Related ArticlesSimultaneous Electrophysiology and Fiber Photometry in Freely Behaving Mice. Front Neurosci. 2020;14:148 Authors: Patel AA, McAlinden N, Mathieson K, Sakata S Abstract In vivo electrophysiology is the gold standard technique used to investigate sub-second neural dynamics in freely behaving animals. However, monitoring cell-type-specific population activity is not a trivial task. Over the last decade, fiber photometry based on genetically...
Wed Mar 11, 2020 14:00
Related ArticlesAmide Proton Transfer Imaging in Predicting Isocitrate Dehydrogenase 1 Mutation Status of Grade II/III Gliomas Based on Support Vector Machine. Front Neurosci. 2020;14:144 Authors: Han Y, Wang W, Yang Y, Sun YZ, Xiao G, Tian Q, Zhang J, Cui GB, Yan LF Abstract Background: To compare the efficacies of univariate and radiomics analyses of amide proton transfer weighted (APTW) imaging in predicting isocitrate dehydrogenase 1 (IDH1) mutation...
Wed Mar 11, 2020 14:00
Related ArticlesCytotoxic Immunity in Peripheral Nerve Injury and Pain. Front Neurosci. 2020;14:142 Authors: Davies AJ, Rinaldi S, Costigan M, Oh SB Abstract Cytotoxicity and consequent cell death pathways are a critical component of the immune response to infection, disease or injury. While numerous examples of inflammation causing neuronal sensitization and pain have been described, there is a growing appreciation of the role of cytotoxic immunity...
Wed Mar 11, 2020 14:00
Related ArticlesMechanisms Linking Olfactory Impairment and Risk of Mortality. Front Neurosci. 2020;14:140 Authors: Van Regemorter V, Hummel T, Rosenzweig F, Mouraux A, Rombaux P, Huart C Abstract Olfaction is a sense involved in a complex set of tasks, influencing eating behavior, increasing awareness of environmental hazards and affecting social communication. Surprisingly, smell disorders are very frequent, especially in the elderly population. Several...
Wed Mar 11, 2020 14:00
Related ArticlesBehavioral Alterations in Mice Carrying Homozygous HDAC4 A778T Missense Mutation Associated With Eating Disorder. Front Neurosci. 2020;14:139 Authors: Davis KC, Saito K, Rodeghiero SR, Toth BA, Lutter M, Cui H Abstract Eating disorders (EDs) are serious mental illnesses thought to arise from the complex gene-environment interactions. DNA methylation patterns in histone deacetylase 4 (HDAC4) locus have been associated with EDs and we have...
Wed Mar 11, 2020 14:00
Related ArticlesThe Myelin Water Fraction Serves as a Marker for Age-Related Myelin Alterations in the Cerebral White Matter - A Multiparametric MRI Aging Study. Front Neurosci. 2020;14:136 Authors: Faizy TD, Thaler C, Broocks G, Flottmann F, Leischner H, Kniep H, Nawabi J, Schön G, Stellmann JP, Kemmling A, Reddy R, Heit JJ, Fiehler J, Kumar D, Hanning U Abstract Quantitative MRI modalities, such as diffusion tensor imaging (DTI) or magnetization transfer...
Wed Mar 11, 2020 14:00
Related ArticlesLow-Power Dynamic Object Detection and Classification With Freely Moving Event Cameras. Front Neurosci. 2020;14:135 Authors: Ramesh B, Ussa A, Della Vedova L, Yang H, Orchard G Abstract We present the first purely event-based, energy-efficient approach for dynamic object detection and categorization with a freely moving event camera. Compared to traditional cameras, event-based object recognition systems are considerably behind in terms...
Wed Mar 11, 2020 14:00
Related ArticlesSIFamide Influences Feeding in the Chagas Disease Vector, Rhodnius prolixus. Front Neurosci. 2020;14:134 Authors: Ayub M, Hermiz M, Lange AB, Orchard I Abstract SIFamides are a family of highly conserved neuropeptides in arthropods, and in insects are mainly expressed in four medial neurons in the pars intercerebralis of the brain. Although SIFamide has been shown to influence sexual behavior, feeding, and sleep regulation in holometabolous...
