Τετάρτη 11 Μαρτίου 2020


Alterations in chromatin at antigen receptor loci define lineage progression during B lymphopoiesis [Immunology and Inflammation]
Developing lymphocytes diversify their antigen receptor (AgR) loci by variable (diversity) joining (V[D]J) recombination. Here, using the micrococcal nuclease (MNase)-based chromatin accessibility (MACC) assay with low-cell count input, we profile both small-scale (kilobase) and large-scale (megabase) changes in chromatin accessibility and nucleosome occupancy in primary cells during lymphoid development, tracking...
Proceedings of the National Academy of Sciences current issue
14h
EPA’s proposed transparency rule: Factors to consider, many; planets to live on, one [Editorials]
“In God we trust. All others bring data.” So reads a T-shirt sold by the American Statistical Association. This pithy quip encapsulates a fundamental principle of science: Scientists rely on evidence rather than authority. Indeed, “doubt has been considered essential to science since long before the scientific method was established...
Proceedings of the National Academy of Sciences current issue
14h
Footprints of natural selection at the mannose-6-phosphate isomerase locus in barnacles [Evolution]
The mannose-6-phosphate isomerase (Mpi) locus in Semibalanus balanoides has been studied as a candidate gene for balancing selection for more than two decades. Previous work has shown that Mpi allozyme genotypes (fast and slow) have different frequencies across Atlantic intertidal zones due to selection on postsettlement survival (i.e., allele zonation)....
Proceedings of the National Academy of Sciences current issue
14h
No evidence of suitability of prophylactic fluids for wildfire prevention at landscape scales [Physical Sciences]
Yu et al. (1) propose a viscoelastic fluid as a prophylactic fire-retardant treatment in landscapes at high risk of wildfires. We argue that, while the idea is worth exploring further, their data do not support its suitability for real landscape-scale applications. First, they report their fluid is environmentally benign because...
Proceedings of the National Academy of Sciences current issue
14h
Representation of distinct reward variables for self and other in primate lateral hypothalamus [Neuroscience]
The lateral hypothalamus (LH) has long been implicated in maintaining behavioral homeostasis essential for the survival of an individual. However, recent evidence suggests its more widespread roles in behavioral coordination, extending to the social domain. The neuronal and circuit mechanisms behind the LH processing of social information are unknown. Here,...
Proceedings of the National Academy of Sciences current issue
14h
Reply to Santin et al.: Viscoelastic retardant fluids enable treatments to prevent wildfire on landscapes subȷect to routine ignitions [Physical Sciences]
Our recent paper (1) reports the development and pilot-scale validation of viscoelastic carrier fluids for ammonium polyphosphate (APP), the primary retardant used in wildland firefighting, to improve retention on common ignition-prone vegetation to protect through environmental exposure. In response to our paper, Santín et al. (2) state that while our...
Proceedings of the National Academy of Sciences current issue
14h
Underactuated fluidic control of a continuous multistable membrane [Engineering]
This work addresses the challenge of underactuated pattern generation in continuous multistable structures. The examined configuration is a slender membrane which can concurrently sustain two different equilibria states, separated by transition regions, and is actuated by a viscous fluid. We first demonstrate the formation and motion of a single transition...
Proceedings of the National Academy of Sciences current issue
14h
Opening of smaller toxin pores by lipid micelle formation [Biological Sciences]
While pore-forming toxins (PFTs) are a large class of molecular weapons employed by organisms across the animal kingdom (1), notably, pathogenic bacteria, many mechanistic steps of pore formation in target membranes are unknown. In PNAS, using molecular dynamics (MD) simulations, Vӧgele et al. (2) observed how central lipids corresponding to...
Proceedings of the National Academy of Sciences current issue
14h
Interferon lambda promotes immune dysregulation and tissue inflammation in TLR7-induced lupus [Immunology and Inflammation]
Type III IFN lambdas (IFN-λ) have recently been described as important mediators of immune responses at barrier surfaces. However, their role in autoimmune diseases such as systemic lupus erythematosus (SLE), a condition characterized by aberrant type I IFN signaling, has not been determined. Here, we identify a nonredundant role for...
Proceedings of the National Academy of Sciences current issue
14h
Reply to Desikan et al.: Micelle formation among various mechanisms of toxin pore formation [Biological Sciences]
Pore-forming toxins (PFTs) are a diverse class of membrane-active proteins employed primarily by bacteria for unregulated perforation of lipid membranes (1). Based on molecular dynamics (MD) simulations (2), electron cryo-microscopy (cryoEM) structures (3), and atomic force microscopy (AFM) experiments (4), we recently identified two distinct pathways for lipid efflux from...
Proceedings of the National Academy of Sciences current issue
14h

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