Holistic tuning and optimization of hybrid MPI and OpenMP applications is becoming focus for parallel code developers as the number of cores and hardware threads in processing nodes of high-end systems continue to increase. For example, there is support for 32 hardware threads on a Cray XE6 node with Interlagos processors while the IBM Blue Gene/Q system could support up to 64 threads per node. Note that, by default, OpenMP threads and MPI tasks are pinned to processor cores on these high-end systems...
18h
In diesem Kapitel wird die Anwendung der Internationalen Klassifikation der Funktionsfähigkeit, Behinderung und Gesundheit (ICF) in der Begutachtung thematisiert. Die ICF steht seit der Publikation im Jahre 2001 auf der Agenda von Praktikern und Wissenschaftlern. In dieser Zeit wurde sehr viel über die ICF publiziert, die Umsetzung in die Praxis jedoch wenig erprobt. Im Bereich der Begutachtung ist die ICF bisher von sekundärer Bedeutung, obwohl sie in der gängigen Literatur (u.a. Leitfäden) zu Begutachtung...
18h
Angola’s contemporary political boundaries resulted from 20th-century colonialism. The roots of Angola, however, reach far into the past. When Portuguese caravels arrived in the Congo River estuary in the late 15th century, independent African polities dotted this vast region. Some people lived in populous, hierarchical states such as the Kingdom of Kongo, but most lived in smaller political entities centered on lineage-village settlements. The Portuguese colony of Angola grew out of a settlement...
19h
While flax culture was a major economic sector in Egypt throughout antiquity and the medieval period, one can only agree with John R. Rea, the editor of P. Coll.Youtie II 68, when he says: “it has not escaped notice that surprisingly little information about [flax and linen] has been recovered from the Greek papyri”. By way of example, the specific word for the flax plant, linokalamē, appears in Greek papyri only in around 60 of more than 60,000 published texts. More specifically, the agricultural...
20h
Despite the overuse of fertilizer in China, yields have stagnated while environmental pollution has risen. To increase sustainable production, the "Three Controls" Technology (3CT) was adopted in Guangdong Province as an agricultural best management practice for rice production. Its goal is to reduce the fertilizer use of farmers while decreasing the number of unproductive tillers and controlling pests and diseases. The objective of this study was to determine the farmers' perception of 3CT focusing...
20h
by Douglas K. Peters, Robert L. Garcea The replication of small DNA viruses requires both host DNA replication and repair factors that are often recruited to subnuclear domains termed viral replication centers (VRCs). Aside from serving as a spatial focus for viral replication, little is known about these dynamic areas in the nucleus. We investigated the organization and function of VRCs during murine polyomavirus (MuPyV) infection using 3D structured illumination microscopy (3D-SIM). We localized...
12h
by Ayat Zawawi, Ruth Forman, Hannah Smith, Iris Mair, Murtala Jibril, Munirah H. Albaqshi, Andrew Brass, Jeremy P. Derrick, Kathryn J. Else Trichuris trichiura is a parasite that infects 500 million people worldwide, leading to colitis, growth retardation and Trichuris dysentery syndrome. There are no licensed vaccines available to prevent Trichuris infection and current treatments are of limited efficacy. Trichuris infections are linked to poverty, reducing children’s educational performance...
12h
Background: Inflammatory and nutritional indexes are prognostic factors in non-small cell lung cancer (NSCLC). Furthermore, a low grade of chronic inflammation has been described in the older population (inflammaging). We aimed to evaluate the neutrophil-to-lymphocyte ratio (NLR), the Prognostic Nutritional Index (PNI), the advanced lung cancer inflammation index (ALI), the platelet-to-lymphocyte ratio (PLR), and the Glasgow Prognostic Score (GPS) in young and older patients diagnosed with locally...
12h
Abstract The ever increasing global warming is affecting both the environment and quality of life. The dependency on the usage of fossil fuels for transportation and power generation sector is harming the environment in terms of greenhouse gas (GHG) emissions. To limit the use of fossil fuel, the world has to move towards a renewable, clean, and economical form of energy. In the transportation sector, the paradigm shift towards electric mobility is a step towards the same goal....