Wed Mar 11, 2020 14:00
Related ArticlesImage-Derived Phenotyping Informed by Independent Component Analysis-An Atlas-Based Approach. Front Neurosci. 2020;14:118 Authors: Moradi M, Ekhtiari H, Victor TA, Paulus M, Kuplicki R PMID: 32153355 [PubMed]
Wed Mar 11, 2020 14:00
Related ArticlesEditorial: The Protein Alpha-Synuclein: Its Normal Role (in Neurons) and Its Role in Disease. Front Neurosci. 2020;14:116 Authors: Perez RG PMID: 32153354 [PubMed]
Wed Mar 11, 2020 14:00
Related ArticlesCorrigendum: Lateral Symmetry of Synergies in Lower Limb Muscles of Acute Post-stroke Patients After Robotic Intervention. Front Neurosci. 2020;14:113 Authors: Tan CK, Kadone H, Watanabe H, Marushima A, Yamazaki M, Sankai Y, Suzuki K Abstract [This corrects the article DOI: 10.3389/fnins.2018.00276.].PMID: 32153353 [PubMed - in process]
Wed Mar 11, 2020 14:00
Related ArticlesEfficacy of a Combined Treatment of Botulinum Toxin and Intensive Physiotherapy in Hereditary Spastic Paraplegia. Front Neurosci. 2020;14:111 Authors: Paparella G, Vavla M, Bernardi L, Girardi G, Stefan C, Martinuzzi A Abstract Introduction: The Hereditary Spastic Paraplegia (HSP) is a heterogeneous group of neurodegenerative disorders characterized by progressive spasticity and lower limbs (LL) weakness. There is no treatment to cure...
Wed Mar 11, 2020 14:00
Related ArticlesFAIM Opposes Aggregation of Mutant SOD1 That Typifies Some Forms of Familial Amyotrophic Lateral Sclerosis. Front Neurosci. 2020;14:110 Authors: Kaku H, Ludlow AV, Gutknecht MF, Rothstein TL Abstract Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative illness that is unremittingly fatal and for which no effective treatment exists. All forms of ALS are characterized by protein aggregation. In familial forms of ALS, specific...
Wed Mar 11, 2020 14:00
Related ArticlesRegionally Distinct Astrocytes Display Unique Transcription Factor Profiles in the Adult Brain. Front Neurosci. 2020;14:61 Authors: Lozzi B, Huang TW, Sardar D, Huang AY, Deneen B Abstract Astrocytes are the most abundant type of glial cell in the central nervous system and perform a myriad of vital functions, however, the nature of their diversity remains a longstanding question in neuroscience. Using transcription factor motif discovery...
Wed Mar 11, 2020 14:00
Related ArticlesSegmentation and Classification in Digital Pathology for Glioma Research: Challenges and Deep Learning Approaches. Front Neurosci. 2020;14:27 Authors: Kurc T, Bakas S, Ren X, Bagari A, Momeni A, Huang Y, Zhang L, Kumar A, Thibault M, Qi Q, Wang Q, Kori A, Gevaert O, Zhang Y, Shen D, Khened M, Ding X, Krishnamurthi G, Kalpathy-Cramer J, Davis J, Zhao T, Gupta R, Saltz J, Farahani K Abstract Biomedical imaging Is an important source of...
Wed Mar 11, 2020 14:00
Structural and Functional Alterations in the Contralesional Medial Temporal Lobe in Glioma Patients.
Related ArticlesStructural and Functional Alterations in the Contralesional Medial Temporal Lobe in Glioma Patients. Front Neurosci. 2020;14:10 Authors: Yuan T, Zuo Z, Ying J, Jin L, Kang J, Gui S, Wang R, Li C Abstract Background: The human brain has an extraordinary ability to functionally change or reorganize its structure in response to disease. The aim of this study is to assess the structural and functional plasticity of contralesional medial temporal...
Wed Mar 11, 2020 14:00
Union of the incus‐otic capsule is distinguishable between the short limb of the incus and the lateral protrusion of the otic capsule. The initial perichondrium and precartilaginous cells are continuous in the incus‐otic capsule union. Abstract In spite of the amount of research on fetal development of the human middle ear and ear ossicles, there has been no report showing a joint between the short limb of incus and the otic capsule or petrous part of the temporal bone. According to observations...
Wed Mar 11, 2020 11:34
A posterior view of an isolated left infrapatellar fat pad, showing its principal morphological features. Note particularly the superior lateral and superior medial extensions that encircle the patella (removed). (1) Superior lateral extension, (2) lateral extension, (3) central body, (4) ligamentum mucosum, (5) vertical cleft, (6) superior tag, (7) medial extension, (8) superior medial extension. Abstract The infrapatellar fat pad (IFP) is an extrasynovial, intracapsular, adipose body occupying...
Wed Mar 11, 2020 11:34
A 38-year-old male presented to the emergency department (ED) complaining of extreme pain and a petechial rash on the left ankle for two weeks associated with generalized fatigue, intermittent fevers, and weight loss. He was discharged home from the ED on pain medications. He returned a few days later with a progressive rash that involved the entire left lower extremity to the level of the knee. He was diagnosed with herpes zoster (shingles) and was prescribed acyclovir and steroids. After several...
Wed Mar 11, 2020 05:05
Abstract Purpose The goal of this study was to assess the morphological variations, location, and morphometric measurements of the foramen venosum (FV) and analyse its interrelationships with other foramina on cone-beam computed tomography (CBCT) scans. Methods A total of 269 individual CBCT scans were evaluated retrospectively. The presence or absence...
Wed Mar 11, 2020 02:00
Chinese yam (Dioscorea opposita) is an important tuberous crop used for both food and medicine. Despite a long history of cultivation, the understanding of D. opposita genetics and molecular biology remains scant, which has limited its genetic improvement. This work presents a de novo transcriptome sequencing analysis of microtuber formation in D. opposita. We assembled cDNA libraries from different stages during the process of microtuber formation, designated as initial explants (EXP), axillary...
Wed Mar 11, 2020 09:50
Background. Freeze-thaw influences soil-dissolved nitrogen (N) pools due to variations in bacterial communities in temperate regions. The availability of soil water is important to soil biogeochemical cycles under frozen conditions. However, it is unclear how soil water content (SWC) mediates the effects of freeze-thaw on soil-dissolved N pools and bacterial communities. Method. In this study, freeze-thaw microcosms were incubated at three levels of SWC, including 10% (air-dried soils), 15% (natural...
Wed Mar 11, 2020 09:20
Objective. To investigate the antibacterial effect of a novel antimicrobial peptide containing oral spray GERM CLEAN on Streptococcus mutans (S. mutans) in vitro and further explore the related mechanisms at phenotypic and transcriptional levels. Methods. The disk diffusion method was used to preliminarily appraise the antimicrobial effect of GERM CLEAN. The minimal inhibitory concentration (MIC) of GREM CLEAN towards S. mutans was determined by the broth dilution method. S. mutans virulence-related...
Wed Mar 11, 2020 08:50
Purpose. The purpose of this study was to cross-culturally adapt and validate the Simplified Chinese version of the Lower Extremity Functional Scale (SC-LEFS). Methods. The original English version of the Lower Extremity Functional Scale was translated and cross-culturally adapted into Simplified Chinese according to international guidelines. The SC-LEFS and 36-Item Short-Form Health Survey were administered to 213 patients with lower extremity musculoskeletal disorders. Psychometric properties including...
Wed Mar 11, 2020 08:35
The mangrove ecosystem of Malaysia remains yet to be fully explored for potential microbes that produce biologically active metabolites. In the present study, a mangrove-derived Streptomyces sp. strain MUSC 14 previously isolated from the state of Pahang, Malaysia Peninsula, was studied for its potential in producing antioxidant metabolites. The identity of Streptomyces sp. strain MUSC14 was consistent with the genotypic and phenotypic characteristics of the Streptomyces genus. The antioxidant potential...
Wed Mar 11, 2020 08:05
Several intestinal parasites of baboons are of zoonotic importance, especially where there is considerable interaction between the baboons and humans. The identification of gastrointestinal parasite infections of baboons (Papio anubis) was undertaken at the Shai Hills Reserve Resort, Ghana. A total of 51 faecal samples were collected randomly from individual baboons (51) and examined for cysts, eggs, and larvae of parasites of medical importance, using the direct saline smear and formol-ether concentration...
Wed Mar 11, 2020 05:50
Background. Idiopathic pulmonary fibrosis (IPF), the most common interstitial lung disease, arises from transforming growth factor beta 1- (TGFβ1-) induced aberrant fibroproliferation in response to epithelial injury. The TGFβ1 antagonists—hyaluronidases (HYALs)—have been used to clinically treat pulmonary fibrosis. This study focused on characterizing the effect of HYAL1, the main enzyme in hyaluronan degradation, on human lung fibroblast proliferation and apoptosis, and elucidating its potential...
Wed Mar 11, 2020 04:35
Background. Egg component-specific IgE can be useful to evaluate and diagnose egg allergy, but their prevalence and clinical significance remain unclear in the local population. Previous studies have led to contradictory results regarding the value of specific IgG and specific IgG4 in sensitization. Objective. We aimed to determine the level of specific IgE, IgG, and IgG4 antibodies to the major egg allergens in egg-allergic children. Methods. Children from 6 months to 10 years of age were recruited....
