Antibiotics, Vol. 9, Pages 134: Simple and Accurate HPTLC-Densitometric Method for Quantification of Delafloxacin (A Novel Fluoroquinolone Antibiotic) in Plasma Samples: Application to Pharmacokinetic Study in Rats Antibiotics doi: 10.3390/antibiotics9030134 Authors: Prawez Alam Muzaffar Iqbal Essam Ezzeldin Nasr Y. Khalil Ahmed I. Foudah Mohammed H. Alqarni Faiyaz Shakeel Delafloxacin (DLX) is a recently-approved fluoroquinolone antibiotic, which is recommended for...
Mon Mar 23, 2020 02:00
Antibiotics, Vol. 9, Pages 133: Whole Genome Sequencing for the Analysis of Drug Resistant Strains of Mycobacterium tuberculosis: A Systematic Review for Bedaquiline and Delamanid Antibiotics doi: 10.3390/antibiotics9030133 Authors: Luisa Maria Nieto Ramirez Karina Quintero Vargas Gustavo Diaz Tuberculosis (TB) remains the deadliest Infectious disease worldwide, partially due to the increasing dissemination of multidrug and extensively drug-resistant (MDR/XDR) strains. Drug regimens...
Mon Mar 23, 2020 02:00
Antioxidants, Vol. 9, Pages 266: Effects of Melatonin Administration to Pregnant Ewes under Heat-Stress Conditions, in Redox Status and Reproductive Outcome Antioxidants doi: 10.3390/antiox9030266 Authors: Bouroutzika Kouretas Papadopoulos Veskoukis Theodosiadou Makri Paliouras Michailidis Caroprese Valasi Heat stress is a known promoter of reactive oxygen species generation, which may compromise pregnancy and foetal development. Melatonin is a pleiotropic...
Mon Mar 23, 2020 02:00
Antioxidants, Vol. 9, Pages 265: Water Ultrasound-Assisted Extraction of Polyphenol Compounds from Brewer’s Spent Grain: Kinetic Study, Extract Characterization, and Concentration Antioxidants doi: 10.3390/antiox9030265 Authors: Alonso-Riaño Sanz Diez Blanco Beltrán Trigueros Benito-Román Brewer’s spent grain (BSG) was chemically characterized obtaining 52.1% of carbohydrates, 17.8% protein, 5.9% lipids, 13.5% insoluble lignin and 24.3% of water-soluble...
Mon Mar 23, 2020 02:00
Antioxidants, Vol. 9, Pages 264: The Benefits and Risks of Certain Dietary Carotenoids that Exhibit both Anti- and Pro-Oxidative Mechanisms—A Comprehensive Review Antioxidants doi: 10.3390/antiox9030264 Authors: Black Boehm Edge Truscott Carotenoid pigments, particularly β-carotene and lycopene, are consumed in human foodstuffs and play a vital role in maintaining health. β-carotene is known to quench singlet oxygen and can have strong antioxidant activity....
Mon Mar 23, 2020 02:00
Antioxidants, Vol. 9, Pages 263: Prevention of Doxorubicin-Induced Autophagy Attenuates Oxidative Stress and Skeletal Muscle Dysfunction Antioxidants doi: 10.3390/antiox9030263 Authors: Doerr Montalvo Kwon Talbert Hain Houston Smuder Clinical use of the chemotherapeutic doxorubicin (DOX) promotes skeletal muscle atrophy and weakness, adversely affecting patient mobility and strength. Although the mechanisms responsible for DOX-induced skeletal muscle dysfunction...
Mon Mar 23, 2020 02:00
Antioxidants, Vol. 9, Pages 262: Astaxanthin Prevents Mitochondrial Impairment Induced by Isoproterenol in Isolated Rat Heart Mitochondria Antioxidants doi: 10.3390/antiox9030262 Authors: Krestinina Baburina Krestinin Odinokova Fadeeva Sotnikova Mitochondria are considered to be a power station of the cell. It is known that they play a major role in both normal and pathological heart function. Alterations in mitochondrial bioenergetics are one of the main causes...
Mon Mar 23, 2020 02:00
Arts, Vol. 9, Pages 40: Women Architects on the Road to an Egalitarian Profession—The Portuguese and Spanish Cases Arts doi: 10.3390/arts9010040 Authors: Pérez-Moreno Santos Pedrosa The 1970s was a key decade in the path towards democracy in the Iberian Peninsula. Portugal and Spain suffered deep social, cultural and political changes, with Salazar’s and Franco’s Totalitarian Regimes ending in 1974 and 1975 respectively. In both countries, located side-by-side...
