Δευτέρα 23 Μαρτίου 2020


Venetoclax with Azacytidine Improved Overall Survival for Patients with AML
Genentech recently announced their phase III study resulted in improved overall survival and composite complete remission rates for patients with previously untreated acute myeloid leukemia. (Source: CancerNetwork)
CancerNetwork
3h
Adults with NSCLC and Impaired Performance Status Face Shorter Survival after ICI Treatment
Adults with advanced non-small cell lung cancer and impaired performance status experience significantly shorter survival after treatment with immune checkpoint inhibitors (ICIs) and receive ICIs more often than those with better performance status. (Source: CancerNetwork)
CancerNetwork
3h
Study Highlights Importance of Progression-Related End Points in Cancer
This study examined the association of disease progression and the deterioration of health-related quality of life for patients with metastatic breast, pancreatic, lung, and colorectal cancer. (Source: CancerNetwork)
CancerNetwork
3h
Potential for Prognostic Biomarkers in T1 Colorectal Cancer Treatment Selection
In this study, researchers found that endoscopic therapy was the most effective strategy for patients with T1 CRC with less aggressive biomarker profiles and laparoscopic colectomy was the most effective for patients with more aggressive profiles. (Source: CancerNetwork)
CancerNetwork
3h
Identification and validation of an immunogenic subtype of gastric cancer with abundant intratumoural CD103<sup>+</sup>CD8<sup>+</sup> T cells conferring favourable prognosis
British Journal of Cancer, Published online: 24 March 2020; doi:10.1038/s41416-020-0813-yIdentification and validation of an immunogenic subtype of gastric cancer with abundant intratumoural CD103+CD8+ T cells conferring favourable prognosis
British Journal of Cancer - Issue - nature.com science feeds
3h
Immune phenotype and histopathological growth pattern in patients with colorectal liver metastases
British Journal of Cancer, Published online: 24 March 2020; doi:10.1038/s41416-020-0812-zImmune phenotype and histopathological growth pattern in patients with colorectal liver metastases
British Journal of Cancer - Issue - nature.com science feeds
3h
Immune phenotype and histopathological growth pattern in patients with colorectal liver metastases
British Journal of Cancer - Issue - nature.com science feeds
6h
Identification and validation of an immunogenic subtype of gastric cancer with abundant intratumoural CD103<sup>+</sup>CD8<sup>+</sup> T cells conferring favourable prognosis
British Journal of Cancer - Issue - nature.com science feeds
6h
Nachruf auf Prof. Dr. med. Wilfried Schilli
Latest Results for Der MKG-Chirurg
3h
A neuroglobin-based hig-affinity ligand trap reverses carbon monoxide-induced mitochondrial poisoning [Molecular Biophysics]
Carbon monoxide (CO) remains the most common cause of human poisoning. The consequences of CO poisoning include cardiac dysfunction, brain injury, and death. CO causes toxicity by binding to hemoglobin and by inhibiting mitochondrial cytochrome c oxidase (CcO), thereby decreasing oxygen delivery and inhibiting oxidative phosphorylation. We have recently developed a CO antidote based on human neuroglobin (Ngb-H64Q-CCC). This molecule enhances clearance of CO from red blood cells in vitro and in vivo....
JBC Papers in Press
4h
5-Ethynyl-2’-deoxycytidine and 5-ethynyl-2’-deoxyuridine are differentially incorporated in cells infected with HSV-1, HCMV, and KSHV viruses [Microbiology]
Nucleoside analogs are a valuable experimental tool. Incorporation of these molecules into newly synthesized DNA (i.e. pulse-labeling) is used to monitor cell proliferation or to isolate nascent DNA. Some of the most common nucleoside analogs used for pulse-labeling of DNA in cells are the deoxypyrimidine analogs 5-ethynyl-2’-deoxyuridine (EdU) and 5-ethynyl-2’-deoxycytidine (EdC). Click chemistry enables conjugation of an azide molecule tagged with a fluorescent dye or biotin to the alkyne of the...
JBC Papers in Press
4h
Endorepellin evokes an angiostatic stress signaling cascade in endothelial cells [Glycobiology and Extracellular Matrices]
Endorepellin, the C-terminal fragment of the heparan sulfate proteoglycan perlecan, influences various signaling pathways in endothelial cells by binding to VEGFR2. In this study, we discovered that soluble endorepellin activates the canonical stress signaling pathway consisting of PERK, eIF2α, ATF4 and GADD45α. Specifically, endorepellin evoked transient activation of VEGFR2 which in turn phosphorylated PERK at Thr980. Subsequently, PERK phosphorylated eIF2αat Ser51, thereby upregulating its downstream...
