Surface-immobilized nanoscale reactors utilizing membrane protein channels are used to generate precisely patterned chemically and biologically active surfaces (see image). The enzymatic conversion of a fluorogenic substrate in the cavity of immobilized nanoreactors is a model reaction demonstrating future potential application of the system in sensors, analytics, microfluidics, and single-molecule spectroscopy.
18h
Coronin proteins are evolutionary conserved WD repeat containing proteins that have been proposed to carry out different functions. In; Dictyostelium; , the short coronin isoform, coronin A, has been implicated in cytoskeletal reorganization, chemotaxis, phagocytosis and the initiation of multicellular development. Generally thought of as modulators of F-actin, coronin A and its mammalian homologs have also been shown to mediate cellular processes in an F-actin-independent manner. Therefore, it remains...
19h
Scientific applications are often complex, irregular, and computationally-intensive. To accommodate their ever-increasing computational demands, the high-performance computing (HPC) systems have become larger and more complex, offering increased hardware parallelism at multiple levels (e.g., nodes, cores per node, threads per core). Scientific applications need to exploit all multilevel hardware parallelism to harness the available computational power. The performance of applications executing on...
20h
In Černý and Wassmer (Probab. Theory Relat. Fields 167:253–303, 2017) [8], it was shown that the clock process associated with the Metropolis dynamics of the Random Energy Model converges to an α-stable process, after being scaled by a random, Hamiltonian dependent, normalisation. We prove here that this random normalisation can be replaced by a deterministic one.
20h
20h
Quantum dot (QD)-sensitized photon upconversion follows a multi-step energy transfer process from the QD to transmitter ligand to a soluble annihilator. Using a novel 10-R-anthracene-1,8-diphosphoric acid (R = octyl, 2-hexyldecyl, phenyl) ligand with high binding affinity for CdSe QD surfaces, we demonstrate a photon upconversion process that is limited by the transmitter to annihilator transfer efficiency. Using 1H NMR spectroscopy, we demonstrate that these bidentate diphosphate ligands rapidly...
21h
In this work we analyze content statistics of the V3C1 dataset, which is the first partition of the Vimeo Creative Commons Collection (V3C). The dataset has been designed to represent true web videos in the wild, with good visual quality and diverse content characteristics, and will serve as evaluation basis for the Video Browser Showdown 2019-2021 and TREC Video Retrieval (TRECVID) Ad-Hoc Video Search tasks 2019-2021. The dataset comes with a shot segmentation (around 1 million shots) for which...
21h
With the increase in sensory capability of mobile devices, the data that can be generated and used in a lifelogging context gets increasingly diverse. Such data is special in the context of multimedia, not only because of its close personal relationship with its originator, but also because of its diverse multimodality and its composition from structured, semi-structured, and unstructured data. This diversity poses retrieval challenges that are unique to lifelog data but which also have implications...
21h
TNF-α- as well as non-TNF-α-targeting biologics are prescribed to treat a variety of immune-mediated inflammatory disorders. The well-documented risk of tuberculosis progression associated with anti-TNF-α treatment highlighted the central role of TNF-α for the maintenance of protective immunity, although the rate of tuberculosis detected among patients varies with the nature of the drug. Using a human, in-vitro granuloma model, we reproduce the increased reactivation rate of tuberculosis following...
21h
We present a tutorial focusing on video retrieval tasks, where state-of-the-art deep learning approaches still benefit from interactive decisions of users. The tutorial covers general introduction to the interactive video retrieval research area, state-of-the-art video retrieval systems, evaluation campaigns and recently observed results. Moreover, a significant part of the tutorial is dedicated to a practical exercise with three selected state-of-the-art systems in the form of an interactive video...
21h
Intracellular pathogens have evolved intricate mechanisms to subvert host cell signaling pathways and ensure their own propagation. A lineage of the protozoan parasite genus Theileria infects bovine leukocytes and induces their uncontrolled proliferation causing a leukemia-like disease. Given the importance of E2F transcription factors in mammalian cell cycle regulation, we investigated the role of E2F signaling in Theileria-induced host cell proliferation. Using comparative genomics and surface...
21h
The steady growth of multimedia collections - both in terms of size and heterogeneity - necessitates systems that are able to conjointly deal with several types of media as well as large volumes of data. This is especially true when it comes to satisfying a particular information need, i.e., retrieving a particular object of interest from a large collection. Nevertheless, existing multimedia management and retrieval systems are mostly organized in silos and treat different media types separately....
21h
Quantitative analysis in football is difficult due to the complexity and continuous fluidity of the game. Even though there is an increased accessibility of spatio-temporal data, scientific approaches to extract valuable information are seldomly useful in practice. We propose a new approach to building an information system for football. This approach consists of a method to extract football-specific concepts from interviews, to formalize them in a performance model, and to define and implement the...
21h
People's knowledge, attitudes, practices and beliefs (KAPB) pertaining to malaria are generally well described. However, little is known about population knowledge and awareness of insecticide resistance in malaria vectors. The aim of this study was to investigate KAPB related to insecticide resistance in malaria vectors due to the use of insecticides in agriculture and the prevention against mosquitoes. In mid-2017, we carried out a cross-sectional survey in Elibou, South Côte d'Ivoire, employing...
21h
P27A is a novel synthetic malaria vaccine candidate derived from the blood stage Plasmodium falciparum protein Trophozoite Exported Protein 1 (TEX1/PFF0165c). In phase 1a/1b clinical trials in malaria unexposed adults in Switzerland and in malaria pre-exposed adults in Tanzania, P27A formulated with Alhydrogel and GLA-SE adjuvants induced antigen-specific antibodies and T-cell activity. The GLA-SE adjuvant induced significantly stronger humoral responses than the Alhydrogel adjuvant. Groups of pre-exposed...
21h
The task of performance analysts and coaches in football (and other team sports) is manifold: they need to assess the performance of individual players of their team, they need to monitor the interaction between players of their team and their tactical compliance, and they need to analyze other teams. For this, they usually have to consider various sources of information: video footage, tracking data, event data, and aggregated statistics. On the basis of this information, analysts have to generate...
21h
Competing priorities in health systems necessitate difficult choices on which health actions and investments to fund: decisions that are complex, value-based, and highly political. In light of the centrality of universal health coverage (UHC) in driving current health policy, we sought to examine the value interests that influence agenda setting in the country's health financing space. Given the plurality of Kenya's health policy levers, we aimed to examine how the perspectives of stakeholders involved...
21h
Incidence trends of airflow obstruction among European adults without asthma: a 20-year cohort study
Investigating COPD trends may help healthcare providers to forecast future disease burden. We estimated sex- and smoking-specific incidence trends of pre-bronchodilator airflow obstruction (AO) among adults without asthma from 11 European countries within a 20-year follow-up (ECRHS and SAPALDIA cohorts). We also quantified the extent of misclassification in the definition based on pre-bronchodilator spirometry (using post-bronchodilator measurements from a subsample of subjects) and we used this...
21h
Globally, an estimated two-thirds of all deaths occur in the community, the majority of which are not attended by a physician and remain unregistered. Identifying and registering these deaths in civil registration and vital statistics (CRVS) systems, and ascertaining the cause of death, is thus a critical challenge to ensure that policy benefits from reliable evidence on mortality levels and patterns in populations. In contrast to traditional processes for registration, death notification can be...
21h
The need to monitor the Sustainable Development Goals (SDGs) and to have access to reliable and timely mortality data has created a strong demand in countries for tools that can assist them in this. ANACONDA (Analysis of National Causes of Death for Action) is a new tool developed for this purpose which allows countries to assess how accurate their mortality and cause of death are. Applying ANACONDA will increase confidence and capacity among data custodians in countries about their mortality data...
21h
All countries need accurate and timely mortality statistics to inform health and social policy debates and to monitor progress towards national and global health development goals. In many countries, however, civil registration and vital statistics (CRVS) systems are poorly developed. Consequently, the statistics they produce are not fit for purpose. In part, this arises because the physicians certifying cause of death (COD) have either not been adequately trained in how to complete a death certificate...
21h
Background Despite attempts to apply standard methods proven to work in high-income nations, nearly all civil registration and vital statistics (CRVS) systems in low- and middle-income countries are failing to achieve adequate levels of registration completeness or produce the high-quality vital statistics needed to support better health outcomes and monitor progress towards the 2030 Sustainable Development Goals. This suggests that, rather than simple technical issues, these countries are facing...
21h
Lymphatic filariasis (LF), a neglected tropical disease (NTD) and leading cause of global disability, is endemic in 32 countries in Africa with almost 350 million people requiring regular drug administration, and only 16 countries achieving target coverage. Community Drug Distributors (CDDs) are critical for the success of NTD programs, and the distribution of medicines during mass drug administration (MDA) in Africa; however they could also be a weak link. The primary aim of this study is to explore...
21h
Several decades of research provides compelling evidence that exposure to air pollution causes various diseases. Time series studies in Europe and the USA examined the short term effects on mortality and found about 1% increase for cardiovascular mortality per 10 μg/m3 increase in daily PM2.5 concentration. A comprehensive analysis of 12 European cohort studies addressing the long term effects found a 13% increased risk of coronary events per 5 μg/m3 increase in estimated annual mean PM2.5. Noise...
21h
Lifelong antiretroviral therapy (ART) improves health outcomes for HIV-positive individuals, but is jeopardized by irregular clinic attendance and hence poor adherence. Loss to follow-up (LTFU) is typically defined retrospectively but this may lead to biased inferences. We assessed incidence of and factors associated with LTFU, prospectively and accounting for recurrent LTFU episodes, in the Kilombero and Ulanga Antiretroviral Cohort (KIULARCO) of HIV-positive persons in rural Tanzania.; We included...
21h
In sub-Saharan Africa, diagnosis and management of extrapulmonary tuberculosis (EPTB) in people living with HIV (PLHIV) remains a major challenge. This study aimed to characterize the epidemiology and risk factors for poor outcome of extrapulmonary tuberculosis in people living with HIV (PLHIV) in a rural setting in Tanzania.; We included PLHIV >18 years of age enrolled into the Kilombero and Ulanga antiretroviral cohort (KIULARCO) from 2013 to 2017. We assessed the diagnosis of tuberculosis by...
21h
Suramin was introduced into the clinic a century ago and is still used to treat the first stage of acute human sleeping sickness. Due to its size and sixfold negative charge, uptake is mediated through endocytosis and the suramin receptor in trypanosomes is thought to be the invariant surface glycoprotein 75 (ISG75). Nevertheless, we recently identified a variant surface glycoprotein (VSG; Sur; ) that confers strong in vitro resistance to suramin in a; Trypanosoma brucei rhodesiense; line. In this...
21h
More than ever, it is crucial to make the best use of existing country data, and analytical tools for developing malaria control strategies as the heterogeneity in malaria risk within countries is increasing, and the available malaria control tools are expanding while large funding gaps exist. Global and local policymakers, as well as funders, increasingly recognize the value of mathematical modelling as a strategic tool to support decision making. This case study article describes the long-term...
21h
Currently, the American Association of Physicists in Medicine (AAPM) TG-21 is the conventional protocol currently used for the calibration of the Leksell Gamma Knife ® (LGK) (despite the publication of the AAPM TG-51 protocol). However, this protocol is based on the air-kerma standards requiring an elaborate conversion process resulting in an increase in the possibility of errors in the clinic. The International Atomic Energy Agency (IAEA) Technical Reports Series (TRS)-483 Code of Practice...
14h
Radio-frequency dosimetry is an important process in assessments for human exposure safety and for compliance of related products. Recently, computational human models generated from medical images have often been used for such assessment, especially to consider the inter-subject variability. However, a common procedure to develop personalized models is time consuming because it involves excessive segmentation of several components that represent different biological tissues, which is a ...
14h
The increasing incidence of pancreatic cancer will make it the second deadliest cancer in 2030. Imaging based early diagnosis and image guided treatment are emerging potential solutions. Artificial intelligence (AI) can help provide and improve widespread diagnostic expertise and accurate interventional image interpretation. Accurate segmentation of the pancreas is essential to create annotated data sets to train AI, and for computer assisted interventional guidance. Automated deep learning...
14h
This JAMA Insights article reviews care for the most severely ill patients with coronavirus disease 2019 (COVID-19), including standards of management of ARDS, preventing SARS-CoV-2 spread in health care settings, and surge preparation.
14h
In the context of an increase in infectious diseases occurring in association with the US epidemic of opioid use disorder (OUD), this Viewpoint summarizes recommendations from a recent National Academies of Sciences, Engineering, and Medicine (NASEM) committee report intended to facilitate and integrate public health responses to both.
14h
This Research Letter reports on detection of SARS-CoV-2 in human specimens, including bronchoalveolar fluid, sputum, feces, blood, and urine, to determine means of transmission besides respiratory droplets.
14h
Publication date: Available online 10 March 2020Source: Biological PsychologyAuthor(s): Yang Wang, Him Cheung, Lydia Ting Sum Yee, Chun-Yu Tse
14h
Abstract Purpose To examine the time of removal of the odontogenic focus, antibiotic therapy and risk factors in odontogenic abscesses. Patients From January 2012 to December 2015, inpatients undergoing incision due to odontogenic abscesses were identified in a retrospective study. All the patients were evaluated for time of removal of the odontogenic focus,...
14h
Abstract Purpose To assess the success rate and complications of sialendoscopy and sialolithotripsy for parotid sialolithiasis. Materials and methods A total of 228 articles were identified by the electronic database search regarding the topics sialendoscopy and sialolithotripsy. Following independent then joint review of titles and abstracts, 109 articles...
18h
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου