Cancers, Vol. 12, Pages 1861: NCL Inhibition Exerts Antineoplastic Effects against Prostate Cancer Cells by Modulating Oncogenic MicroRNAs Cancers doi: 10.3390/cancers12071861 Authors: Tyler Sheetz Joseph Mills Anna Tessari Megan Pawlikowski Ashley E. Braddom Tasha Posid Debra L. Zynger Cindy James Valerio Embrione Kareesma Parbhoo Claudia Foray Vincenzo Coppola Carlo M. Croce Dario Palmieri Prostate cancer (PCa) is the most frequently diagnosed...
Fri Jul 10, 2020 03:00
Cancers, Vol. 12, Pages 1862: Immunotherapy in Hepatocellular Cancer Patients with Mild to Severe Liver Dysfunction: Adjunctive Role of the ALBI Grade Cancers doi: 10.3390/cancers12071862 Authors: David J. Pinato Takahiro Kaneko Anwaar Saeed Tiziana Pressiani Ahmed Kaseb Yinghong Wang David Szafron Tomi Jun Sirish Dharmapuri Abdul Rafeh Naqash Mahvish Muzaffar Musharraf Navaid Chieh-Ju Lee Anushi Bulumulle Bo Yu Sonal Paul Neil Nimkar Dominik...
Fri Jul 10, 2020 03:00
Cancers, Vol. 12, Pages 1860: Tumor-Associated Neutrophils Dampen Adaptive Immunity and Promote Cutaneous Squamous Cell Carcinoma Development Cancers doi: 10.3390/cancers12071860 Authors: Sokchea Khou Alexandra Popa Carmelo Luci Franck Bihl Aida Meghraoui-Kheddar Pierre Bourdely Emie Salavagione Estelle Cosson Alain Rubod Julie Cazareth Pascal Barbry Bernard Mari Roger Rezzonico Fabienne Anjuère Veronique M. Braud Cutaneous squamous cell carcinoma...
Fri Jul 10, 2020 03:00
Cancers, Vol. 12, Pages 1863: A Molecular Stratification of Chilean Gastric Cancer Patients with Potential Clinical Applicability Cancers doi: 10.3390/cancers12071863 Authors: Mauricio P. Pinto Miguel Córdova-Delgado Ignacio N. Retamal Matías Muñoz-Medel M. Loreto Bravo Doris Durán Francisco Villanueva César Sanchez Francisco Acevedo Sebastián Mondaca Érica Koch Carolina Ibañez Héctor Galindo Jorge Madrid Bruno Nervi José Peña Javiera Torres...
Fri Jul 10, 2020 03:00
Cancers, Vol. 12, Pages 1858: Efficient Therapeutic Delivery by a Novel Cell-Penetrating Peptide Derived from Acinus Cancers doi: 10.3390/cancers12071858 Authors: Justine Habault Claire Fraser Ewa Pasquereau-Kotula Maëlys Born-Bony Anne Marie-Cardine Jean-Luc Poyet In this study, we have identified a novel cell-penetrating sequence, termed hAP10, from the C-terminus of the human protein Acinus. hAP10 was able to efficiently enter various normal and cancerous cells, likely...
Fri Jul 10, 2020 03:00
Cancers, Vol. 12, Pages 1857: Metformin and Probiotics in the Crosstalk between Colitis-Associated Colorectal Cancer and Diabetes in Mice Cancers doi: 10.3390/cancers12071857 Authors: Sahar Al Kattar Rosalyn Jurjus Aline Pinon David Yannick Leger Abdo Jurjus Chawki Boukarim Mona Diab-Assaf Bertrand Liagre The co-occurrence of colorectal cancer (CRC) and diabetes mellitus along with inflammation and dismicrobism has been frequently reported. Several studies shed light...
Fri Jul 10, 2020 03:00
Cancers, Vol. 12, Pages 1859: Hormones Secretion and Rho GTPases in Neuroendocrine Tumors Cancers doi: 10.3390/cancers12071859 Authors: Laura Streit Laurent Brunaud Nicolas Vitale Stéphane Ory Stéphane Gasman Neuroendocrine tumors (NETs) belong to a heterogeneous group of neoplasms arising from hormone secreting cells. These tumors are often associated with a dysfunction of their secretory activity. Neuroendocrine secretion occurs through calcium-regulated exocytosis, a process...
Fri Jul 10, 2020 03:00
Cancers, Vol. 12, Pages 1856: Detecting Progression of Melanocytic Choroidal Tumors by Sequential Imaging: Is Ultrasonography Necessary? Cancers doi: 10.3390/cancers12071856 Authors: Kelsey A. Roelofs Roderick O’Day Lamis Al Al Harby Gordon Hay Amit K. Arora Victoria M.L. Cohen Mandeep S. Sagoo Bertil E. Damato Purpose: To determine if ultrasonography is necessary to detect progression of choroidal melanocytic tumors undergoing sequential multi-modal imaging with...
Fri Jul 10, 2020 03:00
Cancers, Vol. 12, Pages 1855: Precision Science on Incidence and Progression of Early-Detected Small Breast Invasive Cancers by Mammographic Features Cancers doi: 10.3390/cancers12071855 Authors: Rene Wei-Jung Chang Shu-Lin Chuang Chen-Yang Hsu Amy Ming-Fang Yen Wendy Yi-Ying Wu Sam Li-Sheng Chen Jean Ching-Yuan Fann Laszlo Tabar Robert A. Smith Stephen W. Duffy Sherry Yueh-Hsia Chiu Hsiu-Hsi Chen The aim was to evaluate how the inter-screening interval...
Fri Jul 10, 2020 03:00
Cells, Vol. 9, Pages 1677: Inhibition of NF-κB Signaling Alters Acute Myelogenous Leukemia Cell Transcriptomics Cells doi: 10.3390/cells9071677 Authors: Håkon Reikvam Acute myelogenous leukemia (AML) is an aggressive hematological malignancy. The pathophysiology of the disease depends on cytogenetic abnormalities, gene mutations, aberrant gene expressions, and altered epigenetic regulation. Although new pharmacological agents have emerged during the last years, the prognosis is still...
Sun Jul 12, 2020 03:00
Cells, Vol. 9, Pages 1676: Maternal Immune Activation Sensitizes Male Offspring Rats to Lipopolysaccharide-Induced Microglial Deficits Involving the Dysfunction of CD200–CD200R and CX3CL1–CX3CR1 Systems Cells doi: 10.3390/cells9071676 Authors: Katarzyna Chamera Magdalena Szuster-Głuszczak Ewa Trojan Agnieszka Basta-Kaim Early life challenges resulting from maternal immune activation (MIA) may exert persistent effects on the offspring, including the development of psychiatric...
Sun Jul 12, 2020 03:00
Cells, Vol. 9, Pages 1675: Evolution of Regulated Transcription Cells doi: 10.3390/cells9071675 Authors: Oleg V. Bylino Airat N. Ibragimov Yulii V. Shidlovskii The genomes of all organisms abound with various cis-regulatory elements, which control gene activity. Transcriptional enhancers are a key group of such elements in eukaryotes and are DNA regions that form physical contacts with gene promoters and precisely orchestrate gene expression programs. Here, we follow gradual evolution...
Sun Jul 12, 2020 03:00
Cells, Vol. 9, Pages 1674: Are FDA-Approved Sunscreen Components Effective in Preventing Solar UV-Induced Skin Cancer? Cells doi: 10.3390/cells9071674 Authors: Ann M. Bode Eunmiri Roh Solar ultraviolet (SUV) exposure is a major risk factor in the etiology of cutaneous squamous cell carcinoma (cSCC). People commonly use sunscreens to prevent SUV-induced skin damage and cancer. Nonetheless, the prevalence of cSCC continues to increase every year, suggesting that commercially available...
Sat Jul 11, 2020 03:00
Cells, Vol. 9, Pages 1672: MRIP Regulates the Myosin IIA Activity and DDR1 Function to Enable Collagen Tractional Remodeling Cells doi: 10.3390/cells9071672 Authors: Nuno M. Coelho Andrew Wang Petar Petrovic Yongqiang Wang Wilson Lee Christopher A. McCulloch DDR1 is a collagen adhesion-mechanoreceptor expressed in fibrotic lesions. DDR1 mediates non-muscle myosin IIA (NMIIA)-dependent collagen remodeling. We discovered that the myosin phosphatase Rho-interacting protein...
Sat Jul 11, 2020 03:00
Cells, Vol. 9, Pages 1673: Formation of Aberrant Myotubes by Myoblasts Lacking Myosin VI Is Associated with Alterations in the Cytoskeleton Organization, Myoblast Adhesion and Fusion Cells doi: 10.3390/cells9071673 Authors: Lilya Lehka Małgorzata Topolewska Dominika Wojton Olena Karatsai Paloma Alvarez-Suarez Paweł Pomorski Maria Jolanta Rędowicz We have previously postulated that unconventional myosin VI (MVI) could be involved in myoblast differentiation. Here, we...
Sat Jul 11, 2020 03:00
Cells, Vol. 9, Pages 1671: Oxygen-Dependent Accumulation of Purine DNA Lesions in Cockayne Syndrome Cells Cells doi: 10.3390/cells9071671 Authors: Marios G. Krokidis Mariarosaria D’Errico Barbara Pascucci Eleonora Parlanti Annalisa Masi Carla Ferreri Chryssostomos Chatgilialoglu Cockayne Syndrome (CS) is an autosomal recessive neurodegenerative premature aging disorder associated with defects in nucleotide excision repair (NER). Cells from CS patients, with mutations...
Sat Jul 11, 2020 03:00
Cells, Vol. 9, Pages 1670: Blockade of 67-kDa Laminin Receptor Facilitates AQP4 Down-Regulation and BBB Disruption Via ERK1/2-and p38 MAPK-Mediated PI3K/AKT Activations Cells doi: 10.3390/cells9071670 Authors: Ji-Eun Kim Hana Park Ji-Eun Lee Tae-Cheon Kang Recently, we have reported that dysfunctions of 67-kDa laminin receptor (67LR) induced by status epilepticus (SE, a prolonged seizure activity) and 67LR neutralization are involved in vasogenic edema formation, accompanied...
Sat Jul 11, 2020 03:00
Cells, Vol. 9, Pages 1669: Granulocyte Colony Stimulating Factor (GCSF) Can Attenuate Neuropathic Pain by Suppressing Monocyte Chemoattractant Protein-1 (MCP-1) Expression, through Upregulating the Early MicroRNA-122 Expression in the Dorsal Root Ganglia Cells doi: 10.3390/cells9071669 Authors: Ming-Feng Liao Jung-Lung Hsu Kwok-Tung Lu Po-Kuan Chao Mei-Yun Cheng Hui-Ching Hsu Ai-Lun Lo Yun-Lin Lee Yu-Hui Hung Rong-Kuo Lyu Hung-Chou Kuo Chun-Che Chu Long-Sun...
Sat Jul 11, 2020 03:00
Cells, Vol. 9, Pages 1668: Cerebral MRI and Clinical Findings in Children with PTEN Hamartoma Tumor Syndrome: Can Cerebral MRI Scan Help to Establish an Earlier Diagnosis of PHTS in Children? Cells doi: 10.3390/cells9071668 Authors: Plamper Michaela Born Mark Gohlke Bettina Schreiner Felix Schulte Sandra Splittstößer Vera Woelfle Joachim Background: PTEN Hamartoma Tumor Syndrome (PHTS) is caused by germline autosomal-dominant mutations of the tumor suppressor gene PTEN....