13h
Abstract Formaldehyde is a major indoor air pollutant, and its removal decreases the health risk of urban inhabitants. Scindapsus and Chlorophytum are indoor plants that have been reported to remove formaldehyde. However, their ability to absorb formaldehyde, their resistance, and their morphological changes in response to formaldehyde absorption have not been reported to date. In this study, both Scindapsus and Chlorophytum were used as test materials and their phenotype, microscopic...
13h
Abstract Follicular help T cells (Tfh) play an important role in the activation and differentiation of B cells, while follicular regulatory T cells (Tfr) control Tfh and resulting humoral immune responses. Accumulating evidence has demonstrated that the dysregulation of Tfr contributed to the pathogenesis of infectious diseases. However, the role of Tfr in Epstein–Barr virus (EBV) infection remains lacking. Fifty-five EBV-infected infectious mononucleosis (IM) patients and 21 healthy...
13h
Abstract Ever increasing environmental presence of cadmium as a consequence of industrial activities is considered a health hazard and is closely linked to deteriorating global health status. General animal and human cadmium exposure ranges from ingestion of foodstuffs sourced from heavily polluted hotspots and cigarette smoke to widespread contamination of air and water, including cadmium-containing microplastics found in household water. Cadmium is promiscuous in its effects...
13h
Publication date: Available online 23 March 2020Source: GeneAuthor(s): Zhenyu Lai, Shipeng Li, Fei Wu, Zihui Zhou, Yuan Gao, Jie Yu, Chuzhao Lei, Ruihua Dang
13h
Abstract Background Previous studies have shown that the copy number of microRNA (miR)-124 is decreased in diffuse large B cell lymphoma (DLBCL), and that miR-124 is a tumor suppressor by targeting NF-κB p65 in B-cell lymphoma. In turn, miR-124 expression is regulated by transcription factors such as HNF4α, ETS2, and p53. However, whether and how miR-124 transcription is modulated by NF-κB transcription factors remain unknown in DLBCL....
13h
Cosmetics, Vol. 7, Pages 18: Effects of Age, Sex, Disease, and Exercise Training on Lip Muscle Strength Cosmetics doi: 10.3390/cosmetics7010018 Authors: Vickie Wong Takashi Abe Robert W. Spitz Zachary W. Bell Yujiro Yamada Raksha N. Chatakondi Jeremy P. Loenneke Lip muscle strength has been shown to influence daily functional activities such as facial expression, speech production, and eating. In this review, recent literature regarding lip strength and exercise...
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Publication date: 26 March 2020Source: Journal of Biomechanics, Volume 102Author(s):
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Publication date: Available online 22 March 2020Source: Journal of BiomechanicsAuthor(s): Sung Yul Shin, Robert K. Lee, Patrick Spicer, James Sulzer
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Publication date: Available online 22 March 2020Source: Journal of BiomechanicsAuthor(s): Babak Roushangar Zineh, Mohammad Reza Shabgard, Leila Roshangar, Kamal Jahani
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Publication date: Available online 22 March 2020Source: Journal of BiomechanicsAuthor(s): Jian-Qing Lv, Peng-Cheng Chen, Wojciech T. Góźdź, Bo Li
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Publication date: 1 July 2020Source: International Journal of Biological Macromolecules, Volume 154Author(s): Liang Guo, Yaqian Fang, Zhipeng Shao, Sheng Fang, Yanhua Li, Jie Chen, Yuecheng Meng
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Publication date: 1 July 2020Source: International Journal of Biological Macromolecules, Volume 154Author(s): Marina de Magalhães Silva, Maria Dayanne de Araújo Dantas, Reginaldo Correia da Silva Filho, Marcos Vinicius dos Santos Sales, Jadriane de Almeida Xavier, Ana Catarina Rezende Leite, Marília Oliveira Fonseca Goulart, Luciano Aparecido Meireles Grillo, Wellington Alves de Barros, Ângelo de Fátima, Isis Martins Figueiredo, Josué Carinhanha Caldas Santos
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Publication date: 1 July 2020Source: International Journal of Biological Macromolecules, Volume 154Author(s): Qianfeng Chen, Jieyao Huang, Jie Gou, Qiao Ren, Lujiang Yuan
