Antibiotics, Vol. 9, Pages 118: Antibiotic Resistance in Marine Microbial Communities Proximal to a Florida Sewage Outfall System Antibiotics doi: 10.3390/antibiotics9030118 Authors: Griffin Banks Gregg Shedler Walker Water samples were collected at several wastewater treatment plants in southeast Florida, and water and sediment samples were collected along and around one outfall pipe, as well as along several transects extending both north and south of the respective...
Wed Mar 11, 2020 02:00
Antibiotics, Vol. 9, Pages 117: A New Penicillin? Antibiotics doi: 10.3390/antibiotics9030117 Authors: Mark Wainwright The spectre of antimicrobial resistance looms very large indeed in the 21st century; the supply of efficacious conventional drugs is short and not guaranteed, for various reasons. It is time to look elsewhere for answers and for protocols which might be used in tandem with our diminishing arsenal in order to protect vital drugs. This could bridge the gap before new development...
Wed Mar 11, 2020 02:00
Antioxidants, Vol. 9, Pages 233: Effect of Dipeptidyl-Peptidase 4 Inhibitors on Circulating Oxidative Stress Biomarkers in Patients with Type 2 Diabetes Mellitus Antioxidants doi: 10.3390/antiox9030233 Authors: Bigagli Luceri Dicembrini Tatti Scavone Giovannelli Mannucci Lodovici : Pre-clinical studies suggested potential cardiovascular benefits of dipeptidyl peptidase-4 inhibitors (DPP4i), however, clinical trials showed neither beneficial nor detrimental...
Wed Mar 11, 2020 02:00
Antioxidants, Vol. 9, Pages 231: Evaluating the In Vitro Potential of Natural Extracts to Protect Lipids from Oxidative Damage Antioxidants doi: 10.3390/antiox9030231 Authors: Félix Valentão Andrade Félix Novais Lemos Lipid peroxidation is a chemical reaction known to have negative impacts on living organisms’ health and on consumer products’ quality and safety. Therefore, it has been the subject of extensive scientific research concerning the...
Wed Mar 11, 2020 02:00
Antioxidants, Vol. 9, Pages 230: Molecular Mechanism of Oxidation of P700 and Suppression of ROS Production in Photosystem I in Response to Electron-Sink Limitations in C3 Plants Antioxidants doi: 10.3390/antiox9030230 Authors: Miyake Photosynthesis fixes CO2 and converts it to sugar, using chemical-energy compounds of both NADPH and ATP, which are produced in the photosynthetic electron transport system. The photosynthetic electron transport system absorbs photon energy to drive electron...
Wed Mar 11, 2020 02:00
Antioxidants, Vol. 9, Pages 229: The Role of Selected Bioactive Compounds in the Prevention of Alzheimer’s Disease Antioxidants doi: 10.3390/antiox9030229 Authors: Wojciech Grodzicki Katarzyna Dziendzikowska Neurodegeneration is a feature of many debilitating, incurable age-dependent diseases that affect the nervous system and represent a major threat to the health of elderly persons. Because of the ongoing process of aging experienced by modern societies, the increasing prevalence...
Wed Mar 11, 2020 02:00
Antioxidants, Vol. 9, Pages 232: Antioxidant and Antitumor Activities of Novel Quercetin-Loaded Electrospun Cellulose Acetate/Polyethylene Glycol Fibrous Materials Antioxidants doi: 10.3390/antiox9030232 Authors: Stoyanova Spasova Manolova Rashkov Georgieva Toshkova The aim of present study was to obtain novel fibrous materials based on cellulose derivative and polyethylene glycol loaded with natural biologically active compound quercetin by electrospinning. Several...
Wed Mar 11, 2020 02:00
Atmosphere, Vol. 11, Pages 276: Optimization of a Method for the Detection of Biomass-Burning Relevant VOCs in Urban Areas using Thermal Desorption Gas Chromatography Mass Spectrometry Atmosphere doi: 10.3390/atmos11030276 Authors: Chandra McClure Mulligan Jaffe Forest fire smoke influence in urban areas is relatively easy to detect at high concentrations but more challenging to detect at low concentrations. In this study, we present a simplified method that can reliably...