Fri Jul 10, 2020 03:00
Cells, Vol. 9, Pages 1667: Soluble St2 Induces Cardiac Fibroblast Activation and Collagen Synthesis via Neuropilin-1 Cells doi: 10.3390/cells9071667 Authors: Lara Matilla Vanessa Arrieta Eva Jover Amaia Garcia-Peña Ernesto Martinez-Martinez Rafael Sadaba Virginia Alvarez Adela Navarro Amaya Fernandez-Celis Alicia Gainza Enrique Santamaria Joaquín Fernandez-Irigoyen Patrick Rossignol Faiez Zannad Natalia Lopez-Andres Circulating levels of soluble...
Fri Jul 10, 2020 03:00
Cells, Vol. 9, Pages 1666: Disclosing the Interactome of Leukemogenic NUP98-HOXA9 and SET-NUP214 Fusion Proteins Using a Proteomic Approach Cells doi: 10.3390/cells9071666 Authors: Adélia Mendes Ramona Jühlen Sabrina Bousbata Birthe Fahrenkrog The interaction of oncogenes with cellular proteins is a major determinant of cellular transformation. The NUP98-HOXA9 and SET-NUP214 chimeras result from recurrent chromosomal translocations in acute leukemia. Functionally, the two fusion...
Fri Jul 10, 2020 03:00
Cells, Vol. 9, Pages 1663: Unravelling the Complex Duplication History of Deuterostome Glycerol Transporters Cells doi: 10.3390/cells9071663 Authors: Ozlem Yilmaz François Chauvigné Alba Ferré Frank Nilsen Per Gunnar Fjelldal Joan Cerdà Roderick Nigel Finn Transmembrane glycerol transport is an ancient biophysical property that evolved in selected subfamilies of water channel (aquaporin) proteins. Here, we conducted broad level genome (>550) and transcriptome...
Fri Jul 10, 2020 03:00
Cells, Vol. 9, Pages 1664: High Mobility Group Box 1 in Human Cancer Cells doi: 10.3390/cells9071664 Authors: Rapoport Steel Theron Heyman Smit Ramdas Anderson High mobility group box 1 (HMGB1) is an extremely versatile protein that is located predominantly in the nucleus of quiescent eukaryotic cells, where it is critically involved in maintaining genomic structure and function. During cellular stress, however, this multifaceted, cytokine-like protein undergoes...
Fri Jul 10, 2020 03:00
Cells, Vol. 9, Pages 1662: Downregulation of Drp1 and Fis1 Inhibits Mitochondrial Fission and Prevents High Glucose-Induced Apoptosis in Retinal Endothelial Cells Cells doi: 10.3390/cells9071662 Authors: Dongjoon Kim Aravind Sankaramoorthy Sayon Roy Diabetic retinopathy is a prevalent microvascular complication characterized by apoptotic vascular cell loss in the retina. Previous studies have shown that high glucose (HG)-induced mitochondrial fragmentation plays a critical role...
Fri Jul 10, 2020 03:00
Cells, Vol. 9, Pages 1665: DNA Damage: From Threat to Treatment Cells doi: 10.3390/cells9071665 Authors: Antonio Carusillo Claudio Mussolino DNA is the source of genetic information, and preserving its integrity is essential in order to sustain life. The genome is continuously threatened by different types of DNA lesions, such as abasic sites, mismatches, interstrand crosslinks, or single-stranded and double-stranded breaks. As a consequence, cells have evolved specialized DNA damage...
Fri Jul 10, 2020 03:00
Cells, Vol. 9, Pages 1661: Inhibition of HDAC1/2 Along with TRAP1 Causes Synthetic Lethality in Glioblastoma Model Systems Cells doi: 10.3390/cells9071661 Authors: Trang T. T. Nguyen Yiru Zhang Enyuan Shang Chang Shu Catarina M. Quinzii Mike-Andrew Westhoff Georg Karpel-Massler Markus D. Siegelin The heterogeneity of glioblastomas, the most common primary malignant brain tumor, remains a significant challenge for the treatment of these devastating tumors. Therefore,...
Fri Jul 10, 2020 03:00
Cells, Vol. 9, Pages 1660: Mechanisms behind the Immunoregulatory Dialogue between Mesenchymal Stem Cells and Th17 Cells Cells doi: 10.3390/cells9071660 Authors: Claudia Terraza-Aguirre Mauricio Campos-Mora Roberto Elizondo-Vega Rafael A. Contreras-López Patricia Luz-Crawford Christian Jorgensen Farida Djouad Mesenchymal stem cells (MSCs) exhibit potent immunoregulatory abilities by interacting with cells of the adaptive and innate immune system. In vitro, MSCs inhibit...
Fri Jul 10, 2020 03:00
Chemosensors, Vol. 8, Pages 53: Evaluation of a Reduced Graphene Oxide-Sb Nanoparticles Electrochemical Sensor for the Detection of Cadmium and Lead in Chamomile Tea Chemosensors doi: 10.3390/chemosensors8030053 Authors: Erik W. Nunes Martin K. L. Silva Ivana Cesarino The development of electroanalytical sensors for heavy metals detection in complex matrices holds great interest. Herein, a sensor based on a reduced graphene oxide (rGO) modified with antimony nanoparticles (Sb)...
Fri Jul 10, 2020 03:00
Cosmetics, Vol. 7, Pages 55: Synthesis of Resorcinol Derivatives and their Effects on Melanin Production Cosmetics doi: 10.3390/cosmetics7030055 Authors: Yoshihiro Tokudome Tsuyoshi Hoshi Sayaka Mori Ichiro Hijikuro Several resorcinol derivatives were synthesized and their effects on the survival rate of B16 murine melanoma cells, melanin production, and tyrosinase activity were investigated with an aim to evaluate their skin whitening effect. Twelve resorcinol derivatives were...
Sat Jul 11, 2020 03:00
Cosmetics, Vol. 7, Pages 54: Preliminary Evidence of a Molecular Detection Method to Analyze Bacterial DNA as a Quality Indicator in Cosmetics Cosmetics doi: 10.3390/cosmetics7030054 Authors: Luca Michelutti Michela Bulfoni Veronica Bolzon Emanuele Nencioni Cosmetics are a category of widely consumed and distributed products, and their manufacture is always subject to specific guidelines. Quality Control (QC) tests provide information supporting the absence of injurious organisms...
Fri Jul 10, 2020 03:00
Diagnostics, Vol. 10, Pages 473: Hemodynamic Changes in the Carotid Artery after Infusion of Normal Saline Using Computational Fluid Dynamics Diagnostics doi: 10.3390/diagnostics10070473 Authors: Ui Yun Lee Chul In Kim Gyung Ho Chung Jinmu Jung Hyo Sung Kwak Purpose: To study the effect of the infusion of normal saline on hemodynamic changes in healthy volunteers using computational fluid dynamics (CFD) simulation. Methods: Eight healthy subjects participated and 16 carotid...
Sun Jul 12, 2020 03:00
Diagnostics, Vol. 10, Pages 472: Evaluation of Commercial qPCR Kits for Detection of SARS-CoV-2 in Pooled Samples Diagnostics doi: 10.3390/diagnostics10070472 Authors: Vlad Petrovan Virgil Vrajmasu Ana Cristina Bucur Dan Sebastian Soare Eugen Radu Paula Dimon Mihaela Zaulet Due to the current pandemic, a global shortage of reagents has drawn interest in developing alternatives to increase the number of coronavirus tests. One such alternative is sample pooling. We compared...
Sat Jul 11, 2020 03:00
Diagnostics, Vol. 10, Pages 470: Azygos Lobe: Prevalence of an Anatomical Variant and Its Recognition among Postgraduate Physicians Diagnostics doi: 10.3390/diagnostics10070470 Authors: Asma’a Al-Mnayyis Zina Al-Alami Neveen Altamimi Khaled Z. Alawneh Abdelwahab Aleshawi The right azygos lobe is a rare anatomical variant of the upper lung lobe that can be misdiagnosed as a neoplasm, a lung abscess, or a bulla. The aim of this study was to assess the prevalence of right azygos...
Fri Jul 10, 2020 03:00
Diagnostics, Vol. 10, Pages 469: The Interrelationship between Ventilatory Inefficiency and Left Ventricular Ejection Fraction in Terms of Cardiovascular Outcomes in Heart Failure Outpatients Diagnostics doi: 10.3390/diagnostics10070469 Authors: Shyh-Ming Chen Lin-Yi Wang Po-Jui Wu Mei-Yun Liaw Yung-Lung Chen An-Ni Chen Tzu-Hsien Tsai Chi-Ling Hang Meng-Chih Lin The relationship between left ventricular ejection fraction (LVEF) and cardiovascular (CV) outcome...
Fri Jul 10, 2020 03:00
Diagnostics, Vol. 10, Pages 471: Diagnostic Ability of Structural Transcranial Sonography in Patients with Alzheimer’s Disease Diagnostics doi: 10.3390/diagnostics10070471 Authors: Daiva Rastenyte Vaidas Matijosaitis Ovidijus Laucius Rymante Gleizniene Simonas Jesmanas Kristina Jureniene The aim of this study was to assess the diagnostic ability of transcranial sonography (TCS) for the evaluation of the medial temporal lobe (MTL) in Alzheimer’s disease (AD)....
Fri Jul 10, 2020 03:00
Diagnostics, Vol. 10, Pages 468: Anthropometric and Biochemical Markers as Possible Indicators of Left Ventricular Abnormal Geometric Pattern and Function Impairment in Obese Normotensive Children Diagnostics doi: 10.3390/diagnostics10070468 Authors: Filippina Giannisi Anastasia Keivanidou Ioanna Sakellari Sofia Balala Maria Hassapidou Areti Hitoglou-Makedou Andreas Giannopoulos Εmerging data indicate that various effects of obesity on the cardiovascular...
Fri Jul 10, 2020 03:00
Diversity, Vol. 12, Pages 278: Oral Microbiome Metabarcoding in Two Invasive Small Mammals from New Zealand Diversity doi: 10.3390/d12070278 Authors: Arsalan Emami-Khoyi Isma Benmazouz Adrian M. Paterson James G. Ross Elaine C. Murphy Jennifer Bothwell Hossein Alizadeh Bettine Jansen van Vuuren Peter R. Teske All multicellular organisms host a wide diversity of microorganisms in and on their bodies, which are collectively known as their microbiome. Characterising...
Fri Jul 10, 2020 03:00
Diversity, Vol. 12, Pages 277: Seasonal and Agricultural Response of Acidobacteria Present in Two Fynbos Rhizosphere Soils Diversity doi: 10.3390/d12070277 Authors: Tersia Conradie Karin Jacobs The Acidobacteria is one of the most abundant phyla in most soil types. Fynbos plants are endemic to South Africa, and these soils provide the ideal habitat for Acidobacteria, because of its low pH and oligotrophic properties. However, little is known about their distribution in the fynbos...
Fri Jul 10, 2020 03:00
Foods, Vol. 9, Pages 918: Recovery of Phytochemicals via Electromagnetic Irradiation (Microwave-Assisted-Extraction): Betalain and Phenolic Compounds in Perspective Foods doi: 10.3390/foods9070918 Authors: Moh Moh Zin Chukwuka Bethel Anucha Szilvia Bánvölgyia Food colorants processed via agro-industrial wastes are in demand as food waste management becomes vital not only for its health benefits but also for cost reduction through waste valorization. Huge efforts have been made...
Sun Jul 12, 2020 03:00
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