Mon Mar 23, 2020 02:00
Atmosphere, Vol. 11, Pages 312: Pillars of Solution for the Problem of Winter PM2.5 Variability in Fresno—Effects of Local Meteorology and Emissions Atmosphere doi: 10.3390/atmos11030312 Authors: Karandana Gamalathge Green Stockwell The mass composition of Particulate Matter (PM) with an aerodynamic diameter of 2.5 microns (PM2.5) in San Joaquin Valley (SJV) is dominated by ammonium nitrate (NH4NO3), a secondary pollutant. The goal of this research was the investigation of the...
Mon Mar 23, 2020 02:00
Atmosphere, Vol. 11, Pages 311: Improvement of Fog Simulation by the Nudging of Meteorological Tower Data in the WRF and PAFOG Coupled Model Atmosphere doi: 10.3390/atmos11030311 Authors: Kim Yum Hong Song Improvement of fog simulation accuracy was investigated for the fogs that occurred on the south coast of the Korean Peninsula using the WRF (3D) and PAFOG (1D) coupled model. In total, 22 fog cases were simulated and accuracy of the fog simulation was examined based on...
Mon Mar 23, 2020 02:00
Biomedicines, Vol. 8, Pages 67: Transcriptomic and Genomic Testing to Guide Individualized Treatment in Chemoresistant Gastric Cancer Case Biomedicines doi: 10.3390/biomedicines8030067 Authors: Moisseev Albert Lubarsky Schroeder Clark Gastric cancer is globally the fifth leading cause of cancer death. We present a case report describing the unique genomic characteristics of an Epstein–Barr virus-negative gastric cancer with esophageal invasion and regional...
Mon Mar 23, 2020 02:00
Biomolecules, Vol. 10, Pages 490: Interactions Under Crowding Milieu: Chemical-Induced Denaturation of Myoglobin is Determined by the Extent of Heme Dissociation on Interaction with Crowders Biomolecules doi: 10.3390/biom10030490 Authors: Nasreen Parray Ahamad Ahmad Ahmed Freeh Alamery Hussain Hassan Islam Generally, in vivo function and structural changes are studied by probing proteins in a dilute solution under in vitro conditions, which is believed...
Mon Mar 23, 2020 02:00
Biomolecules, Vol. 10, Pages 488: BMP-SMAD1/5 Signaling Regulates Retinal Vascular Development Biomolecules doi: 10.3390/biom10030488 Authors: Benn Alonso Mangelschots Génot Lox Zwijsen : Vascular development is an orchestrated process of vessel formation from pre-existing vessels via sprouting and intussusceptive angiogenesis as well as vascular remodeling to generate the mature vasculature. Bone morphogenetic protein (BMP) signaling via intracellular SMAD1 and...
Mon Mar 23, 2020 02:00
Biomolecules, Vol. 10, Pages 489: Site-Specific Lipidomic Signatures of Sea Lettuce (Ulva spp., Chlorophyta) Hold the Potential to Trace Their Geographic Origin Biomolecules doi: 10.3390/biom10030489 Authors: da Costa Ricardo Melo Mamede Abreu Domingues Domingues Calado The wild harvest and aquaculture of Ulva spp. has deserved growing attention in Europe. However, the impact of geographical origin on the biochemical composition of different species and/or...
Mon Mar 23, 2020 02:00
Biomolecules, Vol. 10, Pages 484: Ginsenoside Compound K Induces Adult Hippocampal Proliferation and Survival of Newly Generated Cells in Young and Elderly Mice Biomolecules doi: 10.3390/biom10030484 Authors: Oh Jeong Park Chun Cognitive impairment can be associated with reduced adult hippocampal neurogenesis, and it may contribute to age-associated neurodegenerative diseases such as Alzheimer’s (AD). Compound K (CK) is produced from the protopanaxadiol (PPD)-type...
Mon Mar 23, 2020 02:00
Biomolecules, Vol. 10, Pages 486: Camel Hemorphins Exhibit a More Potent Angiotensin-I Converting Enzyme Inhibitory Activity than Other Mammalian Hemorphins: An In Silico and In Vitro Study Biomolecules doi: 10.3390/biom10030486 Authors: Amanat Ali Seham Abdullah Rashed Alzeyoudi Shamma Abdulla Almutawa Alya Nasir Alnajjar Yusra Al Dhaheri Ranjit Vijayan Angiotensin-I converting enzyme (ACE) is a zinc metallopeptidase that has an important role in regulating the renin-angiotensin-aldosterone...
