AbstractConsidering the important role of the Internet in health information seeking by consumers, it is critical to examine the health information that is available to them through the Internet. This study contributes to existing knowledge by employing a content analysis to examine visual and textual information on prescription medication websites. A stratified random sample was selected from a list of the 100 most-prescribed medications in the United States. Findings point to under-utilization...
AbstractAlcohol education must ensure that young people have appropriate information, motivation and skills. This article describes the fifth phase in a program of intervention development based on principles of social marketing and intervention mapping. The aim was to enhance drink refusal self-efficacy (DRSE) and help develop skills for non-drinking or moderate drinking. We conducted a mixed-methods feasibility trial that measured intervention effects among 277 UK secondary school students aged...
AbstractLimiting ultraviolet radiation exposure during early childhood can significantly reduce the risk of developing skin cancer, making early childhood a critical time for sun protection strategies. This study aimed to measure sun protection practices utilized in Australian early-childhood services over the past decade and evaluate the impact of Cancer Council Australia’s SunSmart Early-Childhood Program. Results are presented from cross-sectional and repeated-measures survey data, completed by...
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Abstract Background The gastro-omental artery (GOA) and the greater omentum are nowadays commonly used in many reconstructive surgeries, including cardiac, vascular, and plastic surgery. There are cases in which the GOA is found to be unsuitable only after partial harvesting following an upper laparotomy, and an improved method of pre-operative evaluation is required to eliminate the need for intraoperative small laparotomy. ...
Abstract Endometriosis constitutes the presence of ectopic endometrial glands and stroma outside the uterine endometrium, which is hormonally responsive and responds to pregnancy hormones as well. Decidualization is a physiologic process, where the normal endometrium readies itself for optimal accommodation of a pregnancy. A similar hormonal response can be seen with ectopic endometrium as well. As such, ovarian endometriomas and deep endometriosis implants can undergo decidualization....
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The UN General Assembly has emphasised that the right to freedom of thought, conscience, and religion or belief applies equally to all people, regardless of their religion or belief and without any...
The UN General Assembly has emphasised that the right to freedom of thought, conscience, and religion or belief applies equally to all people, regardless of their religion or belief and without any...
President Donald Trump said he was activating the National Guard to help the three states hit hardest by covid-19.New York State has more than 15 000 cases: 10 764 in the city and many others in its...
I agree with Heath and Hartling that the emotional impact and societal message of physician assisted dying needs to be considered in the context of a society that does not value older age and wisdom...
President Donald Trump said he was activating the National Guard to help the three states hit hardest by covid-19.New York State has more than 15 000 cases: 10 764 in the city and many others in its...
I agree with Heath and Hartling that the emotional impact and societal message of physician assisted dying needs to be considered in the context of a society that does not value older age and wisdom...
Women who are more than 28 weeks pregnant should avoid direct contact with patients—whether or not they could be infected with covid-19, says updated guidance. Those who are less than 28 weeks...
The World Health Organization is the most influential global body guiding responses to the covid-19 pandemic. It is working around the clock to issue helpful guidance for technical experts and the...
New clinical trials are being suspended to prioritise covid-19 studies and enable the redeployment of clinical staff to frontline care, the National Institute for Health Research (NIHR) has...
A million and a half people in England who are at very high risk of severe illness and admission to hospital because of covid-12 will receive a letter this week asking them to stay at home for at...
An NHS consultant has called for NHS staff working during the covid-19 pandemic to be rewarded with rest areas and free parking.Speaking to LBC radio on 19 March the intensive care consultant known...
The studyPowell J, Atherton H, Williams V, et al. Using online patient feedback to improve NHS services: the INQUIRE multimethod study. Health Serv Deliv Res 2019;7:38.This project was funded by the...
Women who are more than 28 weeks pregnant should avoid direct contact with patients—whether or not they could be infected with covid-19, says updated guidance. Those who are less than 28 weeks...
The World Health Organization is the most influential global body guiding responses to the covid-19 pandemic. It is working around the clock to issue helpful guidance for technical experts and the...
New clinical trials are being suspended to prioritise covid-19 studies and enable the redeployment of clinical staff to frontline care, the National Institute for Health Research (NIHR) has...
A million and a half people in England who are at very high risk of severe illness and admission to hospital because of covid-12 will receive a letter this week asking them to stay at home for at...
