Therapeutic Targeting of the IGF Axis
Osher E and Macaulay VM. Cells 2019 - Review. PMID 31416218 Free PMC article.
Finally, we summarize grounds for cautious optimism for ongoing and future studies of IGF blockade in cancer and non-malignant disorders including thyroid eye disease and aging....
Second-line treatments in children with immune thrombocytopenia: Effect on platelet count and patient-centered outcomes
Grace RF, et al. Am J Hematol 2019 - Clinical Trial. PMID 30945320 Free PMC article.
Combined with future randomized trials, these findings will help clinicians select the optimal second-line treatment for an individual child with ITP....
Imaging of Precision Therapy for Lung Cancer: Current State of the Art
Park H, et al. Radiology 2019 - Review. PMID 31385753 Free PMC article.
The focus of the article includes (a) an update on the recent advances in precision therapy for non-small cell lung cancer and their implications on imaging; (b) molecular and genomic biomarkers and pitfalls of image interpretations for lung cancer precision therapy; and (c) review of the current approaches and future directions of precision imaging for lung cancer, emphasizing emerging observations in longitudinal tumor kinetics, radiomics, and molecular and functional imaging. ...
Japanese encephalitis virus: Associated immune response and recent progress in vaccine development
Kumar A, et al. Microb Pathog 2019 - Review. PMID 31437579
This review highlights the importance of understanding of the immune mechanisms that are operated in the host during JEV infection and would be helpful in improving future vaccination strategy against JEV....
A population-based cohort of young women diagnosed with breast cancer in Geneva, Switzerland
Schaffar R, et al. PLoS One 2019. PMID 31491032 Free PMC article.
FUTURE PLANS: The results of this study will help filling the knowledge gap about treatment of young breast cancer patients and having a child after breast cancer, and will provide clinicians and public health professionals' with additional information to improve quality of care and decrease the impact of breast cancer in young women....
New and emerging systemic therapy options for well-differentiated gastroenteropancreatic neuroendocrine tumors
Scoville SD, et al. Expert Opin Pharmacother 2020 - Review. PMID 31760823
Future research is needed to determine the optimal indications for and sequencing of these novel therapies....
Lung Microvascular Niche, Repair, and Engineering
Tsuchiya T, et al. Front Bioeng Biotechnol 2020 - Review. PMID 32154234 Free PMC article.
The goal of the present review is to confirm the possibility of success in lung microvascular engineering in whole organ engineering and explore the future direction of the current methodology....
Immunotherapy in Malignant Pleural Mesothelioma
de Gooijer CJ, et al. Front Oncol 2020 - Review. PMID 32154179 Free PMC article.
In this review, we will highlight the most important immunotherapy-based research performed and put a focus on the future of MPM. ...
China lung transplantation developing: past, present and future.
Wu B, et al. Ann Transl Med 2020 - Review. PMID 32154286 Free PMC article.
The Key Characteristics of Carcinogens: Relationship to the Hallmarks of Cancer, Relevant Biomarkers, and Assays to Measure Them
Smith MT, et al. Cancer Epidemiol Biomarkers Prev 2020. PMID 32152214
We leveraged this expertise and an examination of the literature to more clearly describe each KC; identify current and emerging assays and in vivo biomarkers that can be used to measure them; and, make recommendations for future assay development. ...CONCLUSION: Future efforts should expand the breadth, specificity and sensitivity of validated assays and biomarkers that can measure the 10 KCs. ...
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Impact of a reduction in follow-up frequency on life expectancy in uterine cervical cancer patients
Matsumoto Y, et al. Int J Clin Oncol 2020. PMID 32152766
The results of this study provide a rationale for future studies investigating the optimal follow-up schedule for patients with cervical cancer....
Downregulation of RIG-I mediated by ITGB3/c-SRC/STAT3 signaling confers resistance to interferon-α-induced apoptosis in tumor-repopulating cells of melanoma
Li Y, et al. J Immunother Cancer 2020. PMID 32152220
Our findings may provide a new concept of combinatorial treatment for future immunotherapy....
Head-to-head comparison of in-house produced CD19 CAR-T cell in ALL and NHL patients
Itzhaki O, et al. J Immunother Cancer 2020. PMID 32152221
In addition, understanding the differences between CAR-T and TIL infusion products, may provide an angle to develop CAR-T cells for the treatment of solid tumors in the future. ...
Genomic landscape of acquired resistance to third-generation EGFR tyrosine kinase inhibitors in EGFR T790M-mutant non-small cell lung cancer
Lee J, et al. Cancer 2020. PMID 32154925
Technical Note: Integrating an open source Monte Carlo code "MCsquare" for clinical use in intensity-modulated proton therapy
Deng W, et al. Med Phys 2020. PMID 32153029
After adopting CT resampling and implementing LET model-dependent biological dose calculation capabilities, MCsquare will be sufficiently efficient and powerful to achieve Monte Carlo-based and LET-guided robust optimization in IMPT, which will be done in the future studies....
Portuguese Patient Dignity Question: A cross-sectional study of palliative patients cared for in primary care
Lemos Caldas M, et al. Palliat Support Care 2020. PMID 32151292
Future trials are now warranted....
Adjuvant therapy following resection of gastroenteropancreatic neuroendocrine tumors provides no recurrence or survival benefit
Barrett JR, et al. J Surg Oncol 2020. PMID 32153032
Selection bias enriching our treatment cohort for individuals with unmeasured high-risk characteristics likely explains some of these results; future studies should focus on patient subsets who may benefit from adjuvant therapy....
Liver Transection-First Approach in Left Trisectionectomy for Perihilar Cholangiocarcinoma
Hosokawa I, et al. Ann Surg Oncol 2020. PMID 32152773
After the completion of liver transection, the RAHA and RAPV, which run into the future resected liver, can be easily identified and divided under the wide surgical field at the hepatic hilus. ...
Barriers and Facilitators to Fertility-Related Discussions with Teenagers and Young Adults with Cancer: Nurses' Experiences
Norton W and Wright E. J Adolesc Young Adult Oncol 2020. PMID 32155354
Conclusions: Nurses should manage parental involvement sensitively if TYAs are to make informed decisions regarding their future reproductive health. ...
Further guidance in implementing the standardized 2018 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) Score
Shams-White MM, et al. Cancer Epidemiol Biomarkers Prev 2020. PMID 32152215
The aim of this commentary is to clarify potential points of ambiguity in its application, focusing on aspects related to specific sub-score components (physical activity, fast foods, alcohol, and sugar sweetened drinks), how to address different data needs due to varied data collection instruments, and future exploratory score approaches. ...
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