Mon Mar 23, 2020 02:00
Biomolecules, Vol. 10, Pages 487: TGF-β Signaling Biomolecules doi: 10.3390/biom10030487 Authors: Kalliopi Tzavlaki Aristidis Moustakas Transforming growth factor-β (TGF-β) represents an evolutionarily conserved family of secreted polypeptide factors that regulate many aspects of physiological embryogenesis and adult tissue homeostasis. The TGF-β family members are also involved in pathophysiological mechanisms that underlie many diseases. Although the family...
Mon Mar 23, 2020 02:00
Biomolecules, Vol. 10, Pages 485: Notch3 in Development, Health and Disease Biomolecules doi: 10.3390/biom10030485 Authors: Hosseini-Alghaderi Baron Notch3 is one of four mammalian Notch proteins, which act as signalling receptors to control cell fate in many developmental and adult tissue contexts. Notch signalling continues to be important in the adult organism for tissue maintenance and renewal and mis-regulation of Notch is involved in many diseases. Genetic studies have shown...
Mon Mar 23, 2020 02:00
Biomolecules, Vol. 10, Pages 483: Interactions between Avibactam and Ceftazidime-Hydrolyzing Class D β-Lactamases Biomolecules doi: 10.3390/biom10030483 Authors: Jean-Marie Frère Pierre Bogaerts Te-Din Huang Patrick Stefanic Joël Moray Fabrice Bouillenne Alain Brans Class D β-lactamases exhibit very heterogeneous hydrolysis activity spectra against the various types of clinically useful β-lactams. Similarly, and according to the available data, their...
Mon Mar 23, 2020 02:00
Biosensors, Vol. 10, Pages 29: Spectroscopic and Structural Analysis of Cu2+-Induced Fluorescence Quenching of ZsYellow Biosensors doi: 10.3390/bios10030029 Authors: Kim Xu Nam Fluorescent proteins exhibit fluorescence quenching by specific transition metals, suggesting their potential as fluorescent protein-based metal biosensors. Each fluorescent protein exhibits unique spectroscopic properties and mechanisms for fluorescence quenching by metals. Therefore, the metal-induced...
Mon Mar 23, 2020 02:00
Brain Sciences, Vol. 10, Pages 186: Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) Combined with Aerobic Exercise on the Recovery of Motor Function in Ischemic Stroke Rat Model Brain Sciences doi: 10.3390/brainsci10030186 Authors: Juanxiu Cui Cuk-Seong Kim Yeongwook Kim Min Kyun Sohn Sungju Jee The therapeutic benefits of repetitive transcranial magnetic stimulation (rTMS) combined with rehabilitation therapy on recovery after stroke have not been fully elucidated....
Mon Mar 23, 2020 02:00
Brain Sciences, Vol. 10, Pages 185: Effects of Transcranial Direct Current Stimulation on Hand Dexterity in Multiple Sclerosis: A Design for a Randomized Controlled Trial Brain Sciences doi: 10.3390/brainsci10030185 Authors: Ayache Riachi Ahdab Chalah Background: Cerebellar and motor tracts are frequently impaired in multiple sclerosis (MS). Altered hand dexterity constitutes a challenge in clinical practice, since medical treatment shows very limited benefits in this domain....
Mon Mar 23, 2020 02:00
Brain Sciences, Vol. 10, Pages 184: A Two-Stage Screening Approach with I-TC and Q-CHAT to Identify Toddlers at Risk for Autism Spectrum Disorder within the Italian Public Health System Brain Sciences doi: 10.3390/brainsci10030184 Authors: Raffaella Devescovi Lorenzo Monasta Maura Bin Giulia Bresciani Alice Mancini Marco Carrozzi Costanza Colombi Standardized screening programs ensure that children are monitored for early signs of autism spectrum disorder (ASD) in order...
Mon Mar 23, 2020 02:00
Brain Sciences, Vol. 10, Pages 183: Overcoming Alzheimer’s Disease Stigma by Leveraging Artificial Intelligence and Blockchain Technologies Brain Sciences doi: 10.3390/brainsci10030183 Authors: Alexander Pilozzi Xudong Huang Alzheimer’s disease (AD) imposes a considerable burden on those diagnosed. Faced with a neurodegenerative decline for which there is no effective cure or prevention method, sufferers of the disease are subject to judgement, both self-imposed and otherwise,...
