Related Articles The Global Phosphorylation Landscape of SARS-CoV-2 Infection. Cell. 2020 Jun 28;: Authors: Bouhaddou M, Memon D, Meyer B, White KM, Rezelj VV, Correa Marrero M, Polacco BJ, Melnyk JE, Ulferts S, Kaake RM, Batra J, Richards AL, Stevenson E, Gordon DE, Rojc A, Obernier K, Fabius JM, Soucheray M, Miorin L, Moreno E, Koh C, Tran QD, Hardy A, Robinot R, Vallet T, Nilsson-Payant BE, Hernandez-Armenta C, Dunham A, Weigang S, Knerr J, Modak M, Quintero...
Fri Jul 10, 2020 14:27
Related Articles S-adenosylmethionine and methylthioadenosine boost cellular productivities of antibody forming Chinese Hamster ovary cells. Biotechnol Bioeng. 2020 Jul 09;: Authors: Verhagen N, Teleki A, Heinrich C, Schilling M, Unsöld A, Takors R Abstract The improvement of cell specific productivities for the formation of therapeutic proteins is an important step towards intensified production processes. Among others, the induction of...
Fri Jul 10, 2020 14:27
Related Articles The CREB-binding protein inhibitor ICG-001: a promising therapeutic strategy in sporadic meningioma with NF2 mutations. Neurooncol Adv. 2020 Jan-Dec;2(1):vdz055 Authors: Deng J, Hua L, Han T, Tian M, Wang D, Tang H, Sun S, Chen H, Cheng H, Zhang T, Xie Q, Wan L, Zhu H, Gong Y Abstract Background: Meningiomas with Neurofibromin 2 gene mutations (NF2-mutant meningiomas) account for ~40% of the sporadic meningiomas. However,...
Fri Jul 10, 2020 14:27
Related Articles RICTOR/mTORC2 affects tumorigenesis and therapeutic efficacy of mTOR inhibitors in esophageal squamous cell carcinoma. Acta Pharm Sin B. 2020 Jun;10(6):1004-1019 Authors: Lu Z, Shi X, Gong F, Li S, Wang Y, Ren Y, Zhang M, Yu B, Li Y, Zhao W, Zhang J, Hou G Abstract Dysregulation of mTORC1/mTORC2 pathway is observed in many cancers and mTORC1 inhibitors have been used clinically in many tumor types; however, the mechanism...
Fri Jul 10, 2020 14:27
Related Articles To be or not to be: whether anti-angiogenic agent combined with immune checkpoint inhibitoris necessary in the treatment of advanced or metastatic renal cell carcinoma. Med Oncol. 2020 Feb 01;37(2):15 Authors: Sun L, Zhang L, Yu J, Zhou Y, Shi C, Wasan HS, Ruan S, Huang D Abstract Although it's widely known that targeted therapy against angiogenesis and immunotherapy agents showed survival benefit over chemoradiotherapy in...
Fri Jul 10, 2020 13:27
Related Articles Functional and behavioral signatures of Kv7 activator drug subtypes. Epilepsia. 2020 Jul 11;: Authors: Kanyo R, Wang CK, Locskai LF, Li J, Allison WT, Kurata HT Abstract OBJECTIVE: Voltage-gated potassium channels of the KCNQ (Kv7) family are targeted by a variety of activator compounds with therapeutic potential for treatment of epilepsy. Exploration of this drug class has revealed a variety of effective compounds with diverse...
Sun Jul 12, 2020 15:22
Related Articles Medicinal applications of cannabis/cannabinoids. Curr Opin Psychol. 2020 Jun 20;38:1-10 Authors: Braithwaite I, Bhagavan C, Doppen M, Kung S, Oldfield K, Newton-Howes G Abstract Regulatory approvals for Epidiolex (purified cannabidiol) in the treatment of childhood drug resistant epilepsy have set a precedent for the use of cannabinoids as a prescribed medicine. Two common reasons cited for the use and prescription of cannabis-based...
Sun Jul 12, 2020 15:22
Related Articles A cross-sectional study on the rate of non-adherence to anti-seizure medications and factors associated with non-adherence among patients with epilepsy. PLoS One. 2020;15(7):e0235674 Authors: Teh KX, Henien NPB, Wong LS, Wong ZKH, Raja Ismail RZ, Achok HN, Mariapun J, Yunos NM Abstract BACKGROUND: Non-adherence to anti-seizure medication (ASM) therapy is an important contributing factor to the higher mortality rate and treatment...
Sat Jul 11, 2020 16:29
Related Articles Oxcarbazepine monotherapy in children with benign epilepsy with centrotemporal spikes improves quality of life. Chin Med J (Engl). 2020 Jul 01;: Authors: Liu WT, Yan XX, Cheng DZ, Zhang HZ, Ding N, Xu KM, Zhou XL, Chen Q Abstract BACKGROUND: Benign epilepsy with centrotemporal spikes (BECTS) is the most common type of childhood idiopathic focal epilepsy. BECTS is associated with pervasive cognitive deficits and behavior problems....
Sat Jul 11, 2020 16:29
Related Articles Scientific evidence underlying contraindications to the ketogenic diet: An update. Obes Rev. 2020 Jul 10;: Authors: Watanabe M, Tuccinardi D, Ernesti I, Basciani S, Mariani S, Genco A, Manfrini S, Lubrano C, Gnessi L Abstract First identified as a feasible treatment for intractable epilepsy, the ketogenic diet (KD) has recently gained popularity thanks to growing evidence on applications such as weight loss, most importantly,...
Sat Jul 11, 2020 16:29
Related Articles When Drugs Do Not Work: Alternatives to Antiseizure Medications. Curr Neurol Neurosci Rep. 2020 Jul 09;20(9):37 Authors: Dawit S, Crepeau AZ Abstract PURPOSE OF REVIEW: Despite the increase in the number of novel antiseizure medications over the past 20 years, approximately one-third of patients will not have adequate seizure control on medications. For these patients, additional options need to be considered, including dietary,...
Sat Jul 11, 2020 16:29
Related Articles The metabolic hypothesis is more likely than the epileptogenic hypothesis to explain stroke-like lesions. Wellcome Open Res. 2020;5:51 Authors: Finsterer J Abstract Stroke-like episodes (SLEs) are a hallmark of mitochondrial encephalopathy, lactic acidosis, and stroke-like episode (MELAS) syndrome but occur in other mitochondrial disorders (MIDs) as well. The morphological equivalent of the SLE is the stroke-like lesion (SLL)...
Sat Jul 11, 2020 16:29
Related Articles Measuring the appropriateness of carbamazepine and valproic acid prescribing and utilization using a newly implemented online system in the Tabuk Region of Saudi Arabia. Saudi Pharm J. 2020 Jul;28(7):844-849 Authors: Al-Balawi RS, Alshehri MA, Alatawi AS, Al Shehri AM, Alshehry MA, Al-Gayyar MMH Abstract Epilepsy is a common neurologic disorder, which is efficiently treated with carbamazepine and valproic acid. Moreover, Saudi...
Sat Jul 11, 2020 16:29
Related Articles Electric source imaging for presurgical epilepsy evaluation: current status and future prospects. Expert Rev Med Devices. 2020 May;17(5):405-412 Authors: Mégevand P, Seeck M Abstract Introduction: Electric source imaging (ESI) refers to the estimation of the cerebral sources of electric signals recorded at the head surface using electroencephalography (EEG). Thanks to the availability of EEG systems with high numbers of electrodes...
Sat Jul 11, 2020 16:29
Related Articles Epilepsy-specific patient-reported outcome measures of children's health-related quality of life: A systematic review of measurement properties. Epilepsia. 2020 02;61(2):230-248 Authors: Crudgington H, Rogers M, Morris H, Gringras P, Pal DK, Morris C Abstract OBJECTIVE: To identify and appraise published evidence of the measurement properties for epilepsy-specific patient-reported outcome measures (PROMs) of children's health-related...
Sat Jul 11, 2020 16:29
Related Articles Seizures induce obstructive apnea in DBA/2J audiogenic seizure-prone mice: Lifesaving impact of tracheal implants. Epilepsia. 2020 02;61(2):e13-e16 Authors: Irizarry R, Sukato D, Kollmar R, Schild S, Silverman J, Sundaram K, Stephenson S, Stewart M Abstract The mechanism(s) for sudden death in epilepsy (SUDEP) remain(s) unknown, but seizure spread to brainstem areas serving autonomic and respiratory function is critical. In...
Sat Jul 11, 2020 16:29
Related Articles Impaired vigilance networks in temporal lobe epilepsy: Mechanisms and clinical implications. Epilepsia. 2020 02;61(2):189-202 Authors: Englot DJ, Morgan VL, Chang C Abstract Mesial temporal lobe epilepsy (mTLE) is a neurological disorder in which patients suffer from frequent consciousness-impairing seizures, broad neurocognitive deficits, and diminished quality of life. Although seizures in mTLE originate focally in the hippocampus...
Sat Jul 11, 2020 16:29
Related Articles Trends in pediatric epilepsy surgery in Europe between 2008 and 2015: Country-, center-, and age-specific variation. Epilepsia. 2020 02;61(2):216-227 Authors: Barba C, Cross JH, Braun K, Cossu M, Klotz KA, De Masi S, Perez Jiménez MA, Gaily E, Specchio N, Cabral P, Toulouse J, Dimova P, Battaglia D, Freri E, Consales A, Cesaroni E, Tarta-Arsene O, Gil-Nagel A, Mindruta I, Di Gennaro G, Giulioni M, Tisdall MM, Eltze C, Tahir MZ, Jansen F, van...
Sat Jul 11, 2020 16:29
Related Articles Doing without valproate in women of childbearing potential with idiopathic generalized epilepsy: Implications on seizure outcome. Epilepsia. 2020 01;61(1):107-114 Authors: Cerulli Irelli E, Morano A, Cocchi E, Casciato S, Fanella M, Albini M, Avorio F, Basili LM, Fisco G, Barone FA, Mascia A, D'Aniello A, Manfredi M, Fattouch J, Quarato P, Giallonardo AT, Di Gennaro G, Di Bonaventura C Abstract OBJECTIVE: Valproate (VPA) use...
Sat Jul 11, 2020 16:29
Related Articles Readmission after neurosurgical intervention in epilepsy: A nationwide cohort analysis. Epilepsia. 2020 01;61(1):61-69 Authors: Kwon CS, Agarwal P, Subramaniam V, Dhamoon M, Mazumdar M, Yeshokumar A, Panov F, Ghatan S, Jetté N Abstract OBJECTIVE: Hospital readmissions result in increased health care costs and are associated with worse outcomes after neurosurgical intervention. Understanding factors associated with readmissions...
Sat Jul 11, 2020 16:29
Related Articles Clinical benefit of presurgical EEG-fMRI in difficult-to-localize focal epilepsy: A single-institution retrospective review. Epilepsia. 2020 01;61(1):49-60 Authors: Kowalczyk MA, Omidvarnia A, Abbott DF, Tailby C, Vaughan DN, Jackson GD Abstract OBJECTIVE: The aim of this report is to present our clinical experience of electroencephalography-functional magnetic resonance imaging (EEG-fMRI) in localizing the epileptogenic focus,...
Sat Jul 11, 2020 16:29
Related Articles Prospective validation of a machine learning model that uses provider notes to identify candidates for resective epilepsy surgery. Epilepsia. 2020 01;61(1):39-48 Authors: Wissel BD, Greiner HM, Glauser TA, Holland-Bouley KD, Mangano FT, Santel D, Faist R, Zhang N, Pestian JP, Szczesniak RD, Dexheimer JW Abstract OBJECTIVE: Delay to resective epilepsy surgery results in avoidable disease burden and increased risk of mortality....
Sat Jul 11, 2020 16:29
Related Articles Expectations and knowledge of cannabidiol therapy for childhood epilepsy - A German caregiver survey. Epilepsy Behav. 2020 Jul 06;111:107268 Authors: Klotz KA, Schönberger J, Nakamura L, San Antonio-Arce V, Bast T, Wiemer-Kruel A, Schubert-Bast S, Borggraefe I, Syrbe S, Jacobs J Abstract BACKGROUND: Cannabidiol (CBD) has gained popularity among parents of children with epilepsy, even before evidence of efficacy and safety was...
Fri Jul 10, 2020 17:38
Related Articles Seizure progression triggered by IQSEC3 loss is mitigated by reducing activated microglia in mice. Glia. 2020 Jul 09;: Authors: Park D, Kim S, Kim H, Shin J, Jung H, Um JW Abstract IQSEC3, a guanine nucleotide exchange factor for ADP-ribosylation factors (ARF-GEFs) is specifically expressed at GABAergic synapses, and its loss increases seizure susceptibility in mice. However, the contribution of microglia to initiation and/or...
Fri Jul 10, 2020 17:38
Related Articles Assessment of the long-term efficacy and safety of adjunctive perampanel in tonic-clonic seizures: Analysis of four open-label extension studies. Epilepsia. 2020 Jul 09;: Authors: Rektor I, Krauss GL, Inoue Y, Kaneko S, Williams B, Patten A, Malhotra M, Laurenza A, Wechsler RT Abstract OBJECTIVE: This post hoc analysis evaluated long-term efficacy and safety in patients with focal to bilateral tonic-clonic seizures (FBTCS) or...
Fri Jul 10, 2020 17:38
Related Articles Prevalence and Factors Influencing Visual Memory Dysfunction among Epilepsy Patients-A Single-Center Study. Neurol India. 2020 May-Jun;68(3):581-585 Authors: Beh HC, Tan HJ, Hod R, Khoo CS, Mohamad K Abstract Background: Epilepsy is associated with cognitive impairment due to the disease itself or side-effects of antiepileptic drugs. Objective: We aimed to study the prevalence of visual memory dysfunction among epilepsy...
Fri Jul 10, 2020 17:38
Related Articles STXBP1 Encephalopathies: Clinical Spectrum, Disease Mechanisms and Therapeutic Strategies. J Neurochem. 2020 Jul 08;: Authors: Abramov D, Guiberson NGL, Burré J Abstract Mutations in Munc18-1/STXBP1 (syntaxin-binding protein 1) are linked to various severe early epileptic encephalopathies and neurodevelopmental disorders. Heterozygous mutations in the STXBP1 gene include missense, nonsense, frameshift, and splice site mutations,...
Fri Jul 10, 2020 17:38
Related Articles Rapid ictal transition of focal epilepsy to infantile spasms in neurofibromatosis type 1 captured with EEG. Epilepsy Behav Rep. 2020;14:100374 Authors: Patel SH, Carson RP, Jordan LC, Pagano LM Abstract We report a novel case of an infant with neurofibromatosis type 1 (NF1) who presented with new onset presumed focal impaired awareness seizures with motor onset followed by rapid progression to infantile spasms (IS). Electroencephalography...
Fri Jul 10, 2020 17:38
Cognitive and behavioral outcome of stereotactic laser amydalohippocampotomy in a pediatric setting.
Related Articles Cognitive and behavioral outcome of stereotactic laser amydalohippocampotomy in a pediatric setting. Epilepsy Behav Rep. 2020;14:100370 Authors: Ono KE, Bearden DJ, Adams E, Doescher J, Koh S, Eksioglu Y, Gross RE, Drane DL Abstract We present neuropsychological and functional outcome data in a teenager undergoing stereotactic laser amygdalohippocampotomy (SLAH) who had drug-resistant mesial temporal lobe epilepsy due to left...
Fri Jul 10, 2020 17:38
Related Articles The Protective Effect of Auraptene Against Oxidative Stress and Pentylenetetrazol-Induced Chemical Kindling in Mice. Iran J Pharm Res. 2019;18(3):1395-1402 Authors: Etemad L, Zamani M, Iranshahi M, Roohbakhsh A Abstract It is believed that some pitfalls in the treatment of epilepsy such as serious side effects of medications and drug resistance may be resolved by natural compounds. Auraptene belongs to coumarins and is found...
Fri Jul 10, 2020 17:38
Related Articles Cost effectiveness of surgery for drug resistant temporal lobe epilepsy in the US. Neurology. 2020 Jul 08;: Authors: Sheikh SR, Kattan MW, Steinmetz M, Singer ME, Udeh BL, Jehi L Abstract OBJECTIVE: Surgery is an effective but costly treatment for many patients with drug resistant temporal lobe epilepsy (DR-TLE). We aim to evaluate whether, in the United States, 1) surgery is cost-effective compared to medical management for...
Fri Jul 10, 2020 17:38
Related Articles Pituitary Apoplexy Accompanying Temporal Lobe Seizure as a Complication. World Neurosurg. 2020 06;138:153-157 Authors: Shijo K, Yoshimura S, Mori F, Yamamuro S, Sumi K, Oshima H, Yoshino A Abstract BACKGROUND: Pituitary apoplexy is an acute clinical syndrome caused by infarction and/or hemorrhage of pituitary adenoma, which typically presents with severe headache, visual deterioration, and endocrine abnormalities. However,...
Fri Jul 10, 2020 13:49
Related Articles Perinatal Stroke. Semin Pediatr Neurol. 2019 12;32:100767 Authors: Dunbar M, Kirton A Abstract Perinatal strokes are a diverse but specific group of focal cerebrovascular injuries that occur early in brain development and affect an estimated 5 million people worldwide. The objective of this review is to describe the epidemiology, clinical presentations, pathophysiology, outcomes, and management for the 6 subtypes of perinatal...
Fri Jul 10, 2020 13:49
Related Articles Epilepsy genetics: clinical impacts and biological insights. Lancet Neurol. 2020 01;19(1):93-100 Authors: Ellis CA, Petrovski S, Berkovic SF Abstract Genomics now has an increasingly important role in neurology clinics. Regarding the epilepsies, innovations centred around technology, analytics, and collaboration have led to remarkable progress in gene discovery and have revealed the diverse array of genetic mechanisms and neurobiological...
Fri Jul 10, 2020 13:49
Related Articles Etiology and Outcomes of Thrombotic Microangiopathies. Clin J Am Soc Nephrol. 2019 04 05;14(4):557-566 Authors: Bayer G, von Tokarski F, Thoreau B, Bauvois A, Barbet C, Cloarec S, Mérieau E, Lachot S, Garot D, Bernard L, Gyan E, Perrotin F, Pouplard C, Maillot F, Gatault P, Sautenet B, Rusch E, Buchler M, Vigneau C, Fakhouri F, Halimi JM Abstract BACKGROUND AND OBJECTIVES: Thrombotic microangiopathies constitute a diagnostic...
Fri Jul 10, 2020 13:49
Related Articles The complexity of neuroinflammation consequent to traumatic brain injury: from research evidence to potential treatments. Acta Neuropathol. 2019 05;137(5):731-755 Authors: Morganti-Kossmann MC, Semple BD, Hellewell SC, Bye N, Ziebell JM Abstract This review recounts the definitions and research evidence supporting the multifaceted roles of neuroinflammation in the injured brain following trauma. We summarise the literature...
Fri Jul 10, 2020 13:49
Related Articles StatPearls Book. 2020 01 Authors: Abstract Valproic acid is a branched, and short-chain fatty acid is a derivative of naturally occurring valeric acid. Valproic acid's primary use is as an anti-seizure medication, as well as in migraine, bipolar, mood, and anxiety disorders. Recent work has also demonstrated its efficacy as adjuvant therapy in HIV, cancer, and neurodegenerative diseases as its histone deacetylase (HDAC) inhibition property. Valproic...
Fri Jul 10, 2020 17:38
Related Articles StatPearls Book. 2020 01 Authors: Abstract Epilepsy is a condition where there are at least two seizures (unprovoked) that occur in more than 24 hours apart. The term epilepsy syndrome is to describe a condition that incorporates clinical features, EEG/seizure type, and imaging as a prognosticate treatment response and clinical course. Features that are important in epilepsy syndromes are age, seizure triggers, comorbidities such as psychiatric...
Fri Jul 10, 2020 17:38
Related Articles Optimal control of acute myeloid leukaemia. J Theor Biol. 2019 06 07;470:30-42 Authors: Sharp JA, Browning AP, Mapder T, Burrage K, Simpson MJ Abstract Acute myeloid leukaemia (AML) is a blood cancer affecting haematopoietic stem cells. AML is routinely treated with chemotherapy, and so it is of great interest to develop optimal chemotherapy treatment strategies. In this work, we incorporate an immune response into a stem cell...
Fri Jul 10, 2020 13:06
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