Genentech recently announced their phase III study resulted in improved overall survival and composite complete remission rates for patients with previously untreated acute myeloid leukemia. (Source: CancerNetwork)
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Adults with advanced non-small cell lung cancer and impaired performance status experience significantly shorter survival after treatment with immune checkpoint inhibitors (ICIs) and receive ICIs more often than those with better performance status. (Source: CancerNetwork)
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This study examined the association of disease progression and the deterioration of health-related quality of life for patients with metastatic breast, pancreatic, lung, and colorectal cancer. (Source: CancerNetwork)
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In this study, researchers found that endoscopic therapy was the most effective strategy for patients with T1 CRC with less aggressive biomarker profiles and laparoscopic colectomy was the most effective for patients with more aggressive profiles. (Source: CancerNetwork)
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British Journal of Cancer, Published online: 24 March 2020; doi:10.1038/s41416-020-0813-yIdentification and validation of an immunogenic subtype of gastric cancer with abundant intratumoural CD103+CD8+ T cells conferring favourable prognosis
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British Journal of Cancer, Published online: 24 March 2020; doi:10.1038/s41416-020-0812-zImmune phenotype and histopathological growth pattern in patients with colorectal liver metastases
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Carbon monoxide (CO) remains the most common cause of human poisoning. The consequences of CO poisoning include cardiac dysfunction, brain injury, and death. CO causes toxicity by binding to hemoglobin and by inhibiting mitochondrial cytochrome c oxidase (CcO), thereby decreasing oxygen delivery and inhibiting oxidative phosphorylation. We have recently developed a CO antidote based on human neuroglobin (Ngb-H64Q-CCC). This molecule enhances clearance of CO from red blood cells in vitro and in vivo....
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Nucleoside analogs are a valuable experimental tool. Incorporation of these molecules into newly synthesized DNA (i.e. pulse-labeling) is used to monitor cell proliferation or to isolate nascent DNA. Some of the most common nucleoside analogs used for pulse-labeling of DNA in cells are the deoxypyrimidine analogs 5-ethynyl-2’-deoxyuridine (EdU) and 5-ethynyl-2’-deoxycytidine (EdC). Click chemistry enables conjugation of an azide molecule tagged with a fluorescent dye or biotin to the alkyne of the...
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Endorepellin, the C-terminal fragment of the heparan sulfate proteoglycan perlecan, influences various signaling pathways in endothelial cells by binding to VEGFR2. In this study, we discovered that soluble endorepellin activates the canonical stress signaling pathway consisting of PERK, eIF2α, ATF4 and GADD45α. Specifically, endorepellin evoked transient activation of VEGFR2 which in turn phosphorylated PERK at Thr980. Subsequently, PERK phosphorylated eIF2αat Ser51, thereby upregulating its downstream...
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Coenzyme Q (Qn) is a vital lipid component of the electron transport chain that functions in cellular energy metabolism and as a membrane antioxidant. In the yeast Saccharomyces cerevisiae, coq1–coq9 deletion mutants are respiratory incompetent, sensitive to lipid peroxidation stress, and unable to synthesize Q6. The yeast coq10 deletion mutant is also respiratory deficient and sensitive to lipid peroxidation, yet continues to produce Q6 at an impaired rate. Thus, Coq10 is required for the function...
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Royal Philips, the parent company of Philips Healthcare, is increasing production...Read more on AuntMinnieEurope.comRelated Reading: Philips lands 8-year equipment deal with Paracelsus Philips, ESR partner on ultrasound program at ECR 2020 Philips reports Q4 growth, but coronavirus begins to bite Philips secures Danish deal for CT scanners Philips to launch clinical stroke workflow trial, sets milestone
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U.K. artificial intelligence (AI) software developer Behold.ai has trained...Read more on AuntMinnieEurope.comRelated Reading: Behold.ai wins FDA approval for red dot AI algorithm Algorithm helps predict cancer in 10 out of 11 cases NHS trust adds AI to radiology reporting AI start-up Behold.AI appoints chief medical officer Medica Group founder acquires AI firm
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The Welsh government has announced a plan to suspend nonurgent outpatient appointments...Read more on AuntMinnieEurope.comRelated Reading: How radiology can get ready for coronavirus crisis Italy leverages 3D printing to combat coronavirus CT helps determine coronavirus severity, treatment RCR sees no role for CT in coronavirus diagnosis French group calls for more coronavirus protection
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The German Röntgen Society (DRG) has posted an overview written by Dr. Thekla...Read more on AuntMinnieEurope.comRelated Reading: How radiology can get ready for coronavirus crisis Prepare for COVID-19 crisis, U.K. experts urge Report: Radiology seminar linked to COVID-19 spread Imaging experts strive to get a grip on COVID-19 Chest CT beats DNA tests for early coronavirus diagnosis
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The largest private imaging network in France, VIDI, is collaborating closely...Read more on AuntMinnieEurope.comRelated Reading: How radiology can get ready for coronavirus crisis ESR's live event on COVID-19 attracts over 100K views Prepare for COVID-19 crisis, U.K. experts urge French group calls for more coronavirus protection VIDI expands network in France
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German and Swiss researchers have developed a PET-based risk classification...Read more on AuntMinnieEurope.comRelated Reading: EANM offers prostate cancer care prerequisites Ga-68 PSMA PET/CT corrects therapy, saves money Swiss cast new light on prostate cancer analysis Ga-68 PMSA PET/CT aids in prostate cancer recurrence PET/CT proves clinical value in prostate cancer
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A European team of nuclear medicine specialists has proposed a 10-point plan...Read more on AuntMinnieEurope.comRelated Reading: MRI-guided radiotherapy progresses in clinical arena ICSCNM updates molecular radiotherapy guidance MRI minimizes toxicity in prostate cancer radiotherapy EANM releases guidance on molecular radiotherapy First-in-human data validate MRI-guided radiotherapy
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A senior U.K. National Health Service (NHS) doctor failed to identify lymphoma...Read more on AuntMinnieEurope.comRelated Reading: U.K. NHS consortium renews Sectra PACS contract NHS trust creates breast cancer screening improvement post More women in England getting screened for breast cancer U.K. public still trusts NHS, despite mammo screening glitch NHS plans artificial intelligence lab
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