Mon Mar 23, 2020 02:00
Cancers, Vol. 12, Pages 757: LRRC15 Targeting in Soft-Tissue Sarcomas: Biological and Clinical Implications Cancers doi: 10.3390/cancers12030757 Authors: Eytan Ben-Ami Raul Perret Ying Huang Félicie Courgeon Prafulla C. Gokhale Audrey Laroche-Clary Benjamin K. Eschle Valérie Velasco François Le Loarer Marie-Paule Algeo James Purcell George D. Demetri Antoine Italiano Background: LRRC15 is a member of the LRR (leucine-rich repeat) superfamily present...
Mon Mar 23, 2020 02:00
Cancers, Vol. 12, Pages 756: Analysis of Dual Class I Histone Deacetylase and Lysine Demethylase Inhibitor Domatinostat (4SC-202) on Growth and Cellular and Genomic Landscape of Atypical Teratoid/Rhabdoid Cancers doi: 10.3390/cancers12030756 Authors: Mariah M. Hoffman Jessica S. Zylla Somshuvra Bhattacharya Kristin Calar Timothy W. Hartman Ratan D. Bhardwaj W. Keith Miskimins Pilar de la Puente Etienne Z. Gnimpieba Shanta M. Messerli Central nervous system...
Mon Mar 23, 2020 02:00
Cancers, Vol. 12, Pages 759: Evaluation of Circulating miRNA Biomarkers of Testicular Germ Cell Tumors during Therapy and Follow-up―A Copenhagen Experience Cancers doi: 10.3390/cancers12030759 Authors: Nina Mørup Ewa Rajpert-De Meyts Anders Juul Gedske Daugaard Kristian Almstrup New microRNA-based serum biomarkers (miRNA-367-3p, -371a-3p, -372-3p, and -373-3p) have shown great potential for the detection of testicular germ cell tumors (TGCTs), but few studies have investigated...
Mon Mar 23, 2020 02:00
Cancers, Vol. 12, Pages 758: MeCP2 Promotes Colorectal Cancer Metastasis by Modulating ZEB1 Transcription Cancers doi: 10.3390/cancers12030758 Authors: Dan Luo Wei Ge Background: Recurrence and distant organ metastasis is a major cause of death in colorectal cancer (CRC); however, the underlying molecular mechanisms regulating this phenomenon are poorly understood. MeCP2 is a key epigenetic regulator and is amplified in many types of cancer. Its role in CRC and the molecular mechanisms...
Mon Mar 23, 2020 02:00
Cancers, Vol. 12, Pages 760: CRIPTO and miR-371a-3p Are Serum Biomarkers of Testicular Germ Cell Tumors and Are Detected in Seminal Plasma from Azoospermic Males Cancers doi: 10.3390/cancers12030760 Authors: Cassy M. Spiller João Lobo Willem P. A. Boellaard Ad J. M. Gillis Josephine Bowles Leendert H. J. Looijenga miR-371a-3p is currently the most informative reported biomarker for germ cell tumors (GCTs). Another developmental-related biomarker, CRIPTO, is involved in...
Mon Mar 23, 2020 02:00
Cancers, Vol. 12, Pages 754: Early Tumor Shrinkage as a Predictive Factor for Outcomes in Hepatocellular Carcinoma Patients Treated with Lenvatinib: A Multicenter Analysis Cancers doi: 10.3390/cancers12030754 Authors: Aya Takahashi Michihisa Moriguchi Yuya Seko Toshihide Shima Yasuhide Mitsumoto Hidetaka Takashima Hiroyuki Kimura Hideki Fujii Hiroki Ishikawa Yo Takaharu Hiroshi Ishiba Atsuhiro Morita Masayasu Jo Yasuyuki Nagao Masahiro Arai Tasuku...
Mon Mar 23, 2020 02:00
Cancers, Vol. 12, Pages 755: Landscape of Mitochondria Genome and Clinical Outcomes in Stage 1 Lung Adenocarcinoma Cancers doi: 10.3390/cancers12030755 Authors: Lovely Raghav Ya-Hsuan Chang Yi-Chiung Hsu Yu-Cheng Li Chih-Yi Chen Tsung-Ying Yang Kun-Chieh Chen Kuo-Hsuan Hsu Jeng-Sen Tseng Cheng-Yen Chuang Mei-Hsuan Lee Chih-Liang Wang Huei-Wen Chen Sung-Liang Yu Sheng-Fang Su Shin-Sheng Yuan Jeremy J.W. Chen Shinn-Ying Ho Ker-Chau Li Pan-Chyr...