Wed Mar 11, 2020 02:00
Biomolecules, Vol. 10, Pages 434: Improved Protocol for the Production of the Low-Expression Eukaryotic Membrane Protein Human Aquaporin 2 in Pichia pastoris for Solid-State NMR Biomolecules doi: 10.3390/biom10030434 Authors: Munro de Vlugt Ladizhansky Brown Solid-state nuclear magnetic resonance (SSNMR) is a powerful biophysical technique for studies of membrane proteins; it requires the incorporation of isotopic labels into the sample. This is usually accomplished through...
Wed Mar 11, 2020 02:00
Biomolecules, Vol. 10, Pages 433: Kinetic Study of the Biodegradation of Acephate by Indigenous Soil Bacterial Isolates in the Presence of Humic Acid and Metal Ions Biomolecules doi: 10.3390/biom10030433 Authors: Singh Kumar Singla Sharma Singh Prasad Thakur Singh Many bacteria have the potential to use specific pesticides as a source of carbon, phosphorous, nitrogen and sulphur. Acephate degradation by microbes is considered to be a safe and effective method....
Wed Mar 11, 2020 02:00
Biosensors, Vol. 10, Pages 23: Simultaneous Determination of Streptomycin and Oxytetracycline using a Oracet-Blue/Silver-Nanoparticle/Graphene-Oxide/Modified Screen-Printed Electrode Biosensors doi: 10.3390/bios10030023 Authors: Akbarzadeh Khajesharifi Thompson In this paper, an electrochemical technique is introduced for the determination of streptomycin (STR) in the presence of oxytetracycline (OTC) in milk samples. A novel bifunctional modified screen-printed electrode (SPE)...
Wed Mar 11, 2020 02:00
Brain Sciences, Vol. 10, Pages 159: Post-Ischaemic Immunological Response in the Brain: Targeting Microglia in Ischaemic Stroke Therapy Brain Sciences doi: 10.3390/brainsci10030159 Authors: Rawlinson Jenkins Thei Dallas Chen Microglia, the major endogenous immune cells of the central nervous system, mediate critical degenerative and regenerative responses in ischaemic stroke. Microglia become “activated”, proliferating, and undergoing changes in morphology,...
Wed Mar 11, 2020 02:00
Cancers, Vol. 12, Pages 657: Safety and Effectiveness of Aflibercept + Fluorouracil, Leucovorin, and Irinotecan (FOLFIRI) for the Treatment of Patients with Metastatic Colorectal Cancer (mCRC) in Current Clinical Practice: OZONE Study Cancers doi: 10.3390/cancers12030657 Authors: Ian Chau Marwan Fakih Pilar García-Alfonso Zdenĕk Linke Ana Ruiz Casado Eduardo Polo Marques Pascaline Picard Marina Celanovic Thomas Cartwright For patients with metastatic colorectal...
Wed Mar 11, 2020 02:00
Cancers, Vol. 12, Pages 652: Human Cancer-Associated Mutations of SF3B1 Lead to a Splicing Modification of Its Own RNA Cancers doi: 10.3390/cancers12030652 Authors: Bergot Lippert Douet-Guilbert Commet Corcos Bernard Deregulation of pre-mRNA splicing is observed in many cancers and hematological malignancies. Genes encoding splicing factors are frequently mutated in myelodysplastic syndromes, in which SF3B1 mutations are the most frequent. SF3B1 is an essential component...
Wed Mar 11, 2020 02:00
Cancers, Vol. 12, Pages 654: MK2 Inhibition Induces p53-Dependent Senescence in Glioblastoma Cells Cancers doi: 10.3390/cancers12030654 Authors: Phoa Recasens Gurgis Betts Menezes Chau Nordfors Haapasalo Haapasalo Johns Stringer Day Buckland Lalaoui Munoz MAPK-activated protein kinase 2 (MK2) has diverse roles in cancer. In response to chemotherapy, MK2 inhibition is synthetically lethal to p53-deficiency. While TP53 deletion is...
Wed Mar 11, 2020 02:00
Cancers, Vol. 12, Pages 656: Modelling Curved Contact Flexible Microstrip Applicators for Patient-Specific Superficial Hyperthermia Treatment Planning Cancers doi: 10.3390/cancers12030656 Authors: Kok Groen Bakker Crezee This paper describes a method to reconstruct bendable superficial hyperthermia applicators for routine clinical patient-specific treatment planning. The reconstruction uses a CT scan with a flexible silicone dummy applicator positioned on the patient. The...
