Cancers, Vol. 12, Pages 657: Safety and Effectiveness of Aflibercept + Fluorouracil, Leucovorin, and Irinotecan (FOLFIRI) for the Treatment of Patients with Metastatic Colorectal Cancer (mCRC) in Current Clinical Practice: OZONE Study Cancers doi: 10.3390/cancers12030657 Authors: Ian Chau Marwan Fakih Pilar García-Alfonso Zdenĕk Linke Ana Ruiz Casado Eduardo Polo Marques Pascaline Picard Marina Celanovic Thomas Cartwright For patients with metastatic...
14h
Cancers, Vol. 12, Pages 652: Human Cancer-Associated Mutations of SF3B1 Lead to a Splicing Modification of Its Own RNA Cancers doi: 10.3390/cancers12030652 Authors: Bergot Lippert Douet-Guilbert Commet Corcos Bernard Deregulation of pre-mRNA splicing is observed in many cancers and hematological malignancies. Genes encoding splicing factors are frequently mutated in myelodysplastic syndromes, in which SF3B1 mutations are the most frequent. SF3B1 is an essential...
15h
Cancers, Vol. 12, Pages 656: Modelling Curved Contact Flexible Microstrip Applicators for Patient-Specific Superficial Hyperthermia Treatment Planning Cancers doi: 10.3390/cancers12030656 Authors: Kok Groen Bakker Crezee This paper describes a method to reconstruct bendable superficial hyperthermia applicators for routine clinical patient-specific treatment planning. The reconstruction uses a CT scan with a flexible silicone dummy applicator positioned on the patient....
15h
Cancers, Vol. 12, Pages 653: Molecular-Clinical Correlation in Pediatric Medulloblastoma: A Cohort Series Study of 52 Cases in Taiwan Cancers doi: 10.3390/cancers12030653 Authors: Wu Ho Jou Yu Tran Liang Chen Lee Chen Lin Chang Tsai Liu Lee Hsieh Huang Sung Chang Changou Liang Hsieh Liu Chao Chen Chu Cho Wong In 2016, a project was initiated in Taiwan...
16h
Cancers, Vol. 12, Pages 655: BNIP3L-Dependent Mitophagy Promotes HBx-Induced Cancer Stemness of Hepatocellular Carcinoma Cells via Glycolysis Metabolism Reprogramming Cancers doi: 10.3390/cancers12030655 Authors: Chen Wang Che Lan Zhang Zhan Huang Lin Lin Hepatitis B virus (HBV) is one of predisposing factors for hepatocellular carcinoma (HCC). The role of HBV x protein (HBx) in mediating the induction and maintenance of cancer stemness during...
16h
Cancers, Vol. 12, Pages 654: MK2 Inhibition Induces p53-Dependent Senescence in Glioblastoma Cells Cancers doi: 10.3390/cancers12030654 Authors: Phoa Recasens Gurgis Betts Menezes Chau Nordfors Haapasalo Haapasalo Johns Stringer Day Buckland Lalaoui Munoz MAPK-activated protein kinase 2 (MK2) has diverse roles in cancer. In response to chemotherapy, MK2 inhibition is synthetically lethal to p53-deficiency. While...
16h
Cancers, Vol. 12, Pages 648: Benefits of Combined All-Trans Retinoic Acid and Arsenic Trioxide Treatment of Acute Promyelocytic Leukemia Cells and Further Enhancement by Inhibition of Atypically Expressed Transglutaminase 2 Cancers doi: 10.3390/cancers12030648 Authors: Jambrovics Uray Keillor Fésüs Balajthy Randomized trials in acute promyelocytic leukemia patients have shown that treatment with a combination of all-trans retinoic acid (ATRA) and arsenic trioxide...
19h
Cancers, Vol. 12, Pages 651: Affibody Molecules as Targeting Vectors for PET Imaging Cancers doi: 10.3390/cancers12030651 Authors: Vladimir Tolmachev Anna Orlova Affibody molecules are small (58 amino acids) engineered scaffold proteins that can be selected to bind to a large variety of proteins with a high affinity. Their small size and high affinity make them attractive as targeting vectors for molecular imaging. High-affinity affibody binders have been selected for several...
19h
Cancers, Vol. 12, Pages 649: Mechanistic and Functional Shades of Mucins and Associated Glycans in Colon Cancer Cancers doi: 10.3390/cancers12030649 Authors: Pothuraju Krishn Gautam Pai Ganguly Chaudhary Rachagani Kaur Batra Mucus serves as the chief protective barrier against pathogenic and mechanical insults in respiratory, gastrointestinal, and urogenital tracts. Altered mucin expression, the major component of mucus, in conjunction with...
19h
Cancers, Vol. 12, Pages 650: Mitochondrial Respiration Correlates with Prognostic Markers in Chronic Lymphocytic Leukemia and Is Normalized by Ibrutinib Treatment Cancers doi: 10.3390/cancers12030650 Authors: Roy Chowdhury Bouchard Saleh Nugent Peltier Mejia Hou McFall Squires Hewitt Davidson Shen Johnston Doucette Hatch Fernyhough Marshall Gibson Dawe Banerji Mitochondrial bioenergetics...
19h
Abstract Objectives The adsorption of bovine milk caseins on the tooth surface might have a positive impact on the prevention of dental diseases. Therefore, the present study aimed to investigate the efficacy of mouthrinses with different types of bovine milk and milk protein isolates to accumulate caseins in the pellicle. Materials/methods An indirect enzyme-linked...
14h
IJMS, Vol. 21, Pages 1928: Identification of Novel Genomic Regions and Superior Alleles Associated With Zn Accumulation in Wheat Using A Genome-Wide Association Analysis Method International Journal of Molecular Sciences doi: 10.3390/ijms21061928 Authors: Zhengfu Zhou Xia Shi Ganqing Zhao Maomao Qin Maria Itria Ibba Yahuan Wang Wenxu Li Pan Yang Zhengqing Wu Zhensheng Lei Jiansheng Wang Micronutrient deficiencies, and especially zinc (Zn)...
15h
IJMS, Vol. 21, Pages 1927: NEAT1 is Required for the Expression of the Liver Cancer Stem Cell Marker CD44 International Journal of Molecular Sciences doi: 10.3390/ijms21061927 Authors: Shigemi Koyama Hiroyuki Tsuchiya Masataka Amisaki Hiromi Sakaguchi Soichiro Honjo Yoshiyuki Fujiwara Goshi Shiota CD44, a cancer stem cell (CSC) marker, is required for maintaining CSC properties in hepatocellular carcinoma (HCC). Nuclear enriched abundant transcript 1 (NEAT1),...
15h
IJMS, Vol. 21, Pages 1923: New Arylethanolimidazole Derivatives as HO-1 Inhibitors with Cytotoxicity against MCF-7 Breast Cancer Cells International Journal of Molecular Sciences doi: 10.3390/ijms21061923 Authors: Valeria Ciaffaglione Sebastiano Intagliata Valeria Pittalà Agostino Marrazzo Valeria Sorrenti Luca Vanella Antonio Rescifina Giuseppe Floresta Ameera Sultan Khaled Greish Loredana Salerno In this paper, a novel series of imidazole-based...
15h
IJMS, Vol. 21, Pages 1926: Ligand Binding Mechanism and Its Relationship With Conformational Changes in Adenine Riboswitch International Journal of Molecular Sciences doi: 10.3390/ijms21061926 Authors: Guodong Hu Haiyan Li Shicai Xu Jihua Wang Riboswitches are naturally occurring RNA aptamers that control the expression of essential bacterial genes by binding to specific small molecules. The binding with both high affinity and specificity induces conformational changes....
15h
IJMS, Vol. 21, Pages 1922: Design, Synthesis, and Renal Targeting of Methylprednisolone-Lysozyme International Journal of Molecular Sciences doi: 10.3390/ijms21061922 Authors: Xingquan Pan Fei Xie Dian Xiao Junhai Xiao Xinbo Zhou Methylprednisolone (MP) is often used in the treatment of various kidney diseases, but overcoming the systemic side effects caused by its nonspecific distribution in the body is a challenge. This article reports the design, synthesis, and...
15h
IJMS, Vol. 21, Pages 1924: Systems Metabolic Alteration in a Semi-Dwarf Rice Mutant Induced by OsCYP96B4 Gene Mutation International Journal of Molecular Sciences doi: 10.3390/ijms21061924 Authors: Limiao Jiang Rengasamy Ramamoorthy Srinivasan Ramachandran Prakash P. Kumar Dwarfism and semi-dwarfism are among the most valuable agronomic traits in crop breeding, which were adopted by the “Green Revolution”. Previously, we reported a novel semi-dwarf...
15h
IJMS, Vol. 21, Pages 1925: Molecular Dynamics Study of the Interaction of Carbon Nanotubes With Telomeric DNA Fragment Containing Noncanonical G-quadruplex and i-Motif Forms International Journal of Molecular Sciences doi: 10.3390/ijms21061925 Authors: Tomasz Panczyk Patrycja Wojton Pawel Wolski This work deals with molecular dynamics simulations of systems composed of telomeric dsDNA fragments, iG, and functionalized carbon nanotubes, fCNT. The iG contains 90 nucleotides...
16h
IJMS, Vol. 21, Pages 1920: From Classical Laboratory Parameters to Novel Biomarkers for the Diagnosis of Venous Thrombosis International Journal of Molecular Sciences doi: 10.3390/ijms21061920 Authors: Anghel Sascău Radu Stătescu Venous thrombosis is a common and potentially fatal disease, because of its high morbidity and mortality, especially in hospitalized patients. To establish the diagnosis of venous thrombosis, in the last years, a multi-modality approach...
16h
IJMS, Vol. 21, Pages 1919: Fibroblast Interaction with Different Abutment Surfaces: In Vitro Study International Journal of Molecular Sciences doi: 10.3390/ijms21061919 Authors: Canullo Genova Gross Trujillo Pradies Petrillo Muzzi Carossa Mussano Background: Attaining an effective mucosal attachment to the transmucosal part of the implant could protect the peri-implant bone. Aim: To evaluate if chair side surface treatments (plasma of Argon and...
16h
IJMS, Vol. 21, Pages 1913: The p38 Pathway: From Biology to Cancer Therapy International Journal of Molecular Sciences doi: 10.3390/ijms21061913 Authors: Adrián Martínez-Limón Manel Joaquin María Caballero Francesc Posas Eulàlia de Nadal The p38 MAPK pathway is well known for its role in transducing stress signals from the environment. Many key players and regulatory mechanisms of this signaling cascade have been described to some extent. Nevertheless, p38 participates...
16h
IJMS, Vol. 21, Pages 1918: Reactive Oxygen Species in Venous Thrombosis International Journal of Molecular Sciences doi: 10.3390/ijms21061918 Authors: Gutmann Siow Gwozdz Saha Smith Reactive oxygen species (ROS) have physiological roles as second messengers, but can also exert detrimental modifications on DNA, proteins and lipids if resulting from enhanced generation or reduced antioxidant defense (oxidative stress). Venous thrombus (DVT) formation and resolution...
16h
IJMS, Vol. 21, Pages 1921: Comparative Transcriptome-Based Mining and Expression Profiling of Transcription Factors Related to Cold Tolerance in Peanut International Journal of Molecular Sciences doi: 10.3390/ijms21061921 Authors: Jiang Zhang Ren Dong Zhao Wang Wang Zhong Zhao Liu Gao Yu Plants tolerate cold stress by regulating gene networks controlling cellular and physiological traits to modify growth and development. Transcription...
16h
IJMS, Vol. 21, Pages 1917: Injection Molded Capsules for Colon Delivery Combining Time-Controlled and Enzyme-Triggered Approaches International Journal of Molecular Sciences doi: 10.3390/ijms21061917 Authors: Federica Alice Saliha Marco Anastasia Alessandra Lucia Christel Florence Juergen Andrea A new type of colon targeting system is presented, combining time-controlled and enzyme-triggered approaches. Empty capsule shells were...
16h
IJMS, Vol. 21, Pages 1916: In Situ Profiling of the Three Dominant Phyla Within the Human Gut Using TaqMan PCR for Pre-Hospital Diagnosis of Gut Dysbiosis International Journal of Molecular Sciences doi: 10.3390/ijms21061916 Authors: Jo Tagele Pham Jung Ibal Choi Kang Park Kang Kim Koh Shin A microbial imbalance called dysbiosis leads to inflammatory bowel disease (IBD), which can include ulcerative colitis (UC). Fecal microbiota...
16h
IJMS, Vol. 21, Pages 1914: Antimicrobial Resistance in Veterinary Medicine: An Overview International Journal of Molecular Sciences doi: 10.3390/ijms21061914 Authors: Palma Tilocca Roncada Antimicrobial resistance (AMR) represents one of the most important human- and animal health-threatening issues worldwide. Bacterial capability to face antimicrobial compounds is an ancient feature, enabling bacterial survival over time and the dynamic surrounding. Moreover, bacteria...
16h
IJMS, Vol. 21, Pages 1915: Electrohypersensitivity as a Newly Identified and Characterized Neurologic Pathological Disorder: How to Diagnose, Treat, and Prevent It International Journal of Molecular Sciences doi: 10.3390/ijms21061915 Authors: Belpomme Irigaray Since 2009, we built up a database which presently includes more than 2000 electrohypersensitivity (EHS) and/or multiple chemical sensitivity (MCS) self-reported cases. This database shows that EHS is associated in 30%...
17h
IJMS, Vol. 21, Pages 1912: Antifungal Activity of Anionic Defense Peptides: Insight into the Action of Galleria mellonella Anionic Peptide 2 International Journal of Molecular Sciences doi: 10.3390/ijms21061912 Authors: Aneta Sowa-Jasiłek Agnieszka Zdybicka-Barabas Sylwia Stączek Bożena Pawlikowska-Pawlęga Katarzyna Grygorczuk-Płaneta Krzysztof Skrzypiec Wiesław I. Gruszecki Paweł Mak Małgorzata Cytryńska Anionic antimicrobial peptides constitute...
18h
IJMS, Vol. 21, Pages 1911: Correlative Light and Electron Microscopy (CLEM) Analysis of Nuclear Reorganization Induced by Clustered DNA Damage Upon Charged Particle Irradiation International Journal of Molecular Sciences doi: 10.3390/ijms21061911 Authors: Tonnemacher Eltsov Jakob Chromatin architecture plays major roles in gene regulation as well as in the repair of DNA damaged by endogenous or exogenous factors, such as after radiation. Opening up the chromatin might...
18h
IJMS, Vol. 21, Pages 1910: NR2F2 Orphan Nuclear Receptor is Involved in Estrogen Receptor Alpha-Mediated Transcriptional Regulation in Luminal A Breast Cancer Cells International Journal of Molecular Sciences doi: 10.3390/ijms21061910 Authors: Edina Erdős Bálint László Bálint Nuclear Receptor Subfamily 2 Group F Member 2 (NR2F2) is a member of the steroid/thyroid hormone receptor superfamily with a crucial role in organogenesis, angiogenesis, cardiovascular development and tumorigenesis....
19h
IJMS, Vol. 21, Pages 1908: Peripheral Circulating Exosomal miRNAs Potentially Contribute to the Regulation of Molecular Signaling Networks in Aging International Journal of Molecular Sciences doi: 10.3390/ijms21061908 Authors: Hongxia Zhang Kunlin Jin People are living longer than ever. Consequently, they have a greater chance for developing a functional impairment or aging-related disease, such as a neurodegenerative disease, later in life. Thus, it is important to identify...
19h
IJMS, Vol. 21, Pages 1907: Antidiabetic Therapy in the Treatment of Nonalcoholic Steatohepatitis International Journal of Molecular Sciences doi: 10.3390/ijms21061907 Authors: Yoshio Sumida Masashi Yoneda Katsutoshi Tokushige Miwa Kawanaka Hideki Fujii Masato Yoneda Kento Imajo Hirokazu Takahashi Yuichiro Eguchi Masafumi Ono Yuichi Nozaki Hideyuki Hyogo Masahiro Koseki Yuichi Yoshida Takumi Kawaguchi Yoshihiro Kamada Takeshi...
19h
IJMS, Vol. 21, Pages 1909: Identification of the Core Pollen-Specific Regulation in the Rice OsSUT3 Promoter International Journal of Molecular Sciences doi: 10.3390/ijms21061909 Authors: Dandan Li Rucong Xu Dong Lv Chunlong Zhang Hong Yang Jianbo Zhang Jiancheng Wen Chengyun Li Xuelin Tan The regulatory mechanisms of pollen development have potential value for applications in agriculture, such as better understanding plant reproductive regularity....
19h
IJMS, Vol. 21, Pages 1906: Novel Molecular Mechanisms of Gangliosides in the Nervous System Elucidated by Genetic Engineering International Journal of Molecular Sciences doi: 10.3390/ijms21061906 Authors: Koichi Furukawa Yuhsuke Ohmi Farhana Yesmin Orie Tajima Yuji Kondo Pu Zhang Noboru Hashimoto Yuki Ohkawa Robiul H. Bhuiyan Keiko Furukawa Acidic glycosphingolipids, i.e., gangliosides, are predominantly and consistently expressed in nervous tissues...
20h
IJMS, Vol. 21, Pages 1905: Natural Products Targeting ER Stress, and the Functional Link to Mitochondria International Journal of Molecular Sciences doi: 10.3390/ijms21061905 Authors: Stefania Martucciello Milena Masullo Antonietta Cerulli Sonia Piacente The endoplasmic reticulum (ER) is a dynamic organelle essential for intracellular homeostasis maintenance, controlling synthesis, the folding of secreted and membrane-bound proteins, and transport of Ca2+. During cellular...
20h
Antibiotics, Vol. 9, Pages 118: Antibiotic Resistance in Marine Microbial Communities Proximal to a Florida Sewage Outfall System Antibiotics doi: 10.3390/antibiotics9030118 Authors: Griffin Banks Gregg Shedler Walker Water samples were collected at several wastewater treatment plants in southeast Florida, and water and sediment samples were collected along and around one outfall pipe, as well as along several transects extending both north and south of the...
15h
Antibiotics, Vol. 9, Pages 117: A New Penicillin? Antibiotics doi: 10.3390/antibiotics9030117 Authors: Mark Wainwright The spectre of antimicrobial resistance looms very large indeed in the 21st century; the supply of efficacious conventional drugs is short and not guaranteed, for various reasons. It is time to look elsewhere for answers and for protocols which might be used in tandem with our diminishing arsenal in order to protect vital drugs. This could bridge the gap before...
17h
Cosmetics, Vol. 7, Pages 17: Symurban Nanocrystals for Advanced Anti-Pollution Skincare Cosmetics doi: 10.3390/cosmetics7010017 Authors: Köpke Pyo Several of most common dermatoses worldwide, e.g., psoriasis and atopic dermatitis, are worsened in their clinical picture when the skin is regularly exposed to an increased air pollution level, e.g., particulate matter. This is explainable by the activation of the aryl hydrocarbon receptor (AhR) in the skin, which results in an...
15h
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου