Viruses, Vol. 12, Pages 305: Barriers to Hepatitis B Screening and Prevention for African Immigrant Populations in the United States: A Qualitative Study Viruses doi: 10.3390/v12030305 Authors: Catherine Freeland Sierra Bodor Udara Perera Chari Cohen Chronic hepatitis B infection (HBV) disproportionately affects African Immigrant (AI) communities in the U.S., with a reported infection rate of 15%. HBV screening rates within these communities are low. This study sought...
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Viruses, Vol. 12, Pages 304: Study on the Antiviral Activities and Hemagglutinin-Based Molecular Mechanism of Novel Chlorogenin 3-O-β-Chacotrioside Derivatives Against H5N1 Subtype Viruses Viruses doi: 10.3390/v12030304 Authors: Shi Jiang Song Wang Xiong Ke The objective of this study was to investigate the inhibitory effect of chlorogenin 3-O-β-chacotrioside derivatives against H5N1 subtype of the highly pathogenic avian influenza (HPAI) viruses...
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Viruses, Vol. 12, Pages 306: Special Issue “Emerging Viruses: Surveillance, Prevention, Evolution, and Control” Viruses doi: 10.3390/v12030306 Authors: Abrahão de Arruda Emerging viruses represent a major concern for public health offices. Climate changes, the international migration of people and products, deforestation, and other anthropogenic activities (and their consequences) have been historically and continuously related to the emerging and re-emerging of new viruses,...
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Viruses, Vol. 12, Pages 302: The Beginning of Ending Hepatitis C Virus: A Summary of the 26th International Symposium on Hepatitis C Virus and Related Viruses Viruses doi: 10.3390/v12030302 Authors: Shin Han Kang Kato Kim Zhong Kim Park Sung Watashi Park Windisch Oh Wakita Han Jang : Hepatitis C virus (HCV) infects ~71 million people worldwide, and 399,000 people die annually due to HCV-related liver cirrhosis...
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Viruses, Vol. 12, Pages 303: Patterns of Autologous and Nonautologous Interactions Between Core Nuclear Egress Complex (NEC) Proteins of α-, β- and γ-Herpesviruses Viruses doi: 10.3390/v12030303 Authors: Sigrun Häge Eric Sonntag Eva Borst Pierre Tannig Lisa Seyler Tobias Bäuerle Susanne Bailer Chung-Pei Lee Regina Müller Christina Wangen Jens Milbradt Manfred Marschall Nuclear egress is a regulated process shared by α-, β- and γ-herpesviruses....
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Viruses, Vol. 12, Pages 300: Successful Infection of Domestic Pigs by Ingestion of the European Soft Tick O. Erraticus That Fed on African Swine Fever Virus Infected Pig Viruses doi: 10.3390/v12030300 Authors: Pereira De Oliveira Hutet Duhayon Guionnet Paboeuf Vial Le Potier African swine fever is a highly lethal hemorrhagic fever of Suidae, threatening pig production globally. Suidae can be infected by different ways like ingestion of contaminated...
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Viruses, Vol. 12, Pages 301: User-Friendly Reverse Genetics System for Modification of the Right End of Fowl Adenovirus 4 Genome Viruses doi: 10.3390/v12030301 Authors: Bingyu Yan Xiaohui Zou Xinglong Liu Jiaming Zhao Wenfeng Zhang Xiaojuan Guo Min Wang Yingtao Lv Zhuozhuang Lu A novel fowl adenovirus 4 (FAdV-4) has caused significant economic losses to the poultry industry in China since 2015. We established an easy-to-use reverse genetics system...
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Objective: Word retrieval difficulty can be distressing for individuals with aphasia. However, physiological stress responses to word retrieval are relatively unstudied. This study aims to measure the physiological response (i.e., heart rate and respiratory rate) and perceived stress in individuals with aphasia during a naming task to understand whether word retrieval may be a stressor to them. Method: An aphasia group (n = 7) and a healthy group (n = 38) participated in 4 experimental conditions,...
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Key Points Surgical treatment is the gold standard for pure aortic regurgitation (AR). In this study, transcatheter aortic valve replacement (TAVR) appears to be a promising option for inoperable/high‐risk patients suffering pure AR. Long‐term results and specific patient‐level data are needed to better clarify the role of TAVR in pure AR treatment.
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Key Points Forty to fifty percent of critical limb ischemia patients have infrainguinal chronic total occlusions, frequently below‐the‐knee. With probabilities ranging from 21 to 90%, the Infrapop‐CTO Score presented here in CCI predicts the likelihood of anterograde crossing of infrapopliteal chronic total occlusions (CTO). Based on cap morphology, occlusion length, calcification, and restenosis status, the score is easily assessed in the lab. An unfavorable Infrapop‐CTO Score of 5 or...
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Key Points Pre‐existing right bundle branch block and the depth of the prosthesis in the left ventricle are predictors of permanent pacemaker implantation (PPI) following transcatheter aortic valve replacement. The recapturable capability of the Evolut R system allows higher and more precise valve implantation and this was associated with halved incidence of PPI as compared with the CoreValve. Larger studies are needed to assess the feasibility of systematic very high implantation (depth...
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Key Points BATMAN is a new technique to prevent left ventricular outflow tract (LVOT) obstruction from transcatheter mitral valve replacement (TMVR) by deploying the transcatheter heart valve from the apex through a perforation of the anterior mitral valve leaflet. The risks of uncontrolled balloon dilatation of the anterior mitral valve leaflet include extension of the tear superiorly into the aorto‐mitral curtain or laterally to avulse the trigone from the annulus. Percutaneous laceration...
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Key Points Multimodality interventions, including both percutaneous and surgical approaches, are paramount in maintaining vascular fistula and graft patency in hemodialysis patients. Mechanical thrombectomy with Angiojet AVX or Solent Proxi of AVFs and AVGs achieved acceptable technical and clinical success rates (>90%) in combination with adjuvant percutaneous transluminal angioplasty and stenting. Future prospective studies using intravascular imaging before therapy may be useful when...
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Key Points Advanced intravascular imaging or fractional flow reserve in acute myocardial infarction patients may be safely performed and may be associated with clinical benefits. Since this is a nonrandomized registry with too few numbers to adequately evaluate mortality, it is uncertain whether clinical outcomes are truly improved. Adequately powered randomized trials using advanced imaging versus angiographic guided percutaneous coronary intervention (PCI) would be helpful.
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Key Points Transradial access is the key bleeding avoidance strategy in percutaneous coronary intervention. This study showed a marked adoption of transradial access over a 10‐year period, however, women had a significantly lower rate compared to men and overall bleeding events did not decrease over time. Strategies to overcome barriers to radial access in women and to maintaining competency in femoral access in all patients are needed.
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Key Points Evaluation of the severity of aortic stenosis in the presence of dynamic left ventricular outflow (LVOT) obstruction is challenging. Invasive hemodynamic assessment with provocative maneuvers can be useful to differentiate of the relative components of obstruction. In patients with both dynamic LVOT obstruction and aortic stenosis, surgical myectomy and concurrent surgical aortic valve replacement is the optimal treatment strategy; combined alcohol septal ablation and transcatheter...
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Abstract Transcatheter tricuspid valve intervention (TTVI) is an emerging treatment for patients with symptomatic severe tricuspid regurgitation (TR). Currently, the issues that arise during TTVI are unclear. Here, a 78‐year‐old woman with severe TR underwent transcatheter tricuspid valve annuloplasty using a Cardioband (Edwards Lifesciences, Irvine, CA). We attempted to cinch the Dacron band after anchoring; however, it was impossible to connect the distal tip of the size adjustment tool and the...
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Abstract Background Reaction time (RT) deficits are reported following concussion, but it is unknown when these deficits normalize to pre-injury status. It is also unclear how factors such as RT measurement technique and participant characteristics influence post-concussion RT. Objective The purpose of this systematic review and meta-analysis was to (1) characterize...