JBC Papers in Press
4h
COQ11 deletion mitigates respiratory deficiency caused by mutations in the gene encoding the coenzyme Q chaperone protein Coq10 [Lipids]
Coenzyme Q (Qn) is a vital lipid component of the electron transport chain that functions in cellular energy metabolism and as a membrane antioxidant. In the yeast Saccharomyces cerevisiae, coq1–coq9 deletion mutants are respiratory incompetent, sensitive to lipid peroxidation stress, and unable to synthesize Q6. The yeast coq10 deletion mutant is also respiratory deficient and sensitive to lipid peroxidation, yet continues to produce Q6 at an impaired rate. Thus, Coq10 is required for the function...
JBC Papers in Press
4h
Philips boosts production in light of COVID-19 demands
Royal Philips, the parent company of Philips Healthcare, is increasing production...Read more on AuntMinnieEurope.comRelated Reading: Philips lands 8-year equipment deal with Paracelsus Philips, ESR partner on ultrasound program at ECR 2020 Philips reports Q4 growth, but coronavirus begins to bite Philips secures Danish deal for CT scanners Philips to launch clinical stroke workflow trial, sets milestone
AuntMinnieEurope.com Headlines
4h
Behold.ai trains AI to detect COVID-19 on x-ray
U.K. artificial intelligence (AI) software developer Behold.ai has trained...Read more on AuntMinnieEurope.comRelated Reading: Behold.ai wins FDA approval for red dot AI algorithm Algorithm helps predict cancer in 10 out of 11 cases NHS trust adds AI to radiology reporting AI start-up Behold.AI appoints chief medical officer Medica Group founder acquires AI firm
AuntMinnieEurope.com Headlines
6h
Breast screening suspended in Wales due to coronavirus
The Welsh government has announced a plan to suspend nonurgent outpatient appointments...Read more on AuntMinnieEurope.comRelated Reading: How radiology can get ready for coronavirus crisis Italy leverages 3D printing to combat coronavirus CT helps determine coronavirus severity, treatment RCR sees no role for CT in coronavirus diagnosis French group calls for more coronavirus protection
AuntMinnieEurope.com Headlines
6h
DRG releases update on children and COVID-19
The German Röntgen Society (DRG) has posted an overview written by Dr. Thekla...Read more on AuntMinnieEurope.comRelated Reading: How radiology can get ready for coronavirus crisis Prepare for COVID-19 crisis, U.K. experts urge Report: Radiology seminar linked to COVID-19 spread Imaging experts strive to get a grip on COVID-19 Chest CT beats DNA tests for early coronavirus diagnosis
AuntMinnieEurope.com Headlines
11h
VIDI joins forces with French public hospitals to deliver imaging
The largest private imaging network in France, VIDI, is collaborating closely...Read more on AuntMinnieEurope.comRelated Reading: How radiology can get ready for coronavirus crisis ESR's live event on COVID-19 attracts over 100K views Prepare for COVID-19 crisis, U.K. experts urge French group calls for more coronavirus protection VIDI expands network in France
AuntMinnieEurope.com Headlines
12h
PET can help predict survival in prostate cancer
German and Swiss researchers have developed a PET-based risk classification...Read more on AuntMinnieEurope.comRelated Reading: EANM offers prostate cancer care prerequisites Ga-68 PSMA PET/CT corrects therapy, saves money Swiss cast new light on prostate cancer analysis Ga-68 PMSA PET/CT aids in prostate cancer recurrence PET/CT proves clinical value in prostate cancer
AuntMinnieEurope.com Headlines
14h
10 key actions to implement molecular radiotherapy
A European team of nuclear medicine specialists has proposed a 10-point plan...Read more on AuntMinnieEurope.comRelated Reading: MRI-guided radiotherapy progresses in clinical arena ICSCNM updates molecular radiotherapy guidance MRI minimizes toxicity in prostate cancer radiotherapy EANM releases guidance on molecular radiotherapy First-in-human data validate MRI-guided radiotherapy
AuntMinnieEurope.com Headlines
22h
U.K. doctor misses lymphoma on 13-year-old girl's x-ray
A senior U.K. National Health Service (NHS) doctor failed to identify lymphoma...Read more on AuntMinnieEurope.comRelated Reading: U.K. NHS consortium renews Sectra PACS contract NHS trust creates breast cancer screening improvement post More women in England getting screened for breast cancer U.K. public still trusts NHS, despite mammo screening glitch NHS plans artificial intelligence lab
AuntMinnieEurope.com Headlines
22h

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