Leukotriene Pathway Activation Associates with Poor Glycemic Control and with Cardiovascular Autonomic Neuropathy in Type 1 Diabetes:
Background and Aims. Since hyperglycemia promotes inflammation by different pathways and inflammation participates in the development of chronic diabetes complications, we investigated the association between the leukotriene (LT) pathway and microvascular diabetes complications. Methods and Results. Quantitative polymerase chain reaction was employed to quantify the expression of ALOX5 (encodes 5-lipoxygenase), LTB4R (encodes one of the LTB4 receptors), and MYD88 in peripheral blood mononuclear cells from 164 type 1 diabetes (T1D) individuals presenting or not diabetes kidney disease, retinopathy, peripheral neuropathy, and cardiovascular autonomic neuropathy (CAN); 26 nondiabetic subjects were included as controls. LTB4 plasmatic concentrations were also evaluated. The expression of LTB4R was significantly higher in T1D individuals than in controls. T1D individuals with microvascular complications presented lower MYD88 mRNA expression when compared to those without microvascular complications. Higher LTB4 concentrations were found in individuals with CAN versus without CAN. The observation of two distinct subgroups of T1D individuals in the correlation analyses motivated us to evaluate the characteristics of each one of these groups separately. The group presenting higher expression of ALOX5 and of LTB4R also presented higher values of HbA1C, of fructosamine, and of plasmatic LTB4. Conclusion. In the diabetes setting, the LT pathway is not only activated by hyperglycemia but is also modulated by the status of the autonomic nervous system.
Medicine RSS-Feeds by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com
Πληροφορίες
Δευτέρα 23 Μαρτίου 2020
Leukotriene Pathway Activation Associates with Poor Glycemic Control and with Cardiovascular Autonomic Neuropathy in Type 1 Diabetes
Αναρτήθηκε από
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
στις
11:39 μ.μ.
Ετικέτες
00302841026182,
00306932607174,
alsfakia@gmail.com,
Anapafseos 5 Agios Nikolaos 72100 Crete Greece,
Medicine by Alexandros G. Sfakianakis,
Telephone consultation 11855 int 1193
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Αρχειοθήκη ιστολογίου
-
►
2023
(366)
- ► Φεβρουαρίου (184)
- ► Ιανουαρίου (182)
-
►
2022
(2814)
- ► Δεκεμβρίου (182)
- ► Σεπτεμβρίου (213)
- ► Φεβρουαρίου (264)
- ► Ιανουαρίου (262)
-
►
2021
(3815)
- ► Δεκεμβρίου (229)
- ► Σεπτεμβρίου (276)
- ► Φεβρουαρίου (64)
-
▼
2020
(5754)
- ► Δεκεμβρίου (401)
- ► Σεπτεμβρίου (365)
-
▼
Μαρτίου
(804)
-
▼
Μαρ 23
(59)
- [Subjective method for tracheal tube cuff inflatio...
- Ophthalmic Plastic & Reconstructive Surgery -...
- Change in Lower Eyelid Contour Following Ectropion...
- Locking Y Lateral Canthopexy as a Treatment for Dr...
- Merocel Surgicel Wrap Technique to Manage Diffuse ...
- Carbon ion radiotherapy for skull base chordomas a...
- Primary empty sella syndrome associated with visua...
- Prediction of failed facemask ventilation: new sco...
- Malignes Melanom
- Magnetic resonance imaging for brain stereotactic ...
- A Systematic Review of the Influence of Bolus Char...
- This ancient optical illusion is a 14,000-year-old...
- Asthma and allergic diseases are a phenotypic mark...
- Pre-Operative Penicillin Allergy Testing in Cardia...
- The Journey to an RSV Vaccine
- Graves Disease With Thyroid-Stimulating Hormone Re...
- A Prospective, Phase 1 Trial of Nivolumab, Ipilimu...
- Efficacy of Botulinum Toxin in Treating Patients w...
- Protein Kinase A Is Involved in Neuropathic Pain b...
- Leukotriene Pathway Activation Associates with Poo...
- Colorimetric Identification of Lanthanide Ions Bas...
- Quantitative analysis of direct oral anticoagulant...
- Lipidomic Profiling of Virus Infection Identifies ...
- Therapeutic effect of intraductal saline irrigatio...
- Roles of CCNB2 and NKX3-1 in Nasopharyngeal Carcinoma
- 7,8-Dihydroxyflavone alleviated the high-fat diet ...
- Intermittent access coc
- The American Journal of Surgical Pathology - ...
- Videolaryngoscopy Quality with Protective Cover of...
- Salivary Secretory Carcinoma Harboring a Novel ALK...
- Pediatric thyroid cancer: Risk factors for central...
- Overlap
- Osmotic Demyelination Syndrome in a Patient with H...
- Endotracheal tube fixation time: a comparison of t...
- Toxins,
- Nanomat
- Journal of Clinical Medicine
- International Journal of Molecular Sciences,
- Cosmetics,
- Antibioti
- Medicine
-
▼
Μαρ 23
(59)
- ► Φεβρουαρίου (754)
- ► Ιανουαρίου (894)
-
►
2019
(146)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου