Abstract Background and Objective Today, osteoporosis is the most common bone disease and an important public health problem in all developed countries. The objective of this study was to estimate the costs associated with the management and treatment of osteoporosis in order to assess the economic burden in Italy for 2017, in terms of direct medical costs and social security costs. ...
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Abstract Vascular dementia (VD) is the second most common cause of dementia following Alzheimer’s disease (AD). The major symptoms of VD including memory loss, language deficits and impairment of executive functions. Its specific etiology and pathogenesis remain unknown. Currently, treatment options of VD are still limited. The therapeutic strategies aim to control the vascular risk factors and improve the cognitive function. In recent years, cell therapy for neurodegenerative...
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Abstract Assessment of donor suitability and criteria development for tissue donation evaluation which appropriately addresses the risk factors for disease transmission, especially high risk for Hepatitis B or C, HIV or other transmissible diseases as defined by the Food and Drug Administration, FDA, is a continuing concern for tissue banks. The relationship of drug use, especially IV drugs, has been determined to be associated with an increased possibility of reactive serology...
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Summary The first person‐to‐person transmission of the 2019‐novel coronavirus in Italy on 21 February 2020 led to an infection chain that represents one of the largest known COVID‐19 outbreaks outside Asia. In Northern Italy in particular, we rapidly experienced a critical care crisis due to a shortage of intensive care beds, as we expected according to data reported in China. Based on our experience of managing this surge, we produced this review to support other healthcare services in preparedness...
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Abstract The key healthcare challenge of the coronavirus disease 2019 (COVID‐19) pandemic is the safe delivery of respiratory support on a large scale. The care of critically ill COVID‐19 patients is guided by our knowledge and experience with acute respiratory distress syndrome (ARDS), but this crisis is pushing patients and their clinicians into unchartered territories. One of the key decisions faced by healthcare systems is in selecting the appropriate devices for oxygen administration. The...
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Summary Personal protective equipment has become an important and emotive subject during the current coronavirus (COVID‐19) epidemic. COVID‐19 is predominantly caused by contact or droplet transmission attributed to relatively large respiratory particles which are subject to gravitational forces and travel only approximately one metre from the patient. Airborne transmission may occur if patient respiratory activity or medical procedures generate respiratory aerosols. These aerosols contain particles...
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Abstract To assess schoolchildren’s exposure to outdoor/indoor air pollution and identify those at a higher risk, it is desirable to conduct personal-level air quality monitoring. This paper documents a 2-month voluntary monitoring campaign with students attending the environmental club of the Spring Valley High School in urban Las Vegas, Nevada. The students wore low-cost sensors to log their exposure to PM2.5 (particulate matter with aerodynamic diameters < 2.5 μm) at 5-min...
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Unfortunately, the original version of this article contained
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Abstract Purpose To assess the relationship between depressive symptoms and self-perceived severity of autonomic dysfunction in patients with multiple system atrophy (MSA). Methods Cross-sectional evaluation of patients with MSA who underwent autonomic testing, Unified MSA Rating Scale (UMSARS)-1 and -2, rating of the presence and severity of depressive symptoms...
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Antibiotics, Vol. 9, Pages 161: Clonal Structure, Virulence Factor-encoding Genes and Antibiotic Resistance of Escherichia coli, Causing Urinary Tract Infections and Other Extraintestinal Infections in Humans in Spain and France during 2016 Antibiotics doi: 10.3390/antibiotics9040161 Authors: Saskia-Camille Flament-Simon Marie-Hélène Nicolas-Chanoine Vanesa García Marion Duprilot Noémie Mayer María Pilar Alonso Isidro García-Meniño Jesús E. Blanco Miguel...
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Antibiotics, Vol. 9, Pages 160: Benzamide Derivatives Targeting the Cell Division Protein FtsZ: Modifications of the Linker and the Benzodioxane Scaffold and Their Effects on Antimicrobial Activity Antibiotics doi: 10.3390/antibiotics9040160 Authors: Valentina Straniero Lorenzo Suigo Andrea Casiraghi Victor Sebastián-Pérez Martina Hrast Carlo Zanotto Irena Zdovc Carlo De Giuli Morghen Antonia Radaelli Ermanno Valoti Filamentous temperature-sensitive...
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Antibiotics, Vol. 9, Pages 159: Innate Antimicrobial Defense of Skin and Oral Mucosa Antibiotics doi: 10.3390/antibiotics9040159 Authors: Philip W. Wertz Sarah de Szalay This special issue intends to review and update our understanding of the antimicrobial defense mechanisms of the skin and oral cavity. These two environments are quite different in terms of water, pH, and nutrient availability, but have some common antimicrobial factors. The skin surface supports the growth...
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Abstract Syndesmotic injuries, also referred as high ankle sprains, may cause significant ankle instability and chronic pain. Ultrasound (US) is a well-proven imaging modality to evaluate the ligaments of the ankle, due to its high spatial resolution and the possibility to perform dynamic examinations. However, considering the syndesmosis complex, the sonographic appearance of the posterior inferior tibiofibular ligament (PITFL) is not well described in the pertinent literature...
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Abstract Purpose Computer-aided diagnosis (CAD) may improve interobserver agreement in the risk stratification of thyroid nodules. This study aims to evaluate the performance of the Korean Thyroid Imaging Reporting and Data System (K-TIRADS) classification as estimated by an expert radiologist, a senior resident, a medical student, and a CAD system, as well as the interobserver agreement among them. ...
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Abstract We have been doing Endoscopic ear surgeries since 2013. Inorder to overcome the disadvantage of the single handed endoscopic ear surgery technique, we have developed the endoscope holders, Justtach® and EndoHold®. Due to its certain limitations, we modified the pre-existing, endoscope holder—Justtach, to add more features as well as to increase the comfort and ease of the technique. The aim of this paper is to describe the design of our modified endoscope holder and to...
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Abstract Intertemporal choice refers to decisions that need to weigh different rewards at different time points in the future. Decision impulsivity manifests in the tendency of choosing smaller immediate options rather than larger later ones. Previous studies have suggested that decision impulsivity in intertemporal decision-making shares similar cognitive and neural mechanisms with risky decision-making. The present study theorizes on and examines whether the activation patterns...
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Student attitudes toward instructor assessment in higher education: Does the delivery method matter?
Abstract This study investigated 113 community college students enrolled in face-to-face and online speech communication courses and their perceptions of instructor speech assessments. Each course completed a self-inventory questionnaire using Google Forms at the completion of the semester. Descriptive statistics and an independent samples t-test analyzed responses. Students enrolled in a face-to-face public speaking course reported statistically significant higher levels of satisfaction...
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Abstract Verjuice is one of the alternative fruit juices recently obtained from unripe grapes. In this study, the aim was primarily to optimize the process conditions for the enrichment of bioactive components in verjuice vinegar with ultrasound treatment. For this purpose, ultrasound treatment was applied to vinegar samples at different times (2, 4, 6, 8 and 10 min), different amplitudes (60%, 65%, 70%, 75% and 80%) and 26 kHz frequency. Total phenolic content (TPC), total flavonoid...
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Abstract Turnip is a vegetable that has many health promoting effects. To diversify the usage and increase the consumption of turnip, the effects of hot air drying, infrared drying, explosion puff drying and freeze drying (FD) on the volatiles of turnip chips were studied. The volatiles of fresh turnip and dried turnip chips were isolated by HS-SPME–GC–MS and a total of 67 volatiles were identified. However, the volatiles in turnip chips dried by different methods are quite different....
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Abstract The human body needs an antioxidant-rich diet that comes from foods, beverages, and herbal products to support the physiological antioxidant systems. Thus, the development of an analytical tool for a simple assay of the total antioxidant capacity (TAC) of the rich antioxidant samples is crucial. The current work demonstrates a simple colorimetric assay of TAC of the herbal extract on the paper microzone plate (PµZP) that was constructed in the 70-well of patterned paper...
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Abstract The body is home to a number of unique and intriguing anatomical structures, plenty of which concern the muscles and their tendons. Of these, the plantaris muscle is reported to present a particularly high range of morphological variations. The muscle, passing distally throughout the length of the lower leg, consists of a small muscle belly and a long, thin tendon. It originates, traditionally, on the popliteal surface of the femur and the knee joint capsule, and then...
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Publication date: Available online 3 April 2020Source: Cellular SignallingAuthor(s): Chau My Ta, Thuy N. Vien, Leo C.T. Ng, Paul G. DeCaen
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Publication date: Available online 2 April 2020Source: Cellular SignallingAuthor(s): Vicente E. Torres, Albert C.M. Ong
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Postoperative sore throat (POST) is a common, undesirable result of endotracheal intubation during general anaesthesia. This study aimed to evaluate the effectiveness of benzydamine hydrochloride (BH) spray in...
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Arm conicity is associated with non-invasive blood pressure (NIBP) measurement error and may be avoided by using finger cuffs. Predicting arm conicity may help decisions regarding NIBP measurement techniques.
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Cataract surgery is one of the most common procedures performed worldwide in the elderly. Various medications can provide effective anesthesia and analgesia for cataract surgery, but undesirable side effects l...
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Following publication of the original article [1], it was brought to our attention of an error in the article title.
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Limited information is available regarding intraoperative ventilator settings and the incidence of postoperative pulmonary complications (PPCs) in patients undergoing neurosurgical procedures. The aim of this ...
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This study was designed to explore the prevalence and risk factors of preoperative deep venous thromboembolism (DVT) in Chinese elderly with hip fracture.
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Abstract Introduction Poliovirus receptor (PVR) is a tumor promoter and a regulatory checkpoint that enhances immunosuppression. We investigated PVR expression by applying immunohistochemistry (IHC) staining. A positive association existed between PVR expression and cytotoxic T lymphocyte-associated antigen 4 (CTLA4) expression in patients with surgically resected non-small-cell lung cancer (NSCLC). PVR expression is a prognosis predictor...
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Abstract Background Pleomorphic liposarcomas (PLS) is an aggressive, high-grade subtype of soft tissue sarcoma representing < 15% of liposarcomas. It most commonly arises in the retroperitoneum and proximal upper extremities. Current prognostic factors are centered around staging, which accounts for the grade, size, and location of the tumor in relation to the superficial fascia. ...
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Abstract Background In the literature, men are often described as unwilling to use healthcare services, whereas women as frequent users. We conducted a systematic literature review to examine the gender differences in healthcare utilisation of lung cancer patients. Our aim was to synthesise evidence to assess whether men and women utilise cancer diagnosis and treatments differently. ...
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Abstract Purpose Fedratinib is an orally administered Janus kinase 2-selective inhibitor that is indicated for the treatment of adult patients with intermediate-2 or high-risk myelofibrosis in the United States. Fedratinib is metabolized by multiple cytochrome P450s (CYPs) in vitro, with the predominant contribution from CYP3A4. The primary objective of this study was to evaluate the effects of 14-day repeated 200 mg twice daily (BID)...
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Abstract Purpose High-dose methotrexate (HD-MTX) is widely used in the treatment of non-Hodgkin lymphoma (NHL), but the pharmacokinetic properties of HD-MTX in Chinese adult patients with NHL have not yet been established through an approach that integrates genetic covariates. The purposes of this study were to identify both physiological and pharmacogenomic covariates that can explain the inter- and intraindividual pharmacokinetic variability...
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Abstract Long non-coding RNA (lncRNA) TP73 antisense RNA 1 (TP73-AS1) has been characterized as an oncogenic lncRNA in GC. However, by analyzing The Cancer Genome Atlas (TCGA) dataset we observed the downregulation of TP73-AS1 in GC. In addition, TP73-AS1 is predicted to interact with microRNA-223-5p (miR-223-5p), which is also a critical player in cancer biology. This study was therefore carried out to investigate the roles of miR-223-5p and TP73-AS1 in gastric cancer (GC) and...
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Abstract Purpose Olfactory training is recommended in olfactory dysfunction (OD) showing promising results. OD patients frequently ask for training modifications in the hope of a better outcome. Also, a lack of knowledge of the flavor system is evident. This investigation sought to implement flavor education (FE) and encourage patients to experience flavors in terms of a flavor training (FT). ...
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Abstract Purpose Day-case thyroid surgery has been endorsed by the American Thyroid Association and the British Association of Day Surgery. Despite the many benefits of day surgery, day-case thyroid surgery is not widely practiced. We describe the use of sensitivity analysis modelling and cost analysis in determining and refining the patient cohort that safely meet the threshold for a new day-case thyroid lobectomy service at a tertiary...
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Abstract Purpose In an effort to make olfactory training (OT) simpler, we designed an ‘olfactory training ball’ (OTB)—a baseball-size ball with four odor-containing tubes to use in OT. The study aimed to investigate the effects of OT with the OTB in comparison to classical OT with special attention to the effects of adherence to OT on olfactory outcome measures. Methods ...
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