Mon Mar 23, 2020 02:00
Cells, Vol. 9, Pages 783: A Wnt-BMP4 Signaling Axis Induces MSX and NOTCH Proteins and Promotes Growth Suppression and Differentiation in Neuroblastoma Cells doi: 10.3390/cells9030783 Authors: Marianna Szemes Zsombor Melegh Jacob Bellamy Alexander Greenhough Madhu Kollareddy Daniel Catchpoole Karim Malik The Wnt and bone morphogenetic protein (BMP) signaling pathways are known to be crucial in the development of neural crest lineages, including the sympathetic nervous...
Mon Mar 23, 2020 02:00
Cells, Vol. 9, Pages 782: Cell-Substrate Patterns Driven by Curvature-Sensitive Actin Polymerization: Waves and Podosomes Cells doi: 10.3390/cells9030782 Authors: Moshe Naoz Nir S. Gov Cells adhered to an external solid substrate are observed to exhibit rich dynamics of actin structures on the basal membrane, which are distinct from those observed on the dorsal (free) membrane. Here we explore the dynamics of curved membrane proteins, or protein complexes, that recruit actin polymerization...
Mon Mar 23, 2020 02:00
Cells, Vol. 9, Pages 780: Role of Histone Deacetylases in Carcinogenesis: Potential Role in Cholangiocarcinoma Cells doi: 10.3390/cells9030780 Authors: Kishor Pant Estanislao Peixoto Seth Richard Sergio A. Gradilone Cholangiocarcinoma (CCA) is a highly invasive and metastatic form of carcinoma with bleak prognosis due to limited therapies, frequent relapse, and chemotherapy resistance. There is an urgent need to identify the molecular regulators of CCA in order to develop novel...
Mon Mar 23, 2020 02:00
Cells, Vol. 9, Pages 781: Electrical Stimulation Induces Retinal Müller Cell Proliferation and Their Progenitor Cell Potential Cells doi: 10.3390/cells9030781 Authors: Sam Enayati Karen Chang Hamida Achour Kin-Sang Cho Fuyi Xu Shuai Guo Katarina Z. Enayati Jia Xie Eric Zhao Tytteli Turunen Amer Sehic Lu Lu Tor Paaske Utheim Dong Feng Chen Non-invasive electrical stimulation (ES) is increasingly applied to improve vision in untreatable eye conditions,...
Mon Mar 23, 2020 02:00
Cells, Vol. 9, Pages 779: Transcriptomic Insights into Mechanisms of Early Seed Maturation in the Garden Pea (Pisum sativum L.) Cells doi: 10.3390/cells9030779 Authors: Yury V. Malovichko Oksana Y. Shtark Ekaterina N. Vasileva Anton A. Nizhnikov Kirill S. Antonets The garden pea (Pisum sativum L.) is a legume crop of immense economic value. Extensive breeding has led to the emergence of numerous pea varieties, of which some are distinguished by accelerated development in...
Mon Mar 23, 2020 02:00
Cells, Vol. 9, Pages 777: The Proteasomal Deubiquitinating Enzyme PSMD14 Regulates Macroautophagy by Controlling Golgi-to-ER Retrograde Transport Cells doi: 10.3390/cells9030777 Authors: Hianara A Bustamante Karina Cereceda Alexis E González Guillermo E Valenzuela Yorka Cheuquemilla Sergio Hernández Eloisa Arias-Muñoz Cristóbal Cerda-Troncoso Susanne Bandau Andrea Soza Gudrun Kausel Bredford Kerr Gonzalo A Mardones Jorge Cancino Ronald T Hay Alejandro...
Mon Mar 23, 2020 02:00
Cells, Vol. 9, Pages 778: Fibronectin Adsorption on Electrospun Synthetic Vascular Grafts Attracts Endothelial Progenitor Cells and Promotes Endothelialization in Dynamic In Vitro Culture Cells doi: 10.3390/cells9030778 Authors: Ruben Daum Dmitri Visser Constanze Wild Larysa Kutuzova Maria Schneider Günter Lorenz Martin Weiss Svenja Hinderer Ulrich A. Stock Martina Seifert Katja Schenke-Layland Appropriate mechanical properties and fast endothelialization...
Mon Mar 23, 2020 02:00
Cells, Vol. 9, Pages 776: Graphene Oxide Nanosheets for Localized Hyperthermia—Physicochemical Characterization, Biocompatibility, and Induction of Tumor Cell Death Cells doi: 10.3390/cells9030776 Authors: Malgorzata J. Podolska Alexandre Barras Christoph Alexiou Benjamin Frey Udo Gaipl Rabah Boukherroub Sabine Szunerits Christina Janko Luis E. Muñoz Background: The main goals of cancer treatment are not only to eradicate the tumor itself but also to elicit a...
Mon Mar 23, 2020 02:00
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου