PCR) was used to determine the expression of SNHG16 in human BCa...
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The lateral wall deflection is the most intuitive parameter to reveal the stability and safety of underground excavations. The existing automated approaches, such as to serialize dozens of inclinometers along casing pipes, are too expensive to be applied in most common projects. To guarantee stable automation and lower the costs, a novel system based on strain measurement is proposed in this paper to achieve real-time automated monitoring of underground excavations. The specially designed components...
21h
The evolution of nonlinear gravity solitary waves in the atmosphere is related to the formation of severe weather. The nonlinear concentration of gravity solitary wave leads to energy accumulation, which further forms the disastrous weather phenomenon such as squall line. This paper theoretically proves that the formation of squall line in baroclinic nonstatic equilibrium atmosphere can be reduced to the fission process of algebraic gravity solitary waves described by the (2 + 1)-dimensional generalized...
21h
With the rapid development of the urbanization, many underpasses are designed and constructed in big cities to alleviate the huge traffic pressure. The construction method has been changed from traditional on-site concrete pouring technology to prefabricated assembly technology. However, this change will inevitably bring out some new problems to be studied such as the behaviour of the radial joints. In this study, the numerical simulation model of Moziqiao precast and assemble underpass with large...
21h
Purpose. It is well known that interstitial photodynamic therapy (iPDT) of large tumors requires effective planning to ensure efficient delivery of therapeutic dose to the target tumors. This should be achieved in parallel with minimal damage to the nearby intact tissues. To that end, clinical iPDT can be attained using cylindrical diffusing optical fibers (CDFs) as light sources. In this work, we optimize output CDF powers in order to deliver a prescribed light dose to a spherical volume such as...
21h
Scale formation on surfaces in contact with water supersaturated with calcium carbonate creates technical problems, including heat transfer hindrance, energy consumption, and equipment shutdown. Thus, nowadays, there is an increasing need for new approaches that are environmentally friendly and economically feasible. In this work, for the first time, calcium carbonate growth was investigated using UV light exposure, and the growth rate was compared with control and commercial antiscalant. Saturated...
21h
In recent years, the request for the functional beverages that promote health and wellness has increased. In fact, fermented juices are an excellent delivering means for bioactive components. Their production is of crucial importance to supply probiotics, in particular, for people with particulars needs like dairy-product allergic consumers and vegetarians. This review focuses on recent findings regarding the microbial composition and the health benefits of fermented fruit and vegetable beverages...
21h
The objective of the present study is the screening of the gross alpha and gross beta activity of some building materials commercialized in Saudi Arabia. The measurements were carried out using a gas flow proportional counter. The study has shown that the gross alpha activity ranged between 0.21 and 8.27 Bq/kg with an average activity of about 1.96 Bq/kg, whereas the gross beta activity ranged between 6.47 and 276.47 Bq/kg with an average activity of about 65.27 Bq/kg. The obtained values of gross...
21h
Down Syndrome (DS) is the most common chromosomal disorder. Although DS individuals are mostly perceived as characterized by some distinct physical features, cognitive disabilities, and cardiac defects, they also show important dysregulations of immune functions. While critical information is available for adults with DS, little literature is available on the neuroinflammation in prepubertal DS children. We aimed to evaluate in prepubertal DS children the serum levels of nerve growth factor (NGF)...
21h
This paper presents the mitigation of rockfall hazard on the large-scale rock slope using the field tests with numerical simulation. To this end, field tests including the pendulum test and real rock falling tests were performed to investigate the rock movements such as rotation, repulsion, and speed. In the simulation, the validation of the developed model followed by calibration processes was made on the field tests. In this study, a simple and new method was proposed to mitigate the rockfall hazard...
21h
Serious adverse reactions following immunisation with adult tick-borne encephalitis (TBE) vaccines are rare, but when they occur, they most frequently involve the nervous system. We present a case of a female patient who developed a sensory and motor L4 monoradiculopathy following self-injection of an inactivated vaccine against TBE in the ipsilateral quadriceps muscle. The motor and sensory L4 dysfunction vanished after 12 months. TBE vaccine-induced radiculopathy should be considered as a mimic...
21h
This paper presents the characteristics of fly ash which was modified by 2-mercaptobenzothiazole (MBT) and sodium dodecyl sulfate (SDS) as the surfactants after treating with 1M NaOH solution. The change in morphology, specific surface area, crystal structure, and composition of the unmodified and modified fly ash was evaluated by FTIR, XRD, FESEM, BET, and EDX methods and techniques. The FTIR spectra of modified fly ash showed that there was no chemical reaction between the surfactants and fly ash....
21h
Nepal is facing a large-scale labour migration—both internal and international—driven by economic and employment opportunities. There is sparse literature available at the national level which examines the link between migration and contraceptive use. This study aimed at identifying contraceptive use and the unmet need for family planning (FP) and exploring its correlates among the married women of reproductive age (MWRA) by their husbands’ residence status, using data from Nepal Demographic Health...
