IntroductionExposure to enviromental flight conditions may impair performance and physical integrity, thus training in simulated environments it is a key factor. This research aimed to study the psychophysiological response, cortical arousal and autonomic modulation of pilots and medical aircrew personnel during disorientation exposure, considering gender, experience, flying hours and body mass index (BMI) as influencial variables.MethodsA total of 47 soldiers (37 men and 10 women, 22 medical aircrew...
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IntroductionTinea pedis is a widely spread infection among military personnel. The aim of the research was to determine the prevalence of tinea pedis and its associated risk factors in Georgian Defense Forces.MethodsA cross-sectional study including interviews and clinical and laboratory examination was performed among randomly selected Georgian soldiers and civilians, after getting the signed consent form from them. In the selected population with clinical evidence of tinea pedis, scrapings were...
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Breast cancer is the leading cause of cancer-related mortality in women worldwide. Long non-coding RNAs (lncRNAs) are of critical importance in tumor drug resistance. Herein, this study aims to determine the r...
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Extensive studies revealed that long non-coding RNAs (lncRNAs) could act as a regulator in tumors, including lung adenocarcinoma (LUAD). LncRNA FTX transcript, XIST regulator (FTX) has been reported to regulat...
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Colorectal cancer (CRC) ranks the third among the most common malignancies globally. It is well known that microRNAs (miRNAs) play vital roles in destabilizing mRNAs and repressing their translations in this d...
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Pregnancy-associated breast cancer (PABC) is an aggressive disease, and since Chinese authority began to encourage childbearing in 2015, the incidence of PABC has increased. This study investigated the charact...
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Approximately one third of all patients with CRC present with, or subsequently develop, colorectal liver metastases (CRLM). The objective of this population-based analysis was to assess the impact of resection...
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Neuroblastoma (NB) tumor rupture is a rare oncology emergency with a poor prognosis. We aimed to evaluate patient clinical characteristics and risk factors for ruptured NB.
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This study sought to detect the expression and clinical significance of miR-4516 and miR-21-5p in serum of patients with colorectal cancer.
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ACS NanoDOI: 10.1021/acsnano.9b09051
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ACS NanoDOI: 10.1021/acsnano.0c01056
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ACS NanoDOI: 10.1021/acsnano.9b09702
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ACS NanoDOI: 10.1021/acsnano.0c00708
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Abstract Three cholangiocarcinoma (CCA) cell line—formerly named, M156, M213 and M214 have been intensively used with discrepancy of their tumor origins. They were assumed to be originated from three different donors without authentication. To verify the origins of these cell lines, the short tandem repeat (STR) analysis of the currently used cell lines, the cell stocks from the establisher and the primary tumor of a CCA patient were performed. Their phenotypic and genotypic originality...
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Gastric cancer (GC) is characterized by high incidence and mortality and it represents the sixth most common cancer type and fifth leading cause of cancer death worldwide [1]. When diagnosed in an advanced stage, GC is characterized by very poor prognosis, with a five-year overall survival rate of about 5% [2]. Historically GC has been classified into two main subgroups, intestinal and diffuse, according to different microscopic features [3]. Several molecular classifications based on comprehensive...
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Thymic epithelial tumors (TETs) are rare tumors arising from thymic epithelial cells.
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We consider the following double phase problem with variable exponents: . By using the mountain pass theorem, we get the existence results of weak solutions for the aforementioned problem under some assumptions. Moreover, infinitely many pairs of solutions are provided by applying the Fountain Theorem, Dual Fountain Theorem, and Krasnoselskii’s genus theory.
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Zusammenfassung Hintergrund Yogainterventionen bekommen in der komplementären Supportivtherapie immer mehr Aufmerksamkeit, mit dem Ziel, Nebenwirkungen der Behandlung zu reduzieren. Die meisten bisherigen Studien zielen auf kurative Brustkrebspatientinnen ab. Ziel der Arbeit Das Ziel dieser Pilotstudie war es, die Durchführbarkeit einer 8‑wöchigen Yogatherapie...
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Zusammenfassung Hintergrund Die Entscheidung eines irreversibel erkrankten Menschen, freiwillig auf Nahrung und Flüssigkeit zu verzichten (FVNF), um das eigene Sterben zu beschleunigen, kann zu einer ethischen Herausforderung für professionell Pflegende werden. Oft werden Befürchtungen geäußert, die Begleitung eines FVNF sei unvereinbar mit einem Pflegeverständnis, nach dem das Leben eines Pflegebedürftigen – auch unter den christlichen...
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Tiger beetles inhabiting sandy beaches and cliffs along the east coast of the United States are facing increasing habitat loss due to erosion, urbanization, and sea level rise. The northeastern beach tiger bee...
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For better clarity, the author would like to amend the title of the original article [1].
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Abstract There have been a number of studies on the effect of bolus volume, consistency, texture, temperature and taste on the oropharyngeal swallowing physiology. However, its influence on the respiratory function associated with swallow is not well understood. This study aimed at systematically analysing and documenting the prevailing research literature on respiratory functions before, during, and after healthy swallows of boluses with varied characteristics. The PRISMA guidelines...
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Abstract Due to its superior soft tissue contrast, magnetic resonance imaging (MRI) is essential for many radiotherapy treatment indications. This is especially true for treatment planning in intracranial tumors, where MRI has a long-standing history for target delineation in clinical practice. Despite its routine use, care has to be taken when selecting and acquiring MRI studies for the purpose of radiotherapy treatment planning. Requirements on MRI are particularly demanding...
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Ibrutinib is a major new addition to the therapeutic armamentarium for chronic lymphocytic leukemia, mantle cell lymphoma, Waldenstrom’s macroglobulinemia, and chronic graft versus host disease. Though ibrutinib has proven to be a revolutionary new small molecule agent, and has relatively minimal toxicity as compared to traditional chemotherapy, infections have emerged as a major complication of therapy. While fungal infections have been the most problematic (including CNS aspergillosis), zoster,...
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To improve the effectiveness and robustness of the existing semisupervised fuzzy clustering for segmenting image corrupted by noise, a kernel space semisupervised fuzzy C-means clustering segmentation algorithm combining utilizing neighborhood spatial gray information with fuzzy membership information is proposed in this paper. The mean intensity information of neighborhood window is embedded into the objective function of the existing semisupervised fuzzy C-means clustering, and the Lagrange multiplier...
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Boundary pixel blur and category imbalance are common problems that occur during semantic segmentation of urban remote sensing images. Inspired by DenseU-Net, this paper proposes a new end-to-end network—SiameseDenseU-Net. First, the network simultaneously uses both true orthophoto (TOP) images and their corresponding normalized digital surface model (nDSM) as the input of the network structure. The deep image features are extracted in parallel by downsampling blocks. Information such as shallow...
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Primary colorectal leiomyosarcoma is an excessively rare entity. It is associated with an aggressive behavior and typically favor hematogenous spread. The current standard of care is surgical resection. A 49-year-old patient presented with a 2-month history of fever. A PET-scan revealed a hypermetabolic mass in the transverse colon, and colonoscopy confirmed a tumor. A right hemicolectomy was performed. Histopathological diagnosis was of a leiomyosarcoma. Fourteen months after the surgery, a follow-up...
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Background. How to effectively control the postoperative pain of patients is extremely important to clinicians. Transversus abdominis plane (TAP) block is a novel analgesic method reported to greatly decrease postoperative pain. However, in many areas, there still exists a phenomenon of surgeons using wound infiltration (WI) with conventional local anesthetics (not liposome anesthetics) as the main means to decrease postoperative pain because of traditional wisdom or convenience. Here, we compared...
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Previous studies have shown that increased cross-link density, reduced free radicals, and increased antioxidant grafting resulting from electron-beam irradiation at elevated temperatures improved the wear performance and the oxidative stability of vitamin E blended UHMWPE. The current study explores the impact of elevated irradiation temperature on vitamin E blended UHMWPE using X-ray. We hypothesize that the effects of temperature would be similar to those observed after electron-beam irradiation...
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Background and Aims. Since hyperglycemia promotes inflammation by different pathways and inflammation participates in the development of chronic diabetes complications, we investigated the association between the leukotriene (LT) pathway and microvascular diabetes complications. Methods and Results. Quantitative polymerase chain reaction was employed to quantify the expression of ALOX5 (encodes 5-lipoxygenase), LTB4R (encodes one of the LTB4 receptors), and MYD88 in peripheral blood mononuclear cells...
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The centrality plays an important role in many community-detection algorithms, which depend on various kinds of centralities to identify seed vertices of communities first and then expand each of communities based on the seeds to get the resulting community structure. The traditional algorithms always use a single centrality measure to recognize seed vertices from the network, but each centrality measure has both pros and cons when being used in this circumstance; hence seed vertices identified using...
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Neuropathic pain is a serious clinical problem to be solved. This study is aimed at investigating protein kinase A (PKA) expression in neuropathic pain and its possible mechanisms of involvement. A neuropathic pain-related gene expression dataset was downloaded from Gene Expression Omnibus, and differentially expressed genes were screened using the R software. cytoHubba was used to screen for hub genes. A spared nerve injury (SNI) rat model was established, and the paw withdrawal threshold was determined...
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Objective. At present, the relationship between autophagosomes and the prognosis of various cancers has become a subject of active investigation. A series of studies have demonstrated the correlation between autophagy microtubule-associated protein light chain 3 (LC-3), Beclin-1, and colorectal cancer (CRC). Since autophagy has dual regulatory roles in tumors, the results of this correlation are also uncertain. Hence, we summarized the relationship between Beclin-1, LC-3, and CRC using systematic...
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Osmotic demyelination syndrome (ODS) is characterized by loss of myelin in various parts of the central nervous system. It is mainly caused by a rapid correction of hyponatremia, although other factors that may cause rapid rise in serum osmolality can also be associated with its development. Its prognosis is poor and the recovery rate is unknown. The authors report a rare case of a patient with multiple risk factors for ODS, without hyponatremia, who developed ODS and surprisingly recovered. This...
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