Summary Objective Mortality from thyroid cancer is reported to be higher in the UK compared to several other European countries, though UK data on mortality by disease stage have not been published. The aim of this study was to ascertain disease‐specific mortality by stage in our centre. Design, Patients And Measurements This was a cohort study of all patients presenting to a single centre. Four hundred and twenty patients treated between 2000‐2010 were identified. The medical records...
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Abstract The recent meta‐analysis by Pang et al.(1) exploring the effect of L‐thyroxine administration before breakfast versus at bedtime concludes that either approach results in similar outcomes. This conclusion stands in stark contrast to another excellent study done examining the timing issues of Pre breakfast vs. with breakfast or at Bedtime (2). Bach‐Huynh TG et al. clearly demonstrate the superiority of pre‐breakfast LT4 ingestion when taken 60 minutes before the first meal of the day with...
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Abstract In the current global home confinement situation due to the COVID‐19 outbreak, most individuals are exposed to an unprecedented stressful situation of unknown duration. This may not only increase daytime stress, anxiety and depression levels but also disrupt sleep. Importantly, because of the fundamental role that sleep plays in emotion regulation, sleep disturbance can have direct consequences upon next day emotional functioning. In this paper we summarize what is known about the stress‐sleep...
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Abstract Physicians belong to the risk group for sleep disorders as a result of work related stress, excessive working time, large amount of on‐call duties and shift work. Poor sleep quality of healthcare providers threatens not only their safety, but also the safety of their patients. This study examines if there are any differences in how working either long hours or at night duties relates to self‐reported sleep time, sleep quality and daytime sleepiness in primary care physicians. We analyzed...
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Abstract Malignant mesothelioma (MM) is one of the most lethal tumors in humans. The onset of MM is linked to exposure to asbestos, which generates reactive oxygen species (ROS). ROS are believed to be derived from the frustrated phagocytosis and the iron in asbestos. To explore the pathogenesis of MM, peritoneal MM was induced in rats by the repeated intraperitoneal injection of iron saccharate and nitrilotriacetate. In this study, we employed microarray techniques to screen the microRNA (miR)...
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Abstract In Japan, the serious adverse events after HPV vaccination were widely reported in the media. The Ministry of Health, Labour and Welfare (MHLW) announced the suspension of the governmental recommendation of HPV vaccine in 2013, and the inoculation rate has sharply declined. The estimated inoculation rate for each birth fiscal year (FY) announced by the MHLW and the actual numbers for each birth FY surveyed by the local governments were far apart. Especially, the cumulative vaccination...
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Abstract Glioblastoma multiform (GBM), a lethal brain tumor developing in the white matter of the adult brain, contains a small population of GBM stem cells (GSCs), which potentially cause chemotherapeutic resistance and tumor recurrence. However, the mechanisms underlying the pathogenesis and maintenance of GSCs remain largely unknown. A recent study reported that incorporation of ribosomes and ribosomal proteins into somatic cells promoted lineage trans‐differentiation toward multipotency. This...
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Microbeam radiation therapy (MRT) utilizes highly collimated synchrotron generated x-rays to create narrow planes of high dose radiation for the treatment of tumors. Individual microbeams have a typical width of 30–50 µm and are separated by a distance of 200–500 µm. The dose delivered at the center of the beam is lethal to cells in the microbeam path, on the order of hundreds of Grays (Gy). The tissue between each microbeam is spared and helps aid in the repair of adjacent damaged tissue. ...
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Radiomic features achieve promising results in cancer diagnosis, treatment response prediction, and survival prediction. Our goal is to compare the handcrafted (explicitly designed) and deep learning (DL)-based radiomic features extracted from pre-treatment diffusion-weighted magnetic resonance images (DWIs) for predicting neoadjuvant chemoradiation treatment (nCRT) response in patients with locally advanced rectal cancer (LARC). 43 Patients receiving nCRT were included. All patients underwent...
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To calculate 3D distributions of microdosimetric-based restricted dose-averaged LET (LETd) and dose-mean lineal energy ( ##IMG## [http://ej.iop.org/images/0031-9155/65/7/075011/pmbab730aieqn001.gif] ) in order to explore their similarities and differences between each other and with the traditional unrestricted LETd. Additionally, a new expression for optimum restricted LETd calculation is derived, allowing for disregarding straggling-associated functions in the classical microdosimetric...
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In this study, a functioning and ventilated anthropomorphic phantom was further enhanced for the purpose of CT and MR imaging of the lung and liver. A deformable lung, including respiratory tract was 3D printed. Within the lung’s inner structures is a solid region shaped from a patient’s lung tumour and six nitro-glycerine capsules as reference landmarks. The full internal mesh was coated, and the tumour filled, with polyorganosiloxane based gel. A moulded liver was created with an external...
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The establishment of an MRI-only workflow in radiotherapy depends on the ability to generate an accurate synthetic CT (sCT) for dose calculation. Previously proposed methods have used a Generative Adversarial Network (GAN) for fast sCT generation in order to simplify the clinical workflow and reduces uncertainties. In the current paper we use a conditional Generative Adversarial Network (cGAN) framework called pix2pixHD to create a robust model prone to multicenter data. This study included...
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We present an automatic bi-objective parameter-tuning approach for inverse planning methods for high-dose-rate prostate brachytherapy, which aims to overcome the difficult and time-consuming manual parameter tuning that is currently required to obtain patient-specific high-quality treatment plans. We modelled treatment planning as a bi-objective optimization problem, in which dose-volume-based planning criteria related to target coverage are explicitly separated from organ-sparing criteria....