21h
Background. Gestational diabetes mellitus (GDM) is a severe threat to the health of both mother and child. The pathogenesis of GDM remains unclear, although much research has found that the levels of hydrogen sulfide (H2S) play an important role in complications of pregnancy. Methods. We collected venous blood samples from parturient women and umbilical vein blood (UVB) and peripheral venous blood (PVB) samples one hour after childbirth in the control, GDM-, and GDM+ groups in order to determine...
21h
Background. Whether DNA methyltransferase 1 (DNMT1)/miR-34a/FoxM1 signaling promotes the stemness of liver cancer stem cells (LCSCs) remains unclear. This study aimed to assess whether methylation-based silencing of miR-34a by DNMT1 contributes to stemness features via FoxM1 upregulation in LCSCs. Methods. The CD133+ subgroup of MHCC97H cells sorted by MACS was used as LCSCs. DNMT1, BMI1, SOX2, and OCT4 mRNA levels, and miR-34a amounts were determined by qRT-PCR. DNMT1, CD44, and FoxM1 proteins were...
21h
The effects of nano-SiO2 and superabsorbent polymer on the hydration process of early-age cement paste are investigated through the physically bound water evolution test by means of the low-field nuclear magnetic resonance technology. The test results show that the hydration process can be characterized by four-stage patterns based on the zero points of the second-order differential hydration curve, i.e., the initial, accelerated, decelerated, and steady periods. The beginning time of each stage...
21h
Many factors influence the shear resistance of rock joints. Among them, the above overburden load is the most important factor. The uneven thickness of the overburden causes the joints to be subjected to the nonuniform distribution load. While the peak shear strength shows nonlinear relationship with normal stress, linear superposition cannot be used to calculate the overall shear resistance of joint under nonuniform normal stress distribution. In this paper, the nonlinear shear strength model, JRC-JCS...
21h
Based on the DSSW model, we analyze the nonlinear impact mechanism of investor sentiment on stock return and volatility by adjusting its hypothesis in Chinese stock market. We examine the relationship between investor sentiment, stock return, and volatility by applying OLS regression and quantile regression. Our empirical results show that the effects of investor sentiment on stock market return are asymmetric. There is “Freedman effect” in Chinese stock market, but only optimistic sentiment has...
21h
In this study, we focus our attention on the forecasting of daily PM2.5 concentrations. According to the principle of “divide and conquer,” we propose a novel decomposition ensemble learning approach by integrating ensemble empirical mode decomposition (EEMD), artificial neural networks (ANNs), and adaptive particle swarm optimization (APSO) for forecasting PM2.5 concentrations. Our proposed decomposition ensemble learning approach is formulated exclusively to deal with difficulties in quantitating...
21h
The lagged time on goodwill is a common phenomenon in the process of quality improvement, which plays an important role in making quality strategy of supply chain. With increasing public attention to quality, supply chain quality management has become a research focus in recent years. This paper probes into the lagged time of quality on goodwill under the competitive environment of retailers and constructs a lagged differential equation of quality on goodwill based on the Nerlove–Arrow model. The...
21h
This paper mainly considers the unicity of meromorphic solutions of the Pielou logistic equation , where , and are nonzero polynomials. It shows that the finite order transcendental meromorphic solution of the Pielou logistic equation is mainly determined by its poles and 1-value points. Examples are given for the sharpness of our result.
21h
AbstractIn theory the most powerful technique for functional localization in cognitive neuroscience, lesion-deficit mapping is in practice distorted by unmodelled network disconnections and strong ‘parasitic’ dependencies between collaterally damaged ischaemic areas. High-dimensional multivariate modelling can overcome these defects, but only at the cost of commonly impracticable data scales. Here we develop lesion-deficit mapping with metabolic lesions—discrete areas of hypometabolism typically...
10h
AbstractAmyotrophic lateral sclerosis is a fatal disease resulting from motor neuron degeneration in the cortex and spinal cord. Cortical hyperexcitability is a hallmark feature of amyotrophic lateral sclerosis and is accompanied by decreased intracortical inhibition. Using electrophysiological patch-clamp recordings, we revealed parvalbumin interneurons to be hypoactive in the late pre-symptomatic SOD1*G93A mouse model of amyotrophic lateral sclerosis. We discovered that using adeno-associated virus-mediated...
10h
AbstractFrontotemporal dementia and amyotrophic lateral sclerosis are clinically and pathologically overlapping disorders with shared genetic causes. We previously identified a disease locus on chromosome 16p12.1-q12.2 with genome-wide significant linkage in a large European Australian family with autosomal dominant inheritance of frontotemporal dementia and amyotrophic lateral sclerosis and no mutation in known amyotrophic lateral sclerosis or dementia genes. Here we demonstrate the segregation...