Wed Mar 11, 2020 04:20
Abstract A novel actinobacterium, YIM 132087T, isolated from Lepraria sp. lichen collected from Yunnan province, south-west PR China. Cells are Gram-stain-positive, catalase-positive and oxidase-negative, aerobic, non-motile and short rod-shaped. Colonies are asporogenous, circular and white brown in colour. Optimal growth occured at 15−35 °C (optimum 28 °C), at pH 5.0−9.0 (optimum pH 6.0), and in the presence of 3% NaCl (w/v). The DNA G+C content of strain YIM 132087T based on...
Wed Mar 11, 2020 02:00
Chest radiograph: patchy or diffuse asymmetric airspace opacitiesCOVID-19 on CT shows bilateral lung involvement on initial chest CT, with a consolidative pattern seen in patients in the ICU and a predominantly ground-glass pattern in patients who were not in the ICU.Multifocal ground-glass opacities and consolidation with a peripheral lung predilectionAlthough the imaging features closely resemble those of MERS and SARS, involvement of both lungs on initial imaging is more likely to be seen with...
Wed Mar 11, 2020 10:22
Abstract Rationale Excessive fear and anxiety, coupled with corticolimbic dysfunction, are core features of stress- and trauma-related psychopathology, such as posttraumatic stress disorder (PTSD). Interestingly, low doses of ∆9-tetrahydrocannabinol (THC) can produce anxiolytic effects, reduce threat-related amygdala activation, and enhance functional coupling between the amygdala and medial prefrontal cortex and adjacent rostral cingulate...
Wed Mar 11, 2020 02:00
Abstract Rationale Working memory deficits are present in schizophrenia (SZ) but remain insufficiently resolved by medications. Similar cognitive dysfunctions can be produced acutely in animals by elevating brain levels of kynurenic acid (KYNA). KYNA’s effects may reflect interference with the function of both the α7 nicotinic acetylcholine receptor (α7nAChR) and the glycineB site of the NMDA receptor. ...
Wed Mar 11, 2020 02:00
Background Immunotherapy for stage IV melanoma has dramatically changed the overall prognosis and treatment strategies. The aim of this study was to evaluate whether changes in systemic immunotherapy options have significantly altered surgical resection rates for patients with stage IV melanoma. Methods The National Cancer Database (2004‐2015) was used to perform a difference‐in‐difference analysis to evaluate whether the rate of surgical resection of metastatic disease for stage IV melanoma...
Wed Mar 11, 2020 10:11
Abstract Background Infection with COVID-19 is currently rare in children. Objective To describe chest CT findings in children with COVID-19. Materials and methods We studied children at a large tertiary-care hospital in China, during the period from 28 January 2019...
Wed Mar 11, 2020 02:00
Abstract American Indians residing in the Northern Plains region of the Indian Health Service experience some of the most severe cancer-related health disparities. We investigated ways in which the community climate among an American Indian population in an urban community in the Northern Plains region influences community readiness to address cancer. A Community Readiness Assessment, following the Community Readiness Model, conducted semi-structured interviews with eight educators,...
Wed Mar 11, 2020 02:00
Abstract After tooth extraction, the alveolar ridge is absorbed and changes shape. Recently, socket preservation has been proposed to prevent alveolar ridge absorption. However, there are few reports of socket preservation in a model without the periosteum, and alveolar bone regeneration and resorption inhibitory effects in this type of model remain unclear. Therefore, in this study, we conducted socket preservation at the bone defect without the periosteum using a canine model....
Wed Mar 11, 2020 02:00
AbstractA mouse single taste bud contains 10–100 taste bud cells (TBCs) in which the elongated TBCs are classified into three cell types (types I–III) equipped with different taste receptors. Accordingly, differences in the cell numbers and ratios of respective cell types per taste bud may affect taste nerve responsiveness. Here we examined the numbers of each immunoreactive cell for the type II (sweet, bitter, or umami receptor cells) and type III (sour and/or salt receptor cells) markers per taste...
Wed Mar 11, 2020 02:00
AbstractSeveral studies have demonstrated that Alzheimer’s disease (AD) is associated not only with difficulty in remembering past events but also with a compromised ability to imagine future ones. Recent empirical research has also demonstrated that odor is an effective cue to alleviate difficulty in remembering past events in AD. We investigated whether odor exposure would help AD patients to imagine future events. To this end, we invited AD patients and control participants to evoke past and future...
Tue Mar 10, 2020 02:00
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