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Publication date: 1 July 2020Source: International Journal of Biological Macromolecules, Volume 154Author(s): Luxing Ge, Xiangchen Dong, Xutong Gong, Jian Kang, Yong Zhang, Fusheng Quan
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Publication date: Available online 23 March 2020Source: International Journal of Biological MacromoleculesAuthor(s): Kummara Madhusudana Rao, Maduru Suneetha, Gyu Tae Park, Anam Giridhar Babu, Sung Soo Han
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Publication date: Available online 21 March 2020Source: International Journal of Biological MacromoleculesAuthor(s): Chuchu Fang, Guangjing Chen, Jianquan Kan
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The competence regulon of pneumococcus regulates both genetic transformation and virulence. However, competence induction during host infection has not been examined. By using the serotype 2 strain D39, we transcriptionally fused the firefly luciferase (luc) to competence-specific genes and spatiotemporally monitored the competence development in a mouse model of pneumonia-derived sepsis. In contrast to the universally reported short transient burst of competent state in vitro, the naturally developed...
13h
The mechanism underlying the pathogenesis of Nocardia is not fully known. The Nfa34810 protein of Nocardia farcinica has been predicted to be a virulence factor. However, relatively little is known regarding the interaction of Nfa34810 with host cells, specifically invasion and innate immune activation. In this study, we aimed to determine the role of recombinant Nfa34810 during infection. We demonstrated that Nfa34810 is an immunodominant protein located in the cell wall. Nfa34810 protein was able...
13h
The complex bacterial populations that constitute the gut microbiota can harbor antibiotic resistance genes (ARGs), including those encoding β-lactamase enzymes (BLA), which degrade commonly prescribed antibiotics such as ampicillin. The prevalence of such genes in commensal bacteria has been increased in recent years by the wide use of antibiotics in human populations and in livestock. While transfer of ARGs between bacterial species has well-established dramatic public health implications, these...
13h
Unbiased identification of individual immunogenic B-cell epitopes in major antigens of a pathogen remains a technology challenge for vaccine discovery. We therefore developed a platform for rapid phage display screening of deep recombinant libraries consisting of as few as one major pathogen antigen. Using the bicomponent pore-forming leukocidin (Luk) exotoxins of the major pathogen Staphylococcus aureus as a prototype, we randomly fragmented and separately ligated the hemolysin gamma A (HlgA)...
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Rodents are critical for the transmission of Toxoplasma gondii to the definitive feline host via predation, and this relationship has been extensively studied as a model for immune responses to parasites. Neospora caninum is a closely related coccidian parasite of ruminants and canines but is not naturally transmitted by rodents. We compared mouse innate immune responses to N. caninum and T. gondii and found marked differences in cytokine levels and parasite growth kinetics during the first 24 h...
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Rickettsiae are cytosolically replicating, obligately intracellular bacteria causing human infections worldwide with potentially fatal outcomes. We previously showed that Rickettsia australis activates ASC inflammasome in macrophages. In the present study, host susceptibility of ASC inflammasome-deficient mice to R. australis was significantly greater than that of C57BL/6 (B6) controls and was accompanied by increased rickettsial loads in various organs. Impaired host control of R. australis in vivo...
13h
Klebsiella pneumoniae is a Gram-negative bacterial pathogen that causes a range of infections, including pneumonias, urinary tract infections, and septicemia, in otherwise healthy and immunocompromised patients. K. pneumoniae has become an increasing concern due to the rise and spread of antibiotic-resistant and hypervirulent strains. However, its virulence determinants remain understudied. To identify novel K. pneumoniae virulence factors needed to cause pneumonia, a high-throughput screen was performed...
13h
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