Replication stress is a common feature of cancer cells. Ataxia Telangiectasia Mutated (ATM) and Rad3 related (ATR) signalling, a DNA damage repair (DDR) pathway, is activated by regions of single‐stranded DNA (ssDNA) that can arise during replication stress. ATR delays cell cycle progression and prevents DNA replication fork collapse, which prohibits cell death and promotes proliferation. Several ATR inhibitors have been developed in order to restrain this protective mechanism in tumours. It is known,...
Wed Mar 11, 2020 18:55
Comparable performance indicators for breast cancer screening in the European Union (EU) have not been previously reported. We estimated adjusted breast cancer screening positivity rate (PR) and detection rates (DR) to investigate variation across EU countries. For the age 50‐69 years, the adjusted EU‐pooled PR for initial screening was 8.9% (cross programme variation range 3.2‐19.5%) while DR of invasive cancers was 5.3/1,000 (range 3.8‐7.4/1,000) and DR of ductal carcinoma in situ (DCIS) was 1.3/1,000...
Wed Mar 11, 2020 18:55
Conditions: Hypocalcemia; Thyroid; Parathyroid Dysfunction; Calcium Disorder; Hormone Disturbance; Postoperative ComplicationsIntervention: Diagnostic Test: Total serum calcium blood testSponsor: University Hospital "Sestre Milosrdnice"Not yet recruiting
Wed Mar 11, 2020 18:00
The Association of hsCRP and Radiotherapy-Induced Toxicity in Patients With Nasopharyngeal Carcinoma
Conditions: Nasopharyngeal Carcinoma; Head and Neck Cancer; Toxicity Due to RadiotherapyIntervention: Other: clinical measurementsSponsor: Jiarong Chen, MDNot yet recruiting
Wed Mar 11, 2020 18:00
Condition: Pain, PostoperativeIntervention: Drug: Regional AnesthesiaSponsor: University of FloridaNot yet recruiting
Wed Mar 11, 2020 18:00
Cancers, Vol. 12, Pages 657: Safety and Effectiveness of Aflibercept + Fluorouracil, Leucovorin, and Irinotecan (FOLFIRI) for the Treatment of Patients with Metastatic Colorectal Cancer (mCRC) in Current Clinical Practice: OZONE Study Cancers doi: 10.3390/cancers12030657 Authors: Ian Chau Marwan Fakih Pilar García-Alfonso Zdenĕk Linke Ana Ruiz Casado Eduardo Polo Marques Pascaline Picard Marina Celanovic Thomas Cartwright For patients with metastatic...
Wed Mar 11, 2020 02:00
Cancers, Vol. 12, Pages 652: Human Cancer-Associated Mutations of SF3B1 Lead to a Splicing Modification of Its Own RNA Cancers doi: 10.3390/cancers12030652 Authors: Bergot Lippert Douet-Guilbert Commet Corcos Bernard Deregulation of pre-mRNA splicing is observed in many cancers and hematological malignancies. Genes encoding splicing factors are frequently mutated in myelodysplastic syndromes, in which SF3B1 mutations are the most frequent. SF3B1 is an essential...
Wed Mar 11, 2020 02:00
Cancers, Vol. 12, Pages 656: Modelling Curved Contact Flexible Microstrip Applicators for Patient-Specific Superficial Hyperthermia Treatment Planning Cancers doi: 10.3390/cancers12030656 Authors: Kok Groen Bakker Crezee This paper describes a method to reconstruct bendable superficial hyperthermia applicators for routine clinical patient-specific treatment planning. The reconstruction uses a CT scan with a flexible silicone dummy applicator positioned on the patient....
Wed Mar 11, 2020 02:00
Cancers, Vol. 12, Pages 653: Molecular-Clinical Correlation in Pediatric Medulloblastoma: A Cohort Series Study of 52 Cases in Taiwan Cancers doi: 10.3390/cancers12030653 Authors: Wu Ho Jou Yu Tran Liang Chen Lee Chen Lin Chang Tsai Liu Lee Hsieh Huang Sung Chang Changou Liang Hsieh Liu Chao Chen Chu Cho Wong In 2016, a project was initiated in Taiwan...
Wed Mar 11, 2020 02:00
Cancers, Vol. 12, Pages 655: BNIP3L-Dependent Mitophagy Promotes HBx-Induced Cancer Stemness of Hepatocellular Carcinoma Cells via Glycolysis Metabolism Reprogramming Cancers doi: 10.3390/cancers12030655 Authors: Chen Wang Che Lan Zhang Zhan Huang Lin Lin Hepatitis B virus (HBV) is one of predisposing factors for hepatocellular carcinoma (HCC). The role of HBV x protein (HBx) in mediating the induction and maintenance of cancer stemness during...
Wed Mar 11, 2020 02:00
Cancers, Vol. 12, Pages 654: MK2 Inhibition Induces p53-Dependent Senescence in Glioblastoma Cells Cancers doi: 10.3390/cancers12030654 Authors: Phoa Recasens Gurgis Betts Menezes Chau Nordfors Haapasalo Haapasalo Johns Stringer Day Buckland Lalaoui Munoz MAPK-activated protein kinase 2 (MK2) has diverse roles in cancer. In response to chemotherapy, MK2 inhibition is synthetically lethal to p53-deficiency. While...
Wed Mar 11, 2020 02:00
Cancers, Vol. 12, Pages 648: Benefits of Combined All-Trans Retinoic Acid and Arsenic Trioxide Treatment of Acute Promyelocytic Leukemia Cells and Further Enhancement by Inhibition of Atypically Expressed Transglutaminase 2 Cancers doi: 10.3390/cancers12030648 Authors: Jambrovics Uray Keillor Fésüs Balajthy Randomized trials in acute promyelocytic leukemia patients have shown that treatment with a combination of all-trans retinoic acid (ATRA) and arsenic trioxide...
Wed Mar 11, 2020 02:00
Cancers, Vol. 12, Pages 651: Affibody Molecules as Targeting Vectors for PET Imaging Cancers doi: 10.3390/cancers12030651 Authors: Vladimir Tolmachev Anna Orlova Affibody molecules are small (58 amino acids) engineered scaffold proteins that can be selected to bind to a large variety of proteins with a high affinity. Their small size and high affinity make them attractive as targeting vectors for molecular imaging. High-affinity affibody binders have been selected for several...
Wed Mar 11, 2020 02:00
Cancers, Vol. 12, Pages 649: Mechanistic and Functional Shades of Mucins and Associated Glycans in Colon Cancer Cancers doi: 10.3390/cancers12030649 Authors: Pothuraju Krishn Gautam Pai Ganguly Chaudhary Rachagani Kaur Batra Mucus serves as the chief protective barrier against pathogenic and mechanical insults in respiratory, gastrointestinal, and urogenital tracts. Altered mucin expression, the major component of mucus, in conjunction with...
Wed Mar 11, 2020 02:00
Cancers, Vol. 12, Pages 650: Mitochondrial Respiration Correlates with Prognostic Markers in Chronic Lymphocytic Leukemia and Is Normalized by Ibrutinib Treatment Cancers doi: 10.3390/cancers12030650 Authors: Roy Chowdhury Bouchard Saleh Nugent Peltier Mejia Hou McFall Squires Hewitt Davidson Shen Johnston Doucette Hatch Fernyhough Marshall Gibson Dawe Banerji Mitochondrial bioenergetics...
Wed Mar 11, 2020 02:00
Publication date: Available online 10 March 2020Source: Journal of Neuroscience MethodsAuthor(s): Adam W. Lester, Adele J. Kapellusch, Carol A. Barnes
Wed Mar 11, 2020 17:49
Publication date: Available online 10 March 2020Source: Journal of Neuroscience MethodsAuthor(s): Chou P. Hung, Chloe Callahan-Flintoft, Anthony J. Walker, Paul D. Fedele, Kim F. Fluitt, Onyekachi Odoemene, Andre V. Harrison, Barry D. Vaughan, Matthew S. Jaswa, Min Wei
Wed Mar 11, 2020 17:49
Publication date: Available online 10 March 2020Source: Annales de Chirurgie Plastique EsthétiqueAuthor(s): F. Goldammer, F. Bodin, C. Bruant-Rodier, L. Ruffenach, C. Dissaux
Wed Mar 11, 2020 17:44
Publication date: Available online 10 March 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): Orkun Koban, Mustafa Turgut Yildizgoren, Mustafa Aras, Sukru Oral, Sadık Ahmet Uyanik, Yurdal Serarslan, Esra Emine Okuyucu, Atilla Yilmaz
Wed Mar 11, 2020 17:29
Publication date: Available online 10 March 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): Pushpa Raj Puri, Bjarni Johannsson, Jian Fernandes Seyedi, Bo Halle, Mette Schulz, Christian Bonde Pedersen, Bjarne Winther Kristensen, Frantz Rom Poulsen
Wed Mar 11, 2020 17:29
Abstract Objectives The adsorption of bovine milk caseins on the tooth surface might have a positive impact on the prevention of dental diseases. Therefore, the present study aimed to investigate the efficacy of mouthrinses with different types of bovine milk and milk protein isolates to accumulate caseins in the pellicle. Materials/methods An indirect enzyme-linked...