Wed Mar 11, 2020 02:00
Cancers, Vol. 12, Pages 655: BNIP3L-Dependent Mitophagy Promotes HBx-Induced Cancer Stemness of Hepatocellular Carcinoma Cells via Glycolysis Metabolism Reprogramming Cancers doi: 10.3390/cancers12030655 Authors: Chen Wang Che Lan Zhang Zhan Huang Lin Lin Hepatitis B virus (HBV) is one of predisposing factors for hepatocellular carcinoma (HCC). The role of HBV x protein (HBx) in mediating the induction and maintenance of cancer stemness during HBV-related...
Wed Mar 11, 2020 02:00
Cancers, Vol. 12, Pages 653: Molecular-Clinical Correlation in Pediatric Medulloblastoma: A Cohort Series Study of 52 Cases in Taiwan Cancers doi: 10.3390/cancers12030653 Authors: Wu Ho Jou Yu Tran Liang Chen Lee Chen Lin Chang Tsai Liu Lee Hsieh Huang Sung Chang Changou Liang Hsieh Liu Chao Chen Chu Cho Wong In 2016, a project was initiated in Taiwan to adopt molecular diagnosis...
Wed Mar 11, 2020 02:00
Cancers, Vol. 12, Pages 648: Benefits of Combined All-Trans Retinoic Acid and Arsenic Trioxide Treatment of Acute Promyelocytic Leukemia Cells and Further Enhancement by Inhibition of Atypically Expressed Transglutaminase 2 Cancers doi: 10.3390/cancers12030648 Authors: Jambrovics Uray Keillor Fésüs Balajthy Randomized trials in acute promyelocytic leukemia patients have shown that treatment with a combination of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO)...
Wed Mar 11, 2020 02:00
Cancers, Vol. 12, Pages 651: Affibody Molecules as Targeting Vectors for PET Imaging Cancers doi: 10.3390/cancers12030651 Authors: Vladimir Tolmachev Anna Orlova Affibody molecules are small (58 amino acids) engineered scaffold proteins that can be selected to bind to a large variety of proteins with a high affinity. Their small size and high affinity make them attractive as targeting vectors for molecular imaging. High-affinity affibody binders have been selected for several cancer-associated...
Wed Mar 11, 2020 02:00
Cancers, Vol. 12, Pages 649: Mechanistic and Functional Shades of Mucins and Associated Glycans in Colon Cancer Cancers doi: 10.3390/cancers12030649 Authors: Pothuraju Krishn Gautam Pai Ganguly Chaudhary Rachagani Kaur Batra Mucus serves as the chief protective barrier against pathogenic and mechanical insults in respiratory, gastrointestinal, and urogenital tracts. Altered mucin expression, the major component of mucus, in conjunction with differential...
Wed Mar 11, 2020 02:00
Cancers, Vol. 12, Pages 650: Mitochondrial Respiration Correlates with Prognostic Markers in Chronic Lymphocytic Leukemia and Is Normalized by Ibrutinib Treatment Cancers doi: 10.3390/cancers12030650 Authors: Roy Chowdhury Bouchard Saleh Nugent Peltier Mejia Hou McFall Squires Hewitt Davidson Shen Johnston Doucette Hatch Fernyhough Marshall Gibson Dawe Banerji Mitochondrial bioenergetics profiling, a measure...
Wed Mar 11, 2020 02:00
Cells, Vol. 9, Pages 693: Effect of Lifestyle Intervention in the Concentration of Adipoquines and Branched Chain Amino Acids in Subjects with High Risk of Developing Type 2 Diabetes: Feel4Diabetes Study Cells doi: 10.3390/cells9030693 Authors: Itziar Lamiquiz-Moneo Ana M. Bea Cristian Palacios-Pérez Pilar De Miguel-Etayo Esther M. González-Gil Chuan López-Ariño Fernando Civeira Luis A. Moreno Rocio Mateo-Gallego Introduction: The global prevalence of type 2 diabetes...
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Cells, Vol. 9, Pages 692: NANOG/NANOGP8 Localizes at the Centrosome and is Spatiotemporally Associated with Centriole Maturation Cells doi: 10.3390/cells9030692 Authors: Mikulenkova Neradil Vymazal Skoda Veselska NANOG is a transcription factor involved in the regulation of pluripotency and stemness. The functional paralog of NANOG, NANOGP8, differs from NANOG in only three amino acids and exhibits similar reprogramming activity. Given the transcriptional regulatory...
Wed Mar 11, 2020 02:00
Cells, Vol. 9, Pages 687: VEGF Triggers Transient Induction of Autophagy in Endothelial Cells via AMPKα1 Cells doi: 10.3390/cells9030687 Authors: Spengler Kryeziu Große Mosig Heller AMP-activated protein kinase (AMPK) is activated by vascular endothelial growth factor (VEGF) in endothelial cells and it is significantly involved in VEGF-induced angiogenesis. This study investigates whether the VEGF/AMPK pathway regulates autophagy in endothelial cells and whether this...
Wed Mar 11, 2020 02:00
Cells, Vol. 9, Pages 684: Proteoglycan 4 is Increased in Human Calcified Aortic Valves and Enhances Valvular Interstitial Cell Calcification Cells doi: 10.3390/cells9030684 Authors: Artiach Carracedo Seime Plunde Laguna-Fernandez Matic Franco-Cereceda Bäck Aortic valve stenosis (AVS), a consequence of increased fibrosis and calcification of the aortic valve leaflets, causes progressive narrowing of the aortic valve. Proteoglycans, structural components of...
Wed Mar 11, 2020 02:00
Cells, Vol. 9, Pages 685: Molecular Regulations and Functions of the Transient Receptor Potential Channels of the Islets of Langerhans and Insulinoma Cells Cells doi: 10.3390/cells9030685 Authors: Islam Insulin secretion from the β-cells of the islets of Langerhans is triggered mainly by nutrients such as glucose, and incretin hormones such as glucagon-like peptide-1 (GLP-1). The mechanisms of the stimulus-secretion coupling involve the participation of the key enzymes that...
Wed Mar 11, 2020 02:00
Cells, Vol. 9, Pages 688: New and Emerging Systemic Therapeutic Options for Advanced Cholangiocarcinoma Cells doi: 10.3390/cells9030688 Authors: Massironi Pilla Elvevi Longarini Rossi Bidoli Invernizzi Cholangiocarcinoma (CCA) represents a disease entity that comprises a heterogeneous group of biliary malignant neoplasms, with variable clinical presentation and severity. It may be classified according to its anatomical location and distinguished in intrahepatic...
Wed Mar 11, 2020 02:00
Cells, Vol. 9, Pages 686: The Role of Tissue-resident T Cells in Stress Surveillance and Tissue Maintenance Cells doi: 10.3390/cells9030686 Authors: Johnson Witherden Havran While forming a minor population in the blood and lymphoid compartments, T cells are significantly enriched within barrier tissues. In addition to providing protection against infection, these tissue-resident T cells play critical roles in tissue homeostasis and repair. T cells in the epidermis and intestinal...
Wed Mar 11, 2020 02:00
Cells, Vol. 9, Pages 690: Is T Cell Negative Selection a Learning Algorithm? Cells doi: 10.3390/cells9030690 Authors: Inge M. N. Wortel Can Keşmir Rob J. de Boer Judith N. Mandl Johannes Textor Our immune system can destroy most cells in our body, an ability that needs to be tightly controlled. To prevent autoimmunity, the thymic medulla exposes developing T cells to normal “self” peptides and prevents any responders from entering the bloodstream. However,...
Wed Mar 11, 2020 02:00
Cells, Vol. 9, Pages 691: Anti-HLA Class II Antibodies Correlate with C-Reactive Protein Levels in Patients with Rheumatoid Arthritis Associated with Interstitial Lung Disease Cells doi: 10.3390/cells9030691 Authors: Alma D. Del Angel-Pablo Ivette Buendía-Roldán Mayra Mejía Gloria Pérez-Rubio Karol J. Nava-Quiroz Jorge Rojas-Serrano Ramcés Falfán-Valencia The pathogenesis of Rheumatoid Arthritis (RA) is not fully understood, probably influenced by genetic and environmental...
Wed Mar 11, 2020 02:00
Cells, Vol. 9, Pages 689: The Galectin Family as Molecular Targets: Hopes for Defeating Pancreatic Cancer Cells doi: 10.3390/cells9030689 Authors: Manero-Rupérez Martínez-Bosch Barranco Visa Navarro Galectins are a family of proteins that bind β-galactose residues through a highly conserved carbohydrate recognition domain. They regulate several important biological functions, including cell proliferation, adhesion, migration, and invasion, and play critical...
Wed Mar 11, 2020 02:00
Cells, Vol. 9, Pages 683: Evaluation of Glycosylated PTGS2 in Colorectal Cancer for NSAIDS-Based Adjuvant Therapy Cells doi: 10.3390/cells9030683 Authors: Venè Costa Augugliaro Carlone Scabini Casoni Pattaccini Boggio Zupo Grillo Mastracci Pitto Minghelli Ferrari Tosetti Romairone Mingari Poggi Benelli Observational/retrospective studies indicate that prostaglandin-endoperoxide synthase-2 (PTGS2) inhibitors could positively...
Wed Mar 11, 2020 02:00
Cells, Vol. 9, Pages 682: 3D Printed Conductive Nanocellulose Scaffolds for the Differentiation of Human Neuroblastoma Cells Cells doi: 10.3390/cells9030682 Authors: Bordoni Karabulut Kuzmenko Fantini Pansarasa Cereda Gatenholm We prepared cellulose nanofibrils-based (CNF), alginate-based and single-walled carbon nanotubes (SWCNT)-based inks for freeform reversible embedding hydrogel (FRESH) 3D bioprinting of conductive scaffolds. The 3D printability of conductive...
Wed Mar 11, 2020 02:00
Children, Vol. 7, Pages 20: Post-Cardiotomy Parasternal Nerve Block with Bupivacaine may be Associated with Reduced Post-Operative Opioid Use in Children: A Retrospective Cohort Study Children doi: 10.3390/children7030020 Authors: Francis X. Moga Mark D. Lo Galbo David M. Overman Stefan J. Friedrichsdorf Postoperative pain treatment affects immediate and long-term outcomes in children undergoing cardiac surgery. Opioids, as part of multimodal analgesia, are effective in treating...
Wed Mar 11, 2020 02:00
Climate, Vol. 8, Pages 40: Probability Risk of Heat- and Cold-Related Mortality to Temperature, Gender, and Age Using GAM Regression Analysis Climate doi: 10.3390/cli8030040 Authors: Andri Pyrgou Mattheos Santamouris We have examined the heat and cold-related mortality risk subject to cold and heat extremes by using a generalized additive model (GAM) regression technique to quantify the effect of the stimulus of mortality in the presence of covariate data for 2007–2014 in...
Wed Mar 11, 2020 02:00
Cosmetics, Vol. 7, Pages 17: Symurban Nanocrystals for Advanced Anti-Pollution Skincare Cosmetics doi: 10.3390/cosmetics7010017 Authors: Köpke Pyo Several of most common dermatoses worldwide, e.g., psoriasis and atopic dermatitis, are worsened in their clinical picture when the skin is regularly exposed to an increased air pollution level, e.g., particulate matter. This is explainable by the activation of the aryl hydrocarbon receptor (AhR) in the skin, which results in an increased...
Wed Mar 11, 2020 02:00
Diagnostics, Vol. 10, Pages 152: Plasma Concentrations of Extracellular DNA in Acute Kidney Injury Diagnostics doi: 10.3390/diagnostics10030152 Authors: Jordanka Homolová Ľubica Janovičová Barbora Konečná Barbora Vlková Peter Celec Ľubomíra Tóthová Janka Bábíčková Current diagnostic methods of acute kidney injury (AKI) have limited sensitivity and specificity. Tissue injury has been linked to an increase in the concentrations of extracellular DNA (ecDNA) in plasma....
Wed Mar 11, 2020 02:00
Diagnostics, Vol. 10, Pages 151: A Novel, Circulating Tumor Cell Enrichment Method Reduces ARv7 False Positivity in Patients with Castration-Resistant Prostate Cancer Diagnostics doi: 10.3390/diagnostics10030151 Authors: Nakasato Kusaka Ota Hasebe Ueda Unoki Oshinomi Morita Maeda Shichijo Naoe Ogawa Background: The AR-V7 splice variant is a cause of castration-resistant prostate cancer (CRPC). However, testing for the presence of AR-V7 by...
Wed Mar 11, 2020 02:00
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