An NHS consultant has called for NHS staff working during the covid-19 pandemic to be rewarded with rest areas and free parking.Speaking to LBC radio on 19 March the intensive care consultant known...
Daily testing for coronavirus infection in the United States is finally approaching levels seen in other developed countries. This follows nearly two months in which tests were difficult to obtain...
Kindness?! We have more pressing needs than that!Yes, you do. But this column is going to focus on the nice things that people are offering to do for NHS staff during this time.Okay, like what?Well,...
Debate over the safety of non-steroidal anti-inflammatory drugs (NSAIDs) in treating covid-19 has continued with the European Medicines Agency saying that the drugs could be considered for treating...
The crisis of gun violence in the United States continues unabated. In 2018, of 39 740 firearm deaths, 24 432 were suicides (roughly half of all suicides) and 13 958 were homicides, with Mississippi,...
An Italian academic has claimed striking evidence that most people infected with covid-19 show no symptoms but are still able to infect others, which he says has huge implications for testing policy,...
Alex Ball, consultant and clinical lead in rehabilitation medicine at Haywood Hospital, Stoke-on-Trent, is a passionate teacher who finds tailored solutions to patients’ problems.She qualified from...
The BMJ says that it “has long advocated for a change in the law in assisted dying.”1 How much time has the editorial team dedicated to advocating for the care of all dying people? Looking back, how...
Drug company Teva has said that it will donate more than six million doses of hydroxychloroquine sulfate tablets to hospitals across the US, to “meet the urgent demand for the medicine as an...
The studyPowell J, Atherton H, Williams V, et al. Using online patient feedback to improve NHS services: the INQUIRE multimethod study. Health Serv Deliv Res 2019;7:38.This project was funded by the...
Life as a doctor in the Royal Navy is incredibly varied and no two days are the same. You could be working on shore providing daily GP care to your colleagues or be the only doctor on board a ship...
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Quantitative proteomics by mass spectrometry is widely used in biomarker research and basic biology research for investigation of phenotype level cellular events. Despite the wide application, the methodology for statistical analysis of differentially expressed proteins has not been unified. Various methods such as t-test, linear model and mixed effect models are used to define changes in proteomics experiments. However, none of these methods consider the specific structure of MS-data. Choices between...
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Nucleic Acid Therapeutics, Ahead of Print.
Nucleic Acid Therapeutics, Ahead of Print.
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Abstract Background Brodalumab is a fully human anti–interleukin-17 receptor A monoclonal antibody efficacious for the treatment of adults with moderate-to-severe plaque psoriasis. Objective This study summarizes malignancy rates in psoriasis clinical studies of brodalumab. Methods ...
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by Hiroshi Yoke, Hironori Ueno, Akihiro Narita, Takafumi Sakai, Kahoru Horiuchi, Chikako Shingyoji, Hiroshi Hamada, Kyosuke Shinohara Motile cilia/flagella are essential for swimming and generating extracellular fluid flow in eukaryotes. Motile cilia harbor a 9+2 arrangement consisting of nine doublet microtubules with dynein arms at the periphery and a pair of singlet microtubules at the center (central pair). In the central system, the radial spoke has a T-shaped architecture and regulates...
by Esther Botterweg-Paredes, Anko Blaakmeer, Shin-Young Hong, Bin Sun, Lorenzo Mineri, Valdeko Kruusvee, Yakun Xie, Daniel Straub, Delphine Ménard, Edouard Pesquet, Stephan Wenkel Plants have evolved strategies to avoid shade and optimize the capture of sunlight. While some species are tolerant to shade, plants such as Arabidopsis thaliana are shade-intolerant and induce elongation of their hypocotyl to outcompete neighboring plants. We report the identification of a developmental module acting...
by Yuh Chwen G. Lee, Yuki Ogiyama, Nuno M. C. Martins, Brian J. Beliveau, David Acevedo, C.-ting Wu, Giacomo Cavalli, Gary H. Karpen Membraneless pericentromeric heterochromatin (PCH) domains play vital roles in chromosome dynamics and genome stability. However, our current understanding of 3D genome organization does not include PCH domains because of technical challenges associated with repetitive sequences enriched in PCH genomic regions. We investigated the 3D architecture of Drosophila...
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