Wed Mar 11, 2020 02:00
Publication date: Available online 11 March 2020Source: TalantaAuthor(s): Chanatda Worawit, Waleed Alahmad, Manuel Miró, Pakorn Varanusupakul
Wed Mar 11, 2020 17:13
Publication date: Available online 11 March 2020Source: TalantaAuthor(s): Elena V. Karpova, Elena E. Karyakina, Arkady A. Karyakin
Wed Mar 11, 2020 17:13
Publication date: Available online 10 March 2020Source: TalantaAuthor(s): Ahlem Laribi, Séverine Allegra, Mina Souiri, Ridha Mzoughi, Ali Othmane, Françoise Girardot
Wed Mar 11, 2020 17:13
Publication date: May 2020Source: Radiotherapy and Oncology, Volume 146Author(s): Holger H. Göbel, Maike J. Büttner-Herold, Nicole Fuhrich, Thomas Aigner, Gerhard G. Grabenbauer, Luitpold V.R. Distel
Wed Mar 11, 2020 17:13
Publication date: Available online 11 March 2020Source: Journal of Surgical EducationAuthor(s): Tahmina Nazari, Floyd W. van de Graaf, Mary E.W. Dankbaar, Johan F. Lange, Jeroen J.G. van Merriënboer, Theo Wiggers
Wed Mar 11, 2020 17:05
Summary Purpose SM-88 (D,L-alpha-metyrosine; racemetyrosine) is a novel anti-cancer agent, used with melanin, phenytoin, and sirolimus (SMK Therapy). This pilot first-in-human study characterized the safety, tolerability, and efficacy of SMK Therapy in subjects with advanced metastatic cancer. Methods All subjects (n = 30) received SMK Therapy for an initial 6 week Cycle (5 days on, 2 off per week) and continued if well tolerated. Safety signals, clinical response, overall survival,...
Wed Mar 11, 2020 16:59
Objective: Word retrieval difficulty can be distressing for individuals with aphasia. However, physiological stress responses to word retrieval are relatively unstudied. This study aims to measure the physiological response (i.e., heart rate and respiratory rate) and perceived stress in individuals with aphasia during a naming task to understand whether word retrieval may be a stressor to them. Method: An aphasia group (n = 7) and a healthy group (n = 38) participated in 4 experimental conditions,...
Wed Mar 11, 2020 16:19
Ερευνητές από την Κλινική του Cleveland εντόπισαν ένα υποπροϊόν που παράγεται στο έντερο, τον μεταβολίτη PAG (phenylacetylglutamine), ο οποίος συνδέεται με την ανάπτυξη καρδιαγγειακών παθήσεων, όπως η καρδιακή προσβολή και το εγκεφαλικό επεισόδιο. Η μελέτη δημοσιεύθηκε στο Cell. Η φαινυλαλανίνη είναι ένα αμινοξύ που βρίσκεται σε πολλά τρόφιμα, συμπεριλαμβανομένων φυτικών και ζωικών πηγών πρωτεΐνης όπως το κρέας, τα φασόλια και η σόγια. Οι ερευνητές, με επικεφαλής τον Stanley Hazen, διευθυντή του...
Wed Mar 11, 2020 13:10
Η ψηφιακή τομοσύνθεση μαστού -γνωστή και ως τρισδιάστατη ψηφιακή μαστογραφία- υπερτερεί έναντι της απλής ψηφιακής μαστογραφίας, όσον αφορά τη δυνατότητα ανίχνευσης του καρκίνου, ενώ παρέχει και λιγότερα ψευδώς θετικά αποτελέσματα, όπως δείχνει μια πενταετούς διάρκεια αμερικανική επιστημονική έρευνα, η μεγαλύτερη του είδους της μέχρι σήμερα. Επιπλέον η τρισδιάστατη ψηφιακή μαστογραφία ανιχνεύει μεγαλύτερο ποσοστό καρκίνων του μαστού με κακή πρόγνωση σε σχέση με τη δεύτερη μέθοδο. Η ψηφιακή τομοσύνθεση...
Wed Mar 11, 2020 12:57
Ο συνδυασμός περιβαλλοντικών και γενετικών παραγόντων καθορίζει το προσδόκιμο ζωής του σύγχρονου ανθρώπου. Μια νέα αμερικανική μελέτη έρχεται να αναδείξει συγκεκριμένα κοινωνικά χαρακτηριστικά που παίζουν καθοριστικό ρόλο στο πόσο θα ζήσουμε. Η Elizabeth Dobis, μεταδιδακτορική φοιτήτρια στο Πολιτειακό Πανεπιστήμιο της Πενσυλβάνια μαζί με συνεργάτες της από το Περιφερειακό Κέντρο Αστικής Ανάπτυξης της αμερικανικής πολιτείας και από άλλα πολιτειακά πανεπιστήμια του Μίσιγκαν ανέλυσαν στοιχεία για...
Wed Mar 11, 2020 12:35
Καθώς ο αριθμός των νεκρών παγκοσμίως λόγω του νέου κορωνοϊού SARS-CoV-2 έχει ξεπεράσει πια τους 4.300 και ενώ από την αρχή της επιδημίας έχουν καταγραφεί περισσότερα από 119.000 κρούσματα σε 120 χώρες, η διεθνής επιστημονική κοινότητα κάνει πραγματικό αγώνα δρόμου να κατανοήσει γιατί μπορεί και εξαπλώνεται τόσο εύκολα και γρήγορα. Μέχρι τώρα έχουν εντοπιστεί κάποια γενετικά και δομικά χαρακτηριστικά που τον κάνουν μοναδικό, όπως μια πρωτεΐνη επιφανείας που εξηγεί γιατί μολύνει τόσο άμεσα τα ανθρώπινα...
Wed Mar 11, 2020 12:25
* Γράφει το METROPOLITAN HOSPITAL σύμφωνα με τις ειδικές οδηγίες της International Diabetes Federation (Europe) Στα τέλη του 2019, ένα νέο στέλεχος κορονωϊού (συγκεκριμένος ιός που προκαλεί νόσο σε ανθρώπους και ζώα) αναγνωρίστηκε ως αίτιο κρουσμάτων πνευμονίας στο Wuhan, μια πόλη της επαρχίας Hubei, στην Κίνα. Η μετάδοση του ιού υπήρξε ραγδαία και οδήγησε αρχικώς σε επιδημία σε όλη την Κίνα, ενώ στη συνέχεια εξαπλώθηκε παγκοσμίως, πλήττοντας πλέον σχεδόν όλες τις ηπείρους. Τα επιστημονικά δεδομένα...
Wed Mar 11, 2020 11:29
Μια νέα προκαταρκτική μελέτη που παρουσιάστηκε στις Επιστημονικές Συναντήσεις της Αμερικανικής Καρδιολογικής Εταιρείας για το 2020 έδειξε ότι οι άνθρωποι μέσης ηλικίας που έκαναν τα περισσότερα βήματα ημερησίως για ένα μέσο διάστημα εννέα ετών είχαν χαμηλότερο κίνδυνο διαβήτη (43%) και υψηλής αρτηριακής πίεσης (31%) συγκριτικά με όσους έκαναν τα λιγότερα βήματα. Ένα ακόμα από τα ευρήματα αφορά στις γυναίκες, για τις οποίες κάθε 1.000 βήματα συντελούσαν σε 13% χαμηλότερο κίνδυνο παχυσαρκίας, με το...
Wed Mar 11, 2020 08:00
Publication date: Available online 11 March 2020Source: Medical HypothesesAuthor(s): Yvang Chang, Ming Yang, Yu Zhang, Gang Xu, Zhonghai Li
Wed Mar 11, 2020 16:52
Publication date: Available online 11 March 2020Source: Medical HypothesesAuthor(s): J.S. Torday
Wed Mar 11, 2020 16:52
Publication date: Available online 11 March 2020Source: Medical HypothesesAuthor(s): Madison Wade, Virginia Delawder, Paul Reneau, Julia M. dos Santos
Wed Mar 11, 2020 16:52
2020 Fall Conference of the Society for Linguistic Anthropology In response to rising concerns regarding COVID-19, the SLA Executive Board, together with the SLA 2020 Organizing Committee, decided on March 6th postpone SLA 2020 until the fall. After working closely with the AAA and the Boulder Hiltons, we have set the new conference date for September 24-26, 2020. The full conference program, available for viewing on our Trello site, will largely remain the same as it was for April, with adjustments...
Wed Mar 11, 2020 16:23
Docosahexaenoic acid (DHA) enriched in brain can yield many important degradation products after the attack of hydroxyl radicals, which is known to serve as a nutraceutical and neuroprotective effects. Oxidati...
Wed Mar 11, 2020 02:00
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