Τετάρτη, 11 Μαρτίου 2020


Mycobacterium hassiacum: a thermophilic Mycobacterium species to demonstrate thermal disinfection of medical devices
Reprocessing reusable medical devices is crucial in the healthcare industry. To ensure patient safety, strict standards are dictated to validate thermal disinfection in automated washer-disinfectors. The Unite...
BMC Research Notes - Latest Articles
11h
N,N,N′,N′-tetrakis(2-pyridylmethyl)ethylenediamine, a zinc chelator, inhibits biofilm and hyphal formation in Trichosporon asahii
Trichosporon asahii is the major causative fungus of disseminated or deep-seated trichosporonosis and forms a biofilm on medical devices. Biofilm formation leads to antifungal drug resistance, so biofilm-related ...
BMC Research Notes - Latest Articles
11h
The impact of point-of-care testing for influenza A and B on patient flow and management in a medical assessment unit of a general hospital
Timely implementation of influenza infection control and treatment can significantly reduce the impact on Hospital resources and patient management when demand is at peak. Turnaround times of Laboratory based ...
BMC Research Notes - Latest Articles
11h
Difference in autonomic nervous effect of blue light depending on the angle of incidence on the eye
Blue light has been attributed to the adverse biological effects caused by the use of smartphones and tablet devices at night. However, it is not realistic to immediately avoid nighttime exposure to blue light...
BMC Research Notes - Latest Articles
11h
Identification of an unconventional sub-peptidome bound to the Behcets disease - associated HLA-B*51:01 that is regulated by endoplasmic reticulum aminopeptidase 1 (ERAP1) [Research]
Human leukocyte antigen (HLA) B*51:01 and endoplasmic reticulum aminopeptidase 1 (ERAP1) are strongly genetically associated with Behcet's disease (BD).  Previous studies have defined two subgroups of HLA-B*51 peptidome containing Proline (Pro) or Alanine (Ala) at position 2 (P2).  Little is known about the unconventional non-Pro/Ala2 HLA-B*51-bound peptides.  We aimed to study the features of this novel sub-peptidome, and investigate its regulation by ERAP1.  CRISPR-Cas9 was used to generate an...
MCP Papers in Press
11h
MaxQuant software for ion mobility enhanced shotgun proteomics [Technological Innovation and Resources]
Ion mobility can add a dimension to LC-MS based shotgun proteomics which has the potential to boost proteome coverage, quantification accuracy and dynamic range.  Required for this is suitable software that extracts the information contained in the four-dimensional (4D) data space spanned by m/z, retention time, ion mobility and signal intensity. Here we describe the ion mobility enhanced MaxQuant software, which utilizes the added data dimension. It offers an end to end computational workflow for...
MCP Papers in Press
11h
<i>Drosophila insulin-like peptide 2</i> mediates dietary regulation of sleep intensity
by Elizabeth B. Brown, Kreesha D. Shah, Richard Faville, Benjamin Kottler, Alex C. Keene Sleep is a nearly universal behavior that is regulated by diverse environmental stimuli and physiological states. A defining feature of sleep is a homeostatic rebound following deprivation, where animals compensate for lost sleep by increasing sleep duration and/or sleep depth. The fruit fly, Drosophila melanogaster, exhibits robust recovery sleep following deprivation and represents a powerful model to...
PLOS Genetics: New Articles
11h
The new article is now available. Endocrine Journal
[ Advance Publication ] [ Title ] The association of the visceral adiposity index with insulin resistance and beta-cell function in Korean adults with and without type 2 diabetes mellitus [ Author ] Hyun Ho Sung,Chang Eun Park,Mi Young Gi,Ju Ae Cha,Ae Eun Moon,Jae Kook Kang,Jeong Min Seong,Jun Ho Lee,Hyun Yoon [ Advance Pub. date ] 2020-03-12 [ DOI ] https://doi.org/10.1507/endocrj.EJ19-0517
J-STAGE
11h
Kriterien der Entscheidungsfindung in der palliativen Onkologie
Zusammenfassung Hintergrund Wohl in kaum einem anderen Fachbereich sind medizinische Therapieentscheidungen von einem so hohen Maß an Abwägung und subjektiver Bewertung gekennzeichnet wie in der palliativen Onkologie. Nicht selten gehen diese mit konflikthaften Dissenssituationen zwischen den verschiedenen involvierten Personengruppen einher. Welche Kriterien sind für die Entscheidungsfindung relevant? Wie kann eine Therapieentscheidung...
Latest Results
11h
Systemtherapie des metastasierten Analkarzinoms
Zusammenfassung Hintergrund Das Analkarzinom ist eine seltene Erkrankung, deren Inzidenz derzeit in Deutschland zunimmt. Mehr als 80 % aller Analkarzinome sind mit einer Infektion mit humanem Papillomvirus (HPV) assoziiert. In der Behandlung des metastasierten Analkarzinoms steht die systemische Therapie im Vordergrund. Hier gibt es nur wenige prospektive Studien, die für die Definition eines therapeutischen Standards herangezogen werden...
Latest Results
20h
Requirement of GTP binding for TIF‐90‐regulated ribosomal RNA synthesis and oncogenic activities in human colon cancer cells
In this study, we show that TIF‐90 binds GTP at Threonine 310, and that GTP binding is required for transcription initiation factor 90 (TIF‐90)‐enhanced ribosomal RNA (rRNA) synthesis. A combination of mycophenolic acid and AZD8055 synergistically inhibits rRNA synthesis, in vivo tumor growth, and other oncogenic activities of primary human colon cancer cells, suggesting a potential avenue for the development of therapeutic treatments by targeting the regulation of rRNA synthesis by TIF proteins....
Journal of Cellular Physiology
12h
PACAP ameliorates fertility in obese male mice via PKA/CREB pathway‐dependent Sirt1 activation and p53 deacetylation
Obesity can cause male infertility. PACAP could ameliorate fertility in obese male mice via PKA/CREB pathway‐dependent Sirt1 activation and p53 deacetylation and may be a promising candidate drug for obesity‐induced male infertility. Abstract Obesity is strongly linked to male infertility. Testicular spermatogenic cell apoptosis plays an important role in obesity‐related male infertility. Pituitary adenylate cyclase‐activating peptide (PACAP) has been recently shown to exhibit antiapoptotic and...
Journal of Cellular Physiology
19h
RCR announces response to coronavirus threat
The U.K. Royal College of Radiologists (RCR) has canceled some exams and events...Read more on AuntMinnieEurope.comRelated Reading: RCR posts clinical, interventional radiology curricula RCR seeks applicants for oncology research fellowships U.K. group calls for action on aortic tear management U.K. unveils learning initiative to tackle errors RCR responds to damning emergency CT access report
AuntMinnieEurope.com Headlines
12h
ESTRO postpones 2020 meeting to summer
Amid concerns about the coronavirus outbreak, the European Society for Radiotherapy...Read more on AuntMinnieEurope.comRelated Reading: ESR may sue authorities over ECR postponement ESR goes ahead with live online coronavirus session ISMRM moves annual meeting to Paris in August HIMSS cancels 2020 conference ECR 2020 gets postponed until mid-July
AuntMinnieEurope.com Headlines
13h
Eckert & Ziegler begins production of lutetium-177
Isotope technology developer Eckert & Ziegler said it has begun commercial...Read more on AuntMinnieEurope.comRelated Reading: Eckert & Ziegler supports new radiopharmaceuticals Isotopia, Eckert & Ziegler partner Eckert & Ziegler records sales, earnings gains Eckert & Ziegler signs deal with Alpha Tau Medical Eckert & Ziegler receives approval for Ga-68 expansion
AuntMinnieEurope.com Headlines
14h
Danish startup explores 3D-bioprinted bone implants
Danish 3D printing startup Particle3D has developed a new technique for creating...Read more on AuntMinnieEurope.comRelated Reading: FossiLabs unveils 3D-printed bone implants 3D printing assists ultrasound-guided liver resection Cardiac patients gain from 3D printing, AR advances 3D printing boosts treatment of urethral injuries Italians use 3D printing to enhance safety in upper GI surgery
AuntMinnieEurope.com Headlines
14h
ESR goes ahead with live online coronavirus session
The European Society of Radiology (ESR) has decided to proceed with this week's...Read more on AuntMinnieEurope.comRelated Reading: ESR may sue authorities over ECR postponement ECR 2020 gets postponed until mid-July ESR, ERS issue statement on CT lung cancer screening ESR: Radiology societies must adapt to new generation ESR unveils ESR Connect streaming platform
AuntMinnieEurope.com Headlines
22h
Accuracy and reliability of automatic three-dimensional cephalometric landmarking
Publication date: Available online 10 March 2020Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): G. Dot, F. Rafflenbeul, M. Arbotto, L. Gajny, P. Rouch, T. Schouman
ScienceDirect Publication: International Journal of Oral and Maxillofacial Surgery
12h
A context-aware mobile learning system for adapting learning content and format of presentation: design, validation and evaluation
Abstract To date, the growth usage of mobile technologies and devices as well as the ubiquitous wireless communication have led to the development of new systems and applications in many fields and areas including education. This technological progress can be used to facilitate the students’ lives by creating smart and personalized solutions considering their personal and academic profiles as well as their real environments. This is because mobile technologies have the capacity...
Latest Results for Education and Information Technologies
12h
Effects of microworld game-based approach on neuromuscular disabled students learning performance in elementary basic science courses
Abstract In conventional classroom driven instructor training, disabled student achieved low personality & motivation, more mental load due to lack of practical learning and unsuitable usage of learning material through different simulated contexts. Therefore, intent of proposed study is to integrate microworld game-based learning to different learning styles of special needs students which enhance their learning performance and encourage them to discover and solve problems...
Latest Results for Education and Information Technologies
14h
Exploring EFL pre-service teachers’ adoption of technology in a CALL program: obstacles, motivators, and maintenance
Abstract In spite of the rise of computer-assisted language learning (CALL) as an alluring field of inquiry, there seems to be a paucity of empirical studies on the actual experience of English as a foreign language (EFL) teachers in the adoption of technology in their classes. In an attempt to remedy this gap, this study was designed to qualitatively examine six Iranian EFL pre-service teachers’ experiences in implementing CALL activities. The pre-service teachers first took the...
Latest Results for Education and Information Technologies
16h
Reactive oxygen species and nitric oxide imbalances lead to <i>in vivo</i> and <i>in vitro</i> arrhythmogenic phenotype in acute phase of experimental chagas disease
by Artur Santos-Miranda, Julliane Vasconcelos Joviano-Santos, Grazielle Alves Ribeiro, Ana Flávia M. Botelho, Peter Rocha, Leda Quercia Vieira, Jader Santos Cruz, Danilo Roman-Campos Chagas Disease (CD) is one of the leading causes of heart failure and sudden death in Latin America. Treatments with antioxidants have provided promising alternatives to ameliorate CD. However, the specific roles of major reactive oxygen species (ROS) sources, including NADPH-oxidase 2 (NOX2), mitochondrial-derived...
PLOS Pathogens: New Articles
12h
Resveratrol treatment increases mitochondrial biogenesis and improves viability of porcine germinal-vesicle stage vitrified-warmed oocytes
Publication date: Available online 11 March 2020Source: CryobiologyAuthor(s): J. Ito, K. Shirasuna, T. Kuwayama, H. Iwata
Cryobiology
12h
Raman spectroscopy evidence of lipid separation in domestic cat oocytes during freezing
Publication date: Available online 11 March 2020Source: CryobiologyAuthor(s): V.I. Mokrousova, K.A. Okotrub, S.Y. Amstislavsky, N.V. Surovtsev
Cryobiology
12h
Large‐Scale In Vitro Functional Testing and Novel Variant Scoring via Protein Modeling Provide Insights Into Alkaline Phosphatase Activity in Hypophosphatasia
Abstract Hypophosphatasia (HPP) is a rare metabolic disorder characterized by low tissue‐nonspecific alkaline phosphatase (TNSALP) typically caused by ALPL gene mutations. HPP is heterogeneous, with clinical presentation correlating with residual TNSALP activity and/or dominant negative effects (DNE). We measured residual activity and DNE for 155 ALPL variants by transient transfection and TNSALP enzymatic activity measurement. Ninety variants showed low residual activity and 24 showed DNE. These...
Human Mutation
13h
Health-related quality of life and associated factors among patients with diabetes mellitus at the University of Gondar referral hospital
Diabetes mellitus, which has a wide range of effects on the physical, social and psychological aspects of the well-being of a person, is a common and challenging chronic disease that causes a significant rate ...
Health and Quality of Life Outcomes - Latest Articles
13h
Quality of life in allergic rhinitis - children’s and their parents’ perspective in polish urban and rural population
Allergic rhinitis is a common chronic condition in the paediatric population. No reports regarding the quality of life in children with allergic rhinitis in the Polish population have been found in the availab...
Health and Quality of Life Outcomes - Latest Articles
13h
A cohort study of factors that influence oral health-related quality of life from age 12 to 18 in Hong Kong
There is a lack of cohort studies on the influence factors of oral health-related quality of life (OHRQoL). This study aimed to follow subjects from age 12 to 18 to analyse the sociodemographic and clinical fa...
Health and Quality of Life Outcomes - Latest Articles
13h
Improved RIDIT statistic approach provides more intuitive and informative interpretation of EQ-5D data
EQ-5D is generic measure of health-related quality of life. Studies using EQ-5D generate ordinal data that are interpreted as categories ordered by severity. New analytic approaches taking into account the ord...
Health and Quality of Life Outcomes - Latest Articles
13h
The effect of different obturation methods on sealer penetration alongside apically separated rotary nickel–titanium instruments: A confocal laser scanning microscopy study
Effects of the obturation technique on sealer penetration alongside apically separated files were investigated. The obturation technique plays a significant role on the sealer penetration beyond the separated instrument. Samples obturated with the cold lateral compaction technique had the lowest penetration depth and percentage values beyond the separated file at a 1 mm level. Abstract The effects of different obturation techniques on calcium silicate‐based sealer penetration in the...
Microscopy Research and Technique
13h
IJERPH, Vol. 17, Pages 1827: Factors Associated with High Mercury Levels in Women and Girls from The Mojana Region, Colombia, 2013–2015
IJERPH, Vol. 17, Pages 1827: Factors Associated with High Mercury Levels in Women and Girls from The Mojana Region, Colombia, 2013–2015 International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17061827 Authors: Sonia Mireya Diaz Ruth Marien Palma Maria Nathalia Muñoz Carolina Becerra-Arias Julián Alfredo Fernández Niño Women are primarily exposed to mercury through the consumption of fish contaminated by gold mining activities. The main...
International Journal of Environmental Research and Public Health
13h
IJERPH, Vol. 17, Pages 1826: Variation in the Occurrence of fimA Genotypes of Porphyromonas gingivalis in Periodontal Health and Disease
IJERPH, Vol. 17, Pages 1826: Variation in the Occurrence of fimA Genotypes of Porphyromonas gingivalis in Periodontal Health and Disease International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17061826 Authors: Manohar Kugaji Uday Muddapur Kishore Bhat Vinayak Joshi Manjunath Manubolu Kavitha Pathakoti Malleswara Rao Peram Vijay Kumbar Porphyromonas gingivalis is regarded as a &ldquo;keystone pathogen&rdquo; in periodontitis....
International Journal of Environmental Research and Public Health
15h
IJERPH, Vol. 17, Pages 1824: Association of Ambient Air Pollution with Nasopharyngeal Carcinoma Incidence in Ten Large Chinese Cities, 2006–2013
IJERPH, Vol. 17, Pages 1824: Association of Ambient Air Pollution with Nasopharyngeal Carcinoma Incidence in Ten Large Chinese Cities, 2006–2013 International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17061824 Authors: Yang Liu Zhao Chen Deng Large cities in China are experiencing severe ambient air pollution. Although China accounts for more than 45% of new cases of nasopharyngeal carcinoma worldwide in 2018, few studies have examined...
International Journal of Environmental Research and Public Health
15h
IJERPH, Vol. 17, Pages 1825: Intracervical Foley Catheter Plus Intravaginal Misoprostol vs Intravaginal Misoprostol Alone for Cervical Ripening: A Meta-Analysis
IJERPH, Vol. 17, Pages 1825: Intracervical Foley Catheter Plus Intravaginal Misoprostol vs Intravaginal Misoprostol Alone for Cervical Ripening: A Meta-Analysis International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17061825 Authors: Lee Huang Cheng Yeh Lin Horng Huang Lee Wang Currently, there is no meta-analysis comparing intravaginal misoprostol plus intracervical Foley catheter versus intravaginal misoprostol...
International Journal of Environmental Research and Public Health
15h
IJERPH, Vol. 17, Pages 1822: Effects of Sulfamethoxazole and 2-Ethylhexyl-4-Methoxycinnamate on the Dissimilatory Nitrate Reduction Processes and N2O Release in Sediments in the Yarlung Zangbo River
IJERPH, Vol. 17, Pages 1822: Effects of Sulfamethoxazole and 2-Ethylhexyl-4-Methoxycinnamate on the Dissimilatory Nitrate Reduction Processes and N2O Release in Sediments in the Yarlung Zangbo River International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17061822 Authors: Xu Lu Xue The nitrogen pollution of rivers as a global environmental problem has received great attentions in recent years. The occurrence of emerging pollutants in high-altitude...
International Journal of Environmental Research and Public Health
16h
IJERPH, Vol. 17, Pages 1818: Prevalence and Risk Factors of Metabolic Associated Fatty Liver Disease in Xinxiang, China
IJERPH, Vol. 17, Pages 1818: Prevalence and Risk Factors of Metabolic Associated Fatty Liver Disease in Xinxiang, China International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17061818 Authors: Hongbin Li Meihao Guo Zhen An Jun Meng Jing Jiang Jie Song Weidong Wu Metabolic associated fatty liver disease (MAFLD) is recognized as the liver disease component of metabolic syndrome, which is mainly related to insulin resistance and...
International Journal of Environmental Research and Public Health
16h
IJERPH, Vol. 17, Pages 1821: Mexican Validation of the Engagement and Disaffection in Physical Education Scale
IJERPH, Vol. 17, Pages 1821: Mexican Validation of the Engagement and Disaffection in Physical Education Scale International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17061821 Authors: René Rodríguez-Medellín Jorge Zamarripa María Marentes-Castillo Fernando Otero-Saborido Raúl Baños Raquel Morquecho-Sánchez To date, no instrument adapted and validated that measures engagement and disaffection in the physical education class has been...
International Journal of Environmental Research and Public Health
16h
IJERPH, Vol. 17, Pages 1820: Analysis and Optimization of Mn Removal from Contaminated Solid Matrixes by Electrokinetic Remediation
IJERPH, Vol. 17, Pages 1820: Analysis and Optimization of Mn Removal from Contaminated Solid Matrixes by Electrokinetic Remediation International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17061820 Authors: Cameselle Gouveia Cabo Electrokinetic remediation is a useful technique for the removal of ionic contaminants in soils, sediments, sludges, and other solid porous matrixes. The efficiency of metal removal and the electricity consumption...
International Journal of Environmental Research and Public Health
16h

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