Reprocessing reusable medical devices is crucial in the healthcare industry. To ensure patient safety, strict standards are dictated to validate thermal disinfection in automated washer-disinfectors. The Unite...
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Trichosporon asahii is the major causative fungus of disseminated or deep-seated trichosporonosis and forms a biofilm on medical devices. Biofilm formation leads to antifungal drug resistance, so biofilm-related ...
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Timely implementation of influenza infection control and treatment can significantly reduce the impact on Hospital resources and patient management when demand is at peak. Turnaround times of Laboratory based ...
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Blue light has been attributed to the adverse biological effects caused by the use of smartphones and tablet devices at night. However, it is not realistic to immediately avoid nighttime exposure to blue light...
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Human leukocyte antigen (HLA) B*51:01 and endoplasmic reticulum aminopeptidase 1 (ERAP1) are strongly genetically associated with Behcet's disease (BD). Previous studies have defined two subgroups of HLA-B*51 peptidome containing Proline (Pro) or Alanine (Ala) at position 2 (P2). Little is known about the unconventional non-Pro/Ala2 HLA-B*51-bound peptides. We aimed to study the features of this novel sub-peptidome, and investigate its regulation by ERAP1. CRISPR-Cas9 was used to generate an...
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Ion mobility can add a dimension to LC-MS based shotgun proteomics which has the potential to boost proteome coverage, quantification accuracy and dynamic range. Required for this is suitable software that extracts the information contained in the four-dimensional (4D) data space spanned by m/z, retention time, ion mobility and signal intensity. Here we describe the ion mobility enhanced MaxQuant software, which utilizes the added data dimension. It offers an end to end computational workflow for...
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by Elizabeth B. Brown, Kreesha D. Shah, Richard Faville, Benjamin Kottler, Alex C. Keene Sleep is a nearly universal behavior that is regulated by diverse environmental stimuli and physiological states. A defining feature of sleep is a homeostatic rebound following deprivation, where animals compensate for lost sleep by increasing sleep duration and/or sleep depth. The fruit fly, Drosophila melanogaster, exhibits robust recovery sleep following deprivation and represents a powerful model to...
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[ Advance Publication ] [ Title ] The association of the visceral adiposity index with insulin resistance and beta-cell function in Korean adults with and without type 2 diabetes mellitus [ Author ] Hyun Ho Sung,Chang Eun Park,Mi Young Gi,Ju Ae Cha,Ae Eun Moon,Jae Kook Kang,Jeong Min Seong,Jun Ho Lee,Hyun Yoon [ Advance Pub. date ] 2020-03-12 [ DOI ] https://doi.org/10.1507/endocrj.EJ19-0517
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Zusammenfassung Hintergrund Wohl in kaum einem anderen Fachbereich sind medizinische Therapieentscheidungen von einem so hohen Maß an Abwägung und subjektiver Bewertung gekennzeichnet wie in der palliativen Onkologie. Nicht selten gehen diese mit konflikthaften Dissenssituationen zwischen den verschiedenen involvierten Personengruppen einher. Welche Kriterien sind für die Entscheidungsfindung relevant? Wie kann eine Therapieentscheidung...
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Zusammenfassung Hintergrund Das Analkarzinom ist eine seltene Erkrankung, deren Inzidenz derzeit in Deutschland zunimmt. Mehr als 80 % aller Analkarzinome sind mit einer Infektion mit humanem Papillomvirus (HPV) assoziiert. In der Behandlung des metastasierten Analkarzinoms steht die systemische Therapie im Vordergrund. Hier gibt es nur wenige prospektive Studien, die für die Definition eines therapeutischen Standards herangezogen werden...
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In this study, we show that TIF‐90 binds GTP at Threonine 310, and that GTP binding is required for transcription initiation factor 90 (TIF‐90)‐enhanced ribosomal RNA (rRNA) synthesis. A combination of mycophenolic acid and AZD8055 synergistically inhibits rRNA synthesis, in vivo tumor growth, and other oncogenic activities of primary human colon cancer cells, suggesting a potential avenue for the development of therapeutic treatments by targeting the regulation of rRNA synthesis by TIF proteins....
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Obesity can cause male infertility. PACAP could ameliorate fertility in obese male mice via PKA/CREB pathway‐dependent Sirt1 activation and p53 deacetylation and may be a promising candidate drug for obesity‐induced male infertility. Abstract Obesity is strongly linked to male infertility. Testicular spermatogenic cell apoptosis plays an important role in obesity‐related male infertility. Pituitary adenylate cyclase‐activating peptide (PACAP) has been recently shown to exhibit antiapoptotic and...
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The U.K. Royal College of Radiologists (RCR) has canceled some exams and events...Read more on AuntMinnieEurope.comRelated Reading: RCR posts clinical, interventional radiology curricula RCR seeks applicants for oncology research fellowships U.K. group calls for action on aortic tear management U.K. unveils learning initiative to tackle errors RCR responds to damning emergency CT access report
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Amid concerns about the coronavirus outbreak, the European Society for Radiotherapy...Read more on AuntMinnieEurope.comRelated Reading: ESR may sue authorities over ECR postponement ESR goes ahead with live online coronavirus session ISMRM moves annual meeting to Paris in August HIMSS cancels 2020 conference ECR 2020 gets postponed until mid-July
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Isotope technology developer Eckert & Ziegler said it has begun commercial...Read more on AuntMinnieEurope.comRelated Reading: Eckert & Ziegler supports new radiopharmaceuticals Isotopia, Eckert & Ziegler partner Eckert & Ziegler records sales, earnings gains Eckert & Ziegler signs deal with Alpha Tau Medical Eckert & Ziegler receives approval for Ga-68 expansion
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Danish 3D printing startup Particle3D has developed a new technique for creating...Read more on AuntMinnieEurope.comRelated Reading: FossiLabs unveils 3D-printed bone implants 3D printing assists ultrasound-guided liver resection Cardiac patients gain from 3D printing, AR advances 3D printing boosts treatment of urethral injuries Italians use 3D printing to enhance safety in upper GI surgery
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The European Society of Radiology (ESR) has decided to proceed with this week's...Read more on AuntMinnieEurope.comRelated Reading: ESR may sue authorities over ECR postponement ECR 2020 gets postponed until mid-July ESR, ERS issue statement on CT lung cancer screening ESR: Radiology societies must adapt to new generation ESR unveils ESR Connect streaming platform
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Publication date: Available online 10 March 2020Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): G. Dot, F. Rafflenbeul, M. Arbotto, L. Gajny, P. Rouch, T. Schouman
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Abstract To date, the growth usage of mobile technologies and devices as well as the ubiquitous wireless communication have led to the development of new systems and applications in many fields and areas including education. This technological progress can be used to facilitate the students’ lives by creating smart and personalized solutions considering their personal and academic profiles as well as their real environments. This is because mobile technologies have the capacity...
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Abstract In conventional classroom driven instructor training, disabled student achieved low personality & motivation, more mental load due to lack of practical learning and unsuitable usage of learning material through different simulated contexts. Therefore, intent of proposed study is to integrate microworld game-based learning to different learning styles of special needs students which enhance their learning performance and encourage them to discover and solve problems...
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Abstract In spite of the rise of computer-assisted language learning (CALL) as an alluring field of inquiry, there seems to be a paucity of empirical studies on the actual experience of English as a foreign language (EFL) teachers in the adoption of technology in their classes. In an attempt to remedy this gap, this study was designed to qualitatively examine six Iranian EFL pre-service teachers’ experiences in implementing CALL activities. The pre-service teachers first took the...
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by Artur Santos-Miranda, Julliane Vasconcelos Joviano-Santos, Grazielle Alves Ribeiro, Ana Flávia M. Botelho, Peter Rocha, Leda Quercia Vieira, Jader Santos Cruz, Danilo Roman-Campos Chagas Disease (CD) is one of the leading causes of heart failure and sudden death in Latin America. Treatments with antioxidants have provided promising alternatives to ameliorate CD. However, the specific roles of major reactive oxygen species (ROS) sources, including NADPH-oxidase 2 (NOX2), mitochondrial-derived...
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Publication date: Available online 11 March 2020Source: CryobiologyAuthor(s): J. Ito, K. Shirasuna, T. Kuwayama, H. Iwata
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Publication date: Available online 11 March 2020Source: CryobiologyAuthor(s): V.I. Mokrousova, K.A. Okotrub, S.Y. Amstislavsky, N.V. Surovtsev
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Abstract Hypophosphatasia (HPP) is a rare metabolic disorder characterized by low tissue‐nonspecific alkaline phosphatase (TNSALP) typically caused by ALPL gene mutations. HPP is heterogeneous, with clinical presentation correlating with residual TNSALP activity and/or dominant negative effects (DNE). We measured residual activity and DNE for 155 ALPL variants by transient transfection and TNSALP enzymatic activity measurement. Ninety variants showed low residual activity and 24 showed DNE. These...
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Diabetes mellitus, which has a wide range of effects on the physical, social and psychological aspects of the well-being of a person, is a common and challenging chronic disease that causes a significant rate ...
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Allergic rhinitis is a common chronic condition in the paediatric population. No reports regarding the quality of life in children with allergic rhinitis in the Polish population have been found in the availab...
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There is a lack of cohort studies on the influence factors of oral health-related quality of life (OHRQoL). This study aimed to follow subjects from age 12 to 18 to analyse the sociodemographic and clinical fa...
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EQ-5D is generic measure of health-related quality of life. Studies using EQ-5D generate ordinal data that are interpreted as categories ordered by severity. New analytic approaches taking into account the ord...
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Effects of the obturation technique on sealer penetration alongside apically separated files were investigated. The obturation technique plays a significant role on the sealer penetration beyond the separated instrument. Samples obturated with the cold lateral compaction technique had the lowest penetration depth and percentage values beyond the separated file at a 1 mm level. Abstract The effects of different obturation techniques on calcium silicate‐based sealer penetration in the...
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IJERPH, Vol. 17, Pages 1827: Factors Associated with High Mercury Levels in Women and Girls from The Mojana Region, Colombia, 2013–2015 International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17061827 Authors: Sonia Mireya Diaz Ruth Marien Palma Maria Nathalia Muñoz Carolina Becerra-Arias Julián Alfredo Fernández Niño Women are primarily exposed to mercury through the consumption of fish contaminated by gold mining activities. The main...
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IJERPH, Vol. 17, Pages 1826: Variation in the Occurrence of fimA Genotypes of Porphyromonas gingivalis in Periodontal Health and Disease International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17061826 Authors: Manohar Kugaji Uday Muddapur Kishore Bhat Vinayak Joshi Manjunath Manubolu Kavitha Pathakoti Malleswara Rao Peram Vijay Kumbar Porphyromonas gingivalis is regarded as a “keystone pathogen” in periodontitis....
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IJERPH, Vol. 17, Pages 1824: Association of Ambient Air Pollution with Nasopharyngeal Carcinoma Incidence in Ten Large Chinese Cities, 2006–2013 International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17061824 Authors: Yang Liu Zhao Chen Deng Large cities in China are experiencing severe ambient air pollution. Although China accounts for more than 45% of new cases of nasopharyngeal carcinoma worldwide in 2018, few studies have examined...
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IJERPH, Vol. 17, Pages 1825: Intracervical Foley Catheter Plus Intravaginal Misoprostol vs Intravaginal Misoprostol Alone for Cervical Ripening: A Meta-Analysis International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17061825 Authors: Lee Huang Cheng Yeh Lin Horng Huang Lee Wang Currently, there is no meta-analysis comparing intravaginal misoprostol plus intracervical Foley catheter versus intravaginal misoprostol...
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IJERPH, Vol. 17, Pages 1822: Effects of Sulfamethoxazole and 2-Ethylhexyl-4-Methoxycinnamate on the Dissimilatory Nitrate Reduction Processes and N2O Release in Sediments in the Yarlung Zangbo River International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17061822 Authors: Xu Lu Xue The nitrogen pollution of rivers as a global environmental problem has received great attentions in recent years. The occurrence of emerging pollutants in high-altitude...
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IJERPH, Vol. 17, Pages 1818: Prevalence and Risk Factors of Metabolic Associated Fatty Liver Disease in Xinxiang, China International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17061818 Authors: Hongbin Li Meihao Guo Zhen An Jun Meng Jing Jiang Jie Song Weidong Wu Metabolic associated fatty liver disease (MAFLD) is recognized as the liver disease component of metabolic syndrome, which is mainly related to insulin resistance and...
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IJERPH, Vol. 17, Pages 1821: Mexican Validation of the Engagement and Disaffection in Physical Education Scale International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17061821 Authors: René Rodríguez-Medellín Jorge Zamarripa María Marentes-Castillo Fernando Otero-Saborido Raúl Baños Raquel Morquecho-Sánchez To date, no instrument adapted and validated that measures engagement and disaffection in the physical education class has been...
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IJERPH, Vol. 17, Pages 1820: Analysis and Optimization of Mn Removal from Contaminated Solid Matrixes by Electrokinetic Remediation International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17061820 Authors: Cameselle Gouveia Cabo Electrokinetic remediation is a useful technique for the removal of ionic contaminants in soils, sediments, sludges, and other solid porous matrixes. The efficiency of metal removal and the electricity consumption...
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