10h
AbstractWe performed post-mortem studies on two patients with advanced Parkinson’s disease 8 and10 years following AAV2-neurturin (CERE120) gene therapy, the longest post-mortem trophic factor gene therapy cases reported to date. CERE120 was delivered to the putamen bilaterally in one case (10 years post-surgery), and to the putamen plus the substantia nigra bilaterally in the second (8 years post-surgery). In both patients there was persistent, albeit limited, neurturin expression in the putamen...
10h
AbstractThis scientific commentary refers to ‘Metabolic lesion-deficit mapping of human cognition’ by Jha etal. (doi:10.1093/brain/awaa032).
10h
Every month, it is hoped that reading the Table of Contents of Brain elicits curiosity and anticipation about the latest developments in translational neuroscience. The reaction that probably does not occur, however, is consternation that men almost always outnumber women among senior authors, at least as far as their genders can be surmised from their first names. The reason that this pattern does not surprise the reader is simply that it has always been thus, yet another manifestation of the under-representation...
10h
AbstractAlzheimer’s disease neurodegeneration is thought to spread across anatomically and functionally connected brain regions. However, the precise sequence of spread remains ambiguous. The prevailing model used to guide in vivo human neuroimaging and non-human animal research assumes that Alzheimer’s degeneration starts in the entorhinal cortices, before spreading to the temporoparietal cortex. Challenging this model, we previously provided evidence that in vivo markers of neurodegeneration within...
10h
AbstractThis scientific commentary refers to ‘Impaired automatic but intact volitional inhibition in primary tic disorders’, by Rawji etal. (doi:10.1093/brain/awaa024).
10h
AbstractThis scientific commentary refers to ‘Gene replacement ameliorates deficits in mouse and human models of cyclin-dependent kinase-like 5 disorder’, by Gao etal. (doi:10.1093/brain/awaa028).
10h
AbstractThis scientific commentary refers to ‘Earliest amyloid and tau deposition modulate the influence of limbic networks during closed-loop hippocampal downregulation’ by Skouras etal. (doi:10.1093/brain/awaa011).
10h
AbstractThe clinical syndromes of frontotemporal dementia are clinically and neuropathologically heterogeneous, but processes such as neuroinflammation may be common across the disease spectrum. We investigated how neuroinflammation relates to the localization of tau and TDP-43 pathology, and to the heterogeneity of clinical disease. We used PET in vivo with (i) 11C-PK-11195, a marker of activated microglia and a proxy index of neuroinflammation; and (ii) 18F-AV-1451, a radioligand with increased...
10h
Dissociation between frontal and temporal-parietal contributions to connected speech in acute stroke
AbstractHumans are uniquely able to retrieve and combine words into syntactic structure to produce connected speech. Previous identification of focal brain regions necessary for production focused primarily on associations with the content produced by speakers with chronic stroke, where function may have shifted to other regions after reorganization occurred. Here, we relate patterns of brain damage with deficits to the content and structure of spontaneous connected speech in 52 speakers during the...
10h
AbstractEpilepsy is a major health burden, calling for new mechanistic insights and therapies. CRISPR-mediated gene editing shows promise to cure genetic pathologies, although hitherto it has mostly been applied ex vivo. Its translational potential for treating non-genetic pathologies is still unexplored. Furthermore, neurological diseases represent an important challenge for the application of CRISPR, because of the need in many cases to manipulate gene function of neurons in situ. A variant of...
10h
AbstractCyclin-dependent kinase-like 5 disorder is a severe neurodevelopmental disorder caused by mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5) gene. It predominantly affects females who typically present with severe early epileptic encephalopathy, global developmental delay, motor dysfunction, autistic features and sleep disturbances. To develop a gene replacement therapy, we initially characterized the human CDKL5 transcript isoforms expressed in the brain, neuroblastoma cell...
10h
AbstractThe defining character of tics is that they can be transiently suppressed by volitional effort of will, and at a behavioural level this has led to the concept that tics result from a failure of inhibition. However, this logic conflates the mechanism responsible for the production of tics with that used in suppressing them. Volitional inhibition of motor output could be increased to prevent the tic from reaching the threshold for expression, although this has been extensively investigated...
10h
AbstractNeurobiological heterogeneity in schizophrenia is poorly understood and confounds current analyses. We investigated neuroanatomical subtypes in a multi-institutional multi-ethnic cohort, using novel semi-supervised machine learning methods designed to discover patterns associated with disease rather than normal anatomical variation. Structural MRI and clinical measures in established schizophrenia (n = 307) and healthy controls (n = 364) were analysed across three sites of PHENOM (Psychosis...
10h
AbstractResearch into hippocampal self-regulation abilities may help determine the clinical significance of hippocampal hyperactivity throughout the pathophysiological continuum of Alzheimer’s disease. In this study, we aimed to identify the effects of amyloid-β peptide 42 (amyloid-β42) and phosphorylated tau on the patterns of functional connectomics involved in hippocampal downregulation. We identified 48 cognitively unimpaired participants (22 with elevated CSF amyloid-β peptide 42 levels, 15...
10h
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