Biomolecules, Vol. 10, Pages 1039: Synthesis and Anticancer Activity of Dimeric Polyether Ionophores
Biomolecules, Vol. 10, Pages 1039: Synthesis and Anticancer Activity of Dimeric Polyether Ionophores Biomolecules doi: 10.3390/biom10071039 Authors: Michał Sulik Ewa Maj Joanna Wietrzyk Adam Huczyński Michał Antoszczak Polyether ionophores represent a group of natural lipid-soluble biomolecules with a broad spectrum of bioactivity, ranging from antibacterial to anticancer activity. Three seem to be particularly interesting in this context, namely lasalocid acid, monensin,...
Sun Jul 12, 2020 03:00
Biomolecules, Vol. 10, Pages 1038: Biodegradable Flame Retardants for Biodegradable Polymer Biomolecules doi: 10.3390/biom10071038 Authors: Maqsood Seide To improve sustainability of polymers and to reduce carbon footprint, polymers from renewable resources are given significant attention due to the developing concern over environmental protection. The renewable materials are progressively used in many technical applications instead of short-term-use products. However, among other...
Sat Jul 11, 2020 03:00
Biomolecules, Vol. 10, Pages 1036: Deoxyribonucleases and Their Applications in Biomedicine Biomolecules doi: 10.3390/biom10071036 Authors: Lucia Lauková Barbora Konečná Ľubica Janovičová Barbora Vlková Peter Celec Extracellular DNA, also called cell-free DNA, released from dying cells or activated immune cells can be recognized by the immune system as a danger signal causing or enhancing inflammation. The cleavage of extracellular DNA is crucial for limiting the inflammatory...
Sat Jul 11, 2020 03:00
Biomolecules, Vol. 10, Pages 1037: Attenuation of Inflammatory Symptoms by Icariside B2 in Carrageenan and LPS-Induced Inflammation Models via Regulation of MAPK/NF-κB Signaling Cascades Biomolecules doi: 10.3390/biom10071037 Authors: Alam Kwon Simu Abrar Shahriyar Lee : Prolonged inflammatory responses can lead to the development of several chronic diseases, such as autoimmune disorders and the development of natural therapeutic agents is required. A murine model was...
Sat Jul 11, 2020 03:00
Biomolecules, Vol. 10, Pages 1034: Mapping the Interactome of the Nuclear Heparan Sulfate Proteoglycan Syndecan-1 in Mesothelioma Cells Biomolecules doi: 10.3390/biom10071034 Authors: Ashish Kumar-Singh Jatin Shrinet Malgorzata Maria Parniewska Jonas Fuxe Katalin Dobra Anders Hjerpe Syndecan-1 (SDC1) is a cell surface heparan sulfate proteoglycan (HSPG), which regulates various signaling pathways controlling the proliferation and migration of malignant mesothelioma and...
Sat Jul 11, 2020 03:00
Biomolecules, Vol. 10, Pages 1033: Anti-Inflammatory and Barrier-Stabilising Effects of Myrrh, Coffee Charcoal and Chamomile Flower Extract in a Co-Culture Cell Model of the Intestinal Mucosa Biomolecules doi: 10.3390/biom10071033 Authors: Laura Weber Katrin Kuck Guido Jürgenliemk Jörg Heilmann Bartosz Lipowicz Cica Vissiennon Recent clinical evidence suggests the efficacy of a traditional herbal medicinal product containing myrrh (Commiphora molmol Engl.), coffee charcoal...
Sat Jul 11, 2020 03:00
Biomolecules, Vol. 10, Pages 1035: Galectin-3 Stimulates Tyro3 Receptor Tyrosine Kinase and Erk Signalling, Cell Survival and Migration in Human Cancer Cells Biomolecules doi: 10.3390/biom10071035 Authors: Nour Al Kafri Sassan Hafizi The TAM (Tyro3, Axl, MerTK) subfamily of receptor tyrosine kinases (RTKs) and their ligands, Gas6 and protein S (ProS1), are implicated in tumorigenesis and chemoresistance in various cancers. The β-galactoside binding protein galectin-3 (Gal-3),...
Sat Jul 11, 2020 03:00
Biomolecules, Vol. 10, Pages 1032: Low Vitamin D States Observed in U.S. Marines and Navy Sailors with Early Multi-Symptom Illness Biomolecules doi: 10.3390/biom10071032 Authors: Sean R. Maloney Paula Goolkasian Research has implicated immune system inflammation as an underlying etiology of multi-symptom illnesses, and vitamin D has been shown to have a significant role in immune system function. In this retrospective review performed on the medical charts of service members who presented...
Sat Jul 11, 2020 03:00
Biomolecules, Vol. 10, Pages 1031: Effects of Jasmonic Acid in ER Stress and Unfolded Protein Response in Tomato Plants Biomolecules doi: 10.3390/biom10071031 Authors: Zalán Czékus Orsolya Csíkos Attila Ördög Irma Tari Péter Poór Endoplasmic reticulum (ER) stress elicits a protective mechanism called unfolded protein response (UPR) to maintain cellular homeostasis, which can be regulated by defence hormones. In this study, the physiological role of jasmonic acid (JA) in ER...
Fri Jul 10, 2020 03:00
Biomolecules, Vol. 10, Pages 1030: Ampicillin/Sulbactam Treatment Modulates NMDA Receptor NR2B Subunit and Attenuates Neuroinflammation and Alcohol Intake in Male High Alcohol Drinking Rats Biomolecules doi: 10.3390/biom10071030 Authors: Alasmari Alhaddad Wong Bell Sari Exposure to ethanol commonly manifests neuroinflammation. Beta (β)-lactam antibiotics attenuate ethanol drinking through upregulation of astroglial glutamate transporters, especially glutamate...
Fri Jul 10, 2020 03:00
Biomolecules, Vol. 10, Pages 1028: Ginsenoside Compound K: Insights into Recent Studies on Pharmacokinetics and Health-Promoting Activities Biomolecules doi: 10.3390/biom10071028 Authors: Anshul Sharma Hae-Jeung Lee Ginseng (Panax ginseng) is an herb popular for its medicinal and health properties. Compound K (CK) is a secondary ginsenoside biotransformed from major ginsenosides. Compound K is more bioavailable and soluble than its parent ginsenosides and hence of immense importance....
Fri Jul 10, 2020 03:00
Biomolecules, Vol. 10, Pages 1027: On the Risks of Phylogeny-Based Strain Prioritization for Drug Discovery: Streptomyces lunaelactis as a Case Study Biomolecules doi: 10.3390/biom10071027 Authors: Martinet Naômé Baiwir De Pauw Mazzucchelli Rigali Strain prioritization for drug discovery aims at excluding redundant strains of a collection in order to limit the repetitive identification of the same molecules. In this work, we wanted to estimate what can be unexploited...
Fri Jul 10, 2020 03:00
Biomolecules, Vol. 10, Pages 1029: Defensins of Grasses: A Systematic Review Biomolecules doi: 10.3390/biom10071029 Authors: Odintsova Slezina Istomina The grass family (Poaceae) is one of the largest families of flowering plants, growing in all climatic zones of all continents, which includes species of exceptional economic importance. The high adaptability of grasses to adverse environmental factors implies the existence of efficient resistance mechanisms that involve the...
Fri Jul 10, 2020 03:00
Biomolecules, Vol. 10, Pages 1025: A Novel Approach to Bacterial Expression and Purification of Myristoylated Forms of Neuronal Calcium Sensor Proteins Biomolecules doi: 10.3390/biom10071025 Authors: Vladimirov Baksheeva Mikhailova Ismailov Litus Tikhomirova Nazipova Permyakov Zernii Zinchenko N-terminal myristoylation is a common co-and post-translational modification of numerous eukaryotic and viral proteins, which affects their interaction with...
Fri Jul 10, 2020 03:00
Biomolecules, Vol. 10, Pages 1024: The Hippo Pathway in Cardiac Regeneration and Homeostasis: New Perspectives for Cell-Free Therapy in the Injured Heart Biomolecules doi: 10.3390/biom10071024 Authors: Mingjie Zheng Joan Jacob Shao-Hsi Hung Jun Wang Intractable cardiovascular diseases are leading causes of mortality around the world. Adult mammalian hearts have poor regenerative capacity and are not capable of self-repair after injury. Recent studies of cell-free therapeutics...
Fri Jul 10, 2020 03:00
Biomolecules, Vol. 10, Pages 1026: Glucose-Induced Expression of DAPIT in Pancreatic β-Cells Biomolecules doi: 10.3390/biom10071026 Authors: Alberto Leguina-Ruzzi Anežka Vodičková Blanka Holendová Vojtěch Pavluch Jan Tauber Hana Engstová Andrea Dlasková Petr Ježek Transcript levels for selected ATP synthase membrane FO-subunits—including DAPIT—in INS-1E cells were found to be sensitive to lowering glucose down from 11 mM, in which these cells...
Fri Jul 10, 2020 03:00
Biomolecules, Vol. 10, Pages 1023: Identification of 5-Fluoro-5-Deoxy-Ribulose as a Shunt Fluorometabolite in Streptomyces sp. MA37 Biomolecules doi: 10.3390/biom10071023 Authors: Linrui Wu Ming Him Tong Kwaku Kyeremeh Hai Deng A fluorometabolite, 5-fluoro-5-deoxy-D-ribulose (5-FDRul), from the culture broth of the soil bacterium Streptomyces sp. MA37, was identified through a combination of genetic manipulation, chemo-enzymatic synthesis and NMR comparison. Although 5-FDRul...
Fri Jul 10, 2020 03:00
Biomolecules, Vol. 10, Pages 1022: The FAAH Inhibitor URB597 Modulates Lipid Mediators in the Brain of Rats with Spontaneous Hypertension Biomolecules doi: 10.3390/biom10071022 Authors: Michał Biernacki Marta Baranowska-Kuczko Gabriella N. Niklińska Elżbieta Skrzydlewska Hypertension is accompanied by oxidative stress, which can be modified by the functioning of the endocannabinoid system playing a prominent modulatory role in the brain. The present study tested whether chronic...
Fri Jul 10, 2020 03:00
Brain Sciences, Vol. 10, Pages 444: “Mom Let’s Go to the Dentist!” Preliminary Feasibility of a Tailored Dental Intervention for Children with Autism Spectrum Disorder in the Italian Public Health Service Brain Sciences doi: 10.3390/brainsci10070444 Authors: Antonio Narzisi Mariasole Bondioli Francesca Pardossi Lucia Billeci Maria Claudia Buzzi Marina Buzzi Martina Pinzino Caterina Senette Valentina Semucci Alessandro Tonacci Fabio Uscidda Benedetta Vagelli...
Sun Jul 12, 2020 03:00
Brain Sciences, Vol. 10, Pages 443: Ictal Asystole in Drug-Resistant Focal Epilepsy: Two Decades of Experience from an Epilepsy Monitoring Unit Brain Sciences doi: 10.3390/brainsci10070443 Authors: Sara Casciato Pier Paolo Quarato Addolorata Mascia Alfredo D’Aniello Vincenzo Esposito Roberta Morace Luigi Pavone Carlo Di Bonaventura Mario Tombini Giovanni Assenza Giancarlo Di Gennaro Background: Ictal asystole (IA) is a rare event observed in people with...
Sun Jul 12, 2020 03:00
Brain Sciences, Vol. 10, Pages 442: Silent Speech Decoding Using Spectrogram Features Based on Neuromuscular Activities Brain Sciences doi: 10.3390/brainsci10070442 Authors: You Wang Ming Zhang RuMeng Wu Han Gao Meng Yang Zhiyuan Luo Guang Li Silent speech decoding is a novel application of the Brain–Computer Interface (BCI) based on articulatory neuromuscular activities, reducing difficulties in data acquirement and processing. In this paper, spatial features...
Sat Jul 11, 2020 03:00
Brain Sciences, Vol. 10, Pages 441: Sleeping without Prescription: Management of Sleep Disorders in Children with Autism with Non-Pharmacological Interventions and Over-the-Counter Treatments Brain Sciences doi: 10.3390/brainsci10070441 Authors: Esposito Belli Ferri Bruni Autism Spectrum Disorders (ASD) are lifelong neurodevelopmental conditions characterized by abnormal social interaction, communication, and behavior. Sleep disturbances represent a common comorbidity in...
Sat Jul 11, 2020 03:00
Brain Sciences, Vol. 10, Pages 440: Brain Abscess Masquerading as Brain Infarction Brain Sciences doi: 10.3390/brainsci10070440 Authors: Da-Eun Jeong Jun Lee Occasionally, acute ischemic stroke can be difficult to differentiate from acute intracranial infection. We describe a patient who presented with sudden onset of right hemiparesis and fever. Magnetic resonance imaging (MRI) was consistent with an acute stroke, showing multiple lesions with restricted diffusion in the left middle...
Sat Jul 11, 2020 03:00
Brain Sciences, Vol. 10, Pages 439: Association of Exercise with Inhibitory Control and Prefrontal Brain Activity Under Acute Psychosocial Stress Brain Sciences doi: 10.3390/brainsci10070439 Authors: Manuel Mücke Sebastian Ludyga Flora Colledge Uwe Pühse Markus Gerber Psychosocial stress has negative effects on cognition in adolescents. The aim of this study was to investigate whether physical exercise can buffer such effects on inhibitory control and associated cortical...