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JCM, Vol. 9, Pages 761: Primary Open Angle Glaucoma and Vascular Risk Factors: A Review of Population Based Studies from 1990 to 2019 Journal of Clinical Medicine doi: 10.3390/jcm9030761 Authors: Andrzej Grzybowski Mariusz Och Piotr Kanclerz Christopher Leffler Carlos Gustavo De Moraes Glaucoma is one of the leading causes of blindness worldwide, and as the proportion of those over age 40 increases, so will the prevalence of glaucoma. The pathogenesis of primary open angle...
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JCM, Vol. 9, Pages 762: Physicians’ Disease Severity Ratings are Non-Inferior to the Emergency Severity Index Journal of Clinical Medicine doi: 10.3390/jcm9030762 Authors: Roland Bingisser Severin Manuel Baerlocher Tobias Kuster Ricardo Nieves Ortega Christian H. Nickel Our objective was to compare informal physicians’ disease severity ratings (PDSR) at presentation with the well-established Emergency Severity Index (ESI) in order to test for non-inferiority of...
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JCM, Vol. 9, Pages 756: Associations between Disease Activity/Severity and Damage and Health-Related Quality of Life in Adult Patients with Localized Scleroderma—A Comparison of LoSCAT and Visual Analogue Scales Journal of Clinical Medicine doi: 10.3390/jcm9030756 Authors: Anna Lis-Święty Alina Skrzypek-Salamon Irmina Ranosz-Janicka Ligia Brzezińska-Wcisło Localized scleroderma (LoS) is a chronic fibrosing disorder of the skin and, less commonly, subcutaneous tissues. As the...
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JCM, Vol. 9, Pages 759: Degenerative Cervical Myelopathy: How to Identify the Best Responders to Surgery? Journal of Clinical Medicine doi: 10.3390/jcm9030759 Authors: Rocco Severino Aria Nouri Enrico Tessitore Surgery is the only definitive treatment for degenerative cervical myelopathy (DCM), however, the degree of neurological recovery is often unpredictable. Here, we assess the utility of a multidimensional diagnostic approach, consisting of clinical, neurophysiological, and...
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JCM, Vol. 9, Pages 757: Cerebellar Astrocytes: Much More Than Passive Bystanders In Ataxia Pathophysiology Journal of Clinical Medicine doi: 10.3390/jcm9030757 Authors: Valentina Cerrato Ataxia is a neurodegenerative syndrome, which can emerge as a major element of a disease or represent a symptom of more complex multisystemic disorders. It comprises several forms with a highly variegated etiology, mainly united by motor, balance, and speech impairments and, at the tissue level, by cerebellar...
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JCM, Vol. 9, Pages 758: En-Bloc Resection of Metastases of the Proximal Femur and Reconstruction by Modular Arthroplasty is Not Only Justified in Patients with a Curative Treatment Option—An Observational Study of a Consecutive Series of 45 Patients Journal of Clinical Medicine doi: 10.3390/jcm9030758 Authors: Oliver E. Bischel Arnold J. Suda Paul M. Böhm Burkhard Lehner Rudi G. Bitsch Jörn B. Seeger Background: There is little conformity regarding the surgical treatment...
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JCM, Vol. 9, Pages 760: Risk, Diagnostic and Predictor Factors for Classical Hodgkin Lymphoma in HIV-1-Infected Individuals: Role of Plasma Exosome-Derived miR-20a and miR-21 Journal of Clinical Medicine doi: 10.3390/jcm9030760 Authors: Francisco J. Hernández-Walias Esther Vázquez Yolanda Pacheco José M. Rodríguez-Fernández María J. Pérez-Elías Fernando Dronda José L. Casado Ana Moreno José M. Hermida Carmen Quereda Asunción Hernando Francisco Tejerina-Picado...
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JCM, Vol. 9, Pages 754: An Overview on Primary Sclerosing Cholangitis Journal of Clinical Medicine doi: 10.3390/jcm9030754 Authors: Cătălina Vlăduţ Mihai Ciocîrlan Dana Bilous Vasile Șandru Mădălina Stan-Ilie Nikola Panic Gabriel Becheanu Mariana Jinga Raluca S. Costache Daniel O. Costache Mircea Diculescu Primary sclerosing cholangitis is a progressive liver disease characterized by chronic inflammation leading to liver fibrosis and cirrhosis. Even though...
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JCM, Vol. 9, Pages 755: Improvement in Subjective Symptoms and Tolerability in Response to Nintedanib Treatment in Elderly Patients with Idiopathic Pulmonary Fibrosis Journal of Clinical Medicine doi: 10.3390/jcm9030755 Authors: Takayuki Takeda Yusuke Kunimatsu Nozomi Tani Izumi Hashimoto Yuri Kurono Kazuki Hirose The efficacy of nintedanib treatment in patients with idiopathic pulmonary fibrosis (IPF) was demonstrated in phase III trials. However, there is limited data...
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JCM, Vol. 9, Pages 753: Antibodies against Malondialdehyde in Haemodialysis Patients and Its Association with Clinical Outcomes: Differences between Subclasses and Isotypes Journal of Clinical Medicine doi: 10.3390/jcm9030753 Authors: Samal Qureshi Rahman Stenvinkel Frostegård Patients on haemodialysis (HD-patients) have an increased risk of premature death. Low levels of IgM antibodies against malondialdehyde (anti-MDA) are associated with increased risk of cardiovascular...
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Docosahexaenoic acid (DHA) enriched in brain can yield many important degradation products after the attack of hydroxyl radicals, which is known to serve as a nutraceutical and neuroprotective effects. Oxidati...
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Objective: To evaluate the role of single-session Gamma Knife stereotactic radiosurgery (GK-SRS) in the treatment of vestibular schwannomas (VSs) with volumes of greater 10 cm3. Methods: A retrospective analysis was performed of 103 patients treated with single-session GK-SRS between 1993 and 2011 with a mean follow-up of 6.2 years ± 4.4 SD. Treatment, clinical and outcome details were recorded and assessed. Results: Eighty-one (78.6%) patients achieved radiological control with slow progression...
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Publication date: Available online 10 March 2020Source: Journal of Infection and ChemotherapyAuthor(s): Miyuki Takao, Nori Yoshioka, Hideharu Hagiya, Matsuo Deguchi, Masanori Kagita, Hiroko Tsukamoto, Yoh Hidaka, Kazunori Tomono, Toru Tobe
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Antioxidants, Vol. 9, Pages 230: Molecular Mechanism of Oxidation of P700 and Suppression of ROS Production in Photosystem I in Response to Electron-Sink Limitations in C3 Plants Antioxidants doi: 10.3390/antiox9030230 Authors: Miyake Photosynthesis fixes CO2 and converts it to sugar, using chemical-energy compounds of both NADPH and ATP, which are produced in the photosynthetic electron transport system. The photosynthetic electron transport system absorbs photon energy to drive electron...
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Antioxidants, Vol. 9, Pages 232: Antioxidant and Antitumor Activities of Novel Quercetin-Loaded Electrospun Cellulose Acetate/Polyethylene Glycol Fibrous Materials Antioxidants doi: 10.3390/antiox9030232 Authors: Stoyanova Spasova Manolova Rashkov Georgieva Toshkova The aim of present study was to obtain novel fibrous materials based on cellulose derivative and polyethylene glycol loaded with natural biologically active compound quercetin by electrospinning. Several...
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Antioxidants, Vol. 9, Pages 231: Evaluating the In Vitro Potential of Natural Extracts to Protect Lipids from Oxidative Damage Antioxidants doi: 10.3390/antiox9030231 Authors: Félix Valentão Andrade Félix Novais Lemos Lipid peroxidation is a chemical reaction known to have negative impacts on living organisms’ health and on consumer products’ quality and safety. Therefore, it has been the subject of extensive scientific research concerning the...
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