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Abstract Triticum boeoticum (2n = 2x = 14, AbAb) contains beneficial traits for common wheat improvement. The discrimination of Ab-genome chromosomes from A-genome chromosomes is an important step in gene transfer from T. boeoticum to common wheat. In this study, fluorescence in situ hybridization (FISH) analysis using nine oligonucleotide probes revealed high divergence between chromosomes of the common wheat germplasm Crocus and T. boeoticum accession G52. The combination of...
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Lung, collapsed: Failure of full expansion of a once fully expanded lung. Medically called atelectasis. The word comes from the Greek "a-" (without) "telos" (complete) + "rectasis" (expansion) = without complete expansion. MedTerms (TM) is the Medical Dictionary of MedicineNet.com.We Bring Doctors' Knowledge To You
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Ventilator: A machine that mechanically assists a patient in the exchange of oxygen and carbon dioxide, a process sometimes referred to as artificial respiration.MedTerms (TM) is the Medical Dictionary of MedicineNet.com.We Bring Doctors' Knowledge To You
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Oxygen: The odorless gas that is present in the air and necessary to maintain life. Oxygen may be given in a medical setting, either to reduce the volume of other gases in the blood or as a vehicle for delivering anesthetics in gas form. It can be delivered via nasal tubes, an oxygen mask, or an oxygen tent. Patients with lung disease or damage may need to use portable oxygen devices on a temporary or permanent basis.MedTerms (TM) is the Medical Dictionary of MedicineNet.com.We Bring Doctors' Knowledge...
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Abstract Ninety percent of childhood renal tumors are Wilms tumors (nephroblastoma). While the Children’s Oncology Group (COG) recommends primary surgery, the International Society of Paediatric Oncology (SIOP) recommends neoadjuvant chemotherapy, which can be initiated without histological confirmation if the presentation is typical for Wilms tumor. This review article describes the clinical, biological and radiologic criteria used by the SIOP community to consider diagnostic...
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Newly identified lncRNA zinc finger protein, FOG family member 2 antisense RNA 1 (ZFPM2-AS1) is identified as an oncogenic gene. However, the role of ZFPM2-AS1 in small cell lung cancer (SCLC) is poorly compre...
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Infections by both human oncoviruses, human Papillomaviruses (HPV) and Epstein–Barr virus (EBV) are very common in the adult human population and are associated with various malignancies. While HPV is generall...
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Two separate studies of pediatric patients in Wuhan, China found that though clinical manifestations of COVID-19 in children were less severe than those of adult patients, young children, particularly infants, were vulnerable to the infection. (Source: CancerNetwork)
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In a letter to Congress, the AACR called for immediate action to be taken to protect patients with cancer against the COVID-19 pandemic. (Source: CancerNetwork)
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The FDA granted fast track designation to ME-401, an investigational selective oral inhibitor of PI3K delta, for the treatment of adult patients with relapsed or refractory follicular lymphoma. (Source: CancerNetwork)
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The trial evaluating the first-line treatment of pembrolizumab in patients with microsatellite instability-high or mismatch repair deficient unresectable or metastatic colorectal cancer demonstrated improved PFS compared with chemotherapy. (Source: CancerNetwork)
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The FDA cleared the investigational new drug (IND) application for the use of CYNK-001 in adults with COVID-19. (Source: CancerNetwork)
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Researchers reported updated findings of infigratinib in upper tract urothelial carcinoma and urothelial carcinoma of the bladder, supporting the development of phase III studies in this setting. (Source: CancerNetwork)
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Clinicians advised the best approaches for treating patients who have been diagnosed or are currently under treatment for cancer during the ongoing COVID-19 pandemic. (Source: CancerNetwork)
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In a webinar hosted by the American Nurses Association, Terri Rebmann, PhD, RN, CIC, FAPIC, discussed how nurses can protect themselves and their patients during the COVID-19 pandemic. (Source: CancerNetwork)
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A study found that, utilizing cell-free DNA sequencing leveraging methylation patterns, a new blood test could detect more than 50 cancer types and the location of these cancer types in the body. (Source: CancerNetwork)
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Planta MedDOI: 10.1055/a-1135-9066 Spondias mobin leaves have been traditionally used for treating cold sores. The study investigated the mechanism of antiherpes action of S. mombin extract, fractions, and geraniin. Different concentrations of samples were used to evaluate the in vitro antiherpes activity (anti-HSV-1) in virucidal, post-infection, attachment, and penetration assays. The mechanism of action of geraniin was investigated considering the glycoproteins gB and gD of HSV-1 surface...
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Imaging is a key clinical tool used to evaluate tumor burden and response to treatment across tumor types [1]. In colorectal cancer (CRC), imaging plays an important role in determining tumor stage and prognostic characteristics, selecting appropriate treatment strategies, and in assessing response to systemic therapy and disease recurrence [2–4]. In solid tumors, response to therapy is typically measured using Response Evaluation Criteria in Solid Tumors (RECIST), which was developed for clinical...
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SLIT with rMal d 1 induced IgG antibodies which block IgE-mediated effects to the apple allergen. This was not observed after SLIT with rBet v 1 and may explain its limited clinical efficacy on apple allergy.
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Measures of subglottal pressure (Ps), phonation threshold pressure (PTP), and laryngeal resistance (LR) can be used as indicators of vocal cord disorders. The gold standard non-invasive measurement uses labial interruption, which has been shown to have reliability inconsistencies. Mechanical interruption methods have demonstrated promise in measurement reliability. The goal of the present study is to compare retest reliability of labial and mechanical interruption methods.
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Unilateral vocal fold paralysis (UVFP) often leads to significant morbidity that may include dysphonia, swallowing problems and aspiration. The best timing for medialization procedures is still controversial. Published data suggest that early intracordal injection positively affects long-term outcomes.
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