Fri Jul 10, 2020 03:00
Brain Sciences, Vol. 10, Pages 438: Neuronal-Specific Inhibition of Endoplasmic Reticulum Mg2+/Ca2+ ATPase Ca2+ Uptake in a Mixed Primary Hippocampal Culture Model of Status Epilepticus Brain Sciences doi: 10.3390/brainsci10070438 Authors: Laxmikant S. Deshpande Robert J. DeLorenzo Severn B. Churn J. Travis Parsons Loss of intracellular calcium homeostasis is an established mechanism associated with neuronal dysfunction and status epilepticus. Sequestration of free cytosolic...
Fri Jul 10, 2020 03:00
Cancers, Vol. 12, Pages 1876: Aspartic Aminopeptidase Is a Novel Biomarker of Aggressive Chronic Lymphocytic Leukemia Cancers doi: 10.3390/cancers12071876 Authors: Pramath Kakodkar Sanket More Kinga András Nikos Papakonstantinou Sharon Kelly Mohammad Adib Makrooni Csaba Ortutay Eva Szegezdi Treatment of chronic lymphocytic leukemia has advanced substantially as our understanding of the kinase signal transduction pathways driven by the B cell receptor (BcR) has developed....
Sun Jul 12, 2020 03:00
Cancers, Vol. 12, Pages 1875: Combinatorial Immunotherapies for Metastatic Colorectal Cancer Cancers doi: 10.3390/cancers12071875 Authors: Eline Janssen Beatriz Subtil Fàtima de la Jara Ortiz Henk M. W. Verheul Daniele V. F. Tauriello Colorectal cancer (CRC) is one of the most frequent and deadly forms of cancer. About half of patients are affected by metastasis, with the cancer spreading to e.g., liver, lungs or the peritoneum. The majority of these patients cannot be cured...
Sun Jul 12, 2020 03:00
Cancers, Vol. 12, Pages 1874: Cost-Effectiveness of Early Detection and Prevention Strategies for Endometrial Cancer—A Systematic Review Cancers doi: 10.3390/cancers12071874 Authors: Gaby Sroczynski Artemisa Gogollari Annette Conrads-Frank Lára R. Hallsson Nora Pashayan Martin Widschwendter Uwe Siebert Endometrial cancer is the most common female genital tract cancer in developed countries. We systematically reviewed the current health-economic evidence on early detection...
Sat Jul 11, 2020 03:00
Cancers, Vol. 12, Pages 1873: A Retrospective Analysis of the Efficacy of Immunotherapy in Metastatic Soft-Tissue Sarcomas Cancers doi: 10.3390/cancers12071873 Authors: Varun Monga Keith M. Skubitz Seth Maliske Sarah L. Mott Hilary Dietz Angela C. Hirbe Brian A. Van Tine Peter Oppelt Scott Okuno Steven Robinson Madeline O’Connor Mahesh Seetharam Steven Attia John Charlson Mark Agulnik Mohammed Milhem Although checkpoint inhibitors have been...
Sat Jul 11, 2020 03:00
Cancers, Vol. 12, Pages 1868: Development of Antibody Immuno-PET/SPECT Radiopharmaceuticals for Imaging of Oncological Disorders—An Update Cancers doi: 10.3390/cancers12071868 Authors: Jonatan Dewulf Karuna Adhikari Christel Vangestel Tim Van Den Wyngaert Filipe Elvas Positron emission tomography (PET) and single-photon emission computed tomography (SPECT) are molecular imaging strategies that typically use radioactively labeled ligands to selectively visualize molecular...
Sat Jul 11, 2020 03:00
Cancers, Vol. 12, Pages 1871: Circulating Tumour DNA Is an Independent Prognostic Biomarker for Survival in Metastatic BRAF or NRAS-Mutated Melanoma Patients Cancers doi: 10.3390/cancers12071871 Authors: Guillaume Herbreteau Audrey Vallée Anne-Chantal Knol Sandrine Théoleyre Gaelle Quéreux Cécile Frénard Emilie Varey Paul Hofman Amir Khammari Brigitte Dréno Marc G. Denis Circulating tumour DNA (ctDNA) can be used to identify gene alterations. The purpose...
Sat Jul 11, 2020 03:00
Cancers, Vol. 12, Pages 1869: New Insights into Diffuse Large B-Cell Lymphoma Pathobiology Cancers doi: 10.3390/cancers12071869 Authors: Antonio Giovanni Solimando Tiziana Annese Roberto Tamma Giuseppe Ingravallo Eugenio Maiorano Angelo Vacca Giorgina Specchia Domenico Ribatti Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma (NHL), accounting for about 40% of all cases of NHL. Analysis of the tumor microenvironment is an important aspect...
Sat Jul 11, 2020 03:00
Cancers, Vol. 12, Pages 1870: SNAIL Promotes Metastatic Behavior of Rhabdomyosarcoma by Increasing EZRIN and AKT Expression and Regulating MicroRNA Networks Cancers doi: 10.3390/cancers12071870 Authors: Klaudia Skrzypek Marta Kot Paweł Konieczny Artur Nieszporek Anna Kusienicka Małgorzata Lasota Wojciech Bobela Urszula Jankowska Sylwia Kędracka-Krok Marcin Majka Rhabdomyosarcoma (RMS) is a predominant soft tissue tumor in children and adolescents. For high-grade...
Sat Jul 11, 2020 03:00
Cancers, Vol. 12, Pages 1872: Molecular Mechanisms and Potential Therapeutic Reversal of Pancreatic Cancer-Induced Immune Evasion Cancers doi: 10.3390/cancers12071872 Authors: Li-Lian Gan Ling-Wei Hii Shew-Fung Wong Chee-Onn Leong Chun-Wai Mai Pancreatic cancer ranks high among the causes of cancer-related mortality. The prognosis of this grim condition has not improved significantly over the past 50 years, despite advancement in imaging techniques, cancer genetics and treatment...
Sat Jul 11, 2020 03:00
Cancers, Vol. 12, Pages 1866: Targeting SRC Family Kinases in Mesothelioma: Time to Upgrade Cancers doi: 10.3390/cancers12071866 Authors: Indovina Forte Pentimalli Giordano Abstract: Malignant mesothelioma (MM) is a deadly tumor mainly caused by exposure to asbestos. Unfortunately, no current treatment is able to change significantly the natural history of the disease, which has a poor prognosis in the majority of patients. The non-receptor tyrosine kinase SRC and other...
Sat Jul 11, 2020 03:00
Cancers, Vol. 12, Pages 1867: Clinical Significance of Adverse Events for Patients with Unresectable Hepatocellular Carcinoma Treated with Lenvatinib: A Multicenter Retrospective Study Cancers doi: 10.3390/cancers12071867 Authors: Shigeo Shimose Hideki Iwamoto Takashi Niizeki Tomotake Shirono Yu Noda Naoki Kamachi Shusuke Okamura Masahito Nakano Hideya Suga Ryoko Kuromatsu Taizo Yamaguchi Takumi Kawaguchi Masatoshi Tanaka Kazunori Noguchi Hironori...
Sat Jul 11, 2020 03:00
Cancers, Vol. 12, Pages 1865: Cancer-Associated Substitutions in RNA Recognition Motifs of PUF60 and U2AF65 Reveal Residues Required for Correct Folding and 3′ Splice-Site Selection Cancers doi: 10.3390/cancers12071865 Authors: Jana Kralovicova Ivana Borovska Monika Kubickova Peter J. Lukavsky Igor Vorechovsky U2AF65 (U2AF2) and PUF60 (PUF60) are splicing factors important for recruitment of the U2 small nuclear ribonucleoprotein to lariat branch points and selection of 3′...
Sat Jul 11, 2020 03:00
Cancers, Vol. 12, Pages 1864: Muscle Characteristics Obtained Using Computed Tomography as Prognosticators in Patients with Castration-Resistant Prostate Cancer Cancers doi: 10.3390/cancers12071864 Authors: Jongsoo Lee Jee Soo Park Ji Eun Heo Hyun Kyu Ahn Won Sik Jang Won Sik Ham Koon Ho Rha Young Deuk Choi Limited studies have investigated the correlation between body composition and prostate cancer outcomes. We analyzed the effect of muscle mass and quality on...
Fri Jul 10, 2020 03:00
Cancers, Vol. 12, Pages 1861: NCL Inhibition Exerts Antineoplastic Effects against Prostate Cancer Cells by Modulating Oncogenic MicroRNAs Cancers doi: 10.3390/cancers12071861 Authors: Tyler Sheetz Joseph Mills Anna Tessari Megan Pawlikowski Ashley E. Braddom Tasha Posid Debra L. Zynger Cindy James Valerio Embrione Kareesma Parbhoo Claudia Foray Vincenzo Coppola Carlo M. Croce Dario Palmieri Prostate cancer (PCa) is the most frequently diagnosed...
Fri Jul 10